{"id":"https://openalex.org/W2016540239","doi":"https://doi.org/10.1172/jci112228","title":"Demonstration and partial characterization of the interferon-gamma receptor on human mononuclear phagocytes.","display_name":"Demonstration and partial characterization of the interferon-gamma receptor on human mononuclear phagocytes.","publication_year":1985,"publication_date":"1985-12-01","ids":{"openalex":"https://openalex.org/W2016540239","doi":"https://doi.org/10.1172/jci112228","mag":"2016540239","pmid":"https://pubmed.ncbi.nlm.nih.gov/2934408","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/424342"},"language":"en","primary_location":{"id":"doi:10.1172/jci112228","doi":"https://doi.org/10.1172/jci112228","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci112228","pdf_url":"http://www.jci.org/articles/view/112228/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/112228/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024300705","display_name":"Antonio Celada","orcid":"https://orcid.org/0000-0003-3883-2171","observed_orcids":["https://orcid.org/0000-0003-3883-2171"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Celada","raw_affiliation_strings":["Department ofImmunology , Research Institute ofScripps Clinic , La Jolla , California 92037 ; and","Department of Pathology, Washington University Medical School, St. Louis, MO 631 10","Department ofImmunology, Research Institute ofScripps Clinic, La Jolla, California 92037; and Department ofMolecular Biology,","Genentech, Incorporated, San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofImmunology , Research Institute ofScripps Clinic , La Jolla , California 92037 ; and","institution_ids":["https://openalex.org/I4210146328"]},{"raw_affiliation_string":"Department of Pathology, Washington University Medical School, St. Louis, MO 631 10","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department ofImmunology, Research Institute ofScripps Clinic, La Jolla, California 92037; and Department ofMolecular Biology,","institution_ids":["https://openalex.org/I4210146328"]},{"raw_affiliation_string":"Genentech, Incorporated, San Francisco, California 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111750646","display_name":"R. Allen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Allen","raw_affiliation_strings":["Department ofImmunology , Research Institute ofScripps Clinic , La Jolla , California 92037 ; and","Department of Pathology, Washington University Medical School, St. Louis, MO 631 10","Department ofImmunology, Research Institute ofScripps Clinic, La Jolla, California 92037; and Department ofMolecular Biology,","Genentech, Incorporated, San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofImmunology , Research Institute ofScripps Clinic , La Jolla , California 92037 ; and","institution_ids":["https://openalex.org/I4210146328"]},{"raw_affiliation_string":"Department of Pathology, Washington University Medical School, St. Louis, MO 631 10","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department ofImmunology, Research Institute ofScripps Clinic, La Jolla, California 92037; and Department ofMolecular Biology,","institution_ids":["https://openalex.org/I4210146328"]},{"raw_affiliation_string":"Genentech, Incorporated, San Francisco, California 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029986928","display_name":"Inmaculada Esparza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I Esparza","raw_affiliation_strings":["Department ofImmunology , Research Institute ofScripps Clinic , La Jolla , California 92037 ; and","Department ofMolecular Biology , Genentech, Incorporated , San Francisco , California 94080","Department of Pathology, Washington University Medical School, St. Louis, MO 631 10","Department ofImmunology, Research Institute ofScripps Clinic, La Jolla, California 92037; and Department ofMolecular Biology,","Genentech, Incorporated, San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofImmunology , Research Institute ofScripps Clinic , La Jolla , California 92037 ; and","institution_ids":["https://openalex.org/I4210146328"]},{"raw_affiliation_string":"Department ofMolecular Biology , Genentech, Incorporated , San Francisco , California 94080","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Department of Pathology, Washington University Medical School, St. Louis, MO 631 10","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department ofImmunology, Research Institute ofScripps Clinic, La Jolla, California 92037; and Department ofMolecular Biology,","institution_ids":["https://openalex.org/I4210146328"]},{"raw_affiliation_string":"Genentech, Incorporated, San Francisco, California 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110907509","display_name":"Patrick W. Gray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P W Gray","raw_affiliation_strings":["Department ofImmunology , Research Institute ofScripps Clinic , La Jolla , California 92037 ; and","Department of Pathology, Washington University Medical School, St. Louis, MO 631 10","Department ofImmunology, Research Institute ofScripps Clinic, La Jolla, California 92037; and Department ofMolecular Biology,","Genentech, Incorporated, San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofImmunology , Research Institute ofScripps Clinic , La Jolla , California 92037 ; and","institution_ids":["https://openalex.org/I4210146328"]},{"raw_affiliation_string":"Department of Pathology, Washington University Medical School, St. Louis, MO 631 10","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department ofImmunology, Research Institute ofScripps Clinic, La Jolla, California 92037; and Department ofMolecular Biology,","institution_ids":["https://openalex.org/I4210146328"]},{"raw_affiliation_string":"Genentech, Incorporated, San Francisco, California 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086001447","display_name":"Robert D. Schreiber","orcid":"https://orcid.org/0000-0003-1590-2341","observed_orcids":["https://orcid.org/0000-0003-1590-2341","https://orcid.org/0000-0001-6311-0432"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R D Schreiber","raw_affiliation_strings":["Department ofImmunology , Research Institute ofScripps Clinic , La Jolla , California 92037 ; and","Department of Pathology, Washington University Medical School, St. Louis, MO 631 10","Department ofImmunology, Research Institute ofScripps Clinic, La Jolla, California 92037; and Department ofMolecular Biology,","Genentech, Incorporated, San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofImmunology , Research Institute ofScripps Clinic , La Jolla , California 92037 ; and","institution_ids":["https://openalex.org/I4210146328"]},{"raw_affiliation_string":"Department of Pathology, Washington University Medical School, St. Louis, MO 631 10","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department ofImmunology, Research Institute ofScripps Clinic, La Jolla, California 92037; and Department ofMolecular Biology,","institution_ids":["https://openalex.org/I4210146328"]},{"raw_affiliation_string":"Genentech, Incorporated, San Francisco, California 94080","institution_ids":["https://openalex.org/I183934855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":4.5394,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":{"value":0.95573116,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"76","issue":"6","first_page":"2196","last_page":"2205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.676800012588501,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.676800012588501,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.1298999935388565,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.12319999933242798,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-gamma-receptor","display_name":"interferon-gamma receptor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8500000238418579},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8119999766349792},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.781000018119812},{"id":"https://openalex.org/keywords/u937-cells","display_name":"U937 cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.6610000133514404},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.7749999761581421},{"id":"https://openalex.org/keywords/receptor-ligand-complex","display_name":"receptor-ligand complex","score":0.7960000038146973},{"id":"https://openalex.org/keywords/receptor-degradation","display_name":"receptor degradation","score":0.5189999938011169},{"id":"https://openalex.org/keywords/mononuclear-phagocytes","display_name":"mononuclear phagocytes","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C108634530","wikidata":"https://www.wikidata.org/wiki/Q7863610","display_name":"U937 cell","level":3,"score":0.7145381569862366},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6909104585647583},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.551032304763794},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.5424389243125916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5082620978355408},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4854605793952942},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.47162461280822754},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.45589566230773926},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41041240096092224},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33467310667037964},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17476540803909302},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11692997813224792},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017471","descriptor_name":"Receptors, Interferon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1172/jci112228","doi":"https://doi.org/10.1172/jci112228","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci112228","pdf_url":"http://www.jci.org/articles/view/112228/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:424342","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/424342","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:2934408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2934408","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:diposit.ub.edu:2445/8064","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2445/8064","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Articles publicats en revistes (Biologia Cel\u00b7lular, Fisiologia i Immunologia)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1013.7735","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1013.7735","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dm5migu4zj3pb.cloudfront.net/manuscripts/112000/112228/JCI85112228.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1026.214","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1026.214","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://diposit.ub.edu/dspace/bitstream/2445/8064/1/50706.pdf","raw_type":"text"},{"id":"pmh:oai:recercat.cat:2072/263982","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2445/8064","pdf_url":null,"source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1172/jci112228","doi":"https://doi.org/10.1172/jci112228","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci112228","pdf_url":"http://www.jci.org/articles/view/112228/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1990359219","display_name":null,"funder_award_id":"CA 34120","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6657989770","display_name":"MOLECULAR BIOLOGY OF INFLAMMATION AND HOST DEFENSE","funder_award_id":"P01AI017354","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306470","display_name":"Elsa U. Pardee Foundation","ror":"https://ror.org/05sjnvv07"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016540239.pdf","grobid_xml":"https://content.openalex.org/works/W2016540239.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W193369054","https://openalex.org/W1483645952","https://openalex.org/W1484545760","https://openalex.org/W1505476215","https://openalex.org/W1538479555","https://openalex.org/W1542531015","https://openalex.org/W1552550319","https://openalex.org/W1558104881","https://openalex.org/W1558985378","https://openalex.org/W1574873789","https://openalex.org/W1595670594","https://openalex.org/W1603292182","https://openalex.org/W1680224209","https://openalex.org/W1729011202","https://openalex.org/W1775749144","https://openalex.org/W1968028322","https://openalex.org/W1968082412","https://openalex.org/W1975676125","https://openalex.org/W1978911051","https://openalex.org/W1994805857","https://openalex.org/W1999689481","https://openalex.org/W2014520088","https://openalex.org/W2015474585","https://openalex.org/W2018289835","https://openalex.org/W2020089973","https://openalex.org/W2034752313","https://openalex.org/W2061883989","https://openalex.org/W2072522791","https://openalex.org/W2072926018","https://openalex.org/W2100837269","https://openalex.org/W2113775661","https://openalex.org/W2126204744","https://openalex.org/W2133764756","https://openalex.org/W2153563728","https://openalex.org/W2156776460","https://openalex.org/W2160040629","https://openalex.org/W2172982769","https://openalex.org/W2325858234","https://openalex.org/W2399676918","https://openalex.org/W2414663727","https://openalex.org/W2440012360"],"related_works":["https://openalex.org/W7101022718","https://openalex.org/W2188934730","https://openalex.org/W25783980","https://openalex.org/W1567059382","https://openalex.org/W1857935440","https://openalex.org/W2152763893","https://openalex.org/W3194625819","https://openalex.org/W2093292249","https://openalex.org/W1550951408","https://openalex.org/W1802120268"],"abstract_inverted_index":{"Radioiodinated":[0],"recombinant":[1],"human":[2,8,244],"interferon-gamma":[3],"(IFN":[4],"gamma)":[5],"bound":[6,29],"to":[7,57,67,116,153],"monocytes,":[9],"U937,":[10],"and":[11,18,35,134,225,236],"HL60":[12],"cells":[13],"in":[14,49],"a":[15,118,211],"specific,":[16],"saturable,":[17],"reversible":[19],"manner.":[20],"At":[21,137],"4":[22,171],"degrees":[23,139,166,172],"C,":[24,140,173],"the":[25,50,61,73,78,103,110,147,206,223,230,239],"different":[26],"cell":[27,62,111],"types":[28],"3,000-7,000":[30],"molecules":[31],"of":[32,38,72,86,102,122,146,178,193,218,243],"IFN":[33,149,240],"gamma,":[34],"binding":[36,131],"was":[37,52,75,107,142,185],"comparable":[39],"affinity":[40],"(Ka":[41],"=":[42],"4-12":[43],"X":[44],"10(8)":[45],"M-1).":[46],"No":[47],"change":[48],"receptor":[51,74,81,105,114,184,242],"observed":[53],"after":[54],"monocytes":[55],"differentiated":[56],"macrophages":[58],"or":[59,126],"when":[60],"lines":[63],"were":[64],"pharmacologically":[65],"induced":[66],"differentiate.":[68],"The":[69,113,183],"functional":[70],"relevance":[71],"validated":[76],"by":[77,132,188],"demonstration":[79],"that":[80,99,197,214],"occupancy":[82],"correlated":[83],"with":[84,96,124,201],"induction":[85],"Fc":[87],"receptors":[88],"on":[89],"U937.":[90],"Binding":[91],"studies":[92],"using":[93],"U937":[94,123,195],"permeabilized":[95],"digitonin":[97],"showed":[98],"only":[100],"46%":[101],"total":[104],"pool":[106],"expressed":[108],"at":[109,164,170,174,222,229],"surface.":[112],"appears":[115],"be":[117],"protein,":[119],"since":[120,144],"treatment":[121],"trypsin":[125,154],"pronase":[127],"reduced":[128],"125I-IFN":[129,158,202],"gamma":[130,150,159,241],"87":[133],"95%,":[135],"respectively.":[136],"37":[138,165],"ligand":[141],"internalized,":[143],"32%":[145],"cell-associated":[148],"became":[151],"resistant":[152],"stripping.":[155],"Monocytes":[156],"degraded":[157],"into":[160],"trichloroacetic":[161],"acid-soluble":[162],"counts":[163],"C":[167],"but":[168],"not":[169],"an":[175,216],"approximate":[176],"rate":[177],"5,000":[179],"molecules/cell":[180],"per":[181],"h.":[182],"partially":[186,237],"characterized":[187],"SDS-polyacrylamide":[189],"gel":[190],"electrophoresis":[191],"analysis":[192],"purified":[194],"membranes":[196],"had":[198],"been":[199],"incubated":[200],"gamma.":[203],"After":[204],"cross-linking,":[205],"receptor-ligand":[207],"complex":[208],"migrated":[209],"as":[210],"broad":[212],"band":[213],"displayed":[215],"Mr":[217],"104,000":[219],"+/-":[220,227],"18,000":[221],"top":[224],"84,000":[226],"6,000":[228],"bottom.":[231],"These":[232],"results":[233],"thereby":[234],"define":[235],"characterize":[238],"mononuclear":[245],"phagocytes.":[246]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}