{"id":"https://openalex.org/W2016585890","doi":"https://doi.org/10.1073/pnas.86.16.6052","title":"Phosphorylation of OmpR by the osmosensor EnvZ modulates expression of the ompF and ompC genes in Escherichia coli.","display_name":"Phosphorylation of OmpR by the osmosensor EnvZ modulates expression of the ompF and ompC genes in Escherichia coli.","publication_year":1989,"publication_date":"1989-08-01","ids":{"openalex":"https://openalex.org/W2016585890","doi":"https://doi.org/10.1073/pnas.86.16.6052","mag":"2016585890","pmid":"https://pubmed.ncbi.nlm.nih.gov/2668953","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/297773"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.86.16.6052","doi":"https://doi.org/10.1073/pnas.86.16.6052","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.86.16.6052","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2016585890"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC297773/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058185953","display_name":"Steven Forst","orcid":"https://orcid.org/0000-0003-2648-9927","observed_orcids":["https://orcid.org/0000-0003-2648-9927"]},"institutions":[{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Forst","raw_affiliation_strings":["Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854-5635"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854-5635","institution_ids":["https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J Delgado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Delgado","raw_affiliation_strings":["Department of Biochemistry, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway 08854-5635","Department of Biochemistry, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854-5635"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway 08854-5635","institution_ids":["https://openalex.org/I4405286694"]},{"raw_affiliation_string":"Department of Biochemistry, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854-5635","institution_ids":["https://openalex.org/I4405286694"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030465724","display_name":"Masayori Inouye","orcid":"https://orcid.org/0000-0003-4490-600X","observed_orcids":["https://orcid.org/0000-0003-4490-600X"]},"institutions":[{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Inouye","raw_affiliation_strings":["Department of Biochemistry, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway 08854-5635"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway 08854-5635","institution_ids":["https://openalex.org/I4405286694"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405286694"],"apc_list":null,"apc_paid":null,"fwci":10.1724,"has_fulltext":false,"cited_by_count":270,"citation_normalized_percentile":{"value":0.99071118,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"86","issue":"16","first_page":"6052","last_page":"6056"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/envz","display_name":"EnvZ","score":0.9240000247955322},{"id":"https://openalex.org/keywords/ompr","display_name":"OmpR","score":0.9950000047683716},{"id":"https://openalex.org/keywords/osmosensing","display_name":"osmosensing","score":0.5099999904632568},{"id":"https://openalex.org/keywords/ompf","display_name":"OmpF","score":0.5659999847412109},{"id":"https://openalex.org/keywords/ompc","display_name":"OmpC","score":0.9819999933242798},{"id":"https://openalex.org/keywords/histidine-phosphorylation","display_name":"histidine phosphorylation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/chea","display_name":"CheA","score":0.6380000114440918},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.7149999737739563},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7397631406784058},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.708600640296936},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.642163872718811},{"id":"https://openalex.org/C201663137","wikidata":"https://www.wikidata.org/wiki/Q21198990","display_name":"Periplasmic space","level":4,"score":0.5124914646148682},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5029253363609314},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.5009727478027344},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.4829367995262146},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4489363133907318},{"id":"https://openalex.org/C2781196521","wikidata":"https://www.wikidata.org/wiki/Q24965710","display_name":"Response regulator","level":4,"score":0.4483703672885895},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42191582918167114},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39476752281188965},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.25438541173934937},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1046772301197052}],"mesh":[{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.86.16.6052","doi":"https://doi.org/10.1073/pnas.86.16.6052","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.86.16.6052","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:2668953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2668953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:297773","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC297773/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:297773","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC297773/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1102266461","display_name":null,"funder_award_id":"GM 1553","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G31390591","display_name":null,"funder_award_id":"GM 19043","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W989606210","https://openalex.org/W1496470508","https://openalex.org/W1504072603","https://openalex.org/W1538207723","https://openalex.org/W1550113274","https://openalex.org/W1551452913","https://openalex.org/W1567412734","https://openalex.org/W1575892927","https://openalex.org/W1598930222","https://openalex.org/W1628900343","https://openalex.org/W1799355856","https://openalex.org/W1888129521","https://openalex.org/W1908944821","https://openalex.org/W1950153034","https://openalex.org/W1962822986","https://openalex.org/W1964670689","https://openalex.org/W1965844459","https://openalex.org/W1976532615","https://openalex.org/W1977051051","https://openalex.org/W1982249278","https://openalex.org/W1986872558","https://openalex.org/W1996283160","https://openalex.org/W2003708205","https://openalex.org/W2024573387","https://openalex.org/W2026986379","https://openalex.org/W2027891270","https://openalex.org/W2039922187","https://openalex.org/W2040344830","https://openalex.org/W2049583838","https://openalex.org/W2086438701","https://openalex.org/W2099773167","https://openalex.org/W2108949591","https://openalex.org/W2120849995","https://openalex.org/W2155825582","https://openalex.org/W7096490390"],"related_works":["https://openalex.org/W1576104289","https://openalex.org/W1540223655","https://openalex.org/W1576655502","https://openalex.org/W1833346845","https://openalex.org/W2001917475","https://openalex.org/W2326461774","https://openalex.org/W2017255816","https://openalex.org/W2157186467","https://openalex.org/W1986390063","https://openalex.org/W2021427887"],"abstract_inverted_index":{"EnvZ":[0,43,78,90,109],"and":[1,8,115,177],"OmpR,":[2],"the":[3,26,34,39,54,63,73,93,97,120,136,152,166,172,175],"regulatory":[4,20],"proteins":[5,21],"for":[6,25],"ompF":[7,176],"ompC":[9,140,178],"expression":[10,141,173],"in":[11,46,58,127,149,164],"Escherichia":[12],"coli,":[13,134],"belong":[14],"to":[15,28,62,77,92,113,124,146],"a":[16,128,162],"modulator-effector":[17],"family":[18],"of":[19,38,72,89,96,103,122,132,169,174],"which":[22,165],"are":[23],"essential":[24],"response":[27],"environmental":[29],"signals.":[30],"We":[31,50],"show":[32],"that":[33,53,80,110,147],"soluble":[35],"cytoplasmic":[36],"domain":[37],"transmembrane":[40],"modulator":[41,99],"protein":[42,66,100],"is":[44,111,142],"phosphorylated":[45,94,167],"vitro":[47],"by":[48],"[gamma-32P]-ATP.":[49],"also":[51],"demonstrate":[52],"phosphate":[55,74,123],"group":[56],"can,":[57],"turn,":[59],"be":[60],"transferred":[61],"transcription":[64],"activator":[65],"OmpR.":[67,125],"The":[68,86],"pH":[69],"stability":[70],"properties":[71],"groups":[75],"linked":[76],"indicate":[79],"this":[81],"molecule":[82],"contains":[83],"histidyl":[84],"phosphate.":[85],"invariant":[87],"His-243":[88,104],"corresponds":[91],"His-48":[95],"chemotactic":[98],"CheA.":[101],"Substitution":[102],"with":[105],"valine":[106],"produces":[107],"an":[108],"refractory":[112],"phosphorylation":[114],"can":[116],"no":[117],"longer":[118],"catalyze":[119],"transfer":[121],"Furthermore,":[126],"delta":[129],"envZ":[130,137,154],"strain":[131],"E.":[133],"containing":[135],"Val-243":[138],"plasmid,":[139],"elevated":[143],"7-fold":[144],"relative":[145],"found":[148],"cells":[150],"carrying":[151],"wild-type":[153],"plasmid.":[155],"Based":[156],"on":[157],"these":[158],"results":[159],"we":[160],"propose":[161],"model":[163],"state":[168],"OmpR":[170],"modulates":[171],"genes.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
