{"id":"https://openalex.org/W2016544836","doi":"https://doi.org/10.1016/j.brainres.2005.08.056","title":"AAV2/5-mediated NGF gene delivery protects septal cholinergic neurons following axotomy","display_name":"AAV2/5-mediated NGF gene delivery protects septal cholinergic neurons following axotomy","publication_year":2005,"publication_date":"2005-10-15","ids":{"openalex":"https://openalex.org/W2016544836","doi":"https://doi.org/10.1016/j.brainres.2005.08.056","mag":"2016544836","pmid":"https://pubmed.ncbi.nlm.nih.gov/16226726"},"language":"en","primary_location":{"id":"doi:10.1016/j.brainres.2005.08.056","doi":"https://doi.org/10.1016/j.brainres.2005.08.056","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.brainres.2005.08.056","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000762263","display_name":"Ke Wu","orcid":"https://orcid.org/0000-0002-4438-1517","observed_orcids":["https://orcid.org/0000-0002-4438-1517"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ke Wu","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida, ARB5-148, 1600 SW Archer Rd, Gainesville, FL 32610, USA. kewu@ufl.edu","Department of Pharmacology and Therapeutics, University of Florida, ARB5-148, 1600 SW Archer Rd, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida, ARB5-148, 1600 SW Archer Rd, Gainesville, FL 32610, USA. kewu@ufl.edu","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida, ARB5-148, 1600 SW Archer Rd, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103491448","display_name":"Edwin M. Meyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin M. Meyer","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida, ARB5-148, 1600 SW Archer Rd, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida, ARB5-148, 1600 SW Archer Rd, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025407530","display_name":"Jennifer A. Bennett","orcid":"https://orcid.org/0000-0001-8155-7131","observed_orcids":["https://orcid.org/0000-0001-8155-7131"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer A. Bennett","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida, ARB5-148, 1600 SW Archer Rd, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida, ARB5-148, 1600 SW Archer Rd, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017362034","display_name":"Craig Meyers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig A. Meyers","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida, ARB5-148, 1600 SW Archer Rd, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida, ARB5-148, 1600 SW Archer Rd, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103689052","display_name":"Jeffrey A. Hughes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Hughes","raw_affiliation_strings":["Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113710492","display_name":"Michael A. King","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. King","raw_affiliation_strings":["Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA","Veterans Administration Medical Center, Gainesville, FL 32602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Veterans Administration Medical Center, Gainesville, FL 32602, USA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5000762263"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":1.2586,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.78100359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1061","issue":"2","first_page":"107","last_page":"113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9449999928474426},{"id":"https://openalex.org/keywords/aav-gene-delivery","display_name":"AAV gene delivery","score":0.777999997138977},{"id":"https://openalex.org/keywords/septal-cholinergic-neurons","display_name":"septal cholinergic neurons","score":0.9789999723434448},{"id":"https://openalex.org/keywords/axotomy","display_name":"axotomy","score":0.9559999704360962},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.972000002861023},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.6990000009536743},{"id":"https://openalex.org/keywords/transduction-efficiency","display_name":"transduction efficiency","score":0.5249999761581421},{"id":"https://openalex.org/keywords/gfp-expression","display_name":"GFP expression","score":0.5339999794960022},{"id":"https://openalex.org/keywords/gene-delivery-to-the-brain","display_name":"gene delivery to the brain","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.7781518697738647},{"id":"https://openalex.org/C2779683492","wikidata":"https://www.wikidata.org/wiki/Q792615","display_name":"Axotomy","level":3,"score":0.6357501745223999},{"id":"https://openalex.org/C2778107364","wikidata":"https://www.wikidata.org/wiki/Q355989","display_name":"Adeno-associated virus","level":5,"score":0.6239684224128723},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.6094726324081421},{"id":"https://openalex.org/C104966671","wikidata":"https://www.wikidata.org/wiki/Q12167532","display_name":"Cholinergic neuron","level":3,"score":0.5999256372451782},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5801432132720947},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.5529763102531433},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5421072840690613},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.5397033095359802},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.5249298214912415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5181666612625122},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.509554386138916},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.4590207040309906},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.45072412490844727},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4011163115501404},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.39741119742393494},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.31126677989959717},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2713099718093872},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.2647456228733063},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1276240050792694},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10055088996887207},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002795","descriptor_name":"Choline O-Acetyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002795","descriptor_name":"Choline O-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010275","descriptor_name":"Parasympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013238","descriptor_name":"Stereotaxic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019771","descriptor_name":"Axotomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020665","descriptor_name":"Septum of Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020712","descriptor_name":"Fornix, Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.brainres.2005.08.056","doi":"https://doi.org/10.1016/j.brainres.2005.08.056","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.brainres.2005.08.056","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},{"id":"pmid:16226726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16226726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1849256353","display_name":null,"funder_award_id":"T32-AG00196","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G299029527","display_name":null,"funder_award_id":"AG10485","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6459785200","display_name":null,"funder_award_id":"N S37432","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G7854534586","display_name":"Training in the Neurobiology of Aging","funder_award_id":"5t32ag000196-20","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8681985893","display_name":"Discovery of Novel Drugs for Alzheimer's Disease","funder_award_id":"P01AG010485","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1500220781","https://openalex.org/W1504723104","https://openalex.org/W1544361309","https://openalex.org/W1597426364","https://openalex.org/W1647778121","https://openalex.org/W1754916819","https://openalex.org/W1922255142","https://openalex.org/W1965227495","https://openalex.org/W1969475775","https://openalex.org/W1972514500","https://openalex.org/W1989386072","https://openalex.org/W1990914056","https://openalex.org/W2003456064","https://openalex.org/W2004983645","https://openalex.org/W2008350281","https://openalex.org/W2018434736","https://openalex.org/W2024228411","https://openalex.org/W2026900697","https://openalex.org/W2027036629","https://openalex.org/W2031606825","https://openalex.org/W2031928363","https://openalex.org/W2033005054","https://openalex.org/W2033219958","https://openalex.org/W2037194302","https://openalex.org/W2038691967","https://openalex.org/W2042812490","https://openalex.org/W2047608515","https://openalex.org/W2048008983","https://openalex.org/W2048162805","https://openalex.org/W2049102811","https://openalex.org/W2051159468","https://openalex.org/W2052186992","https://openalex.org/W2054392351","https://openalex.org/W2063471759","https://openalex.org/W2066015597","https://openalex.org/W2068561853","https://openalex.org/W2073450010","https://openalex.org/W2079895559","https://openalex.org/W2080447191","https://openalex.org/W2081730547","https://openalex.org/W2084947002","https://openalex.org/W2093374391","https://openalex.org/W2096309023","https://openalex.org/W2111279074","https://openalex.org/W2111405228","https://openalex.org/W2114618955","https://openalex.org/W2127703931","https://openalex.org/W2133966135","https://openalex.org/W2139565721","https://openalex.org/W2149793745","https://openalex.org/W2154329712","https://openalex.org/W2313914167","https://openalex.org/W2401087041","https://openalex.org/W2413546846","https://openalex.org/W4245307762"],"related_works":["https://openalex.org/W2031606825","https://openalex.org/W2049102811","https://openalex.org/W1990914056","https://openalex.org/W3010334133","https://openalex.org/W1543486555","https://openalex.org/W1995262469","https://openalex.org/W2412035881","https://openalex.org/W7056496736","https://openalex.org/W2012001030","https://openalex.org/W1555080462"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
