{"id":"https://openalex.org/W2016708971","doi":"https://doi.org/10.1002/ijc.11448","title":"EGF +61 gene polymorphism and susceptibility to and prognostic markers in cutaneous malignant melanoma","display_name":"EGF +61 gene polymorphism and susceptibility to and prognostic markers in cutaneous malignant melanoma","publication_year":2003,"publication_date":"2003-09-24","ids":{"openalex":"https://openalex.org/W2016708971","doi":"https://doi.org/10.1002/ijc.11448","mag":"2016708971","pmid":"https://pubmed.ncbi.nlm.nih.gov/14520709"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.11448","doi":"https://doi.org/10.1002/ijc.11448","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.11448","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021068435","display_name":"Sarah L. McCarron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah L. McCarron","raw_affiliation_strings":["Histocompatibility and Immunogenetics Laboratory, Southampton University Hospitals, Southampton, UK","Human Genetics Division, University of Southampton, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Histocompatibility and Immunogenetics Laboratory, Southampton University Hospitals, Southampton, UK","institution_ids":["https://openalex.org/I2802965805"]},{"raw_affiliation_string":"Human Genetics Division, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020908496","display_name":"Adrian Calvin Bateman","orcid":"https://orcid.org/0000-0003-2222-4104","observed_orcids":["https://orcid.org/0000-0003-2222-4104"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adrian C. Bateman","raw_affiliation_strings":["Department of Cellular Pathology, Southampton General Hospital, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Pathology, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109965309","display_name":"Jeffrey M. Theaker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jeffrey M. Theaker","raw_affiliation_strings":["Department of Cellular Pathology, Southampton General Hospital, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Pathology, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111784343","display_name":"W. M. Howell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"W. Martin Howell","raw_affiliation_strings":["","Histocompatibility and Immunogenetics Laboratory, Southampton University Hospitals, Southampton, UK","Human Genetics Division, University of Southampton, Southampton, UK","Fax: +44-23-8070-1416"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Histocompatibility and Immunogenetics Laboratory, Southampton University Hospitals, Southampton, UK","institution_ids":["https://openalex.org/I2802965805"]},{"raw_affiliation_string":"Human Genetics Division, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"Fax: +44-23-8070-1416","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111784343"],"corresponding_institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":2.8167,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.90371731,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"107","issue":"4","first_page":"673","last_page":"675"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.02539999969303608,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cutaneous-melanoma","display_name":"cutaneous melanoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8610000014305115},{"id":"https://openalex.org/keywords/breslow-thickness","display_name":"Breslow thickness","score":0.871999979019165},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8240000009536743},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7950000166893005},{"id":"https://openalex.org/keywords/uv-exposure","display_name":"UV exposure","score":0.48399999737739563},{"id":"https://openalex.org/keywords/mitotic-count","display_name":"mitotic count","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.8142353296279907},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.6846249103546143},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.6838010549545288},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5489887595176697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5254563093185425},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.47226276993751526},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44692984223365784},{"id":"https://openalex.org/C143660080","wikidata":"https://www.wikidata.org/wiki/Q7684883","display_name":"TaqMan","level":4,"score":0.4446754455566406},{"id":"https://openalex.org/C2908643394","wikidata":"https://www.wikidata.org/wiki/Q827546","display_name":"Breslow Thickness","level":5,"score":0.4302780330181122},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40803995728492737},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40083250403404236},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3330901861190796},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3204922676086426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3038419485092163},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2890997529029846},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.24396103620529175},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20333731174468994},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19140496850013733},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.10553485155105591},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08120653033256531},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.08104142546653748},{"id":"https://openalex.org/C2780212769","wikidata":"https://www.wikidata.org/wiki/Q776290","display_name":"Sentinel lymph node","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.11448","doi":"https://doi.org/10.1002/ijc.11448","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.11448","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:14520709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14520709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W41835213","https://openalex.org/W333351152","https://openalex.org/W1487350429","https://openalex.org/W1956236734","https://openalex.org/W1977492141","https://openalex.org/W1979580952","https://openalex.org/W1989369718","https://openalex.org/W1998427519","https://openalex.org/W2020122711","https://openalex.org/W2092492912","https://openalex.org/W2118094114","https://openalex.org/W2137370771","https://openalex.org/W2141218945","https://openalex.org/W2141829510","https://openalex.org/W2152922289","https://openalex.org/W2156145383","https://openalex.org/W2332938399"],"related_works":["https://openalex.org/W2000944621","https://openalex.org/W2152922289","https://openalex.org/W1963931152","https://openalex.org/W1996965751","https://openalex.org/W2071376322","https://openalex.org/W2008265220","https://openalex.org/W2110237328","https://openalex.org/W7100595339","https://openalex.org/W2065563537","https://openalex.org/W1965705376"],"abstract_inverted_index":{"CMM":[0,63,167],"is":[1,8,22,29],"the":[2,17,32,137,157],"most":[3,13,18],"serious":[4],"cutaneous":[5],"malignancy":[6],"and":[7,39,58,81,106,126],"increasing":[9],"in":[10,41,74,100,134,154,176],"frequency":[11,135],"among":[12,141],"Caucasian":[14],"populations,":[15],"where":[16],"important":[19],"risk":[20,164],"factor":[21,165],"exposure":[23],"to":[24,38],"UV":[25],"light.":[26],"Relatively":[27],"little":[28],"known":[30],"of":[31,47,61,71,78,136],"genetic":[33],"factors":[34],"that":[35],"mediate":[36],"susceptibility":[37],"prognosis":[40],"sporadic":[42],"CMM,":[43],"although":[44],"a":[45,130,163,174],"number":[46],"genes":[48],"have":[49,68],"been":[50,65],"implicated.":[51],"A":[52],"striking":[53],"association":[54],"between":[55,104,123],"EGF":[56,89,101,110,124,138,158],"polymorphism":[57,160,171],"Breslow":[59,127],"thickness":[60,128],"invasive":[62],"has":[64],"reported.":[66],"We":[67],"sought":[69],"confirmation":[70],"this":[72,170],"finding":[73],"an":[75],"independent":[76],"study":[77,93],"159":[79],"patients":[80,105],"310":[82],"controls":[83,107],"using":[84],"TaqMan":[85],"fluorescence-based":[86],"genotyping":[87],"for":[88,166],"+61.":[90],"In":[91,152],"our":[92,155],"group,":[94,156],"there":[95],"were":[96],"no":[97],"significant":[98,132],"differences":[99],"genotype":[102,111,125,140],"frequencies":[103],"nor":[108],"was":[109,161],"associated":[112],"with":[113],"tumour":[114],"growth":[115],"phase,":[116],"stage":[117],"or":[118],"mitotic":[119],"count.":[120],"However,":[121],"correlation":[122],"showed":[129],"modestly":[131],"increase":[133],"(G/G)":[139],"tumours":[142],">3.5":[143],"mm":[144],"thick":[145],"(30.0%":[146],"vs.":[147],"9.8%,":[148],"p":[149],"=":[150],"0.03).":[151],"summary,":[153],"+61":[159],"not":[162],"susceptibility,":[168],"but":[169],"may":[172],"play":[173],"role":[175],"disease":[177],"progression.":[178]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
