{"id":"https://openalex.org/W2016659985","doi":"https://doi.org/10.1056/nejmoa054186","title":"Vitamins C and E and the Risks of Preeclampsia and Perinatal Complications","display_name":"Vitamins C and E and the Risks of Preeclampsia and Perinatal Complications","publication_year":2006,"publication_date":"2006-04-26","ids":{"openalex":"https://openalex.org/W2016659985","doi":"https://doi.org/10.1056/nejmoa054186","mag":"2016659985","pmid":"https://pubmed.ncbi.nlm.nih.gov/16641396"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa054186","doi":"https://doi.org/10.1056/nejmoa054186","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa054186","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa054186?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa054186?articleTools=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021348845","display_name":"Alice R. Rumbold","orcid":"https://orcid.org/0000-0002-4453-9425","observed_orcids":["https://orcid.org/0000-0002-4453-9425"]},"institutions":[{"id":"https://openalex.org/I2801308011","display_name":"Women's and Children's Hospital","ror":"https://ror.org/03kwrfk72","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801308011"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Alice R. Rumbold","raw_affiliation_strings":["Discipline of Obstetrics and Gynaecology, University of Adelaide, Women's and Children's Hospital, North Adelaide, Australia","Discipline of Obstetrics and Gynaecology, University of Adelaide, Women's and Children's Hospital, North Adelaide"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Obstetrics and Gynaecology, University of Adelaide, Women's and Children's Hospital, North Adelaide, Australia","institution_ids":["https://openalex.org/I2801308011","https://openalex.org/I5681781"]},{"raw_affiliation_string":"Discipline of Obstetrics and Gynaecology, University of Adelaide, Women's and Children's Hospital, North Adelaide","institution_ids":["https://openalex.org/I2801308011","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084711970","display_name":"Caroline Anne Crowther","orcid":"https://orcid.org/0000-0002-9079-4451","observed_orcids":["https://orcid.org/0000-0002-9079-4451"]},"institutions":[{"id":"https://openalex.org/I2801308011","display_name":"Women's and Children's Hospital","ror":"https://ror.org/03kwrfk72","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801308011"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Caroline A. Crowther","raw_affiliation_strings":["Discipline of Obstetrics and Gynaecology, University of Adelaide, Women's and Children's Hospital, North Adelaide"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Obstetrics and Gynaecology, University of Adelaide, Women's and Children's Hospital, North Adelaide","institution_ids":["https://openalex.org/I2801308011","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046060798","display_name":"Ross Roger Haslam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801308011","display_name":"Women's and Children's Hospital","ror":"https://ror.org/03kwrfk72","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801308011"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ross R. Haslam","raw_affiliation_strings":["Department of Perinatal Medicine, Women's and Children's Hospital, North Adelaide"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Perinatal Medicine, Women's and Children's Hospital, North Adelaide","institution_ids":["https://openalex.org/I2801308011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080879162","display_name":"Gustaaf Dekker","orcid":"https://orcid.org/0000-0002-7362-6683","observed_orcids":["https://orcid.org/0000-0002-7362-6683"]},"institutions":[{"id":"https://openalex.org/I2801308011","display_name":"Women's and Children's Hospital","ror":"https://ror.org/03kwrfk72","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801308011"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gustaaf A. Dekker","raw_affiliation_strings":["Discipline of Obstetrics and Gynaecology, University of Adelaide, Women's and Children's Hospital, North Adelaide"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Obstetrics and Gynaecology, University of Adelaide, Women's and Children's Hospital, North Adelaide","institution_ids":["https://openalex.org/I2801308011","https://openalex.org/I5681781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106181600","display_name":"Jeffrey Samuel Robinson","orcid":"https://orcid.org/0000-0002-4515-6039","observed_orcids":["https://orcid.org/0000-0002-4515-6039"]},"institutions":[{"id":"https://openalex.org/I2801308011","display_name":"Women's and Children's Hospital","ror":"https://ror.org/03kwrfk72","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801308011"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jeffrey S. Robinson","raw_affiliation_strings":["Discipline of Obstetrics and Gynaecology, University of Adelaide, Women's and Children's Hospital, North Adelaide"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Obstetrics and Gynaecology, University of Adelaide, Women's and Children's Hospital, North Adelaide","institution_ids":["https://openalex.org/I2801308011","https://openalex.org/I5681781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":64.8011,"has_fulltext":true,"cited_by_count":477,"citation_normalized_percentile":{"value":0.99967437,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"354","issue":"17","first_page":"1796","last_page":"1806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.8309999704360962},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":1.0},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.8650000095367432},{"id":"https://openalex.org/keywords/perinatal-complications","display_name":"perinatal complications","score":0.8980000019073486},{"id":"https://openalex.org/keywords/prenatal-supplementation","display_name":"prenatal supplementation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/antioxidant-vitamins","display_name":"antioxidant vitamins","score":0.8230000138282776},{"id":"https://openalex.org/keywords/nulliparous-women","display_name":"nulliparous women","score":0.8820000290870667},{"id":"https://openalex.org/keywords/intrauterine-growth-restriction","display_name":"fetal growth restriction","score":0.9639999866485596},{"id":"https://openalex.org/keywords/infant-mortality","display_name":"infant mortality","score":0.5180000066757202},{"id":"https://openalex.org/keywords/birth-weight","display_name":"birth weight","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9306907653808594},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.718512237071991},{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.7092089653015137},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.6199178695678711},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5968352556228638},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5756893157958984},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5472081899642944},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.530811071395874},{"id":"https://openalex.org/C66322754","wikidata":"https://www.wikidata.org/wiki/Q4128476","display_name":"Birth weight","level":3,"score":0.5032495856285095},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.4923192262649536},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.44254428148269653},{"id":"https://openalex.org/C2779083892","wikidata":"https://www.wikidata.org/wiki/Q6692979","display_name":"Low birth weight","level":3,"score":0.420958936214447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18428733944892883},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005313","descriptor_name":"Fetal Death","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D005317","descriptor_name":"Fetal Growth Retardation","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007226","descriptor_name":"Infant Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007236","descriptor_name":"Infant, Small for Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010298","descriptor_name":"Parity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011256","descriptor_name":"Pregnancy Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012127","descriptor_name":"Respiratory Distress Syndrome, Newborn","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1056/nejmoa054186","doi":"https://doi.org/10.1056/nejmoa054186","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa054186","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa054186?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:16641396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16641396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/23161","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2440/23161","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dx.doi.org/10.1056/nejmoa054186","raw_type":"Journal article"},{"id":"pmh:oai:researchspace.auckland.ac.nz:2292/19154","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2292/19154","pdf_url":null,"source":{"id":"https://openalex.org/S7407055463","display_name":"ResearchSpace (University of Auckland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I154130895","host_organization_name":"University of Auckland","host_organization_lineage":["https://openalex.org/I154130895"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1056/nejmoa054186","doi":"https://doi.org/10.1056/nejmoa054186","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa054186","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa054186?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016659985.pdf","grobid_xml":"https://content.openalex.org/works/W2016659985.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1788301041","https://openalex.org/W1887679324","https://openalex.org/W1973905104","https://openalex.org/W1978407431","https://openalex.org/W1983687348","https://openalex.org/W1986766737","https://openalex.org/W1986868208","https://openalex.org/W1997917263","https://openalex.org/W1998985189","https://openalex.org/W2022239213","https://openalex.org/W2035813218","https://openalex.org/W2040204859","https://openalex.org/W2063095299","https://openalex.org/W2065046349","https://openalex.org/W2076130594","https://openalex.org/W2084688828","https://openalex.org/W2086657052","https://openalex.org/W2103825558","https://openalex.org/W2111984223","https://openalex.org/W2134070386","https://openalex.org/W2135352951","https://openalex.org/W2160222455","https://openalex.org/W2167515138","https://openalex.org/W2172069911","https://openalex.org/W2334025156","https://openalex.org/W2334645872","https://openalex.org/W2398201067","https://openalex.org/W2468453849","https://openalex.org/W2559256714","https://openalex.org/W3160565403","https://openalex.org/W3162964430","https://openalex.org/W4205210034","https://openalex.org/W4233842068","https://openalex.org/W4246913131","https://openalex.org/W4379522092"],"related_works":["https://openalex.org/W2004134688","https://openalex.org/W2506281632","https://openalex.org/W2161116053","https://openalex.org/W2106703642","https://openalex.org/W2032231831","https://openalex.org/W1986766737","https://openalex.org/W1570192366","https://openalex.org/W2167559287","https://openalex.org/W2283029594","https://openalex.org/W1981056305"],"abstract_inverted_index":{"BACKGROUND:":[0],"Supplementation":[1,226],"with":[2,48,199,227],"antioxidant":[3],"vitamins":[4,228],"has":[5],"been":[6],"proposed":[7],"to":[8,45,123,129,171,193,223],"reduce":[9,236],"the":[10,18,69,79,82,88,104,112,117,124,130,136,147,153,178,204,237,244,251],"risk":[11,154,238,245,252],"of":[12,20,32,40,51,57,71,84,135,155,239,246,253],"preeclampsia":[13,156,240],"and":[14,37,54,90,95,127,149,159,182,212,230],"perinatal":[15],"complications,":[16],"but":[17],"effects":[19],"this":[21],"intervention":[22],"are":[23],"uncertain.":[24],"METHODS:":[25],"We":[26],"conducted":[27],"a":[28,200],"multicenter,":[29],"randomized":[30],"trial":[31],"nulliparous":[33,242],"women":[34,114],"between":[35,146],"14":[36],"22":[38],"weeks":[39],"gestation.":[41],"Women":[42],"were":[43,68,120,139,142],"assigned":[44,122],"daily":[46],"supplementation":[47],"1000":[49],"mg":[50],"vitamin":[52,58,125,148],"C":[53,229],"400":[55],"IU":[56],"E":[59,231],"or":[60,75,174,195,250,255],"placebo":[61,131,150],"(microcrystalline":[62],"cellulose)":[63],"until":[64],"delivery.":[65],"Primary":[66],"outcomes":[67,77,176,258],"risks":[70],"maternal":[72],"preeclampsia,":[73],"death":[74,173,254],"serious":[76,175,257],"in":[78,116,152,177,241,259],"infants":[80],"(on":[81],"basis":[83],"definitions":[85],"used":[86],"by":[87],"Australian":[89],"New":[91],"Zealand":[92],"Neonatal":[93],"Network),":[94],"delivering":[96],"an":[97,197],"infant":[98,179,198],"whose":[99],"birth":[100,201],"weight":[101,202],"was":[102],"below":[103,203],"10th":[105,205],"percentile":[106,206],"for":[107,207],"gestational":[108,208],"age.":[109],"RESULTS:":[110],"Of":[111],"1877":[113],"enrolled":[115],"study,":[118],"935":[119],"randomly":[121],"group":[126],"942":[128],"group.":[132],"Baseline":[133],"characteristics":[134],"two":[137],"groups":[138,151],"similar.":[140],"There":[141],"no":[143],"significant":[144],"differences":[145],"(6.0":[157],"percent":[158,167,181,189,211,219],"5.0":[160],"percent,":[161],"respectively;":[162],"relative":[163,185,215],"risk,":[164,186,216],"1.20;":[165],"95":[166,188,218],"confidence":[168,190,220],"interval,":[169,191,221],"0.82":[170],"1.75),":[172],"(9.5":[180],"12.1":[183],"percent;":[184,214],"0.79;":[187],"0.61":[192],"1.02),":[194],"having":[196],"age":[209],"(8.7":[210],"9.9":[213],"0.87;":[217],"0.66":[222],"1.16).":[224],"CONCLUSIONS:":[225],"during":[232],"pregnancy":[233],"does":[234],"not":[235],"women,":[243],"intrauterine":[247],"growth":[248],"restriction,":[249],"other":[256],"their":[260],"infants.":[261],"(Controlledtrials.com":[262],"number,":[263],"ISRCTN00416244.).":[264]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":27}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}