{"id":"https://openalex.org/W2016567802","doi":"https://doi.org/10.1007/s10637-010-9588-y","title":"Histone deacetylase inhibitors in Hodgkin lymphoma","display_name":"Histone deacetylase inhibitors in Hodgkin lymphoma","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2016567802","doi":"https://doi.org/10.1007/s10637-010-9588-y","mag":"2016567802","pmid":"https://pubmed.ncbi.nlm.nih.gov/21127943","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3003791"},"language":"en","primary_location":{"id":"doi:10.1007/s10637-010-9588-y","doi":"https://doi.org/10.1007/s10637-010-9588-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10637-010-9588-y","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10637-010-9588-y.pdf","source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10637-010-9588-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112106255","display_name":"Daniela Buglio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela Buglio","raw_affiliation_strings":["Department of Lymphoma/Myeloma, 1515 Holcombe Boulevard, Box # 429, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Lymphoma/Myeloma, 1515 Holcombe Boulevard, Box # 429, Houston, TX 77030, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068152076","display_name":"Anas Younes","orcid":"https://orcid.org/0000-0002-0001-4133","observed_orcids":["https://orcid.org/0000-0002-0001-4133"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anas Younes","raw_affiliation_strings":["Department of Lymphoma/Myeloma, 1515 Holcombe Boulevard, Box # 429, Houston, TX, 77030, USA","Department of Lymphoma/Myeloma, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Lymphoma/Myeloma, 1515 Holcombe Boulevard, Box # 429, Houston, TX, 77030, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Lymphoma/Myeloma, Houston, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068152076"],"corresponding_institution_ids":[],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":{"value":4690,"currency":"USD","value_usd":4690},"fwci":0.3088,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.2438658,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"28","issue":"S1","first_page":"21","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.5479000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.5479000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.43799999356269836,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hodgkin-lymphoma","display_name":"Hodgkin's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/relapsed-hodgkin-lymphoma","display_name":"relapsed Hodgkin lymphoma","score":0.9319999814033508},{"id":"https://openalex.org/keywords/refractory-hodgkin-lymphoma","display_name":"refractory Hodgkin lymphoma","score":0.9309999942779541},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/novel-therapeutic-agents","display_name":"novel therapeutic agents","score":0.5189999938011169},{"id":"https://openalex.org/keywords/early-mortality","display_name":"early mortality","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7697485685348511},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.7051283121109009},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.6324841380119324},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5759411454200745},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5630436539649963},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5377976894378662},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5373733043670654},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5007259845733643},{"id":"https://openalex.org/C2779050716","wikidata":"https://www.wikidata.org/wiki/Q4826373","display_name":"Autologous stem-cell transplantation","level":3,"score":0.497257262468338},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4731655716896057},{"id":"https://openalex.org/C2992779791","wikidata":"https://www.wikidata.org/wiki/Q209369","display_name":"Hodgkin lymphoma","level":3,"score":0.45988544821739197},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.45810365676879883},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.1997382640838623},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09635064005851746},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10637-010-9588-y","doi":"https://doi.org/10.1007/s10637-010-9588-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10637-010-9588-y","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10637-010-9588-y.pdf","source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3003791","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3003791","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Invest New Drugs","raw_type":"Text"},{"id":"pmid:21127943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21127943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational new drugs","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s10637-010-9588-y","doi":"https://doi.org/10.1007/s10637-010-9588-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10637-010-9588-y","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10637-010-9588-y.pdf","source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8100000023841858}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016567802.pdf","grobid_xml":"https://content.openalex.org/works/W2016567802.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W154212680","https://openalex.org/W1583417813","https://openalex.org/W1963536316","https://openalex.org/W1965837349","https://openalex.org/W1967018540","https://openalex.org/W1972149587","https://openalex.org/W1975615991","https://openalex.org/W1975692560","https://openalex.org/W1978111967","https://openalex.org/W1978449568","https://openalex.org/W1984807040","https://openalex.org/W1986250542","https://openalex.org/W1991660464","https://openalex.org/W1993273200","https://openalex.org/W2003600960","https://openalex.org/W2008549312","https://openalex.org/W2008953417","https://openalex.org/W2012707832","https://openalex.org/W2050931169","https://openalex.org/W2055907134","https://openalex.org/W2066052727","https://openalex.org/W2066077385","https://openalex.org/W2071115015","https://openalex.org/W2094623849","https://openalex.org/W2095361625","https://openalex.org/W2099803844","https://openalex.org/W2102650381","https://openalex.org/W2107040737","https://openalex.org/W2113155233","https://openalex.org/W2125514026","https://openalex.org/W2125663112","https://openalex.org/W2126199679","https://openalex.org/W2133653334","https://openalex.org/W2133958055","https://openalex.org/W2141410747","https://openalex.org/W2141631785","https://openalex.org/W2145879583","https://openalex.org/W2153183019","https://openalex.org/W2156517973","https://openalex.org/W2169329800","https://openalex.org/W2179756380","https://openalex.org/W2540182167","https://openalex.org/W2557428466","https://openalex.org/W2558950888","https://openalex.org/W2559269147","https://openalex.org/W2562456938","https://openalex.org/W2562731214","https://openalex.org/W2564793703","https://openalex.org/W2993385101","https://openalex.org/W3016656752","https://openalex.org/W4245628390"],"related_works":["https://openalex.org/W7099026398","https://openalex.org/W4378746721","https://openalex.org/W2024277839","https://openalex.org/W2112900688","https://openalex.org/W7099330583","https://openalex.org/W2302499530","https://openalex.org/W2771710356","https://openalex.org/W2167987546","https://openalex.org/W2293585960","https://openalex.org/W2769286997"],"abstract_inverted_index":{"Although":[0],"Hodgkin":[1],"lymphoma":[2],"(HL)":[3],"is":[4,56],"considered":[5],"one":[6],"of":[7,15,35,39,44,50,92,120],"the":[8,13,36,42,48,90,117],"most":[9],"curable":[10],"human":[11],"cancers,":[12],"treatment":[14,80,91],"patients":[16,93,125],"with":[17,59,94,126],"relapsed":[18,60,127],"and":[19,71,78],"refractory":[20],"disease,":[21],"especially":[22],"those":[23],"who":[24],"relapse":[25],"after":[26],"autologous":[27],"stem":[28,63],"cell":[29,64],"transplantation,":[30],"remains":[31],"challenging.":[32],"Furthermore,":[33],"because":[34],"young":[37],"age":[38],"these":[40],"patients,":[41],"impact":[43],"early":[45,109],"mortality":[46],"on":[47,116],"number":[49],"years":[51],"lost":[52],"from":[53],"productive":[54],"life":[55],"remarkable.":[57],"Patients":[58],"HL":[61,95],"post":[62],"transplantation":[65],"currently":[66],"have":[67,86],"no":[68,83],"curative":[69],"therapy,":[70],"are":[72,104],"in":[73,96,108,124],"need":[74],"for":[75,89],"new":[76,84,102],"drugs":[77,85],"novel":[79],"strategies.":[81],"While":[82],"been":[87],"approved":[88],"more":[97],"than":[98],"three":[99],"decades,":[100],"several":[101],"agents":[103],"demonstrating":[105],"promising":[106],"results":[107],"clinical":[110],"trials.":[111],"This":[112],"review":[113],"will":[114],"focus":[115],"emerging":[118],"role":[119],"histone":[121],"deacetylase":[122],"inhibitors":[123],"HL.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}
