{"id":"https://openalex.org/W2016678432","doi":"https://doi.org/10.1016/s0021-5198(19)36181-5","title":"EFFECT OF HYPOTHYROID STATUS ON MYOCARDIAL RESPONSES TO SYMPATHOMIMETIC DRUGS","display_name":"EFFECT OF HYPOTHYROID STATUS ON MYOCARDIAL RESPONSES TO SYMPATHOMIMETIC DRUGS","publication_year":1971,"publication_date":"1971-01-01","ids":{"openalex":"https://openalex.org/W2016678432","doi":"https://doi.org/10.1016/s0021-5198(19)36181-5","mag":"2016678432","pmid":"https://pubmed.ncbi.nlm.nih.gov/5316867"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-5198(19)36181-5","doi":"https://doi.org/10.1016/s0021-5198(19)36181-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-5198(19)36181-5","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/s0021-5198(19)36181-5","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100877458","display_name":"Mitsuyoshi Nakashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuyoshi Nakashima","raw_affiliation_strings":["Department of Pharmacology","Department of Pharmacology, Nagoya University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology, Nagoya University, School of Medicine","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017230904","display_name":"Kiyoshi Maeda","orcid":"https://orcid.org/0000-0002-5138-4767","observed_orcids":["https://orcid.org/0000-0002-5138-4767"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Maeda","raw_affiliation_strings":["Department of Pharmacology","Department of Pharmacology, Nagoya University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology, Nagoya University, School of Medicine","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111821900","display_name":"Atsushi Sekiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Sekiya","raw_affiliation_strings":["Department of Pharmacology","Department of Pharmacology, Nagoya University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology, Nagoya University, School of Medicine","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108729382","display_name":"Yasumichi Hagino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasumichi Hagino","raw_affiliation_strings":["Department of Biochemistry, Nagoya University School of Medicine, Showa-ku, Nagoya","Department of Biochemistry, Nagoya University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Nagoya University School of Medicine, Showa-ku, Nagoya","institution_ids":["https://openalex.org/I60134161"]},{"raw_affiliation_string":"Department of Biochemistry, Nagoya University School of Medicine","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I60134161"],"apc_list":null,"apc_paid":null,"fwci":2.8386,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.89926189,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"21","issue":"6","first_page":"819","last_page":"825"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.9879999756813049},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.8769999742507935},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.8379999995231628},{"id":"https://openalex.org/keywords/myocardial-response","display_name":"myocardial response","score":0.7260000109672546},{"id":"https://openalex.org/keywords/sympathomimetic-drugs","display_name":"sympathomimetic drugs","score":0.8769999742507935},{"id":"https://openalex.org/keywords/alpha-adrenergic-receptors","display_name":"alpha-adrenergic receptors","score":0.8709999918937683},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":1.0},{"id":"https://openalex.org/keywords/6-n-propylthiouracil","display_name":"6-n-propylthiouracil","score":0.9649999737739563},{"id":"https://openalex.org/keywords/thyroidectomy","display_name":"thyroidectomy","score":0.6259999871253967},{"id":"https://openalex.org/keywords/cardiac-adrenergic-receptors","display_name":"cardiac adrenergic receptors","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.7329710721969604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.707878828048706},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.7008001804351807},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6991127729415894},{"id":"https://openalex.org/C40465926","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Adrenergic receptor","level":3,"score":0.6355443000793457},{"id":"https://openalex.org/C2777074255","wikidata":"https://www.wikidata.org/wiki/Q1351681","display_name":"Thyroidectomy","level":3,"score":0.6130003929138184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5676349401473999},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5543199181556702},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.5454375147819519},{"id":"https://openalex.org/C2776501357","wikidata":"https://www.wikidata.org/wiki/Q409332","display_name":"Thiouracil","level":3,"score":0.4497973620891571},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.44280073046684265},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.05462595820426941},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010656","descriptor_name":"Phenylephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013566","descriptor_name":"Sympathomimetics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0021-5198(19)36181-5","doi":"https://doi.org/10.1016/s0021-5198(19)36181-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-5198(19)36181-5","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},{"id":"doi:10.1254/jjp.21.819","doi":"https://doi.org/10.1254/jjp.21.819","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.21.819","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Japanese Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:5316867","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5316867","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-5198(19)36181-5","doi":"https://doi.org/10.1016/s0021-5198(19)36181-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-5198(19)36181-5","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1991896830","https://openalex.org/W2007586754","https://openalex.org/W2015002982","https://openalex.org/W2017813687","https://openalex.org/W2037386064","https://openalex.org/W2050443458","https://openalex.org/W2053338043","https://openalex.org/W2063152699","https://openalex.org/W2079263171","https://openalex.org/W2140537787","https://openalex.org/W2175628288","https://openalex.org/W2281938476"],"related_works":["https://openalex.org/W2044265494","https://openalex.org/W157549237","https://openalex.org/W1990181720","https://openalex.org/W2089124522","https://openalex.org/W2341044342","https://openalex.org/W2058435963","https://openalex.org/W2070055155","https://openalex.org/W2033143658","https://openalex.org/W1989805893","https://openalex.org/W2108442115"],"abstract_inverted_index":{"The":[0],"physiological":[1],"relationship":[2],"between":[3,138],"thyroid":[4,28,43,63],"hormone":[5,44],"and":[6,87,105],"the":[7,31,34,46,49,62,66,83,100,109,128],"catecholamines":[8,93],"has":[9,40],"been":[10],"investigated":[11],"for":[12],"many":[13,131],"years":[14],"(1,":[15],"2).":[16],"In":[17],"spite":[18],"of":[19,33,48,80,85,102,111,127,141],"numerous":[20],"studies":[21,116],"it":[22,73],"is":[23],"still":[24],"not":[25],"clear":[26],"whether":[27],"status":[29,64],"alters":[30],"sensitivity":[32],"heart":[35],"to":[36,51,58,68,76,92,124],"catecholamines.":[37],"Coville":[38],"(3)":[39],"reported":[41,99,117],"that":[42,60],"increased":[45],"magnitude":[47],"response":[50,67,84],"catecholamines,":[52],"while":[53],"some":[54,78,126],"authors":[55],"have":[56,98],"failed":[57],"show":[59],"altering":[61],"affects":[65],"catecholarnines":[69],"(4,":[70],"5).":[71],"Recently,":[72],"was":[74],"tried":[75],"explore":[77],"effects":[79],"thyroidectomy":[81],"on":[82],"alpha":[86,104],"beta":[88,106],"adrenergic":[89,143],"receptor":[90,144],"mechanisms":[91,145],"(6).":[94],"A":[95],"few":[96],"workers":[97],"existence":[101],"both":[103],"receptors":[107],"in":[108,121,130],"hearts":[110],"mammals":[112],"(7,":[113],"8).":[114],"Present":[115],"here":[118],"were":[119],"made":[120],"an":[122],"attempt":[123],"clarify":[125],"discrepancies":[129],"reports":[132],"by":[133],"seeking":[134],"a":[135],"quantitative":[136],"difference":[137],"different":[139],"types":[140],"cardiac":[142],"after":[146],"6-propyl-2-thiouracil":[147],"(PTU)":[148],"treatment.":[149]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
