{"id":"https://openalex.org/W201653061","doi":"https://doi.org/10.3748/wjg.v13.i22.3056","title":"Transforming growth factor-\u03b2 and fibrosis","display_name":"Transforming growth factor-\u03b2 and fibrosis","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W201653061","doi":"https://doi.org/10.3748/wjg.v13.i22.3056","mag":"201653061","pmid":"https://pubmed.ncbi.nlm.nih.gov/17589920","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4172611"},"language":"en","primary_location":{"id":"doi:10.3748/wjg.v13.i22.3056","doi":"https://doi.org/10.3748/wjg.v13.i22.3056","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v13.i22.3056","pdf_url":null,"source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3748/wjg.v13.i22.3056","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046241990","display_name":"Franck Verrecchia","orcid":"https://orcid.org/0000-0003-4920-2554","observed_orcids":["https://orcid.org/0000-0003-4920-2554"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Franck Verrecchia","raw_affiliation_strings":["INSERM U697, Hopital Saint-Louis, Pavillon Bazin, 1 avenue Claude Vellefaux, Paris 75010, France. franck.verrecchia@stlouis.inserm.fr","INSERM U697, Hopital Saint-Louis, Pavillon Bazin, 1 avenue Claude Vellefaux, Paris 75010, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U697, Hopital Saint-Louis, Pavillon Bazin, 1 avenue Claude Vellefaux, Paris 75010, France. franck.verrecchia@stlouis.inserm.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210144610"]},{"raw_affiliation_string":"INSERM U697, Hopital Saint-Louis, Pavillon Bazin, 1 avenue Claude Vellefaux, Paris 75010, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210144610"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059074778","display_name":"Alain Mauviel","orcid":"https://orcid.org/0000-0002-0438-2793","observed_orcids":["https://orcid.org/0000-0002-0438-2793"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]},{"id":"https://openalex.org/I4405270644","display_name":"Association des Scl\u00e9rodermiques de France","ror":"https://ror.org/013a9tb95","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4405270644"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alain Mauviel","raw_affiliation_strings":["Groupe Fran\u00e7ais de Recherche sur la Scl\u00e9rodermie, and Associa-tion des Sl\u00e9rodermiques de France","INSERM U697, H\u00f4pi-tal Saint-Louis, Pavillon Bazin, \ufffd avenue Claude Vellefaux, Paris 7\ufffd\ufffd\ufffd\ufffd,","INSERM U697, Paris 7\ufffd\ufffd\ufffd\ufffd, 7\ufffd\ufffd\ufffd\ufffd, , France Supported by Programme National de Recherche Dermatologie 2\ufffd\ufffd6,","Institut Nationale de la Sant\u00e9 Et de la Recherche M\u00e9dicale,","PO Box 2345, Beijing 100023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe Fran\u00e7ais de Recherche sur la Scl\u00e9rodermie, and Associa-tion des Sl\u00e9rodermiques de France","institution_ids":["https://openalex.org/I4405270644"]},{"raw_affiliation_string":"INSERM U697, H\u00f4pi-tal Saint-Louis, Pavillon Bazin, \ufffd avenue Claude Vellefaux, Paris 7\ufffd\ufffd\ufffd\ufffd,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210144610"]},{"raw_affiliation_string":"INSERM U697, Paris 7\ufffd\ufffd\ufffd\ufffd, 7\ufffd\ufffd\ufffd\ufffd, , France Supported by Programme National de Recherche Dermatologie 2\ufffd\ufffd6,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387154366"]},{"raw_affiliation_string":"Institut Nationale de la Sant\u00e9 Et de la Recherche M\u00e9dicale,","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"PO Box 2345, Beijing 100023, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.4867,"has_fulltext":false,"cited_by_count":531,"citation_normalized_percentile":{"value":0.98910783,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"13","issue":"22","first_page":"3056","last_page":"3056"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9890000224113464},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.7860000133514404},{"id":"https://openalex.org/keywords/smad3","display_name":"Smad3","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tgf-beta-receptor","display_name":"TGF-beta receptor","score":0.8040000200271606},{"id":"https://openalex.org/keywords/smad-signaling","display_name":"Smad signaling","score":0.7540000081062317},{"id":"https://openalex.org/keywords/connective-tissue-deposition","display_name":"connective tissue deposition","score":0.8119999766349792},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.7670000195503235},{"id":"https://openalex.org/keywords/mesenchymal-cells","display_name":"mesenchymal cells","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.7114032506942749},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.6582919955253601},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6533392667770386},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5969375967979431},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5559228658676147},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.526183009147644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5258006453514099},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4831242263317108},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.41412001848220825},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3898928761482239},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.36370208859443665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17327004671096802},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15911006927490234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07353368401527405}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003238","descriptor_name":"Connective Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055513","descriptor_name":"Connective Tissue Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3748/wjg.v13.i22.3056","doi":"https://doi.org/10.3748/wjg.v13.i22.3056","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v13.i22.3056","pdf_url":null,"source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3144527","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4172611","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4172611","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4172611","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Gastroenterol","raw_type":"Text"},{"id":"pmid:17589920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17589920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:inserm-00166108v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/inserm-00166108v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"World Journal of Gastroenterology, 2007, 13 (22), pp.3056-62","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3151816576","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/84123X/200722/24826302.html","pdf_url":null,"source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e16\u754c\u80c3\u80a0\u75c5\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248\uff08\u7535\u5b50\u7248\uff09","raw_type":null}],"best_oa_location":{"id":"doi:10.3748/wjg.v13.i22.3056","doi":"https://doi.org/10.3748/wjg.v13.i22.3056","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v13.i22.3056","pdf_url":null,"source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W131398339","https://openalex.org/W1519911954","https://openalex.org/W1536476892","https://openalex.org/W1550325341","https://openalex.org/W1575754639","https://openalex.org/W1662963035","https://openalex.org/W1674231565","https://openalex.org/W1760933578","https://openalex.org/W1964941505","https://openalex.org/W1967615479","https://openalex.org/W1968496339","https://openalex.org/W1971915848","https://openalex.org/W1975244118","https://openalex.org/W1976599453","https://openalex.org/W1978146894","https://openalex.org/W1979528064","https://openalex.org/W1980524119","https://openalex.org/W1987018125","https://openalex.org/W1996211554","https://openalex.org/W2000708019","https://openalex.org/W2001093897","https://openalex.org/W2004902531","https://openalex.org/W2005566723","https://openalex.org/W2007101888","https://openalex.org/W2025086989","https://openalex.org/W2026386550","https://openalex.org/W2029144169","https://openalex.org/W2029327578","https://openalex.org/W2030148120","https://openalex.org/W2033624423","https://openalex.org/W2033641649","https://openalex.org/W2035653659","https://openalex.org/W2036969566","https://openalex.org/W2041172831","https://openalex.org/W2044984355","https://openalex.org/W2048221993","https://openalex.org/W2050331605","https://openalex.org/W2050928977","https://openalex.org/W2052054447","https://openalex.org/W2052649367","https://openalex.org/W2054415231","https://openalex.org/W2056880729","https://openalex.org/W2057955197","https://openalex.org/W2058278041","https://openalex.org/W2064607214","https://openalex.org/W2068721652","https://openalex.org/W2070192533","https://openalex.org/W2071115409","https://openalex.org/W2072624567","https://openalex.org/W2073653948","https://openalex.org/W2075864840","https://openalex.org/W2077103009","https://openalex.org/W2078460335","https://openalex.org/W2084660313","https://openalex.org/W2089754366","https://openalex.org/W2100880370","https://openalex.org/W2117200840","https://openalex.org/W2124887937","https://openalex.org/W2130769950","https://openalex.org/W2132803823","https://openalex.org/W2133485412","https://openalex.org/W2134024560","https://openalex.org/W2135401778","https://openalex.org/W2136358097","https://openalex.org/W2138605058","https://openalex.org/W2149593182","https://openalex.org/W2154568166","https://openalex.org/W2164615751","https://openalex.org/W2168995491","https://openalex.org/W2169175478","https://openalex.org/W2171409767","https://openalex.org/W2203655011","https://openalex.org/W2287792026","https://openalex.org/W2321037169","https://openalex.org/W2335607449","https://openalex.org/W2476542314","https://openalex.org/W4233947395"],"related_works":["https://openalex.org/W7074216696","https://openalex.org/W2029327578","https://openalex.org/W2001093897","https://openalex.org/W1980524119","https://openalex.org/W7096772854","https://openalex.org/W205625670","https://openalex.org/W4235550082","https://openalex.org/W2133485412","https://openalex.org/W2383088931","https://openalex.org/W2095198882"],"abstract_inverted_index":{"Transforming":[0],"growth":[1],"factor-beta":[2],"(TGF-beta),":[3],"a":[4,10,154],"prototype":[5],"of":[6,13,30,41,48,60,74,90,94,98,127,133,143,157,160,183],"multifunctional":[7],"cytokine,":[8],"is":[9,159],"key":[11],"regulator":[12],"extracellular":[14],"matrix":[15],"(ECM)":[16],"assembly":[17],"and":[18,36,57,139,149,187],"remodeling.":[19],"Specifically,":[20],"TGF-beta":[21,52,61,100,106],"isoforms":[22],"have":[23,121],"the":[24,28,39,49,65,72,78,88,91,99,113,130,141,178],"ability":[25],"to":[26,37,116,167,191],"induce":[27],"expression":[29,53,138,186],"ECM":[31],"proteins":[32],"in":[33,54,87,129,140,147,150],"mesenchymal":[34],"cells,":[35],"stimulate":[38],"production":[40],"protease":[42],"inhibitors":[43],"that":[44,110],"prevent":[45],"enzymatic":[46],"breakdown":[47],"ECM.":[50],"Elevated":[51],"affected":[55],"organs,":[56],"subsequent":[58],"deregulation":[59],"functions,":[62],"correlates":[63],"with":[64,153],"abnormal":[66],"connective":[67],"tissue":[68],"deposition":[69],"observed":[70],"during":[71],"onset":[73],"fibrotic":[75,192],"diseases.":[76,173],"During":[77],"last":[79],"few":[80],"years,":[81],"tremendous":[82],"progress":[83],"has":[84],"been":[85,122],"made":[86],"understanding":[89],"molecular":[92],"aspects":[93],"intracellular":[95],"signaling":[96],"downstream":[97],"receptors.":[101],"In":[102],"particular,":[103],"Smad":[104,181],"proteins,":[105],"receptor":[107],"kinase":[108],"substrates":[109],"translocate":[111],"into":[112],"cell":[114],"nucleus":[115],"act":[117],"as":[118],"transcription":[119],"factors,":[120],"studied":[123],"extensively.":[124],"The":[125],"role":[126],"Smad3":[128],"transcriptional":[131],"regulation":[132],"type":[134],"I":[135],"collagen":[136,185],"gene":[137],"development":[142],"fibrosis,":[144],"demonstrated":[145],"both":[146],"vitro":[148],"animal":[151],"models":[152],"targeted":[155],"deletion":[156],"Smad3,":[158],"critical":[161],"importance":[162],"because":[163],"it":[164,189],"may":[165],"lead":[166],"novel":[168],"therapeutic":[169],"strategies":[170],"against":[171],"these":[172],"This":[174],"review":[175],"focuses":[176],"on":[177],"mechanisms":[179],"underlying":[180],"modulation":[182],"fibrillar":[184],"how":[188],"relates":[190],"processes.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":30},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":32},{"year":2019,"cited_by_count":41},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":35},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":32},{"year":2012,"cited_by_count":25}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}