{"id":"https://openalex.org/W2016575939","doi":"https://doi.org/10.1093/jnci/95.13.961","title":"p53 Mutations and Survival in Stage I Non-Small-Cell Lung Cancer: Results of a Prospective Study","display_name":"p53 Mutations and Survival in Stage I Non-Small-Cell Lung Cancer: Results of a Prospective Study","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W2016575939","doi":"https://doi.org/10.1093/jnci/95.13.961","mag":"2016575939","pmid":"https://pubmed.ncbi.nlm.nih.gov/12837832"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/95.13.961","doi":"https://doi.org/10.1093/jnci/95.13.961","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/95.13.961","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072174076","display_name":"Steven Arthur Ahrendt","orcid":"https://orcid.org/0000-0002-3029-2126","observed_orcids":["https://orcid.org/0000-0002-3029-2126"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S. A. Ahrendt","raw_affiliation_strings":["Department of Surgery, University of Rochester, Rochester, NY 14642, USA. steven_ahrendt@urmc.rochester.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Rochester, Rochester, NY 14642, USA. steven_ahrendt@urmc.rochester.edu","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101932705","display_name":"Ying Chuan Hu","orcid":"https://orcid.org/0000-0003-2763-580X","observed_orcids":["https://orcid.org/0000-0003-2763-580X"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Hu","raw_affiliation_strings":["Department of Surgery , Uni- versity of Rochester , Rochester , NY ;","University of Rochester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery , Uni- versity of Rochester , Rochester , NY ;","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071575004","display_name":"Martin R. Buta","orcid":"https://orcid.org/0000-0001-6959-4204","observed_orcids":["https://orcid.org/0000-0001-6959-4204"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Buta","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery , The Johns Hopkins School of Medicine , Baltimore , MD ;","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery , The Johns Hopkins School of Medicine , Baltimore , MD ;","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060095007","display_name":"Michael McDermott","orcid":"https://orcid.org/0000-0002-1015-0745","observed_orcids":["https://orcid.org/0000-0002-1015-0745"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. P. McDermott","raw_affiliation_strings":["Department of Biosta- tistics , University of Rochester ; S. C. Yang , Department of Surgery , The Johns Hopkins School of Medicine ","University of Rochester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosta- tistics , University of Rochester ; S. C. Yang , Department of Surgery , The Johns Hopkins School of Medicine ","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107656336","display_name":"Nicole E. Benoit","orcid":"https://orcid.org/0000-0002-4074-136X","observed_orcids":["https://orcid.org/0000-0002-4074-136X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Benoit","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery , The Johns Hopkins School of Medicine , Baltimore , MD ;","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery , The Johns Hopkins School of Medicine , Baltimore , MD ;","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022602121","display_name":"Stephen C. Yang","orcid":"https://orcid.org/0000-0002-2392-1756","observed_orcids":["https://orcid.org/0000-0002-2392-1756"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. C. Yang","raw_affiliation_strings":["Department of Biosta-tistics, University of Rochester; S. C. Yang, Department of Surgery, The Johns Hopkins School of Medicine","Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, MD;","Department of Surgery, Uni-versity of Rochester, 601 Elmwood Ave., Rochester, NY 14642","Department of Surgery, Uni-versity of Rochester, Rochester, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosta-tistics, University of Rochester; S. C. Yang, Department of Surgery, The Johns Hopkins School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, MD;","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Surgery, Uni-versity of Rochester, 601 Elmwood Ave., Rochester, NY 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Surgery, Uni-versity of Rochester, Rochester, NY;","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086270619","display_name":"Lin Wu","orcid":"https://orcid.org/0000-0001-7078-7767","observed_orcids":["https://orcid.org/0000-0001-7078-7767"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Wu","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery , The Johns Hopkins School of Medicine , Baltimore , MD ;","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery , The Johns Hopkins School of Medicine , Baltimore , MD ;","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109152183","display_name":"David Sidransky","orcid":"https://orcid.org/0000-0003-4178-2072","observed_orcids":["https://orcid.org/0000-0003-4178-2072"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Sidransky","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, MD;","Department of Biosta-tistics, University of Rochester; S. C. Yang, Department of Surgery, The Johns Hopkins School of Medicine","Department of Surgery, Uni-versity of Rochester, 601 Elmwood Ave., Rochester, NY 14642","Department of Surgery, Uni-versity of Rochester, Rochester, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, MD;","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Biosta-tistics, University of Rochester; S. C. Yang, Department of Surgery, The Johns Hopkins School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Surgery, Uni-versity of Rochester, 601 Elmwood Ave., Rochester, NY 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Surgery, Uni-versity of Rochester, Rochester, NY;","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5072174076"],"corresponding_institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":null,"fwci":6.5812,"has_fulltext":true,"cited_by_count":222,"citation_normalized_percentile":{"value":0.97381958,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"95","issue":"13","first_page":"961","last_page":"970"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.4138000011444092,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.4138000011444092,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.2791000008583069,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.1817999929189682,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/stage-i-lung-cancer","display_name":"stage I lung cancer","score":0.9359999895095825},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6079999804496765},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.9459999799728394},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7250000238418579},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.8009999990463257},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.48100000619888306},{"id":"https://openalex.org/keywords/wild-type-p53","display_name":"wild-type p53","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6700503826141357},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6693968772888184},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6678302884101868},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6518430709838867},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6045461893081665},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5916352272033691},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5769761204719543},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4988691806793213},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44671934843063354},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4436441957950592},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4141947627067566},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.410855770111084},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4102446436882019},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2233400046825409},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18742752075195312},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10189229249954224},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015224","descriptor_name":"Dideoxynucleosides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/jnci/95.13.961","doi":"https://doi.org/10.1093/jnci/95.13.961","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/95.13.961","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},{"id":"pmid:12837832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12837832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Cancer Institute","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8700000047683716}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1963318082","display_name":null,"funder_award_id":"CA58184","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G416397078","display_name":null,"funder_award_id":"K08-CA-76452-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4751020653","display_name":"MOLECULAR STAGING AND SCREENING OF LUNG CANCER","funder_award_id":"5k08ca076452-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6941127517","display_name":"SPORE in Lung Cancer","funder_award_id":"P50CA058184","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W602470663","https://openalex.org/W1513951943","https://openalex.org/W1552426876","https://openalex.org/W1564956131","https://openalex.org/W1879998198","https://openalex.org/W1963717547","https://openalex.org/W1964489870","https://openalex.org/W1976056213","https://openalex.org/W1979300931","https://openalex.org/W1979610420","https://openalex.org/W1982097971","https://openalex.org/W1988145726","https://openalex.org/W1993312546","https://openalex.org/W1997293123","https://openalex.org/W2001258296","https://openalex.org/W2018436722","https://openalex.org/W2020263475","https://openalex.org/W2026864697","https://openalex.org/W2036915951","https://openalex.org/W2038660406","https://openalex.org/W2040387779","https://openalex.org/W2061805562","https://openalex.org/W2072560922","https://openalex.org/W2075123742","https://openalex.org/W2078979652","https://openalex.org/W2081540197","https://openalex.org/W2095713842","https://openalex.org/W2096276671","https://openalex.org/W2104928141","https://openalex.org/W2112224924","https://openalex.org/W2113633344","https://openalex.org/W2119363473","https://openalex.org/W2122087372","https://openalex.org/W2125831750","https://openalex.org/W2125949119","https://openalex.org/W2126269666","https://openalex.org/W2132979902","https://openalex.org/W2135911067","https://openalex.org/W2137583207","https://openalex.org/W2140726494","https://openalex.org/W2161252269","https://openalex.org/W2166075028","https://openalex.org/W2169990287","https://openalex.org/W2172142216","https://openalex.org/W2312641146","https://openalex.org/W2312732552","https://openalex.org/W2327259869","https://openalex.org/W2333919678","https://openalex.org/W2418624531","https://openalex.org/W2796700885","https://openalex.org/W4231423721","https://openalex.org/W4232719563","https://openalex.org/W4293241248"],"related_works":["https://openalex.org/W7097067239","https://openalex.org/W2036915951","https://openalex.org/W2346134716","https://openalex.org/W2020263475","https://openalex.org/W2327259869","https://openalex.org/W2171399882","https://openalex.org/W4409433348","https://openalex.org/W2074045669","https://openalex.org/W2333919678","https://openalex.org/W2314636756"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,150],"p53":[2,16,35,63,72,92,101,125,161,186,196,221,282,288,311],"gene":[3,17,36,93],"is":[4],"frequently":[5],"mutated":[6],"in":[7,40,129,158,163,182,187,209,278,284,294,321],"non-small-cell":[8],"lung":[9],"cancer":[10],"(NSCLC);":[11],"however,":[12,214],"the":[13,32,91,192,210,215],"effect":[14,219],"of":[15,34,76,90,132,143,152,194,206,220,318],"mutations":[18,37,64,126,135,162,312],"on":[19],"patient":[20,148,200,207,212],"prognosis":[21],"remains":[22],"unclear.":[23],"Therefore,":[24],"we":[25],"initiated":[26],"a":[27,113,141,195,314],"prospective":[28],"study":[29],"to":[30,177,225,240,251,263,303],"determine":[31],"association":[33],"with":[38,42,55,88,138,160,184,227,267,280,286,323],"survival":[39,109,273,296],"patients":[41,54,159,183,226,266,322],"stage":[43,228,242,254,268,324],"I":[44,229,232,269,325],"NSCLC.":[45,326],"METHODS:":[46],"Tumor":[47,190,310],"samples":[48],"were":[49,65,110,122,127,136,202],"collected":[50],"prospectively":[51],"from":[52],"188":[53],"operable":[56],"NSCLC":[57,230],"(stages":[58],"I,":[59],"II,":[60],"and":[61,71,78,105,108,146,198,253],"IIIA).":[62],"detected":[66,128],"by":[67,96],"direct":[68],"dideoxynucleotide":[69],"sequencing":[70],"GeneChip":[73],"analysis.":[74],"Association":[75],"clinical":[77,104],"pathologic":[79,86,106],"variables":[80],"(e.g.,":[81],"alcohol":[82,144],"consumption,":[83,145],"sex,":[84],"age,":[85],"stage)":[87],"mutation":[89,102,222],"was":[94,154,223,274],"determined":[95],"logistic":[97],"regression.":[98],"Associations":[99],"between":[100],"status,":[103],"variables,":[107],"assessed":[111],"using":[112],"Cox":[114],"proportional":[115],"hazards":[116],"regression":[117],"model.":[118],"All":[119],"statistical":[120],"tests":[121],"two-sided.":[123],"RESULTS:":[124],"55%":[130],"(104/188)":[131],"tumors.":[133,189],"These":[134],"associated":[137],"non-bronchoalveolar":[139],"tumors,":[140],"history":[142],"younger":[147],"age.":[149],"risk":[151],"death":[153,208],"statistically":[155,203,216,275,315],"significantly":[156,276],"higher":[157,277],"their":[164,188],"tumors":[165],"(hazard":[166],"ratio":[167],"[HR]":[168],"=":[169,175,234,238,245,249,257,261,297,301],"1.6,":[170],"95%":[171,236,247,259,299],"confidence":[172],"interval":[173],"[CI]":[174],"1.0":[176],"2.4;":[178],"P":[179,305],"=.049)":[180],"than":[181,283],"wild-type":[185,281],"stage,":[191],"presence":[193],"mutation,":[197],"increasing":[199],"age":[201],"significant":[204,217,316],"predictors":[205],"entire":[211],"group;":[213],"prognostic":[218],"limited":[224],"(stage":[231],"HR":[233,244,256],"2.8,":[235],"CI":[237,248,260,300],"1.4":[239],"5.6;":[241],"II":[243],"1.8,":[246],"0.74":[250],"4.4;":[252],"III":[255],"0.70,":[258],"0.32":[262],"1.5).":[264],"Among":[265],"NSCLC,":[270],"actuarial":[271],"4-year":[272,295],"those":[279,285],"mutant":[287],"(78%":[289],"versus":[290],"52%,":[291],"respectively;":[292],"difference":[293],"26%,":[298],"6%":[302],"46%;":[304],"=.009,":[306],"log-rank":[307],"test).":[308],"CONCLUSION:":[309],"are":[313],"predictor":[317],"poor":[319],"outcome":[320]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}