{"id":"https://openalex.org/W2016655706","doi":"https://doi.org/10.1126/science.2981431","title":"Bovine Leukemia Virus Long Terminal Repeat: A Cell Type-Specific Promoter","display_name":"Bovine Leukemia Virus Long Terminal Repeat: A Cell Type-Specific Promoter","publication_year":1985,"publication_date":"1985-01-18","ids":{"openalex":"https://openalex.org/W2016655706","doi":"https://doi.org/10.1126/science.2981431","mag":"2016655706","pmid":"https://pubmed.ncbi.nlm.nih.gov/2981431"},"language":"en","primary_location":{"id":"doi:10.1126/science.2981431","doi":"https://doi.org/10.1126/science.2981431","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.2981431","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060177702","display_name":"David Derse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Derse","raw_affiliation_strings":["Section of Genetics, Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Genetics, Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079929590","display_name":"Salvatore J. Caradonna","orcid":"https://orcid.org/0000-0002-2104-581X","observed_orcids":["https://orcid.org/0000-0002-2104-581X"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I2801463575","display_name":"University Medical Center New Orleans","ror":"https://ror.org/02zrb2v54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I2801463575","https://openalex.org/I75420490"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salvatore J. Caradonna","raw_affiliation_strings":["Department of Pharmacology, Louisiana State University Medical Center, New Orleans 70112"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Louisiana State University Medical Center, New Orleans 70112","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I2801463575","https://openalex.org/I75420490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110232444","display_name":"James W. Casey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James W. Casey","raw_affiliation_strings":["Section of Genetics, Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Genetics, Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.3319,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.98528926,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"227","issue":"4684","first_page":"317","last_page":"320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.08529999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-leukemia-virus","display_name":"bovine leukemia virus","score":0.996999979019165},{"id":"https://openalex.org/keywords/long-terminal-repeat","display_name":"long terminal repeat","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cell-type-specific-promoters","display_name":"cell type-specific promoters","score":0.8640000224113464},{"id":"https://openalex.org/keywords/transient-expression","display_name":"transient expression","score":0.7260000109672546},{"id":"https://openalex.org/keywords/chloramphenicol-acetyltransferase-reporter","display_name":"chloramphenicol acetyltransferase reporter","score":0.9340000152587891},{"id":"https://openalex.org/keywords/retroviral-gene-regulation","display_name":"retroviral gene regulation","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C199491388","wikidata":"https://www.wikidata.org/wiki/Q1869477","display_name":"Long terminal repeat","level":4,"score":0.7715716361999512},{"id":"https://openalex.org/C2779664074","wikidata":"https://www.wikidata.org/wiki/Q3518405","display_name":"Terminal (telecommunication)","level":2,"score":0.5470335483551025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5289233922958374},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5179292559623718},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5066007375717163},{"id":"https://openalex.org/C2778645089","wikidata":"https://www.wikidata.org/wiki/Q895365","display_name":"Bovine leukemia virus","level":3,"score":0.4201594889163971},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.40920788049697876},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35381144285202026},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3448023200035095},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19592410326004028},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.08829635381698608},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08401134610176086},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.05689716339111328}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001909","descriptor_name":"Leukemia Virus, Bovine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002685","descriptor_name":"Chiroptera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004274","descriptor_name":"DNA, Recombinant","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017977","descriptor_name":"Deltaretrovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.2981431","doi":"https://doi.org/10.1126/science.2981431","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.2981431","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:2981431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2981431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8105642377","display_name":null,"funder_award_id":"CA07392","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8376292119","display_name":"POST-TRANSLATIONAL MECHANISMS IN URACIL-DNA REPAIR","funder_award_id":"R01CA084421","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1515587227","https://openalex.org/W1681242094","https://openalex.org/W1947635334","https://openalex.org/W1968244375","https://openalex.org/W1972707809","https://openalex.org/W1981083554","https://openalex.org/W1990998019","https://openalex.org/W1999053228","https://openalex.org/W2010356985","https://openalex.org/W2011694898","https://openalex.org/W2038218774","https://openalex.org/W2045679225","https://openalex.org/W2057893650","https://openalex.org/W2060880451","https://openalex.org/W2061102119","https://openalex.org/W2065716796","https://openalex.org/W2071219626","https://openalex.org/W2075031614","https://openalex.org/W2090516269","https://openalex.org/W2094703003","https://openalex.org/W2144206181","https://openalex.org/W2273508797","https://openalex.org/W2326728045"],"related_works":["https://openalex.org/W1967425449","https://openalex.org/W2442152001","https://openalex.org/W1539006922","https://openalex.org/W7100079679","https://openalex.org/W2129439235","https://openalex.org/W213862950","https://openalex.org/W2520269819","https://openalex.org/W1988333200","https://openalex.org/W2072463437","https://openalex.org/W2425204774"],"abstract_inverted_index":{"The":[0,84,146],"functional":[1],"activity":[2,58,88,142],"of":[3,14,25,56,86,100,112,119,126,134,140,173],"the":[4,9,42,50,61,68,113,120,127,132,135,138,168,174],"promoter":[5,155],"unit":[6],"contained":[7],"within":[8,104],"long":[10],"terminal":[11],"repeat":[12],"(LTR)":[13],"bovine":[15],"leukemia":[16],"virus":[17],"(BLV)":[18],"was":[19,64,94],"examined":[20],"by":[21,60,98,143],"monitoring":[22],"transient":[23],"expression":[24,55,139],"a":[26,105,159],"heterologous":[27],"gene":[28,47,180],"placed":[29],"under":[30],"its":[31],"control.":[32],"Various":[33],"cell":[34,71,160],"lines":[35,72],"were":[36],"transfected":[37],"with":[38],"recombinant":[39],"plasmids":[40],"carrying":[41],"bacterial":[43],"chloramphenicol":[44],"acetyltransferase":[45],"(CAT)":[46],"coupled":[48],"to":[49,108,131,151],"BLV":[51,62,147],"LTR":[52,63,101,136,148],"(pBL-cat).":[53],"Transient":[54],"CAT":[57,87,141],"directed":[59],"observed":[65],"only":[66],"in":[67,91,158],"established":[69],"BLV-producer":[70],"derived":[73],"from":[74],"fetal":[75],"lamb":[76],"kidney":[77],"(FLK)":[78],"cells":[79,93],"and":[80,163,170],"bat":[81],"lung":[82],"cells.":[83],"amount":[85],"transiently":[89],"expressed":[90],"FLK-BLV":[92],"decreased":[95],"approximately":[96],"tenfold":[97],"deletion":[99],"sequences":[102,165],"located":[103],"region":[106,121],"100":[107],"170":[109],"nucleotides":[110],"upstream":[111],"RNA":[114,128,175],"start":[115,176],"site.":[116],"Surprisingly,":[117],"removal":[118],"50":[122],"base":[123],"pairs":[124],"downstream":[125],"initiation":[129],"site":[130,177],"3'-end":[133],"reduced":[137],"87":[144],"percent.":[145],"thus":[149],"appears":[150],"be":[152],"an":[153],"unusual":[154],"unit,":[156],"functioning":[157],"type-specific":[161],"manner":[162],"possessing":[164],"on":[166],"both":[167],"5'":[169],"3'":[171],"sides":[172],"that":[178],"influence":[179],"expression.":[181]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}