{"id":"https://openalex.org/W2016589481","doi":"https://doi.org/10.1152/japplphysiol.01489.2010","title":"Acute effects of hydrogen peroxide on skeletal muscle microvascular oxygenation from rest to contractions","display_name":"Acute effects of hydrogen peroxide on skeletal muscle microvascular oxygenation from rest to contractions","publication_year":2011,"publication_date":"2011-03-04","ids":{"openalex":"https://openalex.org/W2016589481","doi":"https://doi.org/10.1152/japplphysiol.01489.2010","mag":"2016589481","pmid":"https://pubmed.ncbi.nlm.nih.gov/21372096"},"language":"en","primary_location":{"id":"doi:10.1152/japplphysiol.01489.2010","doi":"https://doi.org/10.1152/japplphysiol.01489.2010","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.01489.2010","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071657250","display_name":"Daniel M. Hirai","orcid":"https://orcid.org/0000-0002-7861-637X","observed_orcids":["https://orcid.org/0000-0002-7861-637X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel M. Hirai","raw_affiliation_strings":["Departments of 1Anatomy and Physiology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Anatomy and Physiology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025464587","display_name":"Steven W. Copp","orcid":"https://orcid.org/0000-0002-6633-3364","observed_orcids":["https://orcid.org/0000-0002-6633-3364"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven W. Copp","raw_affiliation_strings":["Departments of 1Anatomy and Physiology, and","Kinesiology, Kansas State University, Manhattan, Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Anatomy and Physiology, and","institution_ids":[]},{"raw_affiliation_string":"Kinesiology, Kansas State University, Manhattan, Kansas","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074761808","display_name":"Peter J. Schwagerl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Schwagerl","raw_affiliation_strings":["Kinesiology, Kansas State University, Manhattan, Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kinesiology, Kansas State University, Manhattan, Kansas","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057426982","display_name":"Timothy I. Musch","orcid":"https://orcid.org/0000-0003-1599-1751","observed_orcids":["https://orcid.org/0000-0003-1599-1751"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy I. Musch","raw_affiliation_strings":["Departments of 1Anatomy and Physiology, and","Kinesiology, Kansas State University, Manhattan, Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Anatomy and Physiology, and","institution_ids":[]},{"raw_affiliation_string":"Kinesiology, Kansas State University, Manhattan, Kansas","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002404195","display_name":"David C. Poole","orcid":"https://orcid.org/0000-0003-2441-3793","observed_orcids":["https://orcid.org/0000-0003-2441-3793"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David C. Poole","raw_affiliation_strings":["Departments of 1Anatomy and Physiology, and","Kinesiology, Kansas State University, Manhattan, Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Anatomy and Physiology, and","institution_ids":[]},{"raw_affiliation_string":"Kinesiology, Kansas State University, Manhattan, Kansas","institution_ids":["https://openalex.org/I189590672"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002404195"],"corresponding_institution_ids":["https://openalex.org/I189590672"],"apc_list":null,"apc_paid":null,"fwci":6.8346,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.95262239,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"110","issue":"5","first_page":"1290","last_page":"1298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.058800000697374344,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.05130000039935112,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":1.0},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8600000143051147},{"id":"https://openalex.org/keywords/muscle-blood-flow","display_name":"muscle blood flow","score":0.5960000157356262},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.7570000290870667},{"id":"https://openalex.org/keywords/twitch-contraction","display_name":"twitch contraction","score":0.7039999961853027},{"id":"https://openalex.org/keywords/muscle-force-production","display_name":"muscle force production","score":0.7250000238418579},{"id":"https://openalex.org/keywords/exercise-economy","display_name":"exercise economy","score":0.7440000176429749},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9190000295639038},{"id":"https://openalex.org/keywords/spinotrapezius-muscle","display_name":"spinotrapezius muscle","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6612327694892883},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6158936023712158},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.5784788727760315},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5432312488555908},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5389869809150696},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.5226587653160095},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.45063796639442444},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.43674802780151367},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3290705680847168},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21952927112579346},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012146","descriptor_name":"Rest","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/japplphysiol.01489.2010","doi":"https://doi.org/10.1152/japplphysiol.01489.2010","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.01489.2010","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:21372096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21372096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1496671849","https://openalex.org/W1511189929","https://openalex.org/W1528220495","https://openalex.org/W1541276119","https://openalex.org/W1565656270","https://openalex.org/W1797124606","https://openalex.org/W1867229320","https://openalex.org/W1889843409","https://openalex.org/W1919315131","https://openalex.org/W1975288614","https://openalex.org/W1984396722","https://openalex.org/W1985883345","https://openalex.org/W1986886094","https://openalex.org/W1987160301","https://openalex.org/W1987981231","https://openalex.org/W1990202173","https://openalex.org/W2005602619","https://openalex.org/W2007405130","https://openalex.org/W2009817860","https://openalex.org/W2011480706","https://openalex.org/W2014374142","https://openalex.org/W2016378441","https://openalex.org/W2021635018","https://openalex.org/W2035346726","https://openalex.org/W2036765113","https://openalex.org/W2038971362","https://openalex.org/W2040559102","https://openalex.org/W2046690044","https://openalex.org/W2059383552","https://openalex.org/W2067632283","https://openalex.org/W2071186420","https://openalex.org/W2071621393","https://openalex.org/W2074939086","https://openalex.org/W2076752411","https://openalex.org/W2093071893","https://openalex.org/W2094866017","https://openalex.org/W2096668802","https://openalex.org/W2099375619","https://openalex.org/W2101164971","https://openalex.org/W2101444644","https://openalex.org/W2102874450","https://openalex.org/W2106052969","https://openalex.org/W2108339487","https://openalex.org/W2109919392","https://openalex.org/W2111880775","https://openalex.org/W2113529945","https://openalex.org/W2113820431","https://openalex.org/W2117309406","https://openalex.org/W2119114877","https://openalex.org/W2119504244","https://openalex.org/W2129739017","https://openalex.org/W2130140191","https://openalex.org/W2133244276","https://openalex.org/W2135609788","https://openalex.org/W2136301623","https://openalex.org/W2146056013","https://openalex.org/W2156172044","https://openalex.org/W2160615772","https://openalex.org/W2227174102","https://openalex.org/W2234733724","https://openalex.org/W2287732602","https://openalex.org/W2289643233","https://openalex.org/W2328279966","https://openalex.org/W2404103831","https://openalex.org/W2423810330","https://openalex.org/W2426138182"],"related_works":["https://openalex.org/W2083357977","https://openalex.org/W4387061218","https://openalex.org/W1974004829","https://openalex.org/W1994662347","https://openalex.org/W289653241","https://openalex.org/W2058136686","https://openalex.org/W1565656270","https://openalex.org/W4413103277","https://openalex.org/W1994677649","https://openalex.org/W3166148016"],"abstract_inverted_index":{"Reactive":[0],"oxygen":[1],"species,":[2],"such":[3],"as":[4,163],"hydrogen":[5],"peroxide":[6],"(H(2)O(2)),":[7],"exert":[8],"a":[9],"critical":[10],"regulatory":[11],"role":[12],"on":[13],"skeletal":[14,221],"muscle":[15,23,222],"function.":[16],"Whether":[17],"acute":[18,112],"increases":[19,128],"in":[20,129,158,194,218,233,239],"H(2)O(2)":[21,51,118,124,156,182,219],"modulate":[22],"microvascular":[24,30],"O(2)":[25,34,212],"delivery-utilization":[26],"(Qo(2)/Vo(2))":[27],"matching":[28],"[i.e.,":[29],"partial":[31],"pressure":[32],"of":[33,42,80,93],"(Pmv(O(2)))]":[35],"at":[36,136],"rest":[37,137],"and":[38,58,87,117,131,138,141],"following":[39,111],"the":[40,166,169,195,207,235],"onset":[41],"contractions":[43,63,99,140,191],"is":[44],"unknown.":[45],"The":[46],"hypothesis":[47],"was":[48,178],"tested":[49],"that":[50,133],"treatment":[52,125,183],"(exogenous":[53],"H(2)O(2))":[54],"would":[55],"enhance":[56],"Pmv(O(2))":[57,60,135,144,170],"slow":[59],"kinetics":[61,145],"during":[62,190,227],"compared":[64],"with":[65,114,181,242],"control.":[66],"Anesthetized,":[67],"healthy":[68],"young":[69],"Sprague-Dawley":[70],"rats":[71],"had":[72],"their":[73],"spinotrapezius":[74],"muscles":[75],"either":[76],"exposed":[77],"for":[78,91,210],"measurement":[79,92],"blood":[81],"flow":[82],"(and":[83],"therefore":[84],"QO(2)),":[85],"VO(2),":[86],"Pmv(O(2)),":[88,162],"or":[89],"exteriorized":[90],"force":[94,176,209],"production.":[95],"Electrically":[96],"stimulated":[97],"twitch":[98],"(1":[100],"Hz,":[101],"~7":[102],"V,":[103],"2-ms":[104],"pulse":[105],"duration,":[106],"3":[107],"min)":[108],"were":[109],"evoked":[110],"superfusion":[113],"Krebs-Henseleit":[115],"(control)":[116],"(100":[119],"\u03bcM).":[120],"Relative":[121],"to":[122],"control,":[123],"elicited":[126],"disproportionate":[127],"QO(2)":[130],"VO(2)":[132],"elevated":[134],"throughout":[139],"slowed":[142],"overall":[143,161],"(i.e.,":[146,214,224],"~85%":[147],"slower":[148],"mean":[149],"response":[150],"time;":[151],"P":[152,198],"<":[153,173,199],"0.05).":[154,174,200],"Accordingly,":[155],"resulted":[157],"~33%":[159],"greater":[160],"assessed":[164],"by":[165],"area":[167],"under":[168],"curve":[171],"(P":[172,184],"Muscle":[175],"production":[177],"not":[179],"altered":[180],">":[185],"0.05),":[186],"evidencing":[187],"reduced":[188,225,236],"economy":[189,226],"(~40%":[192],"decrease":[193],"force/VO(2)":[196],"relationship;":[197],"These":[201],"findings":[202],"indicate":[203],"that,":[204],"although":[205],"increasing":[206],"driving":[208],"blood-myocyte":[211],"flux":[213],"Pmv(O(2))),":[215],"transient":[216],"elevations":[217],"impair":[220],"function":[223],"contractions),":[228],"which":[229],"mechanistically":[230],"may":[231],"underlie,":[232],"part,":[234],"exercise":[237],"tolerance":[238],"conditions":[240],"associated":[241],"oxidative":[243],"stress.":[244]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}