{"id":"https://openalex.org/W2016502418","doi":"https://doi.org/10.1111/j.1365-2125.1989.tb03507.x","title":"Pharmacokinetics of halofantrine in man: effects of food and dose size.","display_name":"Pharmacokinetics of halofantrine in man: effects of food and dose size.","publication_year":1989,"publication_date":"1989-07-01","ids":{"openalex":"https://openalex.org/W2016502418","doi":"https://doi.org/10.1111/j.1365-2125.1989.tb03507.x","mag":"2016502418","pmid":"https://pubmed.ncbi.nlm.nih.gov/2775616","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1379972"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2125.1989.tb03507.x","doi":"https://doi.org/10.1111/j.1365-2125.1989.tb03507.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.1989.tb03507.x","pdf_url":null,"source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1379972/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023525514","display_name":"K. Ashley Milton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"KA Milton","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool","Department of Pharmacology & Therapeutics, University of Liverpool"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"Department of Pharmacology & Therapeutics, University of Liverpool","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113522515","display_name":"G. Edwards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G Edwards","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool","Department of Pharmacology & Therapeutics, University of Liverpool"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"Department of Pharmacology & Therapeutics, University of Liverpool","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061182167","display_name":"Stephen Andrew Ward","orcid":"https://orcid.org/0000-0003-2331-3192","observed_orcids":["https://orcid.org/0000-0003-2331-3192"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"SA Ward","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool","Department of Pharmacology & Therapeutics, University of Liverpool"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"Department of Pharmacology & Therapeutics, University of Liverpool","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110254906","display_name":"ML Orme","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"ML Orme","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool","Department of Pharmacology & Therapeutics, University of Liverpool"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"Department of Pharmacology & Therapeutics, University of Liverpool","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110325039","display_name":"AM Breckenridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"AM Breckenridge","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool","Department of Pharmacology & Therapeutics, University of Liverpool"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"Department of Pharmacology & Therapeutics, University of Liverpool","institution_ids":["https://openalex.org/I146655781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I146655781"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":3.8645,"has_fulltext":false,"cited_by_count":156,"citation_normalized_percentile":{"value":0.94087694,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"28","issue":"1","first_page":"71","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.06069999933242798,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/halofantrine","display_name":"halofantrine","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9760000109672546},{"id":"https://openalex.org/keywords/dose-proportionality","display_name":"dose proportionality","score":0.8029999732971191},{"id":"https://openalex.org/keywords/food-effect","display_name":"food effect","score":0.7540000081062317},{"id":"https://openalex.org/keywords/fatty-meal","display_name":"fatty meal","score":0.9639999866485596},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.621999979019165},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.6499999761581421},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.7070000171661377},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.375}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7947819232940674},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.7782575488090515},{"id":"https://openalex.org/C2778345441","wikidata":"https://www.wikidata.org/wiki/Q6460735","display_name":"Meal","level":2,"score":0.6671643853187561},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.642573356628418},{"id":"https://openalex.org/C2777498558","wikidata":"https://www.wikidata.org/wiki/Q947595","display_name":"Halofantrine","level":5,"score":0.48962026834487915},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4369296133518219},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.43466565012931824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42660897970199585},{"id":"https://openalex.org/C3941253","wikidata":"https://www.wikidata.org/wiki/Q47270","display_name":"Half-life","level":3,"score":0.4223375916481018},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4086127281188965},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.3876844644546509},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33027583360671997},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10320326685905457},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.0},{"id":"https://openalex.org/C2777199930","wikidata":"https://www.wikidata.org/wiki/Q736270","display_name":"Mefloquine","level":4,"score":0.0},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005502","descriptor_name":"Food","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010616","descriptor_name":"Phenanthrenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010616","descriptor_name":"Phenanthrenes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2125.1989.tb03507.x","doi":"https://doi.org/10.1111/j.1365-2125.1989.tb03507.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.1989.tb03507.x","pdf_url":null,"source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:2775616","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2775616","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Clinical Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:1379972","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1379972/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1379972","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1379972/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1954241613","https://openalex.org/W1969984752","https://openalex.org/W1980766303","https://openalex.org/W1992190965","https://openalex.org/W2006246928","https://openalex.org/W2041235523","https://openalex.org/W2055738436","https://openalex.org/W2084090088","https://openalex.org/W2105650062","https://openalex.org/W2474743831"],"related_works":["https://openalex.org/W2019776085","https://openalex.org/W2152669826","https://openalex.org/W2025197315","https://openalex.org/W2022925898","https://openalex.org/W2016024346","https://openalex.org/W1493995303","https://openalex.org/W2046695404","https://openalex.org/W2063063692","https://openalex.org/W2330130059","https://openalex.org/W2390724060"],"abstract_inverted_index":{"1.":[0],"Plasma":[1],"concentrations":[2,175],"of":[3,25,39,53,96,184],"halofantrine":[4,13],"(Hf)":[5],"and":[6,42,81,103,178,180],"its":[7],"putative":[8],"principal":[9],"plasma":[10,105],"metabolite":[11],"desbutyl":[12],"(Hfm)":[14],"have":[15],"been":[16],"measured":[17],"in":[18,77,87,111,135,146,148,151,156],"two":[19],"separate":[20],"studies":[21],"after":[22,46,82],"oral":[23,37,68],"administration":[24],"the":[26,73,114,124,136,149,162,181,189],"hydrochloride":[27],"salt.":[28],"2.":[29],"Six":[30],"healthy":[31],"male":[32],"volunteers":[33],"each":[34,61],"received":[35],"single":[36,67],"doses":[38],"250,":[40],"500":[41,129,167],"1000":[43,131,169],"mg":[44,66,225,233],"administered":[45,71],"an":[47],"overnight":[48],"fast.":[49],"A":[50,63],"washout":[51,94],"period":[52,95],"at":[54,97],"least":[55,98],"6":[56,99],"weeks":[57],"was":[58,70,121,126,159,164,200,219],"allowed":[59],"between":[60],"dose.":[62],"further":[64],"250":[65,242],"dose":[69,115,125,137,152,163],"to":[72,113,130,168,172,209,229],"same":[74],"six":[75],"subjects":[76],"a":[78,83,88,93,194,237],"fasting":[79],"state":[80],"standardised":[84],"fatty":[85,195,238],"meal":[86],"randomised":[89],"study,":[90],"again":[91],"with":[92],"weeks.":[100],"3.":[101],"AUC":[102,141,216],"maximum":[104],"concentration":[106],"(Cmax)":[107],"for":[108,176,198,217],"Hf":[109,177,185,199,218],"increased":[110,127,145,165,201,220],"proportion":[112,147],"from":[116,128,166,202,221],"250-500":[117,139],"mg.":[118,132,170],"This":[119],"increase":[120,150,155],"non-proportional":[122,160],"when":[123,161],"For":[133],"Hfm,":[134],"range":[138],"mg,":[140],"but":[142],"not":[143],"Cmax":[144,197],"size.":[153],"The":[154],"these":[157],"parameters":[158],"Time":[171],"reach":[173],"peak":[174],"Hfm":[179],"elimination":[182],"half-life":[183],"remained":[186],"unchanged":[187],"across":[188],"dosage":[190],"range.":[191],"4.":[192],"Following":[193],"meal,":[196],"184":[203],"+/-":[204,211,223,231],"115":[205],"micrograms":[206,213],"l-1":[207,214,226,234],"(fasting)":[208,228],"1218":[210],"464":[212],"(fed).":[215],"3.9":[222],"2.6":[224],"h":[227,235],"11.3":[230],"3.5":[232],"following":[236],"meal.(ABSTRACT":[239],"TRUNCATED":[240],"AT":[241],"WORDS)":[243]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}