{"id":"https://openalex.org/W2016632734","doi":"https://doi.org/10.1161/circulationaha.111.041418","title":"Long-Term Dipeptidyl-Peptidase 4 Inhibition Reduces Atherosclerosis and Inflammation via Effects on Monocyte Recruitment and Chemotaxis","display_name":"Long-Term Dipeptidyl-Peptidase 4 Inhibition Reduces Atherosclerosis and Inflammation via Effects on Monocyte Recruitment and Chemotaxis","publication_year":2011,"publication_date":"2011-10-18","ids":{"openalex":"https://openalex.org/W2016632734","doi":"https://doi.org/10.1161/circulationaha.111.041418","mag":"2016632734","pmid":"https://pubmed.ncbi.nlm.nih.gov/22007077","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4224594"},"language":"en","primary_location":{"id":"doi:10.1161/circulationaha.111.041418","doi":"https://doi.org/10.1161/circulationaha.111.041418","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.111.041418","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.111.041418","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.111.041418","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zubair Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zubair Shah","raw_affiliation_strings":["From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087732477","display_name":"Thomas Kampfrath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Kampfrath","raw_affiliation_strings":["From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102967840","display_name":"Jeffrey A. Deiuliis","orcid":"https://orcid.org/0000-0002-5665-8894","observed_orcids":["https://orcid.org/0000-0002-5665-8894"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Deiuliis","raw_affiliation_strings":["From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077862629","display_name":"Jixin Zhong","orcid":"https://orcid.org/0000-0002-3534-7480","observed_orcids":["https://orcid.org/0000-0002-3534-7480"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jixin Zhong","raw_affiliation_strings":["From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103328407","display_name":"Colleen A. Pineda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen Pineda","raw_affiliation_strings":["From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100679202","display_name":"Zhekang Ying","orcid":"https://orcid.org/0000-0001-5543-9502","observed_orcids":["https://orcid.org/0000-0001-5543-9502"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhekang Ying","raw_affiliation_strings":["From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102093928","display_name":"Xiaohua Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohua Xu","raw_affiliation_strings":["From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044220823","display_name":"Bo L\u00fc","orcid":"https://orcid.org/0000-0002-3807-7869","observed_orcids":["https://orcid.org/0000-0002-3807-7869"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo Lu","raw_affiliation_strings":["From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111364859","display_name":"Susan D. Moffatt","orcid":"https://orcid.org/0000-0002-0999-5505","observed_orcids":["https://orcid.org/0000-0002-0999-5505"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Moffatt-Bruce","raw_affiliation_strings":["From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013602671","display_name":"Rekha Durairaj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rekha Durairaj","raw_affiliation_strings":["From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028193901","display_name":"Qinghua Sun","orcid":"https://orcid.org/0000-0001-5029-587X","observed_orcids":["https://orcid.org/0000-0001-5029-587X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qinghua Sun","raw_affiliation_strings":["From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110040774","display_name":"Georgeta Mihai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georgeta Mihai","raw_affiliation_strings":["From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087596691","display_name":"Andrei Maiseyeu","orcid":"https://orcid.org/0000-0001-8830-1809","observed_orcids":["https://orcid.org/0000-0001-8830-1809"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrei Maiseyeu","raw_affiliation_strings":["From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022334933","display_name":"Sanjay Rajagopalan","orcid":"https://orcid.org/0000-0001-6669-8163","observed_orcids":["https://orcid.org/0000-0001-6669-8163"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjay Rajagopalan","raw_affiliation_strings":["From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Davis Heart &amp; Lung Research Institute, The Ohio State University College of Medicine, Columbus","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":14.8654,"has_fulltext":true,"cited_by_count":378,"citation_normalized_percentile":{"value":0.99489485,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"124","issue":"21","first_page":"2338","last_page":"2349"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.5410000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.5410000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.1906999945640564,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.15809999406337738,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dpp-4-inhibitors","display_name":"DPP-4 inhibitors","score":0.9380000233650208},{"id":"https://openalex.org/keywords/alogliptin","display_name":"alogliptin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/monocyte-recruitment","display_name":"monocyte recruitment","score":0.9259999990463257},{"id":"https://openalex.org/keywords/monocyte-chemotaxis","display_name":"monocyte chemotaxis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/monocyte-activation","display_name":"monocyte activation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/aortic-plaque","display_name":"aortic plaque","score":0.49900001287460327},{"id":"https://openalex.org/keywords/cd11b-cells","display_name":"CD11b+ cells","score":0.7670000195503235},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.6880000233650208},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7900000214576721},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7910000085830688},{"id":"https://openalex.org/keywords/rac-signaling","display_name":"Rac signaling","score":0.7049999833106995},{"id":"https://openalex.org/keywords/actin-polymerization","display_name":"actin polymerization","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.859000027179718},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7480000257492065},{"id":"https://openalex.org/keywords/ldlr-knockout-mice","display_name":"Ldlr knockout mice","score":0.7110000252723694},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.9750000238418579}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6892045140266418},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6495668888092041},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5970321297645569},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5902506709098816},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5891714692115784},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5703878998756409},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.5576128959655762},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.48001188039779663},{"id":"https://openalex.org/C2910375186","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"M2 Macrophage","level":4,"score":0.4174092411994934},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.41329237818717957},{"id":"https://openalex.org/C17675752","wikidata":"https://www.wikidata.org/wiki/Q12898553","display_name":"Adipose tissue macrophages","level":4,"score":0.4132421910762787},{"id":"https://openalex.org/C156490143","wikidata":"https://www.wikidata.org/wiki/Q412214","display_name":"Dipeptidyl peptidase-4","level":4,"score":0.4129522442817688},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.372795045375824},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.28456413745880127},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.2379433810710907},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20837080478668213},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.17617526650428772},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13952448964118958},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08340173959732056}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054873","descriptor_name":"Dipeptidyl-Peptidase IV Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054873","descriptor_name":"Dipeptidyl-Peptidase IV Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1161/circulationaha.111.041418","doi":"https://doi.org/10.1161/circulationaha.111.041418","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.111.041418","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.111.041418","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:22007077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22007077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3194446","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4224594","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4224594","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4224594","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circulation","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.968.6891","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.968.6891","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/circulationaha/124/21/2338.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1161/circulationaha.111.041418","doi":"https://doi.org/10.1161/circulationaha.111.041418","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.111.041418","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.111.041418","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1446194173","display_name":"T Regulatory Cells as Determinants of Inflammation in Adipose Tissue","funder_award_id":"R21DK088522","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2299117708","display_name":"Air Pollution and Hypertension: Vascular Mechanisms","funder_award_id":"R01ES015146","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G2447481771","display_name":"The Ohio State University Center for Clinical and Translational Science (UL1)","funder_award_id":"UL1RR025755","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4695470780","display_name":"Diet-Environment Interactions in Inflammation","funder_award_id":"R01ES017290","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7127548699","display_name":"Inflammatory Mechanisms In Insulin Resistance","funder_award_id":"F32DK083903","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8371392929","display_name":"Air Pollution and Microvascular Dysfunction: Leukocyte-Dependent NAD(P)H Oxidase","funder_award_id":"K01ES016588","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000887552","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016058","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016632734.pdf","grobid_xml":"https://content.openalex.org/works/W2016632734.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W193673277","https://openalex.org/W1490075410","https://openalex.org/W1502314841","https://openalex.org/W1540732733","https://openalex.org/W1890473919","https://openalex.org/W1967256054","https://openalex.org/W1971954476","https://openalex.org/W1983950007","https://openalex.org/W1986044732","https://openalex.org/W1986970309","https://openalex.org/W1987113439","https://openalex.org/W1989619519","https://openalex.org/W1991969856","https://openalex.org/W2000976083","https://openalex.org/W2001031720","https://openalex.org/W2002937262","https://openalex.org/W2003870922","https://openalex.org/W2005140805","https://openalex.org/W2019927946","https://openalex.org/W2025077799","https://openalex.org/W2033315581","https://openalex.org/W2041953777","https://openalex.org/W2052553326","https://openalex.org/W2052554962","https://openalex.org/W2063400466","https://openalex.org/W2071173492","https://openalex.org/W2084403835","https://openalex.org/W2085513130","https://openalex.org/W2088748627","https://openalex.org/W2091638124","https://openalex.org/W2091796233","https://openalex.org/W2104391911","https://openalex.org/W2107949845","https://openalex.org/W2110725041","https://openalex.org/W2111242088","https://openalex.org/W2118609667","https://openalex.org/W2124633895","https://openalex.org/W2128077095","https://openalex.org/W2134141467","https://openalex.org/W2145697808","https://openalex.org/W2152037832","https://openalex.org/W2152835319","https://openalex.org/W2156280702","https://openalex.org/W2160286139","https://openalex.org/W2166848153","https://openalex.org/W2167218320","https://openalex.org/W2167522349","https://openalex.org/W2169562373","https://openalex.org/W2169951035","https://openalex.org/W2170271198"],"related_works":["https://openalex.org/W7101160188","https://openalex.org/W7099089509","https://openalex.org/W2331416063","https://openalex.org/W2202834599","https://openalex.org/W2768050313","https://openalex.org/W6907342732","https://openalex.org/W2161214956","https://openalex.org/W2999883837","https://openalex.org/W2047255460","https://openalex.org/W1962268158"],"abstract_inverted_index":{"BACKGROUND:":[0],"Dipeptidyl-peptidase":[1],"4":[2,55],"(DPP-4)":[3],"inhibitors":[4],"are":[5],"increasingly":[6],"used":[7],"to":[8,60,215,220],"accomplish":[9],"glycemic":[10],"targets":[11],"in":[12,23,35,91,112,124,131,169,179,190,200,201,209,218,253],"patients":[13],"with":[14,101,161,174,186],"type":[15],"II":[16],"diabetes":[17],"mellitus.":[18],"Because":[19],"DPP-4":[20,66,116,165],"is":[21],"expressed":[22,168],"inflammatory":[24,107],"cells,":[25,173],"we":[26],"hypothesized":[27],"that":[28],"its":[29],"inhibition":[30,117,236],"will":[31],"exert":[32],"favorable":[33],"effects":[34,231],"atherosclerosis.":[36,254],"METHODS":[37],"AND":[38],"RESULTS:":[39],"Male":[40],"LDLR(-/-)":[41],"mice":[42],"(6":[43],"weeks)":[44],"were":[45,89,122],"fed":[46],"a":[47,64,132,187],"high-fat":[48],"diet":[49,53],"or":[50,62],"normal":[51],"chow":[52],"for":[54,74,245],"weeks":[56],"and":[57,85,98,105,111,127,130,143,197,207,225,232],"then":[58],"randomized":[59],"vehicle":[61],"alogliptin,":[63],"high-affinity":[65],"inhibitor":[67],"(40":[68],"mg":[69],"\u00b7":[70,72],"kg(-1)":[71],"d(-1)),":[73],"12":[75],"weeks.":[76],"Metabolic":[77],"parameters,":[78],"blood":[79,145],"pressure,":[80],"vascular":[81],"function,":[82],"atherosclerosis":[83],"burden,":[84],"indexes":[86],"of":[87,103,115,140,163,212,237,248,251],"inflammation":[88,234],"obtained":[90],"target":[92],"tissues,":[93],"including":[94],"the":[95,216,246],"vasculature,":[96],"adipose,":[97],"bone":[99,170],"marrow,":[100],"assessment":[102],"global":[104],"cell-specific":[106],"pathways.":[108],"In":[109],"vitro":[110,202],"vivo":[113,210],"assays":[114,203],"(DPP-4i)":[118],"on":[119],"monocyte":[120,195,238],"activation/migration":[121],"conducted":[123],"both":[125],"human":[126],"murine":[128],"cells":[129],"short-term":[133],"ApoE(-/-)":[134],"mouse":[135],"model.":[136],"DPP-4i":[137,147,175,182,193,228],"improved":[138],"markers":[139],"insulin":[141],"resistance":[142],"reduced":[144,148],"pressure.":[146],"visceral":[149],"adipose":[150],"tissue":[151,155],"macrophage":[152],"content":[153],"(adipose":[154],"macrophages;":[156],"CD11b(+),":[157],"CD11c(+),":[158],"Ly6C(hi))":[159],"concomitant":[160],"upregulation":[162],"CD163.":[164],"was":[166],"highly":[167],"marrow-derived":[171],"CD11b(+)":[172],"downregulating":[176],"proinflammatory":[177],"genes":[178],"these":[180],"cells.":[181],"decreased":[183],"aortic":[184],"plaque":[185,191],"striking":[188],"reduction":[189],"macrophages.":[192],"prevented":[194,208],"migration":[196,211],"actin":[198],"polymerization":[199],"via":[204,235],"Rac-dependent":[205],"mechanisms":[206],"labeled":[213],"monocytes":[214],"aorta":[217],"response":[219],"exogenous":[221],"tumor":[222],"necrosis":[223],"factor-\u03b1":[224],"DPP-4.":[226],"CONCLUSION:":[227],"exerts":[229],"antiatherosclerotic":[230],"reduces":[233],"activation/chemotaxis.":[239],"These":[240],"findings":[241],"have":[242],"important":[243],"implications":[244],"use":[247],"this":[249],"class":[250],"drugs":[252]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":29},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":26},{"year":2016,"cited_by_count":43},{"year":2015,"cited_by_count":36},{"year":2014,"cited_by_count":42},{"year":2013,"cited_by_count":41},{"year":2012,"cited_by_count":28}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
