{"id":"https://openalex.org/W2016704565","doi":"https://doi.org/10.1586/14737140.6.7.1053","title":"Gene therapeutics: the future of brain tumor therapy?","display_name":"Gene therapeutics: the future of brain tumor therapy?","publication_year":2006,"publication_date":"2006-07-01","ids":{"openalex":"https://openalex.org/W2016704565","doi":"https://doi.org/10.1586/14737140.6.7.1053","mag":"2016704565","pmid":"https://pubmed.ncbi.nlm.nih.gov/16831077"},"language":"en","primary_location":{"id":"doi:10.1586/14737140.6.7.1053","doi":"https://doi.org/10.1586/14737140.6.7.1053","is_oa":false,"landing_page_url":"https://doi.org/10.1586/14737140.6.7.1053","pdf_url":null,"source":{"id":"https://openalex.org/S93370067","display_name":"Expert Review of Anticancer Therapy","issn_l":"1473-7140","issn":["1473-7140","1744-8328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Anticancer Therapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064626327","display_name":"Jennifer L. Cutter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L Cutter","raw_affiliation_strings":["Dardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery and Comprehensive Cancer Center, The Ohio State University Medical Center, 410 West 12th Avenue, Columbus, OH 43210, USA. jennifer.cutter@osumc.edu","The Ohio State University, Columbus, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery and Comprehensive Cancer Center, The Ohio State University Medical Center, 410 West 12th Avenue, Columbus, OH 43210, USA. jennifer.cutter@osumc.edu","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"The Ohio State University, Columbus, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059538840","display_name":"Kazuhiko Kurozumi","orcid":"https://orcid.org/0000-0002-6942-9919","observed_orcids":["https://orcid.org/0000-0002-6942-9919"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazuhiko Kurozumi","raw_affiliation_strings":["Postdoctoral Researcher, Dardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery and Comprehensive Cancer Center, The Ohio State University Medical Center, 410 West 12th Avenue, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Postdoctoral Researcher, Dardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery and Comprehensive Cancer Center, The Ohio State University Medical Center, 410 West 12th Avenue, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033917464","display_name":"Ennio Antonio Chiocca","orcid":"https://orcid.org/0000-0001-5183-1670","observed_orcids":["https://orcid.org/0000-0001-5183-1670"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Antonio Chiocca","raw_affiliation_strings":["Professor and Department Chair of Neurological Surgery, Dardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery and Comprehensive Cancer Center, The Ohio State University Medical Center, 410 West 12th Avenue, Columbus, OH 43210, USA. ea.chicca@osumc.edu","The Ohio State University, Columbus, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor and Department Chair of Neurological Surgery, Dardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery and Comprehensive Cancer Center, The Ohio State University Medical Center, 410 West 12th Avenue, Columbus, OH 43210, USA. ea.chicca@osumc.edu","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"The Ohio State University, Columbus, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041131555","display_name":"Balveen Kaur","orcid":"https://orcid.org/0000-0001-7738-0804","observed_orcids":["https://orcid.org/0000-0001-7738-0804"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Balveen Kaur","raw_affiliation_strings":["Assistant Professor, Dardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery and Comprehensive Cancer Center, The Ohio State University Medical Center, 410 West 12th Avenue, Columbus, OH 43210, USA. kaur.11@osu.edu","The Ohio State University, Columbus, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Dardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery and Comprehensive Cancer Center, The Ohio State University Medical Center, 410 West 12th Avenue, Columbus, OH 43210, USA. kaur.11@osu.edu","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"The Ohio State University, Columbus, United States","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2999,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.2542735,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6","issue":"7","first_page":"1053","last_page":"1064"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8970000147819519},{"id":"https://openalex.org/keywords/oncolytic-viruses","display_name":"oncolytic viruses","score":0.9269999861717224},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.9210000038146973},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.9539999961853027},{"id":"https://openalex.org/keywords/oncolytic-virotherapy","display_name":"oncolytic virotherapy","score":0.8080000281333923},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.6110000014305115},{"id":"https://openalex.org/keywords/tumor-resection","display_name":"tumor resection","score":0.4909999966621399},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.7289999723434448},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.939629077911377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8637701272964478},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6117530465126038},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5719527006149292},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5509299039840698},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.5425591468811035},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4409612715244293},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.403738796710968},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32520508766174316},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2917158901691437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27448147535324097},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2513807415962219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D050130","descriptor_name":"Oncolytic Virotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1586/14737140.6.7.1053","doi":"https://doi.org/10.1586/14737140.6.7.1053","is_oa":false,"landing_page_url":"https://doi.org/10.1586/14737140.6.7.1053","pdf_url":null,"source":{"id":"https://openalex.org/S93370067","display_name":"Expert Review of Anticancer Therapy","issn_l":"1473-7140","issn":["1473-7140","1744-8328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Anticancer Therapy","raw_type":"journal-article"},{"id":"pmid:16831077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16831077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of anticancer therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":111,"referenced_works":["https://openalex.org/W6230759","https://openalex.org/W1504783700","https://openalex.org/W1533379125","https://openalex.org/W1574784185","https://openalex.org/W1589945847","https://openalex.org/W1593420214","https://openalex.org/W1791027840","https://openalex.org/W1864600310","https://openalex.org/W1904972315","https://openalex.org/W1964598686","https://openalex.org/W1965016620","https://openalex.org/W1970212185","https://openalex.org/W1970551361","https://openalex.org/W1972455109","https://openalex.org/W1972887015","https://openalex.org/W1977643218","https://openalex.org/W1980260496","https://openalex.org/W1983766005","https://openalex.org/W1984519174","https://openalex.org/W1986599407","https://openalex.org/W1988078932","https://openalex.org/W1988700867","https://openalex.org/W1990375242","https://openalex.org/W2006191739","https://openalex.org/W2006902703","https://openalex.org/W2006922381","https://openalex.org/W2008393860","https://openalex.org/W2009994985","https://openalex.org/W2011486273","https://openalex.org/W2013241294","https://openalex.org/W2016080258","https://openalex.org/W2021423477","https://openalex.org/W2026406742","https://openalex.org/W2033642093","https://openalex.org/W2035347355","https://openalex.org/W2037171350","https://openalex.org/W2038354618","https://openalex.org/W2040344541","https://openalex.org/W2040549178","https://openalex.org/W2044296969","https://openalex.org/W2045415534","https://openalex.org/W2049092411","https://openalex.org/W2049265285","https://openalex.org/W2049309316","https://openalex.org/W2050216826","https://openalex.org/W2052132644","https://openalex.org/W2054319806","https://openalex.org/W2057382033","https://openalex.org/W2064752967","https://openalex.org/W2066890949","https://openalex.org/W2073134590","https://openalex.org/W2076708416","https://openalex.org/W2078103037","https://openalex.org/W2078125985","https://openalex.org/W2079935861","https://openalex.org/W2082757992","https://openalex.org/W2083120527","https://openalex.org/W2090599158","https://openalex.org/W2090634114","https://openalex.org/W2090732350","https://openalex.org/W2092499288","https://openalex.org/W2093424805","https://openalex.org/W2097068344","https://openalex.org/W2102236923","https://openalex.org/W2103659075","https://openalex.org/W2105754648","https://openalex.org/W2105882438","https://openalex.org/W2106627189","https://openalex.org/W2106899106","https://openalex.org/W2109415128","https://openalex.org/W2110592777","https://openalex.org/W2110814986","https://openalex.org/W2113128219","https://openalex.org/W2116672872","https://openalex.org/W2117210608","https://openalex.org/W2117974261","https://openalex.org/W2120867214","https://openalex.org/W2121623797","https://openalex.org/W2121857951","https://openalex.org/W2122622689","https://openalex.org/W2126002712","https://openalex.org/W2126397856","https://openalex.org/W2127471889","https://openalex.org/W2127954678","https://openalex.org/W2129818141","https://openalex.org/W2131816598","https://openalex.org/W2132191840","https://openalex.org/W2134045444","https://openalex.org/W2139104080","https://openalex.org/W2142072987","https://openalex.org/W2143666652","https://openalex.org/W2145190984","https://openalex.org/W2146261786","https://openalex.org/W2146798773","https://openalex.org/W2151242353","https://openalex.org/W2159723167","https://openalex.org/W2163643581","https://openalex.org/W2163842931","https://openalex.org/W2171807420","https://openalex.org/W2172477250","https://openalex.org/W2173140585","https://openalex.org/W2177597220","https://openalex.org/W2246273267","https://openalex.org/W2320059776","https://openalex.org/W2329568265","https://openalex.org/W2410735561","https://openalex.org/W2410910437","https://openalex.org/W2412506624","https://openalex.org/W2444572374","https://openalex.org/W3022598401","https://openalex.org/W4211126864"],"related_works":["https://openalex.org/W4282925559","https://openalex.org/W4412892889","https://openalex.org/W4378528510","https://openalex.org/W2005613207","https://openalex.org/W3161526711","https://openalex.org/W2074111828","https://openalex.org/W4415625731","https://openalex.org/W4399013020","https://openalex.org/W2510032021","https://openalex.org/W2106984937"],"abstract_inverted_index":{"Primary":[0],"glioblastoma":[1],"multiforme":[2],"is":[3],"an":[4],"aggressive":[5],"brain":[6,109],"tumor":[7],"that":[8,39],"has":[9],"no":[10],"cure.":[11],"Current":[12],"treatments":[13],"include":[14],"gross":[15],"resection":[16],"of":[17,36,71,85],"the":[18,34,83],"tumor,":[19],"radiation":[20],"and":[21,43,61],"chemotherapy.":[22],"Despite":[23],"valiant":[24],"efforts,":[25],"prognosis":[26],"remains":[27,92],"dismal.":[28],"A":[29],"promising":[30],"new":[31],"technique":[32],"involves":[33],"use":[35],"oncolytic":[37,79],"viruses":[38,80],"can":[40],"specifically":[41],"replicate":[42],"lyse":[44],"in":[45,57,99,108],"cancers,":[46],"without":[47],"spreading":[48],"to":[49],"normal":[50],"tissues.":[51],"Currently,":[52],"these":[53],"are":[54,97],"being":[55],"tested":[56],"relevant":[58],"preclinical":[59],"models":[60],"clinical":[62,76],"trials":[63,77],"as":[64],"a":[65,103],"therapeutic":[66],"modality":[67],"for":[68,90],"many":[69],"types":[70],"cancer.":[72],"Results":[73],"from":[74],"recent":[75],"with":[78,102],"have":[81],"revealed":[82],"safety":[84],"this":[86,100],"approach,":[87],"although":[88],"evidence":[89],"efficacy":[91],"elusive.":[93],"Oncolytic":[94],"viral":[95],"strategies":[96],"summarized":[98],"review,":[101],"focus":[104],"on":[105],"therapies":[106],"used":[107],"tumors.":[110]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
