{"id":"https://openalex.org/W2016620115","doi":"https://doi.org/10.1073/pnas.92.14.6319","title":"Cyclophilin catalyzes protein folding in yeast mitochondria.","display_name":"Cyclophilin catalyzes protein folding in yeast mitochondria.","publication_year":1995,"publication_date":"1995-07-03","ids":{"openalex":"https://openalex.org/W2016620115","doi":"https://doi.org/10.1073/pnas.92.14.6319","mag":"2016620115","pmid":"https://pubmed.ncbi.nlm.nih.gov/7603990","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/41509"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.92.14.6319","doi":"https://doi.org/10.1073/pnas.92.14.6319","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.92.14.6319","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC41509","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047553318","display_name":"Andreas T. Matouschek","orcid":"https://orcid.org/0000-0001-6016-2341","observed_orcids":["https://orcid.org/0000-0001-6016-2341"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"A Matouschek","raw_affiliation_strings":["Department of Biochemistry, Biozentrum, Universit\u00e4t Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Biozentrum, Universit\u00e4t Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027534198","display_name":"Sabine Rospert","orcid":"https://orcid.org/0000-0002-3089-9614","observed_orcids":["https://orcid.org/0000-0002-3089-9614"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"S Rospert","raw_affiliation_strings":["Department of Biochemistry, Biozentrum, Universit\u00e4t Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Biozentrum, Universit\u00e4t Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K Schmid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"K Schmid","raw_affiliation_strings":["Department of Biochemistry, Biozentrum, Universit\u00e4t Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Biozentrum, Universit\u00e4t Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006514294","display_name":"Benjamin S. Glick","orcid":"https://orcid.org/0000-0002-7921-1374","observed_orcids":["https://orcid.org/0000-0002-7921-1374"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"B S Glick","raw_affiliation_strings":["Department of Biochemistry, Biozentrum, Universit\u00e4t Basel, Switzerland","University of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Biozentrum, Universit\u00e4t Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]},{"raw_affiliation_string":"University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025917067","display_name":"Gottfried Schatz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"G Schatz","raw_affiliation_strings":["Department of Biochemistry, Biozentrum, Universit\u00e4t Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Biozentrum, Universit\u00e4t Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.3086,"has_fulltext":false,"cited_by_count":191,"citation_normalized_percentile":{"value":0.98029967,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"92","issue":"14","first_page":"6319","last_page":"6323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.44850000739097595,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.44850000739097595,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.43209999799728394,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.05920000001788139,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclophilin","display_name":"cyclophilin","score":0.9319999814033508},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.7129999995231628},{"id":"https://openalex.org/keywords/mitochondrial-matrix","display_name":"mitochondrial matrix","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/protein-import","display_name":"protein import","score":0.6269999742507935},{"id":"https://openalex.org/keywords/dihydrofolate-reductase","display_name":"dihydrofolate reductase","score":0.9660000205039978},{"id":"https://openalex.org/keywords/protein-refolding","display_name":"protein refolding","score":0.6740000247955322},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9129999876022339}],"concepts":[{"id":"https://openalex.org/C2781320022","wikidata":"https://www.wikidata.org/wiki/Q417149","display_name":"Dihydrofolate reductase","level":3,"score":0.6608350872993469},{"id":"https://openalex.org/C11701378","wikidata":"https://www.wikidata.org/wiki/Q3493378","display_name":"Mitochondrial matrix","level":4,"score":0.6526901125907898},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6310868859291077},{"id":"https://openalex.org/C2776326521","wikidata":"https://www.wikidata.org/wiki/Q3774751","display_name":"Cyclophilin","level":3,"score":0.6101211905479431},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.5613914132118225},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5566843748092651},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5279870629310608},{"id":"https://openalex.org/C2777200438","wikidata":"https://www.wikidata.org/wiki/Q408668","display_name":"Ricin","level":3,"score":0.4314824342727661},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.4295240044593811},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.414861798286438},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.29825639724731445},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25035110116004944},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.1005520224571228},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000591","descriptor_name":"Amino Acid Isomerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006180","descriptor_name":"Proton-Translocating ATPases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006180","descriptor_name":"Proton-Translocating ATPases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008961","descriptor_name":"Models, Structural","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009492","descriptor_name":"Neurospora crassa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013762","descriptor_name":"Tetrahydrofolate Dehydrogenase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013762","descriptor_name":"Tetrahydrofolate Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016324","descriptor_name":"Sequence Tagged Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018833","descriptor_name":"Chaperonins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019696","descriptor_name":"Peptidylprolyl Isomerase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.92.14.6319","doi":"https://doi.org/10.1073/pnas.92.14.6319","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.92.14.6319","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:82749","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC41509","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:41509","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/41509","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:7603990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7603990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:82749","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC41509","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W24469765","https://openalex.org/W116814209","https://openalex.org/W190285082","https://openalex.org/W323363336","https://openalex.org/W1588317987","https://openalex.org/W1601844248","https://openalex.org/W1975085160","https://openalex.org/W1976129849","https://openalex.org/W1988864942","https://openalex.org/W1992271142","https://openalex.org/W1992593876","https://openalex.org/W1993031156","https://openalex.org/W2012124354","https://openalex.org/W2017639307","https://openalex.org/W2020597127","https://openalex.org/W2024695552","https://openalex.org/W2041579704","https://openalex.org/W2055267793","https://openalex.org/W2062120260","https://openalex.org/W2076811542","https://openalex.org/W2084520521","https://openalex.org/W2097931914","https://openalex.org/W2144458008","https://openalex.org/W2149227294","https://openalex.org/W2162130926","https://openalex.org/W2178119444","https://openalex.org/W2282355535"],"related_works":["https://openalex.org/W2097931914","https://openalex.org/W2055176898","https://openalex.org/W7097480431","https://openalex.org/W3094800136","https://openalex.org/W2158196711","https://openalex.org/W2146619857","https://openalex.org/W1518065087","https://openalex.org/W2103126456","https://openalex.org/W2279132882","https://openalex.org/W2160090073"],"abstract_inverted_index":{"Cyclophilins":[0],"are":[1,8],"a":[2,43,55,62,117],"family":[3],"of":[4,12,48,54,70,78,82,85,93,105,112,119,129,150,162],"ubiquitous":[5],"proteins":[6],"that":[7,41,58],"the":[9,13,46,52,68,79,94,99],"intracellular":[10],"target":[11],"immunosuppressant":[14],"drug":[15],"cyclosporin":[16,124,146,157],"A.":[17,125,147],"Although":[18],"cyclophilins":[19],"catalyze":[20],"peptidylprolyl":[21],"cis-trans":[22],"isomerization":[23],"in":[24,36,45,61,98],"vitro,":[25],"it":[26],"has":[27],"remained":[28],"open":[29],"whether":[30],"they":[31],"also":[32,132],"perform":[33],"this":[34],"function":[35],"vivo.":[37],"Here":[38],"we":[39],"show":[40],"Cpr3p,":[42],"cyclophilin":[44],"matrix":[47,69,100],"yeast":[49,72],"mitochondria,":[50,140],"accelerates":[51],"refolding":[53,113],"fusion":[56,75],"protein":[57,76,141,151],"was":[59,101,114,131,143,153],"synthesized":[60],"reticulocyte":[63],"lysate":[64],"and":[65],"imported":[66],"into":[67],"isolated":[71],"mitochondria.":[73],"The":[74,110,148],"consisted":[77],"matrix-targeting":[80],"sequence":[81],"subunit":[83],"9":[84],"F1F0-ATPase":[86],"fused":[87],"to":[88,107,145],"mouse":[89],"dihydrofolate":[90,95],"reductase.":[91],"Refolding":[92],"reductase":[96],"moiety":[97],"monitored":[102],"by":[103,116,121,156,160],"acquisition":[104],"resistance":[106],"proteinase":[108],"K.":[109],"rate":[111,128,149],"reduced":[115,127],"factor":[118],"2-6":[120],"2.5":[122],"microM":[123],"This":[126],"folding":[130,142],"observed":[133],"with":[134],"mitochondria":[135],"lacking":[136],"Cpr3p.":[137,163],"In":[138],"these":[139],"insensitive":[144],"import":[152],"not":[154],"affected":[155],"A":[158],"or":[159],"deletion":[161]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}