{"id":"https://openalex.org/W2016605751","doi":"https://doi.org/10.2133/dmpk.7.477","title":"Studies on the Metabolic Fate of 3H-TJN-101. (I): Absorption, Distribution and Excretion following Single Oral Administration to Rats.","display_name":"Studies on the Metabolic Fate of 3H-TJN-101. (I): Absorption, Distribution and Excretion following Single Oral Administration to Rats.","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2016605751","doi":"https://doi.org/10.2133/dmpk.7.477","mag":"2016605751"},"language":"en","primary_location":{"id":"doi:10.2133/dmpk.7.477","doi":"https://doi.org/10.2133/dmpk.7.477","is_oa":true,"landing_page_url":"https://doi.org/10.2133/dmpk.7.477","pdf_url":"https://www.jstage.jst.go.jp/article/dmpk1986/7/4/7_4_477/_pdf","source":{"id":"https://openalex.org/S4210239568","display_name":"Drug Metabolism and Pharmacokinetics","issn_l":"0916-1139","issn":["0916-1139"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Pharmacokinetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/dmpk1986/7/4/7_4_477/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055591503","display_name":"Yutaka Matsuzaki","orcid":"https://orcid.org/0009-0003-8446-8339","observed_orcids":["https://orcid.org/0009-0003-8446-8339"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yutaka MATSUZAKI","raw_affiliation_strings":["Research Institute for Pharmacology, TSUMURA & Co"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Pharmacology, TSUMURA & Co","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034646741","display_name":"Tamae MATSUZAKI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tamae MATSUZAKI","raw_affiliation_strings":["Research Institute for Pharmacology, TSUMURA & Co"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Pharmacology, TSUMURA & Co","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041779831","display_name":"Shuichi Takeda","orcid":"https://orcid.org/0000-0003-1383-8518","observed_orcids":["https://orcid.org/0000-0003-1383-8518"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuichi TAKEDA","raw_affiliation_strings":["Research Institute for Pharmacology, TSUMURA & Co"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Pharmacology, TSUMURA & Co","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039589478","display_name":"Hiromi Sasaki","orcid":"https://orcid.org/0000-0001-9601-4287","observed_orcids":["https://orcid.org/0000-0001-9601-4287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiromi SASAKI","raw_affiliation_strings":["Research Institute for Pharmacology, TSUMURA & Co"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Pharmacology, TSUMURA & Co","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074728211","display_name":"Masaki Aburada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaki ABURADA","raw_affiliation_strings":["Research Institute for Pharmacology, TSUMURA & Co"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Pharmacology, TSUMURA & Co","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110722313","display_name":"Eikichi Hosoya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eikichi HOSOYA","raw_affiliation_strings":["Research Institute for Pharmacology, TSUMURA & Co"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Pharmacology, TSUMURA & Co","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030722089","display_name":"Tsutomu Oyama","orcid":"https://orcid.org/0000-0002-7883-7818","observed_orcids":["https://orcid.org/0000-0002-7883-7818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsutomu OYAMA","raw_affiliation_strings":["Research Institute for Pharmacology, TSUMURA & Co"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Pharmacology, TSUMURA & Co","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018934585","display_name":"Yukinobu Ikeya","orcid":"https://orcid.org/0000-0003-2383-4801","observed_orcids":["https://orcid.org/0000-0003-2383-4801"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yukinobu IKEYA","raw_affiliation_strings":["Research Institute for Biology and Chemistry, TSUMURA & Co"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Biology and Chemistry, TSUMURA & Co","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110619172","display_name":"Hiroshi Mitsuhashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi MITSUHASHI","raw_affiliation_strings":["Research Institute for Biology and Chemistry, TSUMURA & Co"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Biology and Chemistry, TSUMURA & Co","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112570323","display_name":"Yoshio ESUMI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshio ESUMI","raw_affiliation_strings":["Tokai Research Laboratories, Daiichi Pure Chemicals Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokai Research Laboratories, Daiichi Pure Chemicals Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075903129","display_name":"Yoshitaka Jin","orcid":"https://orcid.org/0000-0002-1814-9167","observed_orcids":["https://orcid.org/0000-0002-1814-9167"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshitaka JIN","raw_affiliation_strings":["Tokai Research Laboratories, Daiichi Pure Chemicals Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokai Research Laboratories, Daiichi Pure Chemicals Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006259030","display_name":"Hisako Ishikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hisako ISHIKAWA","raw_affiliation_strings":["Tokai Research Laboratories, Daiichi Pure Chemicals Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokai Research Laboratories, Daiichi Pure Chemicals Co., Ltd","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111780238","display_name":"Tetsuyoshi YOKOSHIMA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tetsuyoshi YOKOSHIMA","raw_affiliation_strings":["Tokai Research Laboratories, Daiichi Pure Chemicals Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokai Research Laboratories, Daiichi Pure Chemicals Co., Ltd","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.629,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.57452725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"4","first_page":"477","last_page":"494"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.5370000004768372},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8460000157356262},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.7519999742507935},{"id":"https://openalex.org/keywords/absorption","display_name":"absorption","score":0.6309999823570251},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.9649999737739563},{"id":"https://openalex.org/keywords/excretion","display_name":"excretion","score":0.8450000286102295},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.5569999814033508},{"id":"https://openalex.org/keywords/fecal-excretion","display_name":"fecal excretion","score":0.9010000228881836},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6570000052452087},{"id":"https://openalex.org/keywords/dose-dependence","display_name":"dose dependence","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.931763768196106},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.7844268083572388},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.6606360673904419},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6571532487869263},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.6562603712081909},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6167699098587036},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5625900626182556},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.53737473487854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4377244710922241},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3969985842704773},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37271633744239807},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2133/dmpk.7.477","doi":"https://doi.org/10.2133/dmpk.7.477","is_oa":true,"landing_page_url":"https://doi.org/10.2133/dmpk.7.477","pdf_url":"https://www.jstage.jst.go.jp/article/dmpk1986/7/4/7_4_477/_pdf","source":{"id":"https://openalex.org/S4210239568","display_name":"Drug Metabolism and Pharmacokinetics","issn_l":"0916-1139","issn":["0916-1139"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Pharmacokinetics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.2133/dmpk.7.477","doi":"https://doi.org/10.2133/dmpk.7.477","is_oa":true,"landing_page_url":"https://doi.org/10.2133/dmpk.7.477","pdf_url":"https://www.jstage.jst.go.jp/article/dmpk1986/7/4/7_4_477/_pdf","source":{"id":"https://openalex.org/S4210239568","display_name":"Drug Metabolism and Pharmacokinetics","issn_l":"0916-1139","issn":["0916-1139"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Pharmacokinetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016605751.pdf","grobid_xml":"https://content.openalex.org/works/W2016605751.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W277181778","https://openalex.org/W1969910484","https://openalex.org/W1998837907","https://openalex.org/W2006408955","https://openalex.org/W2064840421","https://openalex.org/W2082297573"],"related_works":["https://openalex.org/W2009246547","https://openalex.org/W2313159830","https://openalex.org/W2323033748","https://openalex.org/W2040051072","https://openalex.org/W2321583603","https://openalex.org/W2273953534","https://openalex.org/W2392736277","https://openalex.org/W2401420706","https://openalex.org/W2412533991","https://openalex.org/W2048191327"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,14,47,76,84,107,110,130,133,178,192,202,207,225,250,259,265,270,300,305],"absorption,":[3],"distribution":[4],"and":[5,37,60,102,115,126,154,168,172,204,212,227,234,240,247,267,302],"excretion":[6],"of":[7,13,20,29,32,40,53,64,93,95,106,109,120,122,129,132,147,149,160,175,187,189,219,221,236,249,258,280,294],"3H-TJN-101":[8,33,96,123,190,291],"following":[9,117],"single":[10],"oral":[11,27,91,118,145,185,217],"administration":[12,28,92,119,146,186,218,279],"drug":[15],"in":[16,22,34,97,177,201,206,224,229,242,264,269,299,304],"rats.1.":[17],"The":[18,72,81],"concentration":[19,73],"radioactivity":[21,48,183,223,261,296],"blood":[23],"increased":[24],"rapidly":[25],"after":[26,70,144,165,184,216,255,277],"4":[30,58,111,134],"mg/kg":[31,112],"male":[35,98,179,230],"rats":[36,231,244,286],"reached":[38,191],"Cmax":[39,101,114,151,167],"816ng/ml":[41],"(TJN-101":[42],"base)":[43],"at":[44,79,142],"0.75hr.":[45],"Thereafter,":[46],"decreased,":[49,156],"with":[50,61,157],"a":[51,62,158],"half-life":[52,63,159],"1.":[54],"1hr":[55],"up":[56,162],"to":[57,68,163,197],"hr":[59],"7.6hr":[65],"from":[66,284],"6":[67],"24hr":[69],"dosing.":[71,166],"dropped":[74],"below":[75],"detection":[77],"limit":[78],"48hr.":[80],"area":[82],"under":[83],"concentration-time":[85],"curve":[86],"(AUC0-24h)":[87],"was":[88,152,232,245,262,297],"3.12\u03bcg\u2022hr/ml.":[89],"Following":[90],"0.8mg/kg":[94],"rats,":[99,141,180],"both":[100],"AUC0-24hr":[103],"were":[104,124,170],"12%":[105],"values":[108,131],"group.":[113],"AUC0-24h,":[116,169],"20mg/kg":[121],"5.4":[125],"9.2":[127],"times":[128,174],"mg/":[135],"kg":[136],"group,":[137],"respectively.2.":[138],"In":[139],"female":[140,243],"0.75hr":[143],"4mg/kg":[148,188,220],"3H-TJN-101,":[150,222],"682ng/ml,":[153],"it":[155],"2.9hr":[161],"8hr":[164],"84%":[171],"1.3":[173],"those":[176],"respectively.3.":[181],"Tissue":[182],"maximum":[193],"level":[194],"within":[195],"0.25":[196],"0.75hr,":[198],"being":[199],"higher":[200],"liver,":[203],"lower":[205],"central":[208],"nervous":[209],"system,":[210],"testis,":[211],"eyeball.4.":[213],"Within":[214,253,275],"168hr":[215],"urine":[226],"feces":[228],"13.6%":[233],"83.1%":[235],"administered":[237,290],"dose,":[238,251],"respectively,":[239],"that":[241],"20.9%":[246],"73.9%":[248],"respectively.5.":[252],"48hr":[254,276],"dosing,":[256],"91.1%":[257],"total":[260],"detected":[263],"bile":[266,282,301],"4.5%":[268],"urine,":[271],"as":[272],"determined":[273],"simultaneously.6.":[274],"intraduodenal":[278],"radioactivie":[281],"obtained":[283],"other":[285],"which":[287],"had":[288],"been":[289],"orally,":[292],"52.0%":[293],"injected":[295],"excreted":[298],"4.0%":[303],"urine.":[306]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}