{"id":"https://openalex.org/W2016699484","doi":"https://doi.org/10.1210/en.137.3.1080","title":"Basal and vitamin D-responsive activity of the rat osteocalcin promoter in stably transfected osteosarcoma cells: requirement of upstream sequences for control by the proximal regulatory domain","display_name":"Basal and vitamin D-responsive activity of the rat osteocalcin promoter in stably transfected osteosarcoma cells: requirement of upstream sequences for control by the proximal regulatory domain","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W2016699484","doi":"https://doi.org/10.1210/en.137.3.1080","mag":"2016699484","pmid":"https://pubmed.ncbi.nlm.nih.gov/8603577"},"language":"en","primary_location":{"id":"doi:10.1210/en.137.3.1080","doi":"https://doi.org/10.1210/en.137.3.1080","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.137.3.1080","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054966468","display_name":"Baruch Frenkel","orcid":"https://orcid.org/0000-0001-6295-6858","observed_orcids":["https://orcid.org/0000-0001-6295-6858"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Frenkel","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012717530","display_name":"Martin A. Montecino","orcid":"https://orcid.org/0000-0002-6025-0023","observed_orcids":["https://orcid.org/0000-0002-6025-0023"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Montecino","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049161625","display_name":"Judith L. Green","orcid":"https://orcid.org/0000-0001-6825-9404","observed_orcids":["https://orcid.org/0000-0001-6825-9404"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Green","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109501394","display_name":"Fozia Aslam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F Aslam","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R Desai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Desai","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073628813","display_name":"Chaitali Banerjee","orcid":"https://orcid.org/0000-0001-7668-5112","observed_orcids":["https://orcid.org/0000-0001-7668-5112"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Banerjee","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081119848","display_name":"Janet Lee Stein","orcid":"https://orcid.org/0000-0002-2474-6822","observed_orcids":["https://orcid.org/0000-0002-2474-6822"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J L Stein","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031362021","display_name":"Jane B. Lian","orcid":"https://orcid.org/0000-0001-8683-9138","observed_orcids":["https://orcid.org/0000-0001-8683-9138"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J B Lian","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103217263","display_name":"Gary S. Stein","orcid":"https://orcid.org/0000-0001-8762-5422","observed_orcids":["https://orcid.org/0000-0001-8762-5422"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G S Stein","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I166722992"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.14,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.87962758,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"137","issue":"3","first_page":"1080","last_page":"1088"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.5870000123977661},{"id":"https://openalex.org/keywords/vitamin-d-response-element","display_name":"vitamin D response element","score":0.7950000166893005},{"id":"https://openalex.org/keywords/chromatin-context","display_name":"chromatin context","score":0.6370000243186951},{"id":"https://openalex.org/keywords/upstream-promoter-sequences","display_name":"upstream promoter sequences","score":0.5899999737739563},{"id":"https://openalex.org/keywords/dnase-i-hypersensitive-sites","display_name":"DNase I hypersensitive sites","score":0.8140000104904175},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/osteosarcoma-cells","display_name":"osteosarcoma cells","score":0.8140000104904175},{"id":"https://openalex.org/keywords/transcription-factor-binding","display_name":"transcription factor binding","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6965432167053223},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6924076080322266},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6645511388778687},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6604031920433044},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.6540749669075012},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.5813671350479126},{"id":"https://openalex.org/C2779377703","wikidata":"https://www.wikidata.org/wiki/Q14901483","display_name":"Deoxyribonuclease I","level":4,"score":0.5757951140403748},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.4952022135257721},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4787808656692505},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.42226964235305786},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3423011898994446},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3033689260482788},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29800575971603394},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29717564582824707},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15097156167030334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10201212763786316},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09714159369468689},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.0749344527721405},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1210/en.137.3.1080","doi":"https://doi.org/10.1210/en.137.3.1080","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.137.3.1080","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/endo.137.3.8603577","doi":"https://doi.org/10.1210/endo.137.3.8603577","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.137.3.8603577","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:8603577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8603577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.umassmed.edu:gsbs_sp-1356","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/gsbs_sp/357","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Morningside Graduate School of Biomedical Sciences Student Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2321499154","display_name":"BONE CELL STRUCTURE AND GENE EXPRESSION","funder_award_id":"P01AR042262","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2729082053","display_name":null,"funder_award_id":"AR33920","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4172909306","display_name":"SYNTHESIS OF OSTEOCALCIN IN BONE","funder_award_id":"5r01ar033920-12","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G557202545","display_name":null,"funder_award_id":"AR42262","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G57866040","display_name":null,"funder_award_id":"AR 39588","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6723465385","display_name":"Control of Osteoblast Proliferation and Differentiation","funder_award_id":"R01AR039588","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1545156714","https://openalex.org/W1564306239","https://openalex.org/W1590197184","https://openalex.org/W1787656094","https://openalex.org/W1954929088","https://openalex.org/W1971095040","https://openalex.org/W1986567088","https://openalex.org/W1986860084","https://openalex.org/W1999601565","https://openalex.org/W2000352603","https://openalex.org/W2003002984","https://openalex.org/W2015625188","https://openalex.org/W2018121938","https://openalex.org/W2021323848","https://openalex.org/W2030343318","https://openalex.org/W2030400708","https://openalex.org/W2036684049","https://openalex.org/W2038529651","https://openalex.org/W2039289863","https://openalex.org/W2039887170","https://openalex.org/W2042543706","https://openalex.org/W2046433564","https://openalex.org/W2056137270","https://openalex.org/W2059396392","https://openalex.org/W2070159701","https://openalex.org/W2070267020","https://openalex.org/W2074743609","https://openalex.org/W2075027785","https://openalex.org/W2082831896","https://openalex.org/W2084937656","https://openalex.org/W2087157329","https://openalex.org/W2089210150","https://openalex.org/W2114948431","https://openalex.org/W2130817720","https://openalex.org/W2142256883","https://openalex.org/W2144206181","https://openalex.org/W2163776749","https://openalex.org/W2302993874","https://openalex.org/W2404181394"],"related_works":["https://openalex.org/W4252036240","https://openalex.org/W1486405109","https://openalex.org/W2059396392","https://openalex.org/W2030343318","https://openalex.org/W2074743609","https://openalex.org/W2000352603","https://openalex.org/W745471579","https://openalex.org/W2020122207","https://openalex.org/W2064770581","https://openalex.org/W1985645174"],"abstract_inverted_index":{"Osteocalcin":[0],"(OC)":[1],"is":[2,10,32,98,144,173,295],"a":[3,63,74,207,287],"bone-specific":[4],"vitamin":[5,216,248,276],"D-":[6],"responsive":[7],"protein":[8],"that":[9,44,87,119,254,311],"developmentally":[11],"expressed":[12],"during":[13],"osteoblast":[14],"differentiation.":[15],"In":[16,265],"transient":[17,91,316],"transfection":[18,92,317],"assays,":[19,93],"as":[20,22,42,200,202,286],"little":[21],"approximately":[23],"0.1":[24],"kilobase":[25],"(kb)":[26],"of":[27,58,76,109,125,136,148,178,194,279,289,299,306],"the":[28,56,94,105,123,134,137,162,169,176,190,225,228,234,243,247,261,272,280],"OC":[29,59,78,263,307,329],"proximal":[30,95,140],"promoter":[31,60,97,141,184,230,236,245,285],"sufficient":[33],"for":[34,192],"basal":[35,110,195,212,244,273],"expression.":[36],"Because":[37],"eukaryotic":[38],"genes":[39],"are":[40,219],"packaged":[41],"nucleosomes":[43],"contribute":[45],"to":[46,90],"both":[47,149,242],"chromatin":[48,64,208],"organization":[49],"and":[50,115,155,196,214,246,275],"transcriptional":[51,309],"control,":[52],"we":[53,267],"functionally":[54],"examined":[55],"activity":[57,135,274],"constructs":[61],"within":[62,206],"context.":[65,209],"ROS":[66,323],"17/2.8":[67,324],"osteosarcoma":[68],"cells":[69,172,222,325],"were":[70],"stably":[71,170,281,326],"transfected":[72,171,327],"with":[73,112,146,175,221,328],"series":[75],"rat":[77],"promoter-reporter":[79,330],"constructs,":[80],"containing":[81],"progressive":[82],"5'-deletions.":[83],"The":[84],"results":[85],"demonstrate":[86],"in":[88,104,161,168,260,271,315],"contrast":[89],"0.11-kb":[96],"no":[99],"longer":[100],"active":[101],"when":[102],"integrated":[103,139,282],"genome.":[106],"Progressive":[107],"gain":[108],"expression":[111,213],"0.35-,":[113],"0.53-,":[114],"0.72-kb":[116,226],"promoters":[117],"suggests":[118],"upstream":[120,183],"sequences":[121,188],"facilitate":[122],"formation":[124],"an":[126],"appropriate":[127],"higher":[128],"order":[129],"nuclear":[130,156],"structure,":[131],"thereby":[132],"potentiating":[133],"chromosomally":[138],"elements.":[142],"This":[143],"consistent":[145],"location":[147],"deoxyribonuclease":[150],"I":[151,239,258],"(DNase":[152],"I)-hypersensitive":[153],"sites":[154,160],"matrix":[157],"protein-DNA":[158],"interaction":[159],"osteocalcin":[163],"promoter.":[164,264],"Vitamin":[165],"D":[166,217,249,277],"responsiveness":[167,218,278],"obtained":[174,220],"inclusion":[177],"0.53":[179],"kb":[180,284],"or":[181,227],"additional":[182],"sequences.":[185],"Therefore,":[186],"these":[187],"satisfy":[189],"requirements":[191],"binding":[193],"enhancer":[197],"transcription":[198],"factors":[199],"well":[201],"interactions":[203],"between":[204],"them":[205],"Both":[210],"maximal":[211,215],"carrying":[223,233],"either":[224],"1.1-kb":[229,235],"fragment.":[231],"Cells":[232],"show":[237],"DNase":[238,257],"hypersensitivity":[240,259],"at":[241],"response":[250],"element-containing":[251],"domains,":[252],"locations":[253],"also":[255],"exhibit":[256],"endogenous":[262],"addition,":[266],"have":[268],"documented":[269],"changes":[270],"1.1":[283],"function":[288],"cell":[290],"density-mediated":[291],"growth":[292],"inhibition,":[293],"which":[294],"accompanied":[296],"by":[297],"up-regulation":[298],"bone":[300],"phenotypic":[301],"genes.":[302],"Thus,":[303],"important":[304],"aspects":[305],"gene":[308],"regulation":[310],"cannot":[312],"be":[313,320],"investigated":[314],"assays":[318],"can":[319],"addressed":[321],"using":[322],"constructs.":[331]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}