{"id":"https://openalex.org/W2016555997","doi":"https://doi.org/10.1007/s10165-003-0263-4","title":"HLA-DRB1 haplotype did not affect the medium-term results of total knee arthroplasty in patients with rheumatoid arthritis","display_name":"HLA-DRB1 haplotype did not affect the medium-term results of total knee arthroplasty in patients with rheumatoid arthritis","publication_year":2004,"publication_date":"2004-03-01","ids":{"openalex":"https://openalex.org/W2016555997","doi":"https://doi.org/10.1007/s10165-003-0263-4","mag":"2016555997","pmid":"https://pubmed.ncbi.nlm.nih.gov/17028803"},"language":"en","primary_location":{"id":"doi:10.1007/s10165-003-0263-4","doi":"https://doi.org/10.1007/s10165-003-0263-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10165-003-0263-4","pdf_url":null,"source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047491199","display_name":"Seisuke Takemura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Seisuke Takemura","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kansai Medical University, 10-15 Fumizono-machi, Moriguchi, 570-8506, Japan, seisuke@moon.step.ne.jp","Department of Orthopaedic Surgery, Kansai Medical University, 10-15 Fumizono-machi, Moriguchi 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kansai Medical University, 10-15 Fumizono-machi, Moriguchi, 570-8506, Japan, seisuke@moon.step.ne.jp","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kansai Medical University, 10-15 Fumizono-machi, Moriguchi 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110747261","display_name":"Yoshitaka Toda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshitaka Toda","raw_affiliation_strings":["Toda Orthopedic and Rheumatology Clinic, Suita, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toda Orthopedic and Rheumatology Clinic, Suita, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016250824","display_name":"J\u00f6rg J. Goronzy","orcid":"https://orcid.org/0000-0001-7670-1856","observed_orcids":["https://orcid.org/0000-0001-7670-1856"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J\ufffdrg J. Goronzy","raw_affiliation_strings":["Department of Medicine, Mayo Clinic, Rochester, MN, USA","Department of Medicine Mayo Clinic Rochester USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Medicine Mayo Clinic Rochester USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056587089","display_name":"Cornelia M. Weyand","orcid":"https://orcid.org/0000-0003-2230-9802","observed_orcids":["https://orcid.org/0000-0003-2230-9802"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cornelia M. Weyand","raw_affiliation_strings":["Department of Medicine, Mayo Clinic, Rochester, MN, USA","Department of Medicine Mayo Clinic Rochester USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Medicine Mayo Clinic Rochester USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109162336","display_name":"Ryokei Ogawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryokei Ogawa","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kansai Medical University, 10-15 Fumizono-machi, Moriguchi 570-8506, Japan","Department of Orthopaedic Surgery, Kansai Medical University, Moriguchi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kansai Medical University, 10-15 Fumizono-machi, Moriguchi 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kansai Medical University, Moriguchi, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110172612","display_name":"Hirokazu Iida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirokazu Iida","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kansai Medical University, 10-15 Fumizono-machi, Moriguchi 570-8506, Japan","Department of Orthopaedic Surgery, Kansai Medical University, Moriguchi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kansai Medical University, 10-15 Fumizono-machi, Moriguchi 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kansai Medical University, Moriguchi, Japan","institution_ids":["https://openalex.org/I126884977"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047491199"],"corresponding_institution_ids":["https://openalex.org/I126884977"],"apc_list":{"value":3208,"currency":"USD","value_usd":3208},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15119509,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"1","first_page":"37","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10562","display_name":"Total Knee Arthroplasty Outcomes","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10562","display_name":"Total Knee Arthroplasty Outcomes","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-drb1","display_name":"HLA-DRB1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/total-knee-arthroplasty","display_name":"total knee arthroplasty","score":1.0},{"id":"https://openalex.org/keywords/gene-dosage","display_name":"gene dosage","score":0.5799999833106995},{"id":"https://openalex.org/keywords/implant-survival","display_name":"implant survival","score":0.703000009059906},{"id":"https://openalex.org/keywords/postoperative-knee-function","display_name":"postoperative knee function","score":0.6629999876022339},{"id":"https://openalex.org/keywords/radiolucency","display_name":"radiolucency","score":0.8259999752044678},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.43700000643730164},{"id":"https://openalex.org/keywords/functional-status","display_name":"functional status","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9381446242332458},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.8367412090301514},{"id":"https://openalex.org/C3017871827","wikidata":"https://www.wikidata.org/wiki/Q1693864","display_name":"Total knee arthroplasty","level":2,"score":0.6822109818458557},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6288259625434875},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.47790274024009705},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4765744209289551},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.46825772523880005},{"id":"https://openalex.org/C2908736133","wikidata":"https://www.wikidata.org/wiki/Q37425","display_name":"Knee Joint","level":2,"score":0.45845240354537964},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.45121079683303833},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.44456052780151367},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.43793219327926636},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.42986008524894714},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3553837537765503},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3522372841835022},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.32925254106521606},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09186175465583801},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/s10165-003-0263-4","doi":"https://doi.org/10.1007/s10165-003-0263-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10165-003-0263-4","pdf_url":null,"source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},{"id":"doi:10.3109/s10165-003-0263-4","doi":"https://doi.org/10.3109/s10165-003-0263-4","is_oa":false,"landing_page_url":"https://doi.org/10.3109/s10165-003-0263-4","pdf_url":null,"source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},{"id":"pmid:17028803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17028803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern rheumatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.699999988079071,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4181945085","display_name":"Oligoclonal T Cell Expansion and Rheumatoid Arthritis","funder_award_id":"R01AR042527","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W179550664","https://openalex.org/W1976188884","https://openalex.org/W2005817811","https://openalex.org/W2007055308","https://openalex.org/W2015865604","https://openalex.org/W2033714424","https://openalex.org/W2043547351","https://openalex.org/W2053829949","https://openalex.org/W2053921549","https://openalex.org/W2065419533","https://openalex.org/W2086287386","https://openalex.org/W2091943129","https://openalex.org/W2130709219","https://openalex.org/W2136767090","https://openalex.org/W2152348310","https://openalex.org/W2158695467","https://openalex.org/W2268968056","https://openalex.org/W2291088695","https://openalex.org/W2405167898","https://openalex.org/W4256311010"],"related_works":["https://openalex.org/W3146762847","https://openalex.org/W2398263405","https://openalex.org/W2056886854","https://openalex.org/W2025446304","https://openalex.org/W2166354960","https://openalex.org/W2131321814","https://openalex.org/W1888102361","https://openalex.org/W2171251480","https://openalex.org/W4311273063","https://openalex.org/W2383020358"],"abstract_inverted_index":{"This":[0],"study":[1],"investigated":[2],"whether":[3],"the":[4,49,59,65,72,85,98,102,147,156,159,165],"HLA-DRB1":[5,53,151],"\"susceptible":[6],"allele\"":[7],"(SA)":[8],"genotype":[9,152],"is":[10],"predictive":[11],"for":[12,126],"total":[13],"knee":[14,160,179],"arthroplasty":[15],"(TKA)":[16],"failure":[17],"in":[18,113,119,131,178,183],"patients":[19,66,163],"with":[20,32,141],"rheumatoid":[21],"arthritis":[22],"(RA).":[23],"The":[24,134,150],"results":[25],"of":[26,36,61,75,101,158,185],"49":[27],"TKAs":[28],"(30":[29],"RA":[30,62],"patients)":[31],"an":[33],"average":[34,135],"follow-up":[35],"7.9":[37],"years":[38],"(range":[39],"5-15":[40],"years)":[41],"were":[42,55],"analyzed":[43],"using":[44],"a":[45],"12-item":[46,86],"questionnaire":[47,87,103],"and":[48,63,79,109],"Knee":[50],"Society":[51],"system.":[52],"alleles":[54],"used":[56],"to":[57],"estimate":[58],"severity":[60],"divide":[64],"into":[67,104],"three":[68,83,115,148],"categories":[69],"depending":[70],"upon":[71],"gene":[73,168],"dose":[74],"SA":[76,127],"(SA+/+,":[77],"SA+/-,":[78],"SA-/-).":[80],"For":[81],"all":[82,114],"categories,":[84],"had":[88],"significantly":[89],"improved":[90,117,175],"postoperatively,":[91],"but":[92,181],"without":[93,164],"significant":[94],"difference.":[95],"We":[96],"divided":[97],"12":[99],"items":[100],"two":[105],"groups:":[106],"knee-relevant":[107,120],"parameters":[108,184],"general":[110,132,186],"parameters.":[111,121,133],"Patients":[112],"groups":[116],"similarly":[118],"In":[122],"contrast,":[123],"those":[124],"homozygous":[125],"(SA+/+)":[128],"benefited":[129,169],"less":[130],"radiolucency":[136],"score":[137],"was":[138],"1.87":[139],"mm,":[140],"no":[142],"difference":[143],"being":[144],"detected":[145],"among":[146],"groups.":[149],"did":[153],"not":[154,176],"affect":[155],"survival":[157],"implants.":[161],"Overall,":[162],"RA-associated":[166],"HLA":[167],"most":[170],"from":[171],"TKA":[172],"as":[173],"they":[174],"only":[177],"function,":[180],"also":[182],"functional":[187],"status.":[188]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
