{"id":"https://openalex.org/W2016629308","doi":"https://doi.org/10.1126/science.2159183","title":"Anesthesia Cutoff Phenomenon: Interfacial Hydrogen Bonding","display_name":"Anesthesia Cutoff Phenomenon: Interfacial Hydrogen Bonding","publication_year":1990,"publication_date":"1990-05-04","ids":{"openalex":"https://openalex.org/W2016629308","doi":"https://doi.org/10.1126/science.2159183","mag":"2016629308","pmid":"https://pubmed.ncbi.nlm.nih.gov/2159183"},"language":"en","primary_location":{"id":"doi:10.1126/science.2159183","doi":"https://doi.org/10.1126/science.2159183","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.2159183","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111799060","display_name":"Jang-Shing Chiou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210089864","display_name":"VA Salt Lake City Healthcare System","ror":"https://ror.org/007fyq698","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089864","https://openalex.org/I4210113540"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jang-Shing Chiou","raw_affiliation_strings":["Department of Anesthesia, University of Utah School of Medicine, and Anesthesia Service, Veterans Administration Medical Center, Salt Lake City, UT 84148"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, University of Utah School of Medicine, and Anesthesia Service, Veterans Administration Medical Center, Salt Lake City, UT 84148","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2799886695","https://openalex.org/I4210089864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103562012","display_name":"Shao-Mu Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210089864","display_name":"VA Salt Lake City Healthcare System","ror":"https://ror.org/007fyq698","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089864","https://openalex.org/I4210113540"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shao-Mu Ma","raw_affiliation_strings":["Department of Anesthesia, University of Utah School of Medicine, and Anesthesia Service, Veterans Administration Medical Center, Salt Lake City, UT 84148"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, University of Utah School of Medicine, and Anesthesia Service, Veterans Administration Medical Center, Salt Lake City, UT 84148","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2799886695","https://openalex.org/I4210089864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017712455","display_name":"Hiroshi Kamaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210089864","display_name":"VA Salt Lake City Healthcare System","ror":"https://ror.org/007fyq698","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089864","https://openalex.org/I4210113540"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroshi Kamaya","raw_affiliation_strings":["Department of Anesthesia, University of Utah School of Medicine, and Anesthesia Service, Veterans Administration Medical Center, Salt Lake City, UT 84148"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, University of Utah School of Medicine, and Anesthesia Service, Veterans Administration Medical Center, Salt Lake City, UT 84148","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2799886695","https://openalex.org/I4210089864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110034257","display_name":"Issaku Ueda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210089864","display_name":"VA Salt Lake City Healthcare System","ror":"https://ror.org/007fyq698","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089864","https://openalex.org/I4210113540"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Issaku Ueda","raw_affiliation_strings":["Department of Anesthesia, University of Utah School of Medicine, and Anesthesia Service, Veterans Administration Medical Center, Salt Lake City, UT 84148"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, University of Utah School of Medicine, and Anesthesia Service, Veterans Administration Medical Center, Salt Lake City, UT 84148","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2799886695","https://openalex.org/I4210089864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8891,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.93726048,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"248","issue":"4955","first_page":"583","last_page":"585"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11177","display_name":"Spectroscopy and Quantum Chemical Studies","score":0.5547000169754028,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11177","display_name":"Spectroscopy and Quantum Chemical Studies","score":0.5547000169754028,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.18299999833106995,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":0.07829999923706055,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anesthetic-potency","display_name":"anesthetic potency","score":0.8080000281333923},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.7649999856948853},{"id":"https://openalex.org/keywords/1-alkanols","display_name":"1-alkanols","score":0.9639999866485596},{"id":"https://openalex.org/keywords/dipalmitoylphosphatidylcholine","display_name":"DPPC","score":0.6869999766349792},{"id":"https://openalex.org/keywords/phospholipid-bilayers","display_name":"phospholipid bilayers","score":0.6380000114440918},{"id":"https://openalex.org/keywords/heavy-water","display_name":"heavy water","score":0.7390000224113464},{"id":"https://openalex.org/keywords/reverse-micelles","display_name":"reverse micelles","score":0.7639999985694885},{"id":"https://openalex.org/keywords/chain-length-dependence","display_name":"chain length dependence","score":0.7649999856948853},{"id":"https://openalex.org/keywords/brine-shrimp-lethality","display_name":"brine shrimp lethality","score":0.7670000195503235},{"id":"https://openalex.org/keywords/anesthetic-mechanisms","display_name":"anesthetic mechanisms","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7355804443359375},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.7107261419296265},{"id":"https://openalex.org/C2776482079","wikidata":"https://www.wikidata.org/wiki/Q741844","display_name":"Homologous series","level":2,"score":0.6661691665649414},{"id":"https://openalex.org/C160892712","wikidata":"https://www.wikidata.org/wiki/Q901559","display_name":"Fourier transform infrared spectroscopy","level":2,"score":0.5884972810745239},{"id":"https://openalex.org/C58364064","wikidata":"https://www.wikidata.org/wiki/Q102296","display_name":"Deuterium","level":2,"score":0.566611111164093},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.4664223790168762},{"id":"https://openalex.org/C153642686","wikidata":"https://www.wikidata.org/wiki/Q70906","display_name":"Infrared spectroscopy","level":2,"score":0.44866666197776794},{"id":"https://openalex.org/C512968161","wikidata":"https://www.wikidata.org/wiki/Q556","display_name":"Hydrogen","level":2,"score":0.4116075932979584},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.4094691276550293},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2877359390258789},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.2541201412677765},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.23998364806175232},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.09146237373352051},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000438","descriptor_name":"Alcohols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000758","descriptor_name":"Anesthesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002251","descriptor_name":"Carbon Tetrachloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005583","descriptor_name":"Fourier Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015060","descriptor_name":"1,2-Dipalmitoylphosphatidylcholine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017666","descriptor_name":"Deuterium Oxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.2159183","doi":"https://doi.org/10.1126/science.2159183","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.2159183","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:2159183","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2159183","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8844569424","display_name":"AROMATIC AMINE LOCAL ANESTHETICS AND MEMBRANES","funder_award_id":"R01GM027670","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G950076207","display_name":"INTERFACIAL ACTION OF INHALATION ANESTHETICS","funder_award_id":"R01GM025716","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1604776883","https://openalex.org/W1966050175","https://openalex.org/W1966938314","https://openalex.org/W1978411773","https://openalex.org/W1980897015","https://openalex.org/W1984873650","https://openalex.org/W2002422188","https://openalex.org/W2011164678","https://openalex.org/W2020092866","https://openalex.org/W2020211734","https://openalex.org/W2031309222","https://openalex.org/W2035700103","https://openalex.org/W2037778095","https://openalex.org/W2047131186","https://openalex.org/W2050687568","https://openalex.org/W2054873632","https://openalex.org/W2087288856","https://openalex.org/W2088387911","https://openalex.org/W2088725071","https://openalex.org/W2102780437","https://openalex.org/W2124510984","https://openalex.org/W2190485303","https://openalex.org/W2225098875","https://openalex.org/W2271112592","https://openalex.org/W2318195456","https://openalex.org/W2333346662","https://openalex.org/W2407108966","https://openalex.org/W2420975918","https://openalex.org/W2466569098","https://openalex.org/W2950340970","https://openalex.org/W4244385377"],"related_works":["https://openalex.org/W2039456781","https://openalex.org/W1987228015","https://openalex.org/W2411418882","https://openalex.org/W2047902903","https://openalex.org/W2035700103","https://openalex.org/W1999547985","https://openalex.org/W2128205078","https://openalex.org/W2064250293","https://openalex.org/W4231114266","https://openalex.org/W2082057834"],"abstract_inverted_index":{"Anesthesia":[0],"\"cutoff\"":[1],"refers":[2],"to":[3,35,37,97,109,134],"the":[4,58,65,73,79,85,98,101,126,143,147],"phenomenon":[5],"of":[6,8,15,31,61,78,90,100,104,121,128],"loss":[7],"anesthetic":[9],"potency":[10],"in":[11,48,72,84,146],"a":[12],"homologous":[13],"series":[14,33],"alkanes":[16],"and":[17,63,82,140],"their":[18,21],"derivatives":[19],"when":[20],"sizes":[22],"become":[23],"too":[24],"large.":[25],"In":[26],"this":[27],"study,":[28],"hydrogen":[29,55,135],"bonding":[30],"1-alkanol":[32],"(ethanol":[34],"eicosanol)":[36],"dipalmitoyl-L-alpha-phosphatidylcholine":[38],"(DPPC)":[39],"was":[40],"studied":[41],"by":[42,70,125],"Fourier":[43],"transform":[44],"infrared":[45],"spectroscopy":[46],"(FTIR)":[47],"DPPC-D2O-in-CCl4":[49],"reversed":[50],"micelles.":[51],"The":[52],"alkanols":[53],"formed":[54],"bonds":[56],"with":[57,142],"phosphate":[59],"moiety":[60],"DPPC":[62],"released":[64],"DPPC-bound":[66],"deuterated":[67],"water,":[68],"evidenced":[69],"increases":[71],"bound":[74],"O-H":[75],"stretching":[76,88],"signal":[77],"alkanol-DPPC":[80],"complex":[81],"also":[83],"free":[86],"O-D":[87],"band":[89],"unbound":[91],"D2O.":[92],"These":[93],"effects":[94],"increased":[95],"according":[96],"elongation":[99],"carbon":[102],"chain":[103],"1-alkanols":[105],"from":[106],"ethanol":[107],"(C2)":[108],"1-decanol":[110],"(C10),":[111],"but":[112],"suddenly":[113],"almost":[114],"disappeared":[115],"at":[116,149],"1-tetradecanol":[117],"(C14).":[118],"Anesthetic":[119],"potencies":[120],"these":[122],"alkanols,":[123],"estimated":[124],"activity":[127],"brine":[129],"shrimps,":[130],"were":[131],"linearly":[132],"related":[133],"bond-breaking":[136],"activities":[137],"below":[138],"C10":[139],"agreed":[141],"FTIR":[144],"data":[145],"cutoff":[148],"C10.":[150]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
