{"id":"https://openalex.org/W2016644610","doi":"https://doi.org/10.1080/10799890600623373","title":"Chronic Intracerebroventricular Administration of Relaxin-3 Increases Body Weight in Rats","display_name":"Chronic Intracerebroventricular Administration of Relaxin-3 Increases Body Weight in Rats","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2016644610","doi":"https://doi.org/10.1080/10799890600623373","mag":"2016644610","pmid":"https://pubmed.ncbi.nlm.nih.gov/16777712"},"language":"en","primary_location":{"id":"doi:10.1080/10799890600623373","doi":"https://doi.org/10.1080/10799890600623373","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10799890600623373","pdf_url":null,"source":{"id":"https://openalex.org/S116485566","display_name":"Journal of Receptors and Signal Transduction","issn_l":"1079-9893","issn":["1079-9893","1532-4281"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Receptors and Signal Transduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061155142","display_name":"Takayuki Hida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TAKAYUKI HIDA","raw_affiliation_strings":["Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028201702","display_name":"Eiki Takahashi","orcid":"https://orcid.org/0000-0002-0253-4968","observed_orcids":["https://orcid.org/0000-0002-0253-4968"]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"EIKI TAKAHASHI","raw_affiliation_strings":["Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074963958","display_name":"Kodo Shikata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KODO SHIKATA","raw_affiliation_strings":["Discovery Research Laboratories I, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research Laboratories I, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024282917","display_name":"Tomoko Hirohashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TOMOKO HIROHASHI","raw_affiliation_strings":["Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"TORU SAWAI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TORU SAWAI","raw_affiliation_strings":["Discovery Research Laboratories I, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research Laboratories I, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064486214","display_name":"Takashi Seiki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TAKASHI SEIKI","raw_affiliation_strings":["Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029399554","display_name":"Hirokazu Tanaka","orcid":"https://orcid.org/0000-0003-4312-6466","observed_orcids":["https://orcid.org/0000-0003-4312-6466"]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROKAZU TANAKA","raw_affiliation_strings":["Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090333154","display_name":"Takatoshi Kawai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TAKATOSHI KAWAI","raw_affiliation_strings":["Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"OSAMU ITO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"OSAMU ITO","raw_affiliation_strings":["Discovery Technology Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Technology Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"TORU ARAI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TORU ARAI","raw_affiliation_strings":["Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079407472","display_name":"Akira Yokoi","orcid":"https://orcid.org/0000-0003-0789-5102","observed_orcids":["https://orcid.org/0000-0003-0789-5102","https://orcid.org/0009-0001-7869-2399"]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"AKIRA YOKOI","raw_affiliation_strings":["Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079943615","display_name":"T Hirakawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TETSUYA HIRAKAWA","raw_affiliation_strings":["Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111912607","display_name":"Hiroo Ogura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROO OGURA","raw_affiliation_strings":["Discovery Research Laboratories I, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research Laboratories I, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076670168","display_name":"Takeshi Nagasu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TAKESHI NAGASU","raw_affiliation_strings":["Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102859713","display_name":"Norimasa Miyamoto","orcid":"https://orcid.org/0000-0003-0391-1339","observed_orcids":["https://orcid.org/0000-0003-0391-1339"]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NORIMASA MIYAMOTO","raw_affiliation_strings":["Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059312105","display_name":"Junro Kuromitsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"JUNRO KUROMITSU","raw_affiliation_strings":["Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Seeds Finding Technology, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I55881946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55881946"],"apc_list":null,"apc_paid":null,"fwci":2.9853,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.91393258,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"26","issue":"3","first_page":"147","last_page":"158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12715","display_name":"Pregnancy-related medical research","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relaxin-3","display_name":"relaxin-3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.9729999899864197},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.8560000061988831},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.9290000200271606},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.9259999990463257},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anti-obesity-drugs","display_name":"anti-obesity drugs","score":0.7670000195503235},{"id":"https://openalex.org/keywords/hypothalamic-neuropeptides","display_name":"hypothalamic neuropeptides","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2777121736","wikidata":"https://www.wikidata.org/wiki/Q24773888","display_name":"Relaxin","level":3,"score":0.9813716411590576},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7707314491271973},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7062432765960693},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.6002874374389648},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.5736793279647827},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.5315777063369751},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4846268594264984},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.4827229678630829},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4407346248626709},{"id":"https://openalex.org/C2780320433","wikidata":"https://www.wikidata.org/wiki/Q3403879","display_name":"Weight gain","level":3,"score":0.42935413122177124},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.27262401580810547}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007276","descriptor_name":"Injections, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012065","descriptor_name":"Relaxin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012065","descriptor_name":"Relaxin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D012065","descriptor_name":"Relaxin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D012065","descriptor_name":"Relaxin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/10799890600623373","doi":"https://doi.org/10.1080/10799890600623373","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10799890600623373","pdf_url":null,"source":{"id":"https://openalex.org/S116485566","display_name":"Journal of Receptors and Signal Transduction","issn_l":"1079-9893","issn":["1079-9893","1532-4281"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Receptors and Signal Transduction","raw_type":"journal-article"},{"id":"pmid:16777712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16777712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of receptor and signal transduction research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W307624243","https://openalex.org/W1488424161","https://openalex.org/W1629887654","https://openalex.org/W1928593782","https://openalex.org/W1971865087","https://openalex.org/W1977503450","https://openalex.org/W1986154815","https://openalex.org/W1996343815","https://openalex.org/W1999854623","https://openalex.org/W2001337273","https://openalex.org/W2010296481","https://openalex.org/W2010709434","https://openalex.org/W2011403383","https://openalex.org/W2017214431","https://openalex.org/W2017276900","https://openalex.org/W2020702186","https://openalex.org/W2030953510","https://openalex.org/W2057916223","https://openalex.org/W2058525665","https://openalex.org/W2062291892","https://openalex.org/W2068016224","https://openalex.org/W2074415991","https://openalex.org/W2083891358","https://openalex.org/W2092817365","https://openalex.org/W2104236680","https://openalex.org/W2110011886","https://openalex.org/W2117607600","https://openalex.org/W2125021972","https://openalex.org/W2125686850","https://openalex.org/W2125873842","https://openalex.org/W2131874815","https://openalex.org/W2155819536","https://openalex.org/W2160162119","https://openalex.org/W2164843289","https://openalex.org/W2414829511"],"related_works":["https://openalex.org/W4297798276","https://openalex.org/W2334766648","https://openalex.org/W4299426980","https://openalex.org/W1976252854","https://openalex.org/W2058525665","https://openalex.org/W7096517227","https://openalex.org/W2069103905","https://openalex.org/W2545152086","https://openalex.org/W1578938107","https://openalex.org/W2013933734"],"abstract_inverted_index":{"Bolus-administered":[0],"intracerebroventricular":[1],"(ICV)":[2],"relaxin-3":[3,18,31,48,120,133,146],"has":[4],"been":[5],"reported":[6],"to":[7,13,138],"increase":[8,140],"feeding.":[9],"In":[10,57],"this":[11],"study,":[12],"examine":[14],"the":[15,25,73,77,81,90,106,126],"role":[16],"of":[17,27,43,111,141],"signaling":[19],"in":[20,39,72,102,115,125],"energy":[21],"homeostasis,":[22],"we":[23],"studied":[24],"effects":[26],"chronically":[28,117],"administered":[29],"ICV":[30],"on":[32,84,93],"body":[33,142],"weight":[34,64,143],"gain":[35,65],"and":[36,63,87,89,96,113,144],"locomotor":[37,103],"activity":[38,104],"rats.":[40],"Two":[41],"groups":[42],"animals":[44,58],"received":[45],"vehicle":[46,74],"or":[47],"at":[49],"600":[50],"pmol/head/day,":[51],"delivered":[52],"with":[53,119],"Alzet":[54],"osmotic":[55],"minipumps.":[56],"receiving":[59],"relaxin-3,":[60],"food":[61,135],"consumption":[62],"were":[66,121],"statistically":[67],"significantly":[68,122],"higher":[69,123],"than":[70,124],"those":[71],"group":[75],"during":[76],"14-day":[78],"infusion.":[79],"During":[80],"light":[82],"phase":[83,92],"days":[85,94],"2":[86],"7":[88],"dark":[91],"3":[95],"8,":[97],"there":[98],"was":[99],"no":[100],"difference":[101],"between":[105],"two":[107],"groups.":[108],"Plasma":[109],"concentrations":[110],"leptin":[112],"insulin":[114],"rats":[116],"injected":[118],"vehicle-injected":[127],"controls.":[128],"These":[129],"results":[130],"indicate":[131],"that":[132,145],"up-regulates":[134],"intake,":[136],"leading":[137],"an":[139],"antagonists":[147],"might":[148],"be":[149],"candidate":[150],"antiobesity":[151],"agents.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}