{"id":"https://openalex.org/W2016649530","doi":"https://doi.org/10.1161/01.cir.100.14.1533","title":"Heparin Inhibits Ligand Binding to the Leukocyte Integrin Mac-1 (CD11b/CD18)","display_name":"Heparin Inhibits Ligand Binding to the Leukocyte Integrin Mac-1 (CD11b/CD18)","publication_year":1999,"publication_date":"1999-10-05","ids":{"openalex":"https://openalex.org/W2016649530","doi":"https://doi.org/10.1161/01.cir.100.14.1533","mag":"2016649530","pmid":"https://pubmed.ncbi.nlm.nih.gov/10510057"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.100.14.1533","doi":"https://doi.org/10.1161/01.cir.100.14.1533","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.100.14.1533","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2016649530"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049936296","display_name":"Karlheinz Peter","orcid":"https://orcid.org/0000-0002-8040-2258","observed_orcids":["https://orcid.org/0000-0002-8040-2258"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karlheinz Peter","raw_affiliation_strings":["From the Departments of Internal Medicine III and Biometry (C.C.), University of Heidelberg, Germany","Department of Internal Medicine III, University of Heidelberg, Germany. peter@mm31.ukl.uni-freiburg.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine III and Biometry (C.C.), University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Department of Internal Medicine III, University of Heidelberg, Germany. peter@mm31.ukl.uni-freiburg.de","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103404962","display_name":"Meike Schwarz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Meike Schwarz","raw_affiliation_strings":["From the Departments of Internal Medicine III and Biometry (C.C.), University of Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine III and Biometry (C.C.), University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067392519","display_name":"Christian Conradt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Conradt","raw_affiliation_strings":["From the Departments of Internal Medicine III and Biometry (C.C.), University of Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine III and Biometry (C.C.), University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110168744","display_name":"Thomas K. Nordt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Nordt","raw_affiliation_strings":["From the Departments of Internal Medicine III and Biometry (C.C.), University of Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine III and Biometry (C.C.), University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030654513","display_name":"Martin Moser","orcid":"https://orcid.org/0000-0002-0745-7447","observed_orcids":["https://orcid.org/0000-0002-0745-7447"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Moser","raw_affiliation_strings":["From the Departments of Internal Medicine III and Biometry (C.C.), University of Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine III and Biometry (C.C.), University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111762241","display_name":"W. K\u00fcbler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Ku\u0308bler","raw_affiliation_strings":["From the Departments of Internal Medicine III and Biometry (C.C.), University of Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine III and Biometry (C.C.), University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015202871","display_name":"Christoph Bode","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Bode","raw_affiliation_strings":["From the Departments of Internal Medicine III and Biometry (C.C.), University of Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine III and Biometry (C.C.), University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":null,"apc_paid":null,"fwci":2.9341,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.89881593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"100","issue":"14","first_page":"1533","last_page":"1539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":1.0},{"id":"https://openalex.org/keywords/mac-1","display_name":"Mac-1","score":0.968999981880188},{"id":"https://openalex.org/keywords/cd11b-cd18","display_name":"CD11b/CD18","score":0.9879999756813049},{"id":"https://openalex.org/keywords/beta2-integrins","display_name":"beta2 integrins","score":0.6980000138282776},{"id":"https://openalex.org/keywords/ligand-binding-inhibition","display_name":"ligand binding inhibition","score":0.6980000138282776},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.925000011920929},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.8619999885559082},{"id":"https://openalex.org/keywords/leukocyte-adhesion","display_name":"leukocyte adhesion","score":0.777999997138977},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.7540000081062317},{"id":"https://openalex.org/keywords/granulocytes","display_name":"granulocytes","score":0.9909999966621399},{"id":"https://openalex.org/keywords/low-molecular-weight-heparin","display_name":"low molecular weight heparin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/activated-partial-thromboplastin-time","display_name":"activated partial thromboplastin time","score":0.9309999942779541}],"concepts":[{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.8262252807617188},{"id":"https://openalex.org/C53122370","wikidata":"https://www.wikidata.org/wiki/Q2458503","display_name":"CD18","level":4,"score":0.6027125716209412},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5930303335189819},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.5861416459083557},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5506406426429749},{"id":"https://openalex.org/C171779818","wikidata":"https://www.wikidata.org/wiki/Q3799301","display_name":"Integrin alpha M","level":3,"score":0.5171858072280884},{"id":"https://openalex.org/C2778261982","wikidata":"https://www.wikidata.org/wiki/Q1755136","display_name":"Partial thromboplastin time","level":3,"score":0.5097832083702087},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4845963716506958},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4700157940387726},{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.42892566323280334},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4276789128780365},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3504409193992615},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2561696171760559},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.2258099913597107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18691980838775635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16659528017044067},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005170","descriptor_name":"Factor X","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010314","descriptor_name":"Partial Thromboplastin Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016177","descriptor_name":"Macrophage-1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/01.cir.100.14.1533","doi":"https://doi.org/10.1161/01.cir.100.14.1533","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.100.14.1533","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:10510057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10510057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.597.9706","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.597.9706","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/100/14/1533.full.pdf","raw_type":"text"},{"id":"mag:2886598262","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.100.14.1533?related-urls=yes&legid=circulationaha%3B100%2F14%2F1533","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W3880031","https://openalex.org/W22023160","https://openalex.org/W190347642","https://openalex.org/W1552868989","https://openalex.org/W1991767888","https://openalex.org/W2005020306","https://openalex.org/W2005141599","https://openalex.org/W2005663928","https://openalex.org/W2011260190","https://openalex.org/W2022016068","https://openalex.org/W2022445134","https://openalex.org/W2029231027","https://openalex.org/W2037208843","https://openalex.org/W2037724847","https://openalex.org/W2040122658","https://openalex.org/W2043542087","https://openalex.org/W2064890719","https://openalex.org/W2068153038","https://openalex.org/W2075196907","https://openalex.org/W2080713469","https://openalex.org/W2082264161","https://openalex.org/W2097097037","https://openalex.org/W2099675490","https://openalex.org/W2119132855","https://openalex.org/W2136016201","https://openalex.org/W2136969158","https://openalex.org/W2144801283","https://openalex.org/W2145432598","https://openalex.org/W2149524618","https://openalex.org/W2240345672","https://openalex.org/W2395047360","https://openalex.org/W4205312708","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2119132855","https://openalex.org/W3152063177","https://openalex.org/W7126481983","https://openalex.org/W2317710958","https://openalex.org/W2147642245","https://openalex.org/W2159985197","https://openalex.org/W2080086845","https://openalex.org/W2035158972"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,213],"clinical":[2,45,211],"benefits":[3,209],"of":[4,33,42,47,66,85,96,108,115,135,148,155,159,169,174,187,189,202,215,225],"heparin":[5,21,53,68,86,93,144,164,170,203,216],"reach":[6],"beyond":[7],"its":[8,208],"anticoagulative":[9],"properties.":[10],"Recently,":[11],"it":[12],"has":[13],"been":[14],"described":[15],"that":[16,178,204],"leukocytes":[17],"adhere":[18],"on":[19,71,89,171],"immobilized":[20,121],"mediated":[22],"by":[23,125,137],"the":[24,43,97,109,129,172,185,190,220],"integrin":[25],"Mac-1":[26,55,70,136,177,218,226],"(CD11b/CD18,":[27],"alphaMbeta2,":[28],"or":[29],"CR3).":[30],"Because":[31],"inhibition":[32,134,222],"this":[34],"versatile":[35],"adhesion":[36],"molecule":[37],"could":[38],"explain":[39],"various":[40],"aspects":[41],"beneficial":[44],"effects":[46],"heparin,":[48,127],"we":[49],"evaluated":[50],"whether":[51],"soluble":[52,98],"modulates":[54],"function":[56],"in":[57,60,79,210,223],"vitro":[58],"and":[59,74,103,114,118,219,233],"vivo.":[61],"METHODS":[62],"AND":[63],"RESULTS:":[64],"Binding":[65],"unfractionated":[67,126,163],"to":[69,105,120,128,150,176,184,207,217],"PMA-stimulated":[72],"monocytes":[73,117],"granulocytes":[75,119],"was":[76,87,123],"directly":[77,229],"demonstrated":[78],"flow":[80,153],"cytometry,":[81],"whereas":[82],"no":[83],"binding":[84,95,147,173,214,224],"detected":[88],"unstimulated":[90],"leukocytes.":[91],"Unfractionated":[92],"inhibited":[94],"ligands":[99,227],"fibrinogen,":[100],"factor":[101],"X,":[102],"iC3b":[104],"Mac-1.":[106,151],"Adhesion":[107],"monocytic":[110],"cell":[111,234],"line":[112],"THP-1":[113],"peripheral":[116],"ICAM-1":[122],"impaired":[124],"same":[130],"extent":[131,186],"as":[132,141],"with":[133,162],"monoclonal":[138],"antibodies":[139],"such":[140],"c7E3.":[142],"Low-molecular-weight":[143],"also":[145],"inhibits":[146],"fibrinogen":[149,175],"Additionally,":[152],"cytometry":[154],"whole":[156],"blood":[157],"preparations":[158],"patients":[160],"treated":[161],"revealed":[165],"an":[166],"inhibitory":[167],"effect":[168],"correlates":[179],"(n=":[180],"48,":[181],"r=0.63,":[182],"P<0.001)":[183],"prolongation":[188],"activated":[191],"partial":[192],"thromboplastin":[193],"time.":[194],"CONCLUSIONS:":[195],"We":[196],"describe":[197],"a":[198],"pharmacologically":[199],"relevant":[200],"property":[201],"may":[205,228],"contribute":[206],"use.":[212],"resulting":[221],"modulate":[230],"coagulation,":[231],"inflammation,":[232],"proliferation.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}