{"id":"https://openalex.org/W2016605279","doi":"https://doi.org/10.1007/s12522-015-0204-x","title":"Insulin resistance in nonobese Japanese women with polycystic ovary syndrome is associated with poorer glucose tolerance, delayed insulin secretion, and enhanced insulin response","display_name":"Insulin resistance in nonobese Japanese women with polycystic ovary syndrome is associated with poorer glucose tolerance, delayed insulin secretion, and enhanced insulin response","publication_year":2015,"publication_date":"2015-03-18","ids":{"openalex":"https://openalex.org/W2016605279","doi":"https://doi.org/10.1007/s12522-015-0204-x","mag":"2016605279","pmid":"https://pubmed.ncbi.nlm.nih.gov/29259409","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5715826"},"language":"en","primary_location":{"id":"doi:10.1007/s12522-015-0204-x","doi":"https://doi.org/10.1007/s12522-015-0204-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12522-015-0204-x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1007/s12522-015-0204-x","source":{"id":"https://openalex.org/S86486980","display_name":"Reproductive Medicine and Biology","issn_l":"1445-5781","issn":["1445-5781","1447-0578"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Medicine and Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1007/s12522-015-0204-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113700298","display_name":"Hiroaki Negishi","orcid":"https://orcid.org/0009-0001-5647-2184","observed_orcids":["https://orcid.org/0009-0001-5647-2184"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hiroaki Negishi","raw_affiliation_strings":["Women's Clinic Ooizumigakuen, Higashi-oizumi 1-27-19, 178-0063 Nerima-ku, Tokyo, Japan","+81-3-5935-1010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Clinic Ooizumigakuen, Higashi-oizumi 1-27-19, 178-0063 Nerima-ku, Tokyo, Japan","institution_ids":[]},{"raw_affiliation_string":"+81-3-5935-1010","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113627059","display_name":"Kazuki Nakao","orcid":"https://orcid.org/0009-0001-5407-0819","observed_orcids":["https://orcid.org/0009-0001-5407-0819"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuki Nakao","raw_affiliation_strings":["Women's Clinic Ooizumigakuen, Higashi-oizumi 1-27-19, 178-0063 Nerima-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Clinic Ooizumigakuen, Higashi-oizumi 1-27-19, 178-0063 Nerima-ku, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111605728","display_name":"Michiko Kimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michiko Kimura","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Saitama Medical College, Morohongou 38, Moroyama Town, 350-0495 Iruma-gun, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Saitama Medical College, Morohongou 38, Moroyama Town, 350-0495 Iruma-gun, Saitama, Japan","institution_ids":["https://openalex.org/I8588240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057492600","display_name":"Hiroshi Takenaka","orcid":"https://orcid.org/0000-0002-4702-4961","observed_orcids":["https://orcid.org/0000-0002-4702-4961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Takenaka","raw_affiliation_strings":["Women's Clinic Ooizumigakuen, Higashi-oizumi 1-27-19, 178-0063 Nerima-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Clinic Ooizumigakuen, Higashi-oizumi 1-27-19, 178-0063 Nerima-ku, Tokyo, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015140683","display_name":"Michiharu Horikawa","orcid":"https://orcid.org/0000-0003-1746-9270","observed_orcids":["https://orcid.org/0000-0003-1746-9270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michiharu Horikawa","raw_affiliation_strings":["Women's Clinic Ooizumigakuen, Higashi-oizumi 1-27-19, 178-0063 Nerima-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Clinic Ooizumigakuen, Higashi-oizumi 1-27-19, 178-0063 Nerima-ku, Tokyo, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113700298"],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.2725,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.57220434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"14","issue":"3","first_page":"123","last_page":"129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10673","display_name":"Gestational Diabetes Research and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.953000009059906},{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.8360000252723694},{"id":"https://openalex.org/keywords/non-obese-women","display_name":"non-obese women","score":0.8970000147819519},{"id":"https://openalex.org/keywords/japanese-women","display_name":"Japanese women","score":0.6759999990463257},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.746999979019165},{"id":"https://openalex.org/keywords/glucose-tolerance-test","display_name":"glucose tolerance test","score":0.7170000076293945},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.8619999885559082},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7689999938011169},{"id":"https://openalex.org/keywords/insulin-response","display_name":"insulin response","score":0.7310000061988831},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8810387849807739},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8265093564987183},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8105228543281555},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.8078131675720215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.770977258682251},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.7498326301574707},{"id":"https://openalex.org/C2780609358","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Impaired glucose tolerance","level":4,"score":0.6046606302261353}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/s12522-015-0204-x","doi":"https://doi.org/10.1007/s12522-015-0204-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12522-015-0204-x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1007/s12522-015-0204-x","source":{"id":"https://openalex.org/S86486980","display_name":"Reproductive Medicine and Biology","issn_l":"1445-5781","issn":["1445-5781","1447-0578"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Medicine and Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4646440","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5715826","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5715826","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5715826","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reprod Med Biol","raw_type":"Text"},{"id":"pmid:29259409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29259409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive medicine and biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s12522-015-0204-x","doi":"https://doi.org/10.1007/s12522-015-0204-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12522-015-0204-x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1007/s12522-015-0204-x","source":{"id":"https://openalex.org/S86486980","display_name":"Reproductive Medicine and Biology","issn_l":"1445-5781","issn":["1445-5781","1447-0578"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Medicine and Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016605279.pdf","grobid_xml":"https://content.openalex.org/works/W2016605279.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1973722085","https://openalex.org/W1984254712","https://openalex.org/W1996806039","https://openalex.org/W2007816906","https://openalex.org/W2017738726","https://openalex.org/W2026071202","https://openalex.org/W2029365005","https://openalex.org/W2030350999","https://openalex.org/W2034412703","https://openalex.org/W2046870180","https://openalex.org/W2055744696","https://openalex.org/W2064510684","https://openalex.org/W2072451732","https://openalex.org/W2085645010","https://openalex.org/W2087503103","https://openalex.org/W2089005525","https://openalex.org/W2093049350","https://openalex.org/W2093722445","https://openalex.org/W2106378688","https://openalex.org/W2129503086","https://openalex.org/W2140854296","https://openalex.org/W2145765432","https://openalex.org/W2171871916","https://openalex.org/W2186218348","https://openalex.org/W2345903479","https://openalex.org/W4233562854"],"related_works":["https://openalex.org/W2076795583","https://openalex.org/W2366168517","https://openalex.org/W2029365005","https://openalex.org/W2724128319","https://openalex.org/W2726743507","https://openalex.org/W2072451732","https://openalex.org/W2072711539","https://openalex.org/W2906034820","https://openalex.org/W2921171894","https://openalex.org/W4288049818"],"abstract_inverted_index":{"Abstract":[0],"Purpose":[1],"To":[2],"determine":[3,220],"the":[4,18,83,139,144,186],"prevalence":[5,140],"of":[6,72,102,105,120,131,141,188,192],"insulin":[7,57,113,133,164,193,203,207,212],"resistance":[8],"(IR)":[9],"and":[10,22,29,56,62,65,93,156,205,222],"impaired":[11],"glucose":[12,55,200],"tolerance":[13,49],"(IGT)":[14],"in":[15,41,82,135,158],"PCOS":[16,37],"patients,":[17],"optimal":[19],"screening":[20],"method,":[21],"to":[23,46,150,196,219],"compare":[24],"our":[25],"findings":[26],"between":[27],"nonobese":[28,84,106,121,159,225],"obese":[30,145],"Japanese":[31],"women":[32,107,122,146,160,226],"with":[33,98,161,183,210,227],"PCOS.":[34,228],"Methods":[35],"Ninety\u2010eight":[36],"patients":[38],"were":[39,59,79,166,180],"included":[40],"this":[42],"research":[43],"from":[44,148],"2006":[45],"2013.":[47],"Glucose":[48],"test":[50],"(OGTT)":[51],"was":[52],"performed.":[53],"Serum":[54],"concentration":[58],"assayed":[60],"before":[61],"30,":[63],"60,":[64],"120":[66],"min":[67],"after":[68],"taking":[69],"75":[70],"g":[71],"glucose.":[73],"Results":[74],"All":[75,176],"examined":[76,177],"metabolic":[77,178],"parameters":[78,179],"significantly":[80,181],"favorable":[81],"subjects,":[85],"below":[86],"25":[87],"kg/m2.":[88],"HOMA\u2010IR,":[89],"fasting":[90,112],"insulin,":[91],"glucose120,":[92,155],"insulin120":[94,157],"showed":[95],"strong":[96],"correlations":[97],"BMI.":[99,184],"A":[100],"total":[101],"1.4":[103],"%":[104,118],"had":[108,123],"IR":[109,124,142,221],"based":[110],"on":[111],"or":[114],"HOMA\u2010IR.":[115],"However,":[116],"15.5":[117],"(11/71)":[119],"as":[125],"determined":[126],"by":[127],"a":[128,162,172,189],"continuous":[129,163,173,190],"increase":[130,165,191],"serum":[132],"level":[134,194],"OGTT.":[136],"In":[137],"comparison,":[138],"among":[143],"ranged":[147],"41":[149],"59":[151],"%.":[152],"AUCglucose,":[153],"glucose60,":[154],"higher":[167],"than":[168],"those":[169],"without":[170],"such":[171],"increase.":[174],"Conclusions":[175],"correlated":[182],"As":[185],"presence":[187],"reflects":[195],"some":[197],"degree":[198],"poorer":[199],"tolerance,":[201],"delayed":[202],"secretion,":[204],"enhanced":[206],"response":[208],"compared":[209],"non\u2010continuous":[211],"increase,":[213],"OGTT":[214],"might":[215],"not":[216],"been":[217],"excluded":[218],"IGT":[223],"for":[224]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}