{"id":"https://openalex.org/W2016605777","doi":"https://doi.org/10.1055/s-2000-7587","title":"Suppression of Conditioned Fear by Administration of CRF Receptor Antagonist CP-154,526","display_name":"Suppression of Conditioned Fear by Administration of CRF Receptor Antagonist CP-154,526","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W2016605777","doi":"https://doi.org/10.1055/s-2000-7587","mag":"2016605777","pmid":"https://pubmed.ncbi.nlm.nih.gov/11071021"},"language":"en","primary_location":{"id":"doi:10.1055/s-2000-7587","doi":"https://doi.org/10.1055/s-2000-7587","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2000-7587","pdf_url":null,"source":{"id":"https://openalex.org/S4122505","display_name":"Pharmacopsychiatry","issn_l":"0176-3679","issn":["0176-3679","1439-0795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacopsychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054307062","display_name":"Takatoshi Hikichi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Hikichi","raw_affiliation_strings":["Department of Neuropsychiatry, Oita Medical University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Oita Medical University, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068487342","display_name":"Jotaro Akiyoshi","orcid":"https://orcid.org/0000-0002-1403-5306","observed_orcids":["https://orcid.org/0000-0002-1403-5306"]},"institutions":[{"id":"https://openalex.org/I188815454","display_name":"Oita University","ror":"https://ror.org/01nyv7k26","country_code":"JP","type":"education","lineage":["https://openalex.org/I188815454"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J. Akiyoshi","raw_affiliation_strings":["Department of Neuropsychiatry, Oita Medical University, Oita, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Oita Medical University, Oita, Japan","institution_ids":["https://openalex.org/I188815454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108772266","display_name":"Yukiko Yamamoto","orcid":"https://orcid.org/0000-0002-0551-951X","observed_orcids":["https://orcid.org/0000-0002-0551-951X"]},"institutions":[{"id":"https://openalex.org/I188815454","display_name":"Oita University","ror":"https://ror.org/01nyv7k26","country_code":"JP","type":"education","lineage":["https://openalex.org/I188815454"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Yamamoto","raw_affiliation_strings":["Department of Neuropsychiatry, Oita Medical University, Oita, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Oita Medical University, Oita, Japan","institution_ids":["https://openalex.org/I188815454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019705938","display_name":"Takashi Tsutsumi","orcid":"https://orcid.org/0000-0003-3105-2295","observed_orcids":["https://orcid.org/0000-0003-3105-2295"]},"institutions":[{"id":"https://openalex.org/I188815454","display_name":"Oita University","ror":"https://ror.org/01nyv7k26","country_code":"JP","type":"education","lineage":["https://openalex.org/I188815454"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Tsutsumi","raw_affiliation_strings":["Department of Neuropsychiatry, Oita Medical University, Oita, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Oita Medical University, Oita, Japan","institution_ids":["https://openalex.org/I188815454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004658392","display_name":"Koichi Isogawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188815454","display_name":"Oita University","ror":"https://ror.org/01nyv7k26","country_code":"JP","type":"education","lineage":["https://openalex.org/I188815454"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Isogawa","raw_affiliation_strings":["Department of Neuropsychiatry, Oita Medical University, Oita, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Oita Medical University, Oita, Japan","institution_ids":["https://openalex.org/I188815454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4937,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.78796562,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"33","issue":"5","first_page":"189","last_page":"193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.5439000129699707,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.5439000129699707,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.31029999256134033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.08860000222921371,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9179999828338623},{"id":"https://openalex.org/keywords/crf-receptor-antagonists","display_name":"CRF receptor antagonists","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cp-154-526","display_name":"CP-154,526","score":0.9929999709129333},{"id":"https://openalex.org/keywords/fear-conditioning","display_name":"fear conditioning","score":0.9829999804496765},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.7620000243186951},{"id":"https://openalex.org/keywords/footshock","display_name":"footshock","score":0.7429999709129333},{"id":"https://openalex.org/keywords/freezing-behavior","display_name":"freezing behavior","score":0.9570000171661377},{"id":"https://openalex.org/keywords/fear-acquisition","display_name":"fear acquisition","score":0.652999997138977},{"id":"https://openalex.org/keywords/fear-expression","display_name":"fear expression","score":0.7450000047683716},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3199999928474426}],"concepts":[{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.7887424230575562},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.6015821099281311},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5625346899032593},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.5398890376091003},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5346832275390625},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4583631455898285},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4440324008464813},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3733973503112793},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0767717957496643}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003213","descriptor_name":"Conditioning, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004597","descriptor_name":"Electroshock","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005239","descriptor_name":"Fear","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018019","descriptor_name":"Receptors, Corticotropin-Releasing Hormone","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1055/s-2000-7587","doi":"https://doi.org/10.1055/s-2000-7587","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2000-7587","pdf_url":null,"source":{"id":"https://openalex.org/S4122505","display_name":"Pharmacopsychiatry","issn_l":"0176-3679","issn":["0176-3679","1439-0795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacopsychiatry","raw_type":"journal-article"},{"id":"pmid:11071021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11071021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacopsychiatry","raw_type":"Journal Article"},{"id":"mag:2340819866","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/500000433988?l=ja","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2171846995","https://openalex.org/W2011590385","https://openalex.org/W2145446804","https://openalex.org/W2567979669","https://openalex.org/W2165304067","https://openalex.org/W2009677309","https://openalex.org/W2025270113","https://openalex.org/W2025294582","https://openalex.org/W2048988744","https://openalex.org/W2248184875"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,32,132],"examine":[3],"the":[4,12,41,47,63,66,92,95,116,126],"involvement":[5],"of":[6,14,35,82,120],"corticotropin-releasing":[7],"hormone":[8],"(CRF)":[9],"receptor":[10,20,128],"in":[11,46,65],"formation":[13],"anxiety,":[15],"we":[16],"investigated":[17],"whether":[18],"CRF":[19,127],"antagonist":[21],"CP-154,526":[22,56,71,83,113],"suppressed":[23],"conditioned":[24,88,121],"fear":[25,89],"stress.":[26],"First,":[27],"rats":[28,42,64,93],"were":[29,43],"individually":[30],"subjected":[31],"30":[33,59,76,84],"min":[34,53,60,77,85],"footshock.":[36,80],"Twenty-four":[37],"hours":[38],"after":[39],"footshock,":[40],"again":[44],"placed":[45],"chamber":[48,67],"and":[49,101,118],"observed":[50],"for":[51],"5":[52],"without":[54],"shock.":[55],"was":[57,72],"administered":[58,75],"before":[61,78,87,102],"placing":[62],"again.":[68],"After":[69],"that,":[70],"once":[73],"more":[74],"applying":[79,99],"Administration":[81],"both":[86,115],"stress":[90],"(placing":[91],"inside":[94],"cage":[96],"but":[97],"not":[98],"footshock)":[100],"actual":[103],"footshock":[104],"significantly":[105],"reduced":[106],"freezing":[107],"behavior.":[108],"These":[109],"results":[110],"show":[111],"that":[112,125],"blocked":[114],"acquisition":[117],"expression":[119],"fear,":[122],"thus":[123],"suggesting":[124],"might":[129],"be":[130],"related":[131],"anxiety.":[133]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
