{"id":"https://openalex.org/W2016669505","doi":"https://doi.org/10.1128/aac.36.2.267","title":"Simple assay to screen for inhibitors of interaction between the human immunodeficiency virus envelope glycoprotein and its cellular receptor, CD4","display_name":"Simple assay to screen for inhibitors of interaction between the human immunodeficiency virus envelope glycoprotein and its cellular receptor, CD4","publication_year":1992,"publication_date":"1992-02-01","ids":{"openalex":"https://openalex.org/W2016669505","doi":"https://doi.org/10.1128/aac.36.2.267","mag":"2016669505","pmid":"https://pubmed.ncbi.nlm.nih.gov/1605591","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/188348"},"language":"en","primary_location":{"id":"doi:10.1128/aac.36.2.267","doi":"https://doi.org/10.1128/aac.36.2.267","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.36.2.267","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/188348","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011540927","display_name":"Vida Chams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V Chams","raw_affiliation_strings":["Laboratoire de Biologie et G\u00e9n\u00e9tique des Infections R\u00e9trovirales, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, URA Centre National de la Recherche Scientifique 1463, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie et G\u00e9n\u00e9tique des Infections R\u00e9trovirales, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, URA Centre National de la Recherche Scientifique 1463, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039950013","display_name":"Thierry Idziorek","orcid":"https://orcid.org/0000-0001-5893-9131","observed_orcids":["https://orcid.org/0000-0001-5893-9131"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"T Idziorek","raw_affiliation_strings":["Laboratoire de Biologie et G\u00e9n\u00e9tique des Infections R\u00e9trovirales, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, URA Centre National de la Recherche Scientifique 1463, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie et G\u00e9n\u00e9tique des Infections R\u00e9trovirales, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, URA Centre National de la Recherche Scientifique 1463, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035255731","display_name":"Paul Jay Maddon","orcid":"https://orcid.org/0000-0002-2264-6270","observed_orcids":["https://orcid.org/0000-0002-2264-6270"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P J Maddon","raw_affiliation_strings":["Laboratoire de Biologie et G\u00e9n\u00e9tique des Infections R\u00e9trovirales, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, URA Centre National de la Recherche Scientifique 1463, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie et G\u00e9n\u00e9tique des Infections R\u00e9trovirales, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, URA Centre National de la Recherche Scientifique 1463, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210121705"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044456322","display_name":"David Klatzmann","orcid":"https://orcid.org/0000-0002-0054-3422","observed_orcids":["https://orcid.org/0000-0002-0054-3422"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D Klatzmann","raw_affiliation_strings":["Laboratoire de Biologie et G\u00e9n\u00e9tique des Infections R\u00e9trovirales, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, URA Centre National de la Recherche Scientifique 1463, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie et G\u00e9n\u00e9tique des Infections R\u00e9trovirales, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, URA Centre National de la Recherche Scientifique 1463, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210121705"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.04670775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"2","first_page":"267","last_page":"272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.8600000143051147},{"id":"https://openalex.org/keywords/gp120","display_name":"gp120","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cd4","display_name":"CD4","score":0.8820000290870667},{"id":"https://openalex.org/keywords/gp160","display_name":"gp160","score":0.8159999847412109},{"id":"https://openalex.org/keywords/inhibitor-screening","display_name":"inhibitor screening","score":0.609000027179718},{"id":"https://openalex.org/keywords/enzyme-linked-immunosorbent-assay","display_name":"enzyme-linked immunosorbent assay","score":0.8500000238418579},{"id":"https://openalex.org/keywords/soluble-cd4","display_name":"soluble CD4","score":0.6610000133514404},{"id":"https://openalex.org/keywords/antiviral-drug-discovery","display_name":"antiviral drug discovery","score":0.6349999904632568},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.6240000128746033},{"id":"https://openalex.org/keywords/synthetic-compound-libraries","display_name":"synthetic compound libraries","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.7128878831863403},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6371683478355408},{"id":"https://openalex.org/C97380033","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral envelope","level":3,"score":0.6127974390983582},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5807638168334961},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5353264212608337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5114399194717407},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5070338249206543},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4164489805698395},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2851928770542145},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21115535497665405},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08800995349884033},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07050755620002747}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.36.2.267","doi":"https://doi.org/10.1128/aac.36.2.267","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.36.2.267","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11930","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/188348","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:188348","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/188348","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:1605591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1605591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:11930","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/188348","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1601007012","https://openalex.org/W1610161427","https://openalex.org/W1610555304","https://openalex.org/W1629496165","https://openalex.org/W1830489709","https://openalex.org/W1982887925","https://openalex.org/W1983925230","https://openalex.org/W1991539551","https://openalex.org/W2020785099","https://openalex.org/W2020933095","https://openalex.org/W2021785678","https://openalex.org/W2027203648","https://openalex.org/W2038335567","https://openalex.org/W2040239455","https://openalex.org/W2043388188","https://openalex.org/W2057461438","https://openalex.org/W2060239134","https://openalex.org/W2067694850","https://openalex.org/W2073163802","https://openalex.org/W2090748249","https://openalex.org/W2094675548","https://openalex.org/W2108385781","https://openalex.org/W2124367359","https://openalex.org/W2132936712","https://openalex.org/W2158988444","https://openalex.org/W2460172522"],"related_works":["https://openalex.org/W1994940043","https://openalex.org/W2083489269","https://openalex.org/W2072720012","https://openalex.org/W2038335567","https://openalex.org/W2031886305","https://openalex.org/W2081196925","https://openalex.org/W2059421897","https://openalex.org/W1558864286","https://openalex.org/W1995345622","https://openalex.org/W109279978"],"abstract_inverted_index":{"The":[0],"binding":[1],"of":[2,36,55,68,70],"the":[3,11,15,19,34,49],"human":[4,37],"immunodeficiency":[5,38],"virus":[6,39],"envelope":[7],"glycoprotein":[8],"gp120":[9],"to":[10],"CD4":[12,56],"molecule":[13],"is":[14,25],"initial":[16,66],"step":[17],"in":[18],"viral":[20],"replicative":[21],"cycle.":[22],"This":[23,59],"interaction":[24,50],"therefore":[26],"an":[27,43,65],"important":[28],"target":[29],"for":[30,33],"therapeutic":[31],"intervention":[32],"treatment":[35],"infection.":[40],"We":[41],"designed":[42],"enzyme-linked":[44],"immunosorbent":[45],"assay":[46,60],"which":[47],"detects":[48],"between":[51],"recombinant":[52],"soluble":[53],"forms":[54],"and":[57,74],"gp160.":[58],"could":[61],"be":[62],"used":[63],"as":[64],"screen":[67],"libraries":[69],"synthetic":[71],"chemical":[72],"compounds":[73],"natural":[75],"products.":[76]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
