{"id":"https://openalex.org/W2016705652","doi":"https://doi.org/10.1093/carcin/8.1.173","title":"12-O-Tetradecanoylphorbol-13-acetate activates the synthesis of phosphatidylethanol in animal cells exposed to ethanol","display_name":"12-O-Tetradecanoylphorbol-13-acetate activates the synthesis of phosphatidylethanol in animal cells exposed to ethanol","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2016705652","doi":"https://doi.org/10.1093/carcin/8.1.173","mag":"2016705652","pmid":"https://pubmed.ncbi.nlm.nih.gov/3802389"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/8.1.173","doi":"https://doi.org/10.1093/carcin/8.1.173","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/8.1.173","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110029154","display_name":"Jin-Keon Pai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin-Keon Pai","raw_affiliation_strings":["Present address: Schering Corporation, Bloomlield, NJ 07003, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Present address: Schering Corporation, Bloomlield, NJ 07003, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079941179","display_name":"Eric C. Liebl","orcid":"https://orcid.org/0000-0003-4141-7649","observed_orcids":["https://orcid.org/0000-0003-4141-7649"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric C. Liebl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071216693","display_name":"Connie S. Tettenborn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Connie S. Tettenborn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054270048","display_name":"Fidelis I. Ikegwuonu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fidelis I. Ikegwuonu","raw_affiliation_strings":["Present address: University of Mississippi Medical Center Jackson, MS 39216, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Present address: University of Mississippi Medical Center Jackson, MS 39216, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113522316","display_name":"Gerald C. Mueller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerald C. Mueller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":3.6517,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.94323308,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"1","first_page":"173","last_page":"178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.4661000072956085,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.4661000072956085,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.21629999577999115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.16269999742507935,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9570000171661377},{"id":"https://openalex.org/keywords/phorbol-ester","display_name":"phorbol ester","score":0.9300000071525574},{"id":"https://openalex.org/keywords/phosphatidylethanol","display_name":"phosphatidylethanol","score":0.9110000133514404},{"id":"https://openalex.org/keywords/alcohol-metabolism","display_name":"alcohol metabolism","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.7310000061988831},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.7049999833106995},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.5239999890327454},{"id":"https://openalex.org/keywords/animal-cells","display_name":"animal cells","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2780202252","wikidata":"https://www.wikidata.org/wiki/Q7187448","display_name":"Phosphatidylethanol","level":5,"score":0.9175223112106323},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.5500725507736206},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5465738773345947},{"id":"https://openalex.org/C2780043322","wikidata":"https://www.wikidata.org/wiki/Q2705359","display_name":"Phorbol","level":4,"score":0.48680350184440613},{"id":"https://openalex.org/C2780122803","wikidata":"https://www.wikidata.org/wiki/Q7852681","display_name":"Tumor promotion","level":4,"score":0.47082144021987915},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.46559131145477295},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45522934198379517},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.4222373068332672},{"id":"https://openalex.org/C2777168633","wikidata":"https://www.wikidata.org/wiki/Q416716","display_name":"12-O-Tetradecanoylphorbol-13-acetate","level":5,"score":0.4111517369747162},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3631465435028076},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.35939711332321167},{"id":"https://openalex.org/C3017695315","wikidata":"https://www.wikidata.org/wiki/Q37713691","display_name":"Phorbol ester","level":4,"score":0.30679047107696533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27825409173965454},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.24052122235298157},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.23152241110801697},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.10005313158035278},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004121","descriptor_name":"Dimethyl Sulfoxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010712","descriptor_name":"Phosphatidic Acids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/carcin/8.1.173","doi":"https://doi.org/10.1093/carcin/8.1.173","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/8.1.173","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:3802389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3802389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.800000011920929,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1449315333","display_name":null,"funder_award_id":"CA 23076","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G222495705","display_name":null,"funder_award_id":"CA-07175","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4433733263","display_name":null,"funder_award_id":"CA-09020","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1988735235","https://openalex.org/W2031577443","https://openalex.org/W1605324556","https://openalex.org/W1981754197","https://openalex.org/W299258999","https://openalex.org/W2272683735","https://openalex.org/W2066617963","https://openalex.org/W2061916449","https://openalex.org/W1974731001","https://openalex.org/W2113637824"],"abstract_inverted_index":{"Tumor-promoting":[0],"phorbol":[1,53],"esters":[2],"acutely":[3],"activate":[4],"a":[5,21,26,29,41,69],"pathway":[6,112],"in":[7,35,49,68,113],"lymphocytes":[8],"leading":[9],"to":[10,51],"the":[11,37,99,107],"synthesis":[12,89],"and":[13,63,90],"accumulation":[14],"of":[15,28,32,46,65,71,80,87,101,109],"phosphatidylethanol,":[16],"using":[17],"exogenous":[18],"ethanol":[19],"as":[20,60,104,106],"precursor.":[22],"This":[23],"product":[24],"is":[25,40,83],"representative":[27],"unique":[30],"class":[31],"acidic":[33],"glycerophospholipids":[34],"which":[36],"head":[38],"group":[39],"primary":[42],"alcohol.":[43],"The":[44],"formation":[45],"this":[47,110],"lipid,":[48],"response":[50],"different":[52],"ester":[54],"derivatives,":[55],"correlates":[56],"with":[57],"their":[58],"activity":[59],"tumor":[61,114],"promoters":[62],"inducers":[64],"growth":[66],"changes":[67],"variety":[70],"animal":[72],"cells.":[73],"Since":[74],"phosphatidylethanol":[75],"represents":[76],"an":[77],"unusual":[78],"metabolite":[79],"ethanol,":[81],"it":[82],"proposed":[84],"that":[85],"studies":[86],"its":[88],"biological":[91,111],"functions":[92],"may":[93],"also":[94],"provide":[95],"new":[96],"perspectives":[97],"on":[98],"biology":[100],"alcohol":[102],"addiction":[103],"well":[105],"role":[108],"promotion.":[115]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
