{"id":"https://openalex.org/W2016663509","doi":"https://doi.org/10.1007/bf02064068","title":"Observations of sequential changes in bone mass in postmenopausal women: a controlled trial of oestrogen and calcium therapy","display_name":"Observations of sequential changes in bone mass in postmenopausal women: a controlled trial of oestrogen and calcium therapy","publication_year":1976,"publication_date":"1976-12-01","ids":{"openalex":"https://openalex.org/W2016663509","doi":"https://doi.org/10.1007/bf02064068","mag":"2016663509","pmid":"https://pubmed.ncbi.nlm.nih.gov/334343"},"language":"en","primary_location":{"id":"doi:10.1007/bf02064068","doi":"https://doi.org/10.1007/bf02064068","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02064068","pdf_url":null,"source":{"id":"https://openalex.org/S197748570","display_name":"Calcified Tissue International","issn_l":"0171-967X","issn":["0171-967X","1432-0827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Calcified Tissue Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114008429","display_name":"A. Horsman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Horsman","raw_affiliation_strings":["M.R.C. Mineral Metabolism Unit, The General Infirmary, LS1 3EX, Leeds, U.K","M.R.C. Mineral Metabolism Unit, The General Infirmary, Leeds, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.R.C. Mineral Metabolism Unit, The General Infirmary, LS1 3EX, Leeds, U.K","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"M.R.C. Mineral Metabolism Unit, The General Infirmary, Leeds, U.K","institution_ids":["https://openalex.org/I1295121038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112745311","display_name":"B. E. C. Nordin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B. E. C. Nordin","raw_affiliation_strings":["M.R.C. Mineral Metabolism Unit, The General Infirmary, LS1 3EX, Leeds, U.K","M.R.C. Mineral Metabolism Unit, The General Infirmary, Leeds, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.R.C. Mineral Metabolism Unit, The General Infirmary, LS1 3EX, Leeds, U.K","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"M.R.C. Mineral Metabolism Unit, The General Infirmary, Leeds, U.K","institution_ids":["https://openalex.org/I1295121038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037448661","display_name":"John Christopher Gallagher","orcid":"https://orcid.org/0000-0002-5129-9183","observed_orcids":["https://orcid.org/0000-0002-5129-9183"]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. C. Gallagher","raw_affiliation_strings":["M.R.C. Mineral Metabolism Unit, The General Infirmary, LS1 3EX, Leeds, U.K","M.R.C. Mineral Metabolism Unit, The General Infirmary, Leeds, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.R.C. Mineral Metabolism Unit, The General Infirmary, LS1 3EX, Leeds, U.K","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"M.R.C. Mineral Metabolism Unit, The General Infirmary, Leeds, U.K","institution_ids":["https://openalex.org/I1295121038"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. A. Kirby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. A. Kirby","raw_affiliation_strings":["M.R.C. Mineral Metabolism Unit, The General Infirmary, LS1 3EX, Leeds, U.K","M.R.C. Mineral Metabolism Unit, The General Infirmary, Leeds, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.R.C. Mineral Metabolism Unit, The General Infirmary, LS1 3EX, Leeds, U.K","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"M.R.C. Mineral Metabolism Unit, The General Infirmary, Leeds, U.K","institution_ids":["https://openalex.org/I1295121038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019498129","display_name":"Richard Milner","orcid":"https://orcid.org/0000-0001-9085-3880","observed_orcids":["https://orcid.org/0000-0001-9085-3880"]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. M. Milner","raw_affiliation_strings":["M.R.C. Mineral Metabolism Unit, The General Infirmary, LS1 3EX, Leeds, U.K","M.R.C. Mineral Metabolism Unit, The General Infirmary, Leeds, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.R.C. Mineral Metabolism Unit, The General Infirmary, LS1 3EX, Leeds, U.K","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"M.R.C. Mineral Metabolism Unit, The General Infirmary, Leeds, U.K","institution_ids":["https://openalex.org/I1295121038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000295518","display_name":"Maggie Simpson","orcid":"https://orcid.org/0000-0003-1781-4978","observed_orcids":["https://orcid.org/0000-0003-1781-4978"]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Simpson","raw_affiliation_strings":["M.R.C. Mineral Metabolism Unit, The General Infirmary, LS1 3EX, Leeds, U.K","M.R.C. Mineral Metabolism Unit, The General Infirmary, Leeds, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.R.C. Mineral Metabolism Unit, The General Infirmary, LS1 3EX, Leeds, U.K","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"M.R.C. Mineral Metabolism Unit, The General Infirmary, Leeds, U.K","institution_ids":["https://openalex.org/I1295121038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1295121038"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":5.4289,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.94871795,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S1","first_page":"217","last_page":"224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.03920000046491623,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-mass","display_name":"bone mass","score":0.8069999814033508},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.9649999737739563},{"id":"https://openalex.org/keywords/estrogen-therapy","display_name":"estrogen therapy","score":0.9470000267028809},{"id":"https://openalex.org/keywords/calcium-therapy","display_name":"calcium treatment","score":0.7860000133514404},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.5839999914169312},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.699999988079071},{"id":"https://openalex.org/keywords/osteoporosis-prevention","display_name":"osteoporosis prevention","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C3018603563","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Postmenopausal women","level":2,"score":0.6724249720573425},{"id":"https://openalex.org/C3020687571","wikidata":"https://www.wikidata.org/wiki/Q3354346","display_name":"Estrogen therapy","level":3,"score":0.6050153374671936},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6040620803833008},{"id":"https://openalex.org/C2993253760","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone mass","level":3,"score":0.5642436146736145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5300412178039551},{"id":"https://openalex.org/C3020211606","wikidata":"https://www.wikidata.org/wiki/Q3354346","display_name":"Estrogen replacement therapy","level":3,"score":0.5235273838043213},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.41104254126548767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4109340310096741},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.35601210594177246},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3523186445236206},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32799971103668213}],"mesh":[{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004997","descriptor_name":"Ethinyl Estradiol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008593","descriptor_name":"Menopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf02064068","doi":"https://doi.org/10.1007/bf02064068","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02064068","pdf_url":null,"source":{"id":"https://openalex.org/S197748570","display_name":"Calcified Tissue International","issn_l":"0171-967X","issn":["0171-967X","1432-0827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Calcified Tissue Research","raw_type":"journal-article"},{"id":"pmid:334343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/334343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Calcified tissue research","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W570403558","https://openalex.org/W1899699449","https://openalex.org/W1991626809","https://openalex.org/W1992735938","https://openalex.org/W2021239134","https://openalex.org/W2061294646","https://openalex.org/W2076337769","https://openalex.org/W2093305726","https://openalex.org/W2276770341","https://openalex.org/W2284975705","https://openalex.org/W2794836648","https://openalex.org/W4245803853"],"related_works":["https://openalex.org/W4235815158","https://openalex.org/W2318689086","https://openalex.org/W2048984621","https://openalex.org/W4243246204","https://openalex.org/W2605383150","https://openalex.org/W2736964041","https://openalex.org/W561647716","https://openalex.org/W4231994639","https://openalex.org/W4244569011","https://openalex.org/W4255915743"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}