{"id":"https://openalex.org/W2016668588","doi":"https://doi.org/10.1152/ajplung.00189.2002","title":"Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases","display_name":"Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases","publication_year":2003,"publication_date":"2003-05-01","ids":{"openalex":"https://openalex.org/W2016668588","doi":"https://doi.org/10.1152/ajplung.00189.2002","mag":"2016668588","pmid":"https://pubmed.ncbi.nlm.nih.gov/12676768"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.00189.2002","doi":"https://doi.org/10.1152/ajplung.00189.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00189.2002","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102799187","display_name":"Jennifer L. Ingram","orcid":"https://orcid.org/0000-0001-7054-794X","observed_orcids":["https://orcid.org/0000-0001-7054-794X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer L. Ingram","raw_affiliation_strings":["Laboratories of Pulmonary Pathobiology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories of Pulmonary Pathobiology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050866443","display_name":"Annette B. Rice","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annette B. Rice","raw_affiliation_strings":["Laboratories of Pulmonary Pathobiology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories of Pulmonary Pathobiology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005794655","display_name":"Janine Hertzog Santos","orcid":"https://orcid.org/0000-0001-6384-3070","observed_orcids":["https://orcid.org/0000-0001-6384-3070"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janine Santos","raw_affiliation_strings":["Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055919829","display_name":"Bennett Van Houten","orcid":"https://orcid.org/0000-0002-4009-2478","observed_orcids":["https://orcid.org/0000-0002-4009-2478"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bennett Van Houten","raw_affiliation_strings":["Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082151408","display_name":"James C. Bonner","orcid":"https://orcid.org/0000-0002-4574-9782","observed_orcids":["https://orcid.org/0000-0002-4574-9782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James C. Bonner","raw_affiliation_strings":["Laboratories of Pulmonary Pathobiology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories of Pulmonary Pathobiology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7614,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.90053435,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"284","issue":"5","first_page":"L774","last_page":"L782"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12136","display_name":"Vanadium and Halogenation Chemistry","score":0.7685999870300293,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12136","display_name":"Vanadium and Halogenation Chemistry","score":0.7685999870300293,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.11890000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vanadium-pentoxide","display_name":"vanadium pentoxide","score":0.949999988079071},{"id":"https://openalex.org/keywords/hb-egf","display_name":"HB-EGF","score":0.906000018119812},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.7459999918937683},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9750000238418579},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.718999981880188},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.8289999961853027},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8820000290870667},{"id":"https://openalex.org/keywords/lung-fibroblasts","display_name":"lung fibroblasts","score":0.9350000023841858},{"id":"https://openalex.org/keywords/airway-fibrosis","display_name":"airway fibrosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.7480000257492065},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8040000200271606},{"id":"https://openalex.org/keywords/pd98059","display_name":"PD98059","score":0.9070000052452087}],"concepts":[{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.5504178404808044},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5399909019470215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5361210107803345},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5323513150215149},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5006930828094482},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4853750467300415},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.41033002734184265},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33278119564056396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.314880907535553},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26727965474128723},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12943831086158752}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017968","descriptor_name":"Vanadium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066257","descriptor_name":"Heparin-binding EGF-like Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajplung.00189.2002","doi":"https://doi.org/10.1152/ajplung.00189.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00189.2002","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"pmid:12676768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12676768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Lung cellular and molecular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W82814575","https://openalex.org/W179748458","https://openalex.org/W1514034386","https://openalex.org/W1535745656","https://openalex.org/W1663900005","https://openalex.org/W1804521283","https://openalex.org/W1964493811","https://openalex.org/W1968366568","https://openalex.org/W2009041168","https://openalex.org/W2012104993","https://openalex.org/W2013557200","https://openalex.org/W2022941023","https://openalex.org/W2026038159","https://openalex.org/W2029025220","https://openalex.org/W2031005891","https://openalex.org/W2031906901","https://openalex.org/W2033228419","https://openalex.org/W2033559416","https://openalex.org/W2033636731","https://openalex.org/W2040328392","https://openalex.org/W2041981966","https://openalex.org/W2045293448","https://openalex.org/W2055622229","https://openalex.org/W2063203571","https://openalex.org/W2065032678","https://openalex.org/W2065304993","https://openalex.org/W2067450274","https://openalex.org/W2080129256","https://openalex.org/W2084339088","https://openalex.org/W2084824122","https://openalex.org/W2086661658","https://openalex.org/W2091053844","https://openalex.org/W2091290146","https://openalex.org/W2091928006","https://openalex.org/W2095105178","https://openalex.org/W2110509373","https://openalex.org/W2117111303","https://openalex.org/W2121985048","https://openalex.org/W2122308499","https://openalex.org/W2122948215","https://openalex.org/W2144713692","https://openalex.org/W2157203911","https://openalex.org/W2163295962","https://openalex.org/W2164941877","https://openalex.org/W2430881372","https://openalex.org/W3150361247","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1663900005","https://openalex.org/W2060886600","https://openalex.org/W2082991655","https://openalex.org/W1542936611","https://openalex.org/W2089292329","https://openalex.org/W7098308855","https://openalex.org/W7096300274","https://openalex.org/W4380422114","https://openalex.org/W2033636731","https://openalex.org/W2091053844"],"abstract_inverted_index":{"Vanadium":[0,19],"pentoxide":[1],"(V(2)O(5))":[2],"is":[3,192,212],"a":[4,108,196],"transition":[5],"metal":[6],"derived":[7],"from":[8],"the":[9,27,43,77,95,100,114,121,137,158,205,220],"burning":[10],"of":[11,29,45,79,90,97,111,123,157,190,198,207,222],"petrochemicals":[12],"that":[13,136,178],"causes":[14],"airway":[15],"fibrosis":[16],"and":[17,94,152,184,215],"remodeling.":[18],"compounds":[20],"activate":[21],"many":[22],"intracellular":[23],"signaling":[24],"pathways":[25],"via":[26,182],"generation":[28],"hydrogen":[30],"peroxide":[31],"(H(2)O(2))":[32],"or":[33,148,162,171],"other":[34],"reactive":[35],"oxygen":[36],"species.":[37],"In":[38],"this":[39],"study,":[40],"we":[41],"investigated":[42],"regulation":[44],"heparin-binding":[46],"epidermal":[47],"growth":[48,50],"factor-like":[49],"factor":[51],"(HB-EGF)":[52],"in":[53,81,200,209],"human":[54],"lung":[55],"fibroblasts":[56],"after":[57,127],"V(2)O(5)":[58,80,98,106,147,201,208,223],"treatment.":[59],"V(2)O(5)-induced":[60,124,128],"HB-EGF":[61,83,129,144,173,181,191,211],"mRNA":[62,130],"expression":[63,131],"was":[64],"abolished":[65],"by":[66],"N-acetyl-l-cysteine,":[67],"suggesting":[68],"an":[69],"oxidant-mediated":[70],"effect.":[71],"Exogenous":[72],"H(2)O(2)":[73,91,102,112,125,139,149,199],"(>10":[74],"microM)":[75],"mimicked":[76],"effect":[78],"upregulating":[82,210],"expression.":[84,145,174],"Fibroblasts":[85],"spontaneously":[86],"released":[87],"low":[88],"levels":[89],"(1-2":[92],"microM),":[93],"addition":[96],"depleted":[99],"endogenous":[101,225],"pool":[103],"within":[104],"minutes.":[105],"caused":[107],"subsequent":[109],"increase":[110],"into":[113],"culture":[115],"medium":[116],"at":[117,132],"12":[118],"h.":[119],"However,":[120],"burst":[122,140,197],"occurred":[126],"3":[133],"h,":[134],"indicating":[135],"V(2)O(5)-stimulated":[138],"did":[141],"not":[142,193],"mediate":[143],"Either":[146],"activated":[150],"ERK-1/2":[151,159],"p38":[153,163,185],"MAP":[154,164,186],"kinase.":[155],"Inhibitors":[156],"pathway":[160],"(PD-98059)":[161],"kinase":[165],"(SB-203580)":[166],"significantly":[167],"reduced":[168],"either":[169],"V(2)O(5)-":[170],"H(2)O(2)-induced":[172],"These":[175],"data":[176],"indicate":[177],"vanadium":[179],"upregulates":[180],"ERK":[183],"kinases.":[187],"The":[188],"induction":[189],"related":[194],"to":[195,219],"treated":[202],"cells,":[203],"yet":[204],"action":[206],"oxidant":[213],"dependent":[214],"could":[216],"be":[217],"due":[218],"reaction":[221],"with":[224],"H(2)O(2).":[226]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
