{"id":"https://openalex.org/W2016753680","doi":"https://doi.org/10.1111/j.1349-7006.2001.tb01102.x","title":"Overexpression of CDK2 Is a Prognostic Indicator of Oral Cancer Progression","display_name":"Overexpression of CDK2 Is a Prognostic Indicator of Oral Cancer Progression","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W2016753680","doi":"https://doi.org/10.1111/j.1349-7006.2001.tb01102.x","mag":"2016753680","pmid":"https://pubmed.ncbi.nlm.nih.gov/11267947","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5926707"},"language":"en","primary_location":{"id":"doi:10.1111/j.1349-7006.2001.tb01102.x","doi":"https://doi.org/10.1111/j.1349-7006.2001.tb01102.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.2001.tb01102.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.2001.tb01102.x","source":{"id":"https://openalex.org/S4210193983","display_name":"Japanese Journal of Cancer Research","issn_l":"0910-5050","issn":["0910-5050","1344-6428","1876-4673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.2001.tb01102.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109283774","display_name":"Mariko Mihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mariko Mihara","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, Okayama 700-8525, Japan. marichan@dent.okayama-u.ac.jp","Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, 2\u20105\u20101 Shikata, Okayama 700\u20108525"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, Okayama 700-8525, Japan. marichan@dent.okayama-u.ac.jp","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, 2\u20105\u20101 Shikata, Okayama 700\u20108525","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108566158","display_name":"Satoru Shintani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Shintani","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, 2-5-1 Shikata, Okayama 700-8525"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, 2-5-1 Shikata, Okayama 700-8525","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111558504","display_name":"Yuuji Nakahara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuuji Nakahara","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, 2-5-1 Shikata, Okayama 700-8525"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, 2-5-1 Shikata, Okayama 700-8525","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064839735","display_name":"Akihisa Kiyota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihisa Kiyota","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, 2-5-1 Shikata, Okayama 700-8525"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, 2-5-1 Shikata, Okayama 700-8525","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113598975","display_name":"Yoshiya Ueyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiya Ueyama","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, 2-5-1 Shikata, Okayama 700-8525"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, 2-5-1 Shikata, Okayama 700-8525","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113730451","display_name":"Tomohiro Matsumura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiro Matsumura","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, 2-5-1 Shikata, Okayama 700-8525"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, 2-5-1 Shikata, Okayama 700-8525","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087543035","display_name":"David T. Wong","orcid":"https://orcid.org/0000-0002-0290-2206","observed_orcids":["https://orcid.org/0000-0002-0290-2206"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. W. Wong","raw_affiliation_strings":["Laboratory of Molecular Pathology, Division of Oral Pathology, Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pathology, Division of Oral Pathology, Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109283774"],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":null,"apc_paid":null,"fwci":3.2309,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.90801608,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"92","issue":"3","first_page":"352","last_page":"360"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdk2","display_name":"CDK2","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cyclin-a","display_name":"cyclin A","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cyclin-e","display_name":"cyclin E","score":1.0},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/oral-cancer-progression","display_name":"oral cancer progression","score":0.8809999823570251},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/oral-epithelial-dysplasia","display_name":"oral dysplasia","score":0.8679999709129333},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.7063605785369873},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.6890299916267395},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.6829806566238403},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6108239889144897},{"id":"https://openalex.org/C94561458","wikidata":"https://www.wikidata.org/wiki/Q24724860","display_name":"Cyclin E","level":5,"score":0.5985734462738037},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5626623034477234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5380468368530273},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5278698801994324},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5236104130744934},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5013704299926758},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.4601784944534302},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4495023787021637},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.4486244320869446},{"id":"https://openalex.org/C16438837","wikidata":"https://www.wikidata.org/wiki/Q5198260","display_name":"Cyclin A","level":5,"score":0.4450254440307617},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43309804797172546},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.41838616132736206},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3616500496864319},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3027929961681366},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.14820915460586548}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D019925","descriptor_name":"Cyclin A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019927","descriptor_name":"Cyclin E","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D042846","descriptor_name":"CDC2-CDC28 Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051357","descriptor_name":"Cyclin-Dependent Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051358","descriptor_name":"Cyclin-Dependent Kinase 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1349-7006.2001.tb01102.x","doi":"https://doi.org/10.1111/j.1349-7006.2001.tb01102.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.2001.tb01102.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.2001.tb01102.x","source":{"id":"https://openalex.org/S4210193983","display_name":"Japanese Journal of Cancer Research","issn_l":"0910-5050","issn":["0910-5050","1344-6428","1876-4673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4865135","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5926707","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5926707","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5926707","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jpn J Cancer Res","raw_type":"Text"},{"id":"pmid:11267947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11267947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of cancer research : Gann","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1111/j.1349-7006.2001.tb01102.x","doi":"https://doi.org/10.1111/j.1349-7006.2001.tb01102.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.2001.tb01102.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.2001.tb01102.x","source":{"id":"https://openalex.org/S4210193983","display_name":"Japanese Journal of Cancer Research","issn_l":"0910-5050","issn":["0910-5050","1344-6428","1876-4673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G8251177804","display_name":"CELL CYCLE REGULATORS OF ORAL CANCER","funder_award_id":"P01DE012467","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G8557359483","display_name":"CELLULAR/MOLECULAR DETERMINANTS IN ORAL CARCINOGENESIS","funder_award_id":"R01DE008680","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2016753680.pdf"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W91182734","https://openalex.org/W177595770","https://openalex.org/W1544564404","https://openalex.org/W1597565122","https://openalex.org/W1910656974","https://openalex.org/W1962394042","https://openalex.org/W1967341367","https://openalex.org/W1974391793","https://openalex.org/W1979669293","https://openalex.org/W1989232500","https://openalex.org/W1994066190","https://openalex.org/W1997643531","https://openalex.org/W2001174913","https://openalex.org/W2003141153","https://openalex.org/W2004497068","https://openalex.org/W2013950325","https://openalex.org/W2020408434","https://openalex.org/W2027558915","https://openalex.org/W2029080338","https://openalex.org/W2035500530","https://openalex.org/W2036696412","https://openalex.org/W2038252730","https://openalex.org/W2039263836","https://openalex.org/W2048721919","https://openalex.org/W2053432671","https://openalex.org/W2055347362","https://openalex.org/W2055349083","https://openalex.org/W2065252383","https://openalex.org/W2068494600","https://openalex.org/W2069869793","https://openalex.org/W2070147996","https://openalex.org/W2090303261","https://openalex.org/W2112555367","https://openalex.org/W2134025851","https://openalex.org/W2139561751","https://openalex.org/W2141356253","https://openalex.org/W2152028923","https://openalex.org/W2155103945","https://openalex.org/W2155999053","https://openalex.org/W2156157871","https://openalex.org/W2170542245","https://openalex.org/W2419027605"],"related_works":["https://openalex.org/W1982258349","https://openalex.org/W2127655110","https://openalex.org/W2364492592","https://openalex.org/W7147191456","https://openalex.org/W2019428861","https://openalex.org/W2230741665","https://openalex.org/W2375906018","https://openalex.org/W2165664444","https://openalex.org/W2793359389","https://openalex.org/W568097396"],"abstract_inverted_index":{"Cyclins":[0],"and":[1,23,35,53,56,66,77,80,89,110,138,162],"cyclin-dependent":[2],"kinases":[3],"(CDKs)":[4],"play":[5],"key":[6],"roles":[7],"in":[8,39,58,85,158],"cell":[9,21,70],"cycle":[10],"regulation,":[11],"a":[12,155,167],"process":[13],"of":[14,33,51,75,106,132,152,171],"which":[15],"dysregulation":[16],"can":[17,163],"lead":[18],"to":[19,25,95],"uncontrolled":[20],"growth":[22],"hence":[24],"cancer.":[26,41],"We":[27],"have":[28],"already":[29],"reported":[30],"the":[31,49,86,104,111,149,172],"alteration":[32],"CDK4":[34],"cyclin":[36],"D1":[37],"expression":[38,50,105,115,151],"oral":[40,61,68,159],"In":[42],"this":[43],"study,":[44],"we":[45],"examined":[46],"by":[47],"immunohistochemistry":[48],"CDK2,":[52,76],"cyclins":[54,78,107],"A":[55,79],"E":[57,81,109],"20":[59],"normal":[60,87],"mucosa,":[62],"42":[63],"dysplastic":[64],"epithelia,":[65],"103":[67],"squamous":[69],"carcinomas":[71],"(SCCs).":[72],"The":[73],"expressions":[74],"were":[82,99],"not":[83],"detected":[84],"epithelium":[88],"significantly":[90,117],"altered":[91],"from":[92],"epithelial":[93],"dysplasia":[94],"SCC.":[96],"While":[97],"there":[98],"no":[100],"significant":[101],"correlations":[102],"between":[103],"A,":[108],"patients'":[112,173],"survival,":[113],"CDK2":[114,153],"was":[116],"correlated":[118],"with":[119],"lymph":[120],"node":[121],"involvement":[122],"(P":[123,128,135,142],"=":[124,129,136,143],"0.025),":[125],"tumor":[126,133],"differentiation":[127],"0.032),":[130],"mode":[131],"invasion":[134],"0.017),":[137],"shorter":[139],"survival":[140],"period":[141],"0.0173).":[144],"These":[145],"results":[146],"suggest":[147],"that":[148],"elevated":[150],"is":[154],"critical":[156],"factor":[157],"cancer":[160],"progression":[161],"be":[164],"used":[165],"as":[166],"negative":[168],"predictive":[169],"marker":[170],"prognosis.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
