{"id":"https://openalex.org/W2016573134","doi":"https://doi.org/10.1021/bi7003203","title":"LCAT can Rescue the Abnormal Phenotype Produced by the Natural ApoA-I Mutations (Leu141Arg)Pisa and (Leu159Arg)FIN","display_name":"LCAT can Rescue the Abnormal Phenotype Produced by the Natural ApoA-I Mutations (Leu141Arg)Pisa and (Leu159Arg)FIN","publication_year":2007,"publication_date":"2007-08-21","ids":{"openalex":"https://openalex.org/W2016573134","doi":"https://doi.org/10.1021/bi7003203","mag":"2016573134","pmid":"https://pubmed.ncbi.nlm.nih.gov/17711302"},"language":"en","primary_location":{"id":"doi:10.1021/bi7003203","doi":"https://doi.org/10.1021/bi7003203","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi7003203","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037064799","display_name":"\u0393\u03b5\u03ce\u03c1\u03b3\u03b9\u03bf\u03c2 \u039a\u03bf\u03cd\u03ba\u03bf\u03c2","orcid":"https://orcid.org/0000-0002-9470-0651","observed_orcids":["https://orcid.org/0000-0002-9470-0651"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]},{"id":"https://openalex.org/I4210105723","display_name":"FORTH Institute of Molecular Biology and Biotechnology","ror":"https://ror.org/01gzszr18","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210105723","https://openalex.org/I8901234"]},{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR","US"],"is_corresponding":false,"raw_author_name":"Georgios Koukos","raw_affiliation_strings":["Molecular Genetics, Departments of Medicine and Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, Department of Basic Sciences, University of Crete Medical School, Heraklion, GR-71110, Greece, Institute of Biology, National Center for Scientific Research \u201cDemokritos\u201d, 15310 Agia Paraskevi, Athens, Greece, and Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics, Departments of Medicine and Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, Department of Basic Sciences, University of Crete Medical School, Heraklion, GR-71110, Greece, Institute of Biology, National Center for Scientific Research \u201cDemokritos\u201d, 15310 Agia Paraskevi, Athens, Greece, and Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I142617266","https://openalex.org/I203474044","https://openalex.org/I4210105723","https://openalex.org/I8901234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072662017","display_name":"Angeliki Chroni","orcid":"https://orcid.org/0000-0003-3107-1189","observed_orcids":["https://orcid.org/0000-0003-3107-1189","https://orcid.org/0000-0001-8984-4477"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]},{"id":"https://openalex.org/I4210105723","display_name":"FORTH Institute of Molecular Biology and Biotechnology","ror":"https://ror.org/01gzszr18","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210105723","https://openalex.org/I8901234"]},{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR","US"],"is_corresponding":false,"raw_author_name":"Angeliki Chroni","raw_affiliation_strings":["Molecular Genetics, Departments of Medicine and Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, Department of Basic Sciences, University of Crete Medical School, Heraklion, GR-71110, Greece, Institute of Biology, National Center for Scientific Research \u201cDemokritos\u201d, 15310 Agia Paraskevi, Athens, Greece, and Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics, Departments of Medicine and Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, Department of Basic Sciences, University of Crete Medical School, Heraklion, GR-71110, Greece, Institute of Biology, National Center for Scientific Research \u201cDemokritos\u201d, 15310 Agia Paraskevi, Athens, Greece, and Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I142617266","https://openalex.org/I203474044","https://openalex.org/I4210105723","https://openalex.org/I8901234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025099442","display_name":"Adelina Duka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]},{"id":"https://openalex.org/I4210105723","display_name":"FORTH Institute of Molecular Biology and Biotechnology","ror":"https://ror.org/01gzszr18","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210105723","https://openalex.org/I8901234"]},{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR","US"],"is_corresponding":false,"raw_author_name":"Adelina Duka","raw_affiliation_strings":["Molecular Genetics, Departments of Medicine and Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, Department of Basic Sciences, University of Crete Medical School, Heraklion, GR-71110, Greece, Institute of Biology, National Center for Scientific Research \u201cDemokritos\u201d, 15310 Agia Paraskevi, Athens, Greece, and Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics, Departments of Medicine and Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, Department of Basic Sciences, University of Crete Medical School, Heraklion, GR-71110, Greece, Institute of Biology, National Center for Scientific Research \u201cDemokritos\u201d, 15310 Agia Paraskevi, Athens, Greece, and Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I142617266","https://openalex.org/I203474044","https://openalex.org/I4210105723","https://openalex.org/I8901234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015001336","display_name":"Dimitris Kardassis","orcid":"https://orcid.org/0000-0002-8741-1931","observed_orcids":["https://orcid.org/0000-0002-8741-1931"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]},{"id":"https://openalex.org/I4210105723","display_name":"FORTH Institute of Molecular Biology and Biotechnology","ror":"https://ror.org/01gzszr18","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210105723","https://openalex.org/I8901234"]},{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR","US"],"is_corresponding":false,"raw_author_name":"Dimitris Kardassis","raw_affiliation_strings":["Molecular Genetics, Departments of Medicine and Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, Department of Basic Sciences, University of Crete Medical School, Heraklion, GR-71110, Greece, Institute of Biology, National Center for Scientific Research \u201cDemokritos\u201d, 15310 Agia Paraskevi, Athens, Greece, and Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics, Departments of Medicine and Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, Department of Basic Sciences, University of Crete Medical School, Heraklion, GR-71110, Greece, Institute of Biology, National Center for Scientific Research \u201cDemokritos\u201d, 15310 Agia Paraskevi, Athens, Greece, and Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I142617266","https://openalex.org/I203474044","https://openalex.org/I4210105723","https://openalex.org/I8901234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043402089","display_name":"Vassilis I. Zannis","orcid":"https://orcid.org/0000-0002-1295-7155","observed_orcids":["https://orcid.org/0000-0002-1295-7155"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]},{"id":"https://openalex.org/I4210105723","display_name":"FORTH Institute of Molecular Biology and Biotechnology","ror":"https://ror.org/01gzszr18","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210105723","https://openalex.org/I8901234"]},{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR","US"],"is_corresponding":true,"raw_author_name":"Vassilis I. Zannis","raw_affiliation_strings":["Molecular Genetics, Departments of Medicine and Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, Department of Basic Sciences, University of Crete Medical School, Heraklion, GR-71110, Greece, Institute of Biology, National Center for Scientific Research \u201cDemokritos\u201d, 15310 Agia Paraskevi, Athens, Greece, and Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics, Departments of Medicine and Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, Department of Basic Sciences, University of Crete Medical School, Heraklion, GR-71110, Greece, Institute of Biology, National Center for Scientific Research \u201cDemokritos\u201d, 15310 Agia Paraskevi, Athens, Greece, and Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I142617266","https://openalex.org/I203474044","https://openalex.org/I4210105723","https://openalex.org/I8901234"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5043402089"],"corresponding_institution_ids":["https://openalex.org/I111088046","https://openalex.org/I142617266","https://openalex.org/I203474044","https://openalex.org/I4210105723","https://openalex.org/I8901234"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.0556,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.6854948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"46","issue":"37","first_page":"10713","last_page":"10721"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-a-i","display_name":"apolipoprotein A-I","score":0.8999999761581421},{"id":"https://openalex.org/keywords/lcat","display_name":"lecithin:cholesterol acyltransferase","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.7409999966621399},{"id":"https://openalex.org/keywords/hdl-biogenesis","display_name":"HDL biogenesis","score":0.828000009059906},{"id":"https://openalex.org/keywords/adenoviral-gene-transfer","display_name":"adenoviral gene transfer","score":0.7509999871253967},{"id":"https://openalex.org/keywords/cholesterol-esterification","display_name":"cholesterol esterification","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.7185372710227966},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.6966903209686279},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6697859764099121},{"id":"https://openalex.org/C2779564620","wikidata":"https://www.wikidata.org/wiki/Q241595","display_name":"Lecithin","level":2,"score":0.5939754843711853},{"id":"https://openalex.org/C2780541478","wikidata":"https://www.wikidata.org/wiki/Q410020","display_name":"High-density lipoprotein","level":3,"score":0.5929124355316162},{"id":"https://openalex.org/C964641","wikidata":"https://www.wikidata.org/wiki/Q424716","display_name":"Lecithin\u2014cholesterol acyltransferase","level":4,"score":0.5836215019226074},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5432850122451782},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.51948082447052},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5155313014984131},{"id":"https://openalex.org/C45505151","wikidata":"https://www.wikidata.org/wiki/Q424706","display_name":"Cholesterylester transfer protein","level":4,"score":0.5101278424263},{"id":"https://openalex.org/C110459506","wikidata":"https://www.wikidata.org/wiki/Q7318217","display_name":"Reverse cholesterol transport","level":4,"score":0.4872507154941559},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4867591857910156},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.47631773352622986},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.47136250138282776},{"id":"https://openalex.org/C37002583","wikidata":"https://www.wikidata.org/wiki/Q418755","display_name":"Sterol O-acyltransferase","level":4,"score":0.45864182710647583},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.44689470529556274},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4235732853412628},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.4231044054031372},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42142394185066223},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.414201021194458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33544695377349854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29588693380355835},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25786852836608887},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13777470588684082},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12020885944366455},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000257","descriptor_name":"Adenoviridae Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007862","descriptor_name":"Phosphatidylcholine-Sterol O-Acyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016632","descriptor_name":"Apolipoprotein A-I","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016632","descriptor_name":"Apolipoprotein A-I","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D016632","descriptor_name":"Apolipoprotein A-I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016632","descriptor_name":"Apolipoprotein A-I","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064286","descriptor_name":"ATP Binding Cassette Transporter 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi7003203","doi":"https://doi.org/10.1021/bi7003203","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi7003203","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:17711302","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17711302","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4487614532","display_name":"Molecular and Funcitonal Analysis of Human A-I","funder_award_id":"R01HL048739","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1978921170","https://openalex.org/W2011656212","https://openalex.org/W2029841039","https://openalex.org/W2047374020","https://openalex.org/W2092266405","https://openalex.org/W2117622708","https://openalex.org/W2128006949","https://openalex.org/W2343119560","https://openalex.org/W4285719527","https://openalex.org/W4302792206"],"related_works":["https://openalex.org/W2090375734","https://openalex.org/W2149494472","https://openalex.org/W2092273366","https://openalex.org/W2802948170","https://openalex.org/W2149652424","https://openalex.org/W2151526650","https://openalex.org/W2604981885","https://openalex.org/W2065788443","https://openalex.org/W2022520842","https://openalex.org/W2000312682"],"abstract_inverted_index":{"To":[0],"explain":[1],"the":[2,63,86,121,128,135,142,167,176,179,183],"etiology":[3],"and":[4,28,30,36,78,98,103,131,141,148,151,160],"find":[5],"a":[6],"mode":[7],"of":[8,10,15,60,62,96,120,127,169,175,178],"therapy":[9],"genetically":[11],"determined":[12],"low":[13],"levels":[14],"high-density":[16],"lipoprotein":[17],"(HDL),":[18],"we":[19],"have":[20],"generated":[21,104,152],"recombinant":[22],"adenoviruses":[23,124],"expressing":[24,114,125],"apolipoprotein":[25],"A-I":[26],"(apoA-I)(Leu141Arg)Pisa":[27],"apoA-I(Leu159Arg)FIN":[29,161],"studied":[31],"their":[32],"properties":[33],"in":[34,37,55,66,71,166],"vitro":[35],"vivo.":[38],"Both":[39,186],"mutants":[40,65,130],"were":[41],"secreted":[42],"efficiently":[43],"from":[44],"cells":[45],"but":[46],"had":[47],"diminished":[48],"capacity":[49],"to":[50,89,112,172],"activate":[51],"lecithin/cholesterol":[52],"acyltransferase":[53],"(LCAT)":[54],"vitro.":[56],"Adenovirus-mediated":[57],"gene":[58],"transfer":[59],"either":[61,126],"two":[64,129],"apoA-I-deficient":[67],"(apoA-I-/-)":[68],"mice":[69,113,122],"resulted":[70],"greatly":[72],"decreased":[73,85],"total":[74,90],"plasma":[75,136],"cholesterol,":[76],"apoA-I,":[77,137],"HDL":[79,108,138,170],"cholesterol":[80,91,139,177],"levels.":[81],"The":[82,155],"treatment":[83,119,192],"also":[84],"cholesteryl":[87],"ester":[88],"ratio":[92],"(CE/TC),":[93],"caused":[94],"accumulation":[95],"prebeta1-HDL":[97,180],"small":[99],"size":[100],"alpha4-HDL":[101],"particles,":[102,109],"only":[105],"few":[106],"spherical":[107,153],"as":[110],"compared":[111],"wild-type":[115],"(WT)":[116],"apoA-I.":[117],"Simultaneous":[118],"with":[123,193],"human":[132],"LCAT":[133],"normalized":[134],"levels,":[140],"CE/TC":[143],"ratio,":[144],"restored":[145],"normal":[146],"prebeta-":[147],"alpha-HDL":[149],"subpopulations,":[150],"HDL.":[154],"study":[156],"establishes":[157],"that":[158],"apoA-I(Leu141Arg)Pisa":[159],"inhibit":[162],"an":[163],"early":[164],"step":[165],"biogenesis":[168],"due":[171],"inefficient":[173],"esterification":[174],"particles":[181],"by":[182,191],"endogenous":[184],"LCAT.":[185,194],"defects":[187],"can":[188],"be":[189],"corrected":[190]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}