{"id":"https://openalex.org/W2016646689","doi":"https://doi.org/10.1056/nejmoa012630","title":"Myocardial Gene Expression in Dilated Cardiomyopathy Treated with Beta-Blocking Agents","display_name":"Myocardial Gene Expression in Dilated Cardiomyopathy Treated with Beta-Blocking Agents","publication_year":2002,"publication_date":"2002-05-02","ids":{"openalex":"https://openalex.org/W2016646689","doi":"https://doi.org/10.1056/nejmoa012630","mag":"2016646689","pmid":"https://pubmed.ncbi.nlm.nih.gov/11986409"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa012630","doi":"https://doi.org/10.1056/nejmoa012630","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa012630","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa012630?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa012630?articleTools=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088568680","display_name":"Brian D. Lowes","orcid":"https://orcid.org/0000-0002-5919-2540","observed_orcids":["https://orcid.org/0000-0002-5919-2540"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian D. Lowes","raw_affiliation_strings":["Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver 80262, USA","Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver 80262, USA","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037039739","display_name":"Edward Michael Gilbert","orcid":"https://orcid.org/0000-0002-4298-3645","observed_orcids":["https://orcid.org/0000-0002-4298-3645"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210148268","display_name":"University of Utah Health Care","ror":"https://ror.org/047s7ex42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward M. Gilbert","raw_affiliation_strings":["Division of Cardiology, University of Utah Health Sciences Center, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, University of Utah Health Sciences Center, Salt Lake City","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I4210148268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066384461","display_name":"William T. Abraham","orcid":"https://orcid.org/0000-0003-4805-1037","observed_orcids":["https://orcid.org/0000-0003-4805-1037"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William T. Abraham","raw_affiliation_strings":["Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050293067","display_name":"Wayne A. Minobe","orcid":"https://orcid.org/0000-0001-8257-2368","observed_orcids":["https://orcid.org/0000-0001-8257-2368"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne A. Minobe","raw_affiliation_strings":["Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111662086","display_name":"Patti Larrabee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210148268","display_name":"University of Utah Health Care","ror":"https://ror.org/047s7ex42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patti Larrabee","raw_affiliation_strings":["Division of Cardiology, University of Utah Health Sciences Center, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, University of Utah Health Sciences Center, Salt Lake City","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I4210148268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037445100","display_name":"Debra A. Ferguson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra Ferguson","raw_affiliation_strings":["Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005761607","display_name":"Eugene E. Wolfel","orcid":"https://orcid.org/0009-0007-8924-3787","observed_orcids":["https://orcid.org/0009-0007-8924-3787"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene E. Wolfel","raw_affiliation_strings":["Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111901150","display_name":"JoAnn Lindenfeld","orcid":"https://orcid.org/0000-0001-9207-3634","observed_orcids":["https://orcid.org/0000-0001-9207-3634"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JoAnn Lindenfeld","raw_affiliation_strings":["Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047629879","display_name":"Tatiana O. Tsvetkova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatiana Tsvetkova","raw_affiliation_strings":["Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031187925","display_name":"Alastair D. Robertson","orcid":"https://orcid.org/0000-0002-0970-1722","observed_orcids":["https://orcid.org/0000-0002-0970-1722"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alastair D. Robertson","raw_affiliation_strings":["Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082971182","display_name":"Robert A. Quaife","orcid":"https://orcid.org/0000-0002-0695-8872","observed_orcids":["https://orcid.org/0000-0002-0695-8872"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Quaife","raw_affiliation_strings":["Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042834490","display_name":"Michael R. Bristow","orcid":"https://orcid.org/0000-0002-8860-4698","observed_orcids":["https://orcid.org/0000-0002-8860-4698"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Bristow","raw_affiliation_strings":["Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology and the Cardiovascular Institute, University of Colorado Health Sciences Center, Denver","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":24.6829,"has_fulltext":true,"cited_by_count":500,"citation_normalized_percentile":{"value":0.99631368,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"346","issue":"18","first_page":"1357","last_page":"1365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-dilated-cardiomyopathy","display_name":"idiopathic dilated cardiomyopathy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/beta-blocker-therapy","display_name":"beta-blocker therapy","score":0.847000002861023},{"id":"https://openalex.org/keywords/metoprolol","display_name":"metoprolol","score":0.9750000238418579},{"id":"https://openalex.org/keywords/carvedilol","display_name":"carvedilol","score":1.0},{"id":"https://openalex.org/keywords/myocardial-gene-expression","display_name":"myocardial gene expression","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-calcium-atpase","display_name":"sarcoplasmic reticulum calcium ATPase","score":0.9399999976158142},{"id":"https://openalex.org/keywords/myosin-heavy-chain-isoforms","display_name":"myosin heavy chain isoforms","score":0.9179999828338623},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.9629999995231628},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.8650000095367432},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.6259999871253967},{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.912322998046875},{"id":"https://openalex.org/C2776383484","wikidata":"https://www.wikidata.org/wiki/Q283656","display_name":"Dilated cardiomyopathy","level":3,"score":0.868105947971344},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.7509453296661377},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6573894023895264},{"id":"https://openalex.org/C3018418570","wikidata":"https://www.wikidata.org/wiki/Q1729124","display_name":"Myocardial hypertrophy","level":3,"score":0.6067283153533936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6064169406890869},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.5985697507858276},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.589300274848938},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.5368025898933411},{"id":"https://openalex.org/C2778742482","wikidata":"https://www.wikidata.org/wiki/Q816759","display_name":"Beta blocker","level":3,"score":0.45987123250961304},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.4175513982772827},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2625935673713684},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077261","descriptor_name":"Carvedilol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002311","descriptor_name":"Cardiomyopathy, Dilated","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002311","descriptor_name":"Cardiomyopathy, Dilated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002311","descriptor_name":"Cardiomyopathy, Dilated","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008790","descriptor_name":"Metoprolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008790","descriptor_name":"Metoprolol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024723","descriptor_name":"Ventricular Myosins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D024723","descriptor_name":"Ventricular Myosins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024723","descriptor_name":"Ventricular Myosins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejmoa012630","doi":"https://doi.org/10.1056/nejmoa012630","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa012630","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa012630?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:11986409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11986409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1056/nejmoa012630","doi":"https://doi.org/10.1056/nejmoa012630","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa012630","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa012630?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G3482496003","display_name":"General Clinical Research Center","funder_award_id":"M01RR000051","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G46349248","display_name":"Genetic-Adrenergic Interactions in Myocardial Failure","funder_award_id":"R01HL048013","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8031978833","display_name":"General Clinical Research Center","funder_award_id":"M01RR000064","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016646689.pdf","grobid_xml":"https://content.openalex.org/works/W2016646689.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1511964900","https://openalex.org/W1524057507","https://openalex.org/W1603784945","https://openalex.org/W1916800720","https://openalex.org/W1981731045","https://openalex.org/W1984388571","https://openalex.org/W1989475487","https://openalex.org/W1992540995","https://openalex.org/W2000721478","https://openalex.org/W2006229710","https://openalex.org/W2006254974","https://openalex.org/W2008797417","https://openalex.org/W2021315555","https://openalex.org/W2030553750","https://openalex.org/W2032910151","https://openalex.org/W2035330359","https://openalex.org/W2039555336","https://openalex.org/W2049477595","https://openalex.org/W2052780003","https://openalex.org/W2056126139","https://openalex.org/W2061693585","https://openalex.org/W2063106685","https://openalex.org/W2123495845","https://openalex.org/W2128867957","https://openalex.org/W2138004092","https://openalex.org/W2149495528","https://openalex.org/W2163130289","https://openalex.org/W2170438288","https://openalex.org/W2498474976","https://openalex.org/W2519981891"],"related_works":["https://openalex.org/W2033928961","https://openalex.org/W2036195154","https://openalex.org/W2060205197","https://openalex.org/W2014009557","https://openalex.org/W3028552598","https://openalex.org/W2151966431","https://openalex.org/W2419447045","https://openalex.org/W2002309852","https://openalex.org/W2046719381","https://openalex.org/W336909659"],"abstract_inverted_index":{"BACKGROUND:":[0],"Beta-blocker":[1],"therapy":[2,19],"may":[3],"improve":[4],"cardiac":[5],"function":[6],"in":[7,24,79,112,147,154,179,225,238,245,252,255,279,284,308],"patients":[8,45,170,201,254],"with":[9,46,52,93,105,152,172,197,302,306],"idiopathic":[10,47,294],"dilated":[11,25,48,295],"cardiomyopathy.":[12],"We":[13,41],"tested":[14],"the":[15,29,80,120,155,198,253,256,282],"hypothesis":[16],"that":[17,34],"beta-blocker":[18],"produces":[20],"favorable":[21],"functional":[22,297],"effects":[23],"cardiomyopathy":[26,49],"by":[27,162],"altering":[28],"expression":[30,149,288],"of":[31,64,90,119,127,143,167,184,212,281,289],"myocardial":[32,309],"genes":[33,70,91],"regulate":[35],"contractility":[36],"and":[37,74,83,85,89,99,139,145,230,235,274],"pathologic":[38,94],"hypertrophy.":[39],"METHODS:":[40],"randomly":[42],"assigned":[43],"53":[44],"to":[50,300],"treatment":[51,301],"a":[53,106,206,210,220,236,261,272],"beta-adrenergic-receptor":[54],"blocking":[55],"agent":[56],"(metoprolol":[57],"or":[58,60,286],"carvedilol)":[59],"placebo.":[61],"The":[62,243],"amount":[63],"messenger":[65],"RNA":[66,114],"(mRNA)":[67],"for":[68],"contractility-regulating":[69],"(those":[71,171],"encoding":[72],"beta1-":[73],"beta2-adrenergic":[75],"receptors,":[76],"calcium":[77,227,247],"ATPase":[78,228,248],"sarcoplasmic":[81],"reticulum,":[82],"alpha-":[84],"beta-myosin":[86,239],"heavy-chain":[87],"isoforms)":[88],"associated":[92,305],"hypertrophy":[95],"(beta-myosin":[96],"heavy":[97,232,240],"chain":[98,110,233,241],"atrial":[100],"natriuretic":[101],"peptide)":[102],"was":[103,249],"measured":[104,161],"quantitative":[107],"reverse-transcription":[108],"polymerase":[109],"reaction":[111],"total":[113],"extracted":[115],"from":[116],"biopsy":[117],"specimens":[118],"right":[121],"ventricular":[122,157,181],"septal":[123],"endomyocardium.":[124],"Myocardial":[125],"levels":[126],"beta-adrenergic":[128,290],"receptors":[129],"were":[130,134,150,265],"also":[131],"measured.":[132],"Measurements":[133],"conducted":[135],"at":[136,185],"base":[137],"line":[138],"after":[140],"six":[141,199],"months":[142],"treatment,":[144],"changes":[146,153,307],"gene":[148,310],"compared":[151,196],"left":[156,180],"ejection":[158,182],"fraction":[159,183],"as":[160],"radionuclide":[163],"ventriculography.":[164],"RESULTS:":[165],"Twenty-six":[166],"32":[168],"beta-blocker-treated":[169,200],"complete":[173],"mRNA":[174,229,234,285],"measurements)":[175],"had":[176,222,260,271],"an":[177,223],"improvement":[178,298],"least":[186],"5":[187],"ejection-fraction":[188],"(EF)":[189],"units":[190],"(mean":[191,208],"[+/-SE]":[192],"increase,":[193],"18.8+/-1.8).":[194],"As":[195],"who":[202,217,259,270,276],"did":[203,218,277],"not":[204,250,278],"have":[205,219],"response":[207,221,273],"change,":[209],"decrease":[211,237],"2.5+/-1.8":[213],"EF":[214],"units),":[215],"those":[216,269,275],"increase":[224],"sarcoplasmic-reticulum":[226,246],"alpha-myosin":[231],"mRNA.":[242],"change":[244,283],"present":[251],"placebo":[257],"group":[258],"spontaneous":[262],"response.":[263],"There":[264],"no":[266],"differences":[267],"between":[268],"terms":[280],"protein":[287],"receptors.":[291],"CONCLUSIONS:":[292],"In":[293],"cardiomyopathy,":[296],"related":[299],"beta-blockers":[303],"is":[304],"expression.":[311]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":27}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}