{"id":"https://openalex.org/W2016502122","doi":"https://doi.org/10.1254/fpj.94.351","title":"Cardiovascular effects of beraprost sodium (TRK-100), a prostacyclin analogue in the dog.","display_name":"Cardiovascular effects of beraprost sodium (TRK-100), a prostacyclin analogue in the dog.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2016502122","doi":"https://doi.org/10.1254/fpj.94.351","mag":"2016502122","pmid":"https://pubmed.ncbi.nlm.nih.gov/2514128"},"language":"ja","primary_location":{"id":"doi:10.1254/fpj.94.351","doi":"https://doi.org/10.1254/fpj.94.351","is_oa":true,"landing_page_url":"https://doi.org/10.1254/fpj.94.351","pdf_url":"https://www.jstage.jst.go.jp/article/fpj1944/94/6/94_6_351/_pdf","source":{"id":"https://openalex.org/S156890813","display_name":"Folia Pharmacologica Japonica","issn_l":"0015-5691","issn":["0015-5691","0369-4461","1347-8397","2185-307X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Pharmacologica Japonica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/fpj1944/94/6/94_6_351/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109150357","display_name":"Shintaro Nishio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115317","display_name":"Toray Industries, Inc. (Japan)","ror":"https://ror.org/029xh1r47","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shintaro NISHIO","raw_affiliation_strings":["Basic Research Laboratories, Toray Industries, Inc., Kamakura, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Research Laboratories, Toray Industries, Inc., Kamakura, Japan","institution_ids":["https://openalex.org/I4210115317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110114217","display_name":"Hirotoshi Matsuura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hirotoshi MATSUURA","raw_affiliation_strings":["\u6771\u30ec(\u682a)\u57fa\u790e\u7814\u7a76\u6240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u6771\u30ec(\u682a)\u57fa\u790e\u7814\u7a76\u6240","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101663077","display_name":"Masakazu Hattori","orcid":"https://orcid.org/0000-0002-6160-2510","observed_orcids":["https://orcid.org/0000-0002-6160-2510"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masakazu HATTORI","raw_affiliation_strings":["\u6771\u30ec(\u682a)\u57fa\u790e\u7814\u7a76\u6240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u6771\u30ec(\u682a)\u57fa\u790e\u7814\u7a76\u6240","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113536446","display_name":"Takashi Endoh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takashi ENDOH","raw_affiliation_strings":["\u6771\u30ec(\u682a)\u57fa\u790e\u7814\u7a76\u6240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u6771\u30ec(\u682a)\u57fa\u790e\u7814\u7a76\u6240","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055644244","display_name":"Naohiro Yamada","orcid":"https://orcid.org/0000-0003-0941-8246","observed_orcids":["https://orcid.org/0000-0003-0941-8246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naohiro YAMADA","raw_affiliation_strings":["\u6771\u30ec(\u682a)\u57fa\u790e\u7814\u7a76\u6240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u6771\u30ec(\u682a)\u57fa\u790e\u7814\u7a76\u6240","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104352602","display_name":"Tetsuya Hirano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tetsuya HIRANO","raw_affiliation_strings":["\u6771\u30ec(\u682a)\u57fa\u790e\u7814\u7a76\u6240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u6771\u30ec(\u682a)\u57fa\u790e\u7814\u7a76\u6240","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takeshi MURAI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takeshi MURAI","raw_affiliation_strings":["\u79d1\u7814\u88fd\u85ac(\u682a)\u4e2d\u592e\u7814\u7a76\u6240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u79d1\u7814\u88fd\u85ac(\u682a)\u4e2d\u592e\u7814\u7a76\u6240","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072939745","display_name":"Yoshinobu Miyao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshinobu MIYAO","raw_affiliation_strings":["\u79d1\u7814\u88fd\u85ac(\u682a)\u4e2d\u592e\u7814\u7a76\u6240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u79d1\u7814\u88fd\u85ac(\u682a)\u4e2d\u592e\u7814\u7a76\u6240","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050547530","display_name":"Tomoko Kanai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoko KANAI","raw_affiliation_strings":["\u79d1\u7814\u88fd\u85ac(\u682a)\u4e2d\u592e\u7814\u7a76\u6240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u79d1\u7814\u88fd\u85ac(\u682a)\u4e2d\u592e\u7814\u7a76\u6240","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040589977","display_name":"Teruhiko Umetsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teruhiko UMETSU","raw_affiliation_strings":["\u79d1\u7814\u88fd\u85ac(\u682a)\u4e2d\u592e\u7814\u7a76\u6240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u79d1\u7814\u88fd\u85ac(\u682a)\u4e2d\u592e\u7814\u7a76\u6240","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1942,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.3324479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"94","issue":"6","first_page":"351","last_page":"361"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beraprost-sodium","display_name":"beraprost sodium","score":0.9929999709129333},{"id":"https://openalex.org/keywords/prostacyclin-analogues","display_name":"prostacyclin analogues","score":0.9179999828338623},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.9290000200271606},{"id":"https://openalex.org/keywords/vasodilation","display_name":"vasodilation","score":0.984000027179718},{"id":"https://openalex.org/keywords/arterial-blood-flow","display_name":"arterial blood flow","score":0.8199999928474426},{"id":"https://openalex.org/keywords/coronary-blood-flow","display_name":"coronary blood flow","score":0.5950000286102295},{"id":"https://openalex.org/keywords/renal-blood-flow","display_name":"renal blood flow","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mesenteric-circulation","display_name":"mesenteric blood flow","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.8330000042915344},{"id":"https://openalex.org/keywords/left-ventricular-pressure","display_name":"left ventricular pressure","score":0.8180000185966492},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.597000002861023},{"id":"https://openalex.org/keywords/coronary-vascular-resistance","display_name":"coronary vascular resistance","score":0.7749999761581421},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.7129999995231628},{"id":"https://openalex.org/keywords/systemic-blood-pressure","display_name":"systemic blood pressure","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cardiovascular-effects","display_name":"cardiovascular effects","score":0.6710000038146973},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.7089999914169312},{"id":"https://openalex.org/keywords/anesthetized-animals","display_name":"anesthetized animals","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.9192233085632324},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.4997742176055908},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45096758008003235},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4409262239933014},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.391600638628006},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34690701961517334},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.04371768236160278}],"mesh":[{"descriptor_ui":"D000758","descriptor_name":"Anesthesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007269","descriptor_name":"Injections, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1254/fpj.94.351","doi":"https://doi.org/10.1254/fpj.94.351","is_oa":true,"landing_page_url":"https://doi.org/10.1254/fpj.94.351","pdf_url":"https://www.jstage.jst.go.jp/article/fpj1944/94/6/94_6_351/_pdf","source":{"id":"https://openalex.org/S156890813","display_name":"Folia Pharmacologica Japonica","issn_l":"0015-5691","issn":["0015-5691","0369-4461","1347-8397","2185-307X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Pharmacologica Japonica","raw_type":"journal-article"},{"id":"pmid:2514128","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2514128","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon yakurigaku zasshi. Folia pharmacologica Japonica","raw_type":"English Abstract"}],"best_oa_location":{"id":"doi:10.1254/fpj.94.351","doi":"https://doi.org/10.1254/fpj.94.351","is_oa":true,"landing_page_url":"https://doi.org/10.1254/fpj.94.351","pdf_url":"https://www.jstage.jst.go.jp/article/fpj1944/94/6/94_6_351/_pdf","source":{"id":"https://openalex.org/S156890813","display_name":"Folia Pharmacologica Japonica","issn_l":"0015-5691","issn":["0015-5691","0369-4461","1347-8397","2185-307X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Pharmacologica Japonica","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016502122.pdf","grobid_xml":"https://content.openalex.org/works/W2016502122.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3102258039","https://openalex.org/W2030993849","https://openalex.org/W3101220892","https://openalex.org/W2048011456","https://openalex.org/W2025522155","https://openalex.org/W2072480516","https://openalex.org/W2040711072","https://openalex.org/W2140740325","https://openalex.org/W2075331590","https://openalex.org/W2399526518"],"abstract_inverted_index":{"Effect":[0],"of":[1,19,36,46,51,64,72,103,108,129],"prostacyclin":[2],"analogue,":[3],"beraprost":[4],"sodium":[5],"(Sodium":[6],"(+/-)-(1R*,":[7],"2R*,":[8],"3aS*,":[9],"8bS*)-2,":[10],"3,3a,8b-tetrahydro-2-hydroxy-1-[(E)-(3S*)-3-hydroxy-4-methyl-1-octen+":[11],"++-6-":[12],"ynyl]-1H-cyclopenta-[b]benzofuran-5-butyrate,":[13],"TRK-100),":[14],"on":[15,181],"the":[16,20,33,37,77,88,94],"cardiovascular":[17],"system":[18,127],"anesthetized":[21],"dog":[22],"was":[23,26,135,202],"investigated.":[24],"TRK-100":[25,47,73,109,165,220],"injected":[27],"intra-arterially":[28],"and":[29,57,74,83,87,112,120,131,139,147,160,166,173,195,212,221],"intravenously":[30],"to":[31,66,116,153,204],"study":[32],"vasodilating":[34],"effect":[35,201],"drug":[38],"by":[39,164,177,219],"a":[40,61],"magnetic":[41],"flow":[42,50,115,134,150],"meter.":[43],"Intra-arterial":[44],"injection":[45,107],"augmented":[48,110],"blood":[49,214],"vertebral,":[52,145],"coronary,":[53],"renal,":[54],"supramesenteric,":[55],"hepatic":[56],"femoral":[58,148],"artery":[59,79],"at":[60],"dose":[62],"range":[63],"0.0003":[65,84],"3,000":[67],"micrograms/bed.":[68],"The":[69,200],"threshold":[70],"doses":[71],"PGI2":[75],"in":[76,93],"mesenteric":[78,111,130],"were":[80,91,98,198,216],"0.003":[81],"micrograms":[82],"micrograms,":[85],"respectively,":[86,143,152],"same":[89],"values":[90],"obtained":[92],"splenic":[95],"artery.":[96],"Those":[97],"slightly":[99],"lower":[100],"than":[101],"those":[102],"other":[104],"arteries.":[105],"Intravenous":[106],"renal":[113,132],"arterial":[114,133,149],"193":[117],"+/-":[118,122,137,141,155,158,162,168,171,175],"30%":[119],"118":[121],"4%,":[123],"respectively.":[124],"In":[125],"this":[126],"augmentation":[128],"179":[136],"19%":[138],"135":[140],"1%,":[142],"while":[144],"carotid,":[146],"decreased,":[151],"71.4":[154],"2.1%,":[156],"80.0":[157],"9.4%":[159],"61.4":[161],"5.6%":[163],"70.6":[167],"5.6%,":[169],"79.5":[170],"6.9%":[172],"67.1":[174],"4.7%":[176],"PGI2.":[178,205,222],"Inhibitory":[179],"effects":[180],"heart":[182],"functions":[183],"such":[184],"as":[185],"cardiac":[186,196],"output,":[187],"left":[188],"ventricular":[189],"pressure,":[190],"LV":[191],"dP/dt,":[192],"oxygen":[193],"consumption,":[194],"work":[197],"seen.":[199],"similar":[203],"Coronary":[206],"vascular":[207],"resistance,":[208],"total":[209],"peripheral":[210],"resistance":[211],"systemic":[213],"pressure":[215],"also":[217],"decreased":[218]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
