{"id":"https://openalex.org/W2016459361","doi":"https://doi.org/10.1016/s0014-5793(00)01613-6","title":"Differential degradation of calpastatin by \u03bc\u2010 and m\u2010calpain in Ca2+\u2010enriched human neuroblastoma LAN\u20105 cells","display_name":"Differential degradation of calpastatin by \u03bc\u2010 and m\u2010calpain in Ca2+\u2010enriched human neuroblastoma LAN\u20105 cells","publication_year":2000,"publication_date":"2000-06-09","ids":{"openalex":"https://openalex.org/W2016459361","doi":"https://doi.org/10.1016/s0014-5793(00)01613-6","mag":"2016459361","pmid":"https://pubmed.ncbi.nlm.nih.gov/10854849"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-5793(00)01613-6","doi":"https://doi.org/10.1016/s0014-5793(00)01613-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-5793(00)01613-6","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014147321","display_name":"Roberta DE TULLIO","orcid":"https://orcid.org/0000-0001-6925-3207","observed_orcids":["https://orcid.org/0000-0001-6925-3207"]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta De Tullio","raw_affiliation_strings":["Department of Experimental Medicine, Biochemistry Section, University of Genoa, Viale Benedetto XV, 1-16132, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Biochemistry Section, University of Genoa, Viale Benedetto XV, 1-16132, Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055337483","display_name":"Monica Averna","orcid":"https://orcid.org/0000-0002-9463-7533","observed_orcids":["https://orcid.org/0000-0002-9463-7533"]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Monica Averna","raw_affiliation_strings":["Department of Experimental Medicine, Biochemistry Section, University of Genoa, Viale Benedetto XV, 1-16132 Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Biochemistry Section, University of Genoa, Viale Benedetto XV, 1-16132 Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091744245","display_name":"F. Salamino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Franca Salamino","raw_affiliation_strings":["Department of Experimental Medicine, Biochemistry Section, University of Genoa, Viale Benedetto XV, 1-16132 Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Biochemistry Section, University of Genoa, Viale Benedetto XV, 1-16132 Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113598373","display_name":"S. Pontremoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sandro Pontremoli","raw_affiliation_strings":["Department of Experimental Medicine, Biochemistry Section, University of Genoa, Viale Benedetto XV, 1-16132 Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Biochemistry Section, University of Genoa, Viale Benedetto XV, 1-16132 Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103430545","display_name":"Edon Melloni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Edon Melloni","raw_affiliation_strings":["Department of Experimental Medicine, Biochemistry Section, University of Genoa, Viale Benedetto XV, 1-16132 Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Biochemistry Section, University of Genoa, Viale Benedetto XV, 1-16132 Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103430545"],"corresponding_institution_ids":["https://openalex.org/I83816512"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.4095,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.51034063,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"475","issue":"1","first_page":"17","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calpastatin","display_name":"calpastatin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/calpain","display_name":"calpain","score":0.9359999895095825},{"id":"https://openalex.org/keywords/calpain-2","display_name":"m-calpain","score":0.9819999933242798},{"id":"https://openalex.org/keywords/calpain-activation","display_name":"calpain activation","score":0.5690000057220459},{"id":"https://openalex.org/keywords/calpain-inhibitor-i","display_name":"calpain inhibitor I","score":0.8870000243186951},{"id":"https://openalex.org/keywords/inhibitory-domain","display_name":"inhibitory domain","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hypertensive-rats","display_name":"hypertensive rats","score":0.6190000176429749},{"id":"https://openalex.org/keywords/proteolysis","display_name":"proteolysis","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C2777488010","wikidata":"https://www.wikidata.org/wiki/Q5023908","display_name":"Calpastatin","level":4,"score":0.9973044395446777},{"id":"https://openalex.org/C56928146","wikidata":"https://www.wikidata.org/wiki/Q2934402","display_name":"Calpain","level":3,"score":0.9941889047622681},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6258834600448608},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.526313304901123},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4842636287212372},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.47079744935035706},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3730689287185669},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3386322557926178},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30148738622665405},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27193355560302734},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25438177585601807},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08789238333702087}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002154","descriptor_name":"Calpain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0014-5793(00)01613-6","doi":"https://doi.org/10.1016/s0014-5793(00)01613-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-5793(00)01613-6","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:10854849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10854849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unige.it:11567/378056","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11567/378056","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1156084614","https://openalex.org/W1617349725","https://openalex.org/W1971340527","https://openalex.org/W1972439920","https://openalex.org/W1973935205","https://openalex.org/W1977962646","https://openalex.org/W1983559076","https://openalex.org/W1988916131","https://openalex.org/W1992575945","https://openalex.org/W2003597344","https://openalex.org/W2008338411","https://openalex.org/W2013080645","https://openalex.org/W2015945333","https://openalex.org/W2019802143","https://openalex.org/W2021528141","https://openalex.org/W2021658884","https://openalex.org/W2035938385","https://openalex.org/W2036532215","https://openalex.org/W2044020716","https://openalex.org/W2045881654","https://openalex.org/W2060953087","https://openalex.org/W2068471951","https://openalex.org/W2074562451","https://openalex.org/W2074971340","https://openalex.org/W2081237520","https://openalex.org/W2085292835","https://openalex.org/W2090517455","https://openalex.org/W2101816917","https://openalex.org/W2102957598","https://openalex.org/W2122704155","https://openalex.org/W2155429403","https://openalex.org/W2172682370","https://openalex.org/W2179722004","https://openalex.org/W2259314548","https://openalex.org/W2330982448","https://openalex.org/W2394951169"],"related_works":["https://openalex.org/W2044802305","https://openalex.org/W1971340527","https://openalex.org/W2146213604","https://openalex.org/W2013080645","https://openalex.org/W1966645588","https://openalex.org/W2017020341","https://openalex.org/W2072829340","https://openalex.org/W2033514681","https://openalex.org/W2091797889","https://openalex.org/W2052167203"],"abstract_inverted_index":{"In":[0],"neuroblastoma":[1],"LAN-5":[2],"cells":[3,133],"during":[4],"calpain":[5,65,75,149,163],"activation,":[6,150],"in":[7,57,131,164],"addition":[8],"to":[9],"the":[10,55,70,73,85,90,95,105,117,123,138,157,160],"two":[11,91],"expressed":[12],"70":[13],"kDa":[14,17,30,119],"and":[15,31,41,128,151],"30":[16],"calpastatin":[18,43,60,124],"forms,":[19],"other":[20],"inhibitory":[21,126],"species":[22,44],"are":[23,62],"produced,":[24],"having":[25],"molecular":[26],"masses":[27],"of":[28,37,48,72,84,116,134,147,159,162],"50":[29],"15":[32,118],"kDa.":[33],"At":[34],"longer":[35],"times":[36],"incubation,":[38],"both":[39,80],"native":[40],"new":[42,50],"disappear.":[45],"The":[46,114],"formation":[47],"these":[49],"calpastatins":[51],"as":[52,54,67,137],"well":[53],"decrease":[56],"intracellular":[58,148],"total":[59],"activity":[61],"mediated":[63,101],"by":[64,69,102,112],"itself,":[66],"indicated":[68],"effect":[71],"synthetic":[74],"inhibitor":[76,140],"I,":[77],"which":[78],"prevents":[79],"degradative":[81],"processes.":[82],"Analysis":[83],"calcium":[86],"concentrations":[87],"required":[88],"for":[89,156],"processes":[92],"indicates":[93],"that":[94],"first":[96],"conservative":[97],"proteolytic":[98],"event":[99],"is":[100,108],"micro-calpain,":[103],"whereas":[104],"second":[106],"one":[107],"preferentially":[109],"carried":[110],"out":[111],"m-calpain.":[113],"appearance":[115],"form,":[120,141],"containing":[121],"only":[122],"repetitive":[125],"domain":[127],"identified":[129],"also":[130],"red":[132],"hypertensive":[135],"rats":[136],"major":[139],"can":[142,153],"be":[143,154],"considered":[144],"a":[145],"marker":[146],"it":[152],"used":[155],"monitoring":[158],"involvement":[161],"pathological":[165],"situations.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}