{"id":"https://openalex.org/W2016565293","doi":"https://doi.org/10.1007/bf02414601","title":"The value of the electrocardiogram in the diagnosis of acute rejection after orthotopic heart transplantation","display_name":"The value of the electrocardiogram in the diagnosis of acute rejection after orthotopic heart transplantation","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2016565293","doi":"https://doi.org/10.1007/bf02414601","mag":"2016565293","pmid":"https://pubmed.ncbi.nlm.nih.gov/2803486"},"language":"en","primary_location":{"id":"doi:10.1007/bf02414601","doi":"https://doi.org/10.1007/bf02414601","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02414601","pdf_url":null,"source":{"id":"https://openalex.org/S121647140","display_name":"Transplant International","issn_l":"0934-0874","issn":["0934-0874","1432-2277"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114123126","display_name":"T. J. Locke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801924861","display_name":"Freeman Hospital","ror":"https://ror.org/00cdwy346","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869","https://openalex.org/I2801924861"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T. J. Locke","raw_affiliation_strings":["Department of Cardiothoracic Surgery and Cardiology, Freeman Hospital, Newcastle upon Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery and Cardiology, Freeman Hospital, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Karnik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801924861","display_name":"Freeman Hospital","ror":"https://ror.org/00cdwy346","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869","https://openalex.org/I2801924861"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. Karnik","raw_affiliation_strings":["Department of Cardiothoracic Surgery and Cardiology, Freeman Hospital, NE7 7DN, Newcastle upon Tyne, UK","Freeman Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery and Cardiology, Freeman Hospital, NE7 7DN, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]},{"raw_affiliation_string":"Freeman Hospital","institution_ids":["https://openalex.org/I2801924861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108570476","display_name":"Christoper G.A. McGregor","orcid":"https://orcid.org/0000-0002-2784-5033","observed_orcids":["https://orcid.org/0000-0002-2784-5033"]},"institutions":[{"id":"https://openalex.org/I2801924861","display_name":"Freeman Hospital","ror":"https://ror.org/00cdwy346","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869","https://openalex.org/I2801924861"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. G. A. McGregor","raw_affiliation_strings":["Department of Cardiothoracic Surgery and Cardiology, Freeman Hospital, NE7 7DN, Newcastle upon Tyne, UK","Freeman Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery and Cardiology, Freeman Hospital, NE7 7DN, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]},{"raw_affiliation_string":"Freeman Hospital","institution_ids":["https://openalex.org/I2801924861"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113610273","display_name":"Rodney S. Bexton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801924861","display_name":"Freeman Hospital","ror":"https://ror.org/00cdwy346","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869","https://openalex.org/I2801924861"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. S. Bexton","raw_affiliation_strings":["Department of Cardiothoracic Surgery and Cardiology, Freeman Hospital, NE7 7DN, Newcastle upon Tyne, UK","Freeman Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery and Cardiology, Freeman Hospital, NE7 7DN, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]},{"raw_affiliation_string":"Freeman Hospital","institution_ids":["https://openalex.org/I2801924861"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801924861"],"apc_list":{"value":2700,"currency":"EUR","value_usd":3051},"apc_paid":null,"fwci":0.5785,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.68812705,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"2","issue":"1","first_page":"143","last_page":"146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-rejection","display_name":"acute rejection","score":0.6819999814033508},{"id":"https://openalex.org/keywords/orthotopic-heart-transplantation","display_name":"orthotopic heart transplantation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/electrocardiography","display_name":"electrocardiogram","score":0.9629999995231628},{"id":"https://openalex.org/keywords/qrs-voltage","display_name":"QRS voltage","score":0.949999988079071},{"id":"https://openalex.org/keywords/endomyocardial-biopsy","display_name":"endomyocardial biopsy","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9049999713897705},{"id":"https://openalex.org/keywords/azathioprine","display_name":"azathioprine","score":0.996999979019165},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.9860000014305115},{"id":"https://openalex.org/keywords/myocyte-necrosis","display_name":"myocyte necrosis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.828000009059906},{"id":"https://openalex.org/keywords/pericardial-effusion","display_name":"pericardial effusion","score":0.9549999833106995},{"id":"https://openalex.org/keywords/rejection-prediction","display_name":"rejection prediction","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.921501636505127},{"id":"https://openalex.org/C111773187","wikidata":"https://www.wikidata.org/wiki/Q1969239","display_name":"QRS complex","level":2,"score":0.731212854385376},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6855694651603699},{"id":"https://openalex.org/C2781175549","wikidata":"https://www.wikidata.org/wiki/Q1306218","display_name":"Pericardial effusion","level":2,"score":0.6747294068336487},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6394355297088623},{"id":"https://openalex.org/C2778849806","wikidata":"https://www.wikidata.org/wiki/Q643396","display_name":"Heart transplantation","level":3,"score":0.5756140947341919},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5272946357727051},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.4854331612586975}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001379","descriptor_name":"Azathioprine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003524","descriptor_name":"Cyclosporins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/bf02414601","doi":"https://doi.org/10.1007/bf02414601","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02414601","pdf_url":null,"source":{"id":"https://openalex.org/S121647140","display_name":"Transplant International","issn_l":"0934-0874","issn":["0934-0874","1432-2277"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant International","raw_type":"journal-article"},{"id":"doi:10.1111/j.1432-2277.1989.tb01858.x","doi":"https://doi.org/10.1111/j.1432-2277.1989.tb01858.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1432-2277.1989.tb01858.x","pdf_url":null,"source":{"id":"https://openalex.org/S121647140","display_name":"Transplant International","issn_l":"0934-0874","issn":["0934-0874","1432-2277"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant International","raw_type":"journal-article"},{"id":"pmid:2803486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2803486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant international : official journal of the European Society for Organ Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8100000023841858}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1593482304","https://openalex.org/W1975051725","https://openalex.org/W1996960615","https://openalex.org/W2004571748","https://openalex.org/W2013595520","https://openalex.org/W2046202093","https://openalex.org/W2052155865","https://openalex.org/W2408848802","https://openalex.org/W2412845483","https://openalex.org/W2421804143","https://openalex.org/W4244319882","https://openalex.org/W4249229599"],"related_works":["https://openalex.org/W2408848802","https://openalex.org/W225463766","https://openalex.org/W2081353018","https://openalex.org/W2139834825","https://openalex.org/W2793686511","https://openalex.org/W2040890850","https://openalex.org/W2383629102","https://openalex.org/W2410963843","https://openalex.org/W2007618442","https://openalex.org/W1967663995"],"abstract_inverted_index":{"The":[0],"value":[1,86,136],"of":[2,12,62,71,87,94,121,133,140],"a":[3,10,76,83,110],"change":[4,78],"in":[5,17,79,103,137,143],"summated":[6,39],"electrocardiographic":[7],"voltage":[8,115,131],"as":[9],"predictor":[11],"cardiac":[13,30,141],"rejection":[14,64,72,142],"is":[15,132],"uncertain":[16],"patients":[18,144],"treated":[19,145],"with":[20,65,109,146],"low-dose":[21,147],"triple":[22,148],"immunotherapy":[23],"(cyclosporin,":[24],"azathioprine,":[25],"and":[26,37],"corticosteroids)":[27],"following":[28],"orthotopic":[29],"transplantation.":[31],"Ten":[32],"recipients":[33],"were":[34,45,59,73,98],"studied":[35],"daily":[36],"the":[38,55,90,119,138],"QRS":[40,80,104,114,130],"voltages":[41],"from":[42],"600":[43],"electrocardiograms":[44],"calculated.":[46],"A":[47],"single":[48],"observer":[49],"graded":[50],"147":[51],"endomyocardial":[52],"biopsies.":[53],"During":[54],"study":[56],"period":[57],"there":[58],"18":[60],"episodes":[61,70,93],"acute":[63],"myocyte":[66],"necrosis.":[67],"Only":[68],"three":[69],"heralded":[74],"by":[75,100,124],"significant":[77,101],"voltage,":[81],"yielding":[82],"positive":[84],"predictive":[85],"13%":[88],"for":[89],"technique.":[91],"Three":[92],"severe":[95],"bacterial":[96],"infection":[97],"preceded":[99],"decreases":[102],"voltage.":[105],"In":[106],"one":[107],"patient":[108],"global":[111],"pericardial":[112],"effusion,":[113],"was":[116],"related":[117],"to":[118],"depth":[120],"effusion":[122],"measured":[123],"echocardiography.":[125],"These":[126],"data":[127],"show":[128],"that":[129],"extremely":[134],"limited":[135],"prediction":[139],"immunotherapy.":[149]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}