{"id":"https://openalex.org/W2016457314","doi":"https://doi.org/10.5483/bmbrep.2007.40.1.088","title":"NF-\u03baB-dependent Regulation of Matrix Metalloproteinase-9 Gene Expression by Lipopolysaccharide in a Macrophage Cell Line RAW 264.7","display_name":"NF-\u03baB-dependent Regulation of Matrix Metalloproteinase-9 Gene Expression by Lipopolysaccharide in a Macrophage Cell Line RAW 264.7","publication_year":2007,"publication_date":"2007-01-31","ids":{"openalex":"https://openalex.org/W2016457314","doi":"https://doi.org/10.5483/bmbrep.2007.40.1.088","mag":"2016457314","pmid":"https://pubmed.ncbi.nlm.nih.gov/17244487"},"language":"en","primary_location":{"id":"doi:10.5483/bmbrep.2007.40.1.088","doi":"https://doi.org/10.5483/bmbrep.2007.40.1.088","is_oa":true,"landing_page_url":"https://doi.org/10.5483/bmbrep.2007.40.1.088","pdf_url":"http://koreascience.or.kr:80/article/JAKO200710103472291.pdf","source":{"id":"https://openalex.org/S58514918","display_name":"BMB Reports","issn_l":"1976-6696","issn":["1976-6696","1976-670X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","kci-registered","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319427","host_organization_name":"Korean Society for Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4310319427"],"host_organization_lineage_names":["Korean Society for Biochemistry and Molecular Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMB Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://koreascience.or.kr:80/article/JAKO200710103472291.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109126439","display_name":"Jae Won Rhee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Won Rhee","raw_affiliation_strings":["Department of Biochemistry and Institute of Life Science and Biotechnology, College of Science, Yonsei University, Seoul 120-749, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Institute of Life Science and Biotechnology, College of Science, Yonsei University, Seoul 120-749, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083957292","display_name":"Keunwook Lee","orcid":"https://orcid.org/0000-0002-4713-8547","observed_orcids":["https://orcid.org/0000-0002-4713-8547"]},"institutions":[{"id":"https://openalex.org/I146824383","display_name":"Hallym University","ror":"https://ror.org/03sbhge02","country_code":"KR","type":"education","lineage":["https://openalex.org/I146824383"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Keun-Wook Lee","raw_affiliation_strings":["Center for Medical Science Research, College of Medicine, Hallym University, Chuncheon, Gangwon-do 200-702, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Science Research, College of Medicine, Hallym University, Chuncheon, Gangwon-do 200-702, Republic of Korea","institution_ids":["https://openalex.org/I146824383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103191712","display_name":"Dongbum Kim","orcid":"https://orcid.org/0000-0003-3359-9243","observed_orcids":["https://orcid.org/0000-0003-3359-9243"]},"institutions":[{"id":"https://openalex.org/I146824383","display_name":"Hallym University","ror":"https://ror.org/03sbhge02","country_code":"KR","type":"education","lineage":["https://openalex.org/I146824383"]},{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Dong-Bum Kim","raw_affiliation_strings":["Center for Medical Science Research, College of Medicine, Hallym University, Chuncheon, Gangwon-do 200-702, Republic of Korea","Department of Biochemistry and Institute of Life Science and Biotechnology , College of Science , Yonsei University , Seoul 120-749 , Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Science Research, College of Medicine, Hallym University, Chuncheon, Gangwon-do 200-702, Republic of Korea","institution_ids":["https://openalex.org/I146824383"]},{"raw_affiliation_string":"Department of Biochemistry and Institute of Life Science and Biotechnology , College of Science , Yonsei University , Seoul 120-749 , Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100778647","display_name":"Younghee Lee","orcid":"https://orcid.org/0000-0002-2957-752X","observed_orcids":["https://orcid.org/0000-0002-2957-752X"]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young-Hee Lee","raw_affiliation_strings":["Department of Biochemistry, College of Natural Science, Chungbuk National University, Chungbuk 361-763, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Natural Science, Chungbuk National University, Chungbuk 361-763, Republic of Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103037319","display_name":"Ok\u2010Hee Jeon","orcid":"https://orcid.org/0000-0002-5151-3653","observed_orcids":["https://orcid.org/0000-0002-5151-3653"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ok-Hee Jeon","raw_affiliation_strings":["Department of Biochemistry and Institute of Life Science and Biotechnology, College of Science, Yonsei University, Seoul 120-749, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Institute of Life Science and Biotechnology, College of Science, Yonsei University, Seoul 120-749, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057375627","display_name":"Hyung\u2010Joo Kwon","orcid":"https://orcid.org/0000-0001-5581-9994","observed_orcids":["https://orcid.org/0000-0001-5581-9994"]},"institutions":[{"id":"https://openalex.org/I146824383","display_name":"Hallym University","ror":"https://ror.org/03sbhge02","country_code":"KR","type":"education","lineage":["https://openalex.org/I146824383"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyung-Joo Kwon","raw_affiliation_strings":["Center for Medical Science Research, College of Medicine, Hallym University, Chuncheon, Gangwon-do 200-702, Republic of Korea","Department of Microbiology, College of Medicine, Hallym University, Chuncheon, Gangwon-do 200-702, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Science Research, College of Medicine, Hallym University, Chuncheon, Gangwon-do 200-702, Republic of Korea","institution_ids":["https://openalex.org/I146824383"]},{"raw_affiliation_string":"Department of Microbiology, College of Medicine, Hallym University, Chuncheon, Gangwon-do 200-702, Republic of Korea","institution_ids":["https://openalex.org/I146824383"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064558238","display_name":"Doo\u2010Sik Kim","orcid":"https://orcid.org/0000-0003-3809-0139","observed_orcids":["https://orcid.org/0000-0003-3809-0139"]},"institutions":[{"id":"https://openalex.org/I146824383","display_name":"Hallym University","ror":"https://ror.org/03sbhge02","country_code":"KR","type":"education","lineage":["https://openalex.org/I146824383"]},{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Doo-Sik Kim","raw_affiliation_strings":["Center for Medical Science Research , College of Medicine , Hallym University , Chuncheon , Gangwon -do 200-702 , Republic of Korea","Department of Biochemistry and Institute of Life Science and Biotechnology, College of Science, Yonsei University, Seoul 120-749, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Science Research , College of Medicine , Hallym University , Chuncheon , Gangwon -do 200-702 , Republic of Korea","institution_ids":["https://openalex.org/I146824383"]},{"raw_affiliation_string":"Department of Biochemistry and Institute of Life Science and Biotechnology, College of Science, Yonsei University, Seoul 120-749, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5103191712"],"corresponding_institution_ids":["https://openalex.org/I146824383","https://openalex.org/I193775966"],"apc_list":{"value":550,"currency":"USD","value_usd":550},"apc_paid":{"value":550,"currency":"USD","value_usd":550},"fwci":2.4276,"has_fulltext":true,"cited_by_count":95,"citation_normalized_percentile":{"value":0.90222594,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"40","issue":"1","first_page":"88","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8730000257492065},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9919999837875366},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8790000081062317},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.9850000143051147},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.593999981880188},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/nf-kappab-binding-site","display_name":"NF-kappaB binding site","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ikappabalpha-degradation","display_name":"I\u03baB\u03b1 degradation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/myd88","display_name":"MyD88","score":0.9909999966621399},{"id":"https://openalex.org/keywords/traf6","display_name":"TRAF6","score":1.0},{"id":"https://openalex.org/keywords/extracellular-matrix-turnover","display_name":"extracellular matrix turnover","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6116275787353516},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5938043594360352},{"id":"https://openalex.org/C2991819120","wikidata":"https://www.wikidata.org/wiki/Q13033749","display_name":"Matrix metalloproteinase 9","level":3,"score":0.5919724702835083},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5843809843063354},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5641052722930908},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5212690830230713},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5053160786628723},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4985647201538086},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49182558059692383},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.47651588916778564},{"id":"https://openalex.org/C204258353","wikidata":"https://www.wikidata.org/wiki/Q7670282","display_name":"THP1 cell line","level":3,"score":0.47627514600753784},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47494271397590637},{"id":"https://openalex.org/C198352243","wikidata":"https://www.wikidata.org/wiki/Q37105","display_name":"Line (geometry)","level":2,"score":0.46025407314300537},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37379390001296997},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33176088333129883},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26756513118743896},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18052995204925537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16418248414993286},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12944531440734863},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.12161940336227417},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013859","descriptor_name":"Thiocarbamates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5483/bmbrep.2007.40.1.088","doi":"https://doi.org/10.5483/bmbrep.2007.40.1.088","is_oa":true,"landing_page_url":"https://doi.org/10.5483/bmbrep.2007.40.1.088","pdf_url":"http://koreascience.or.kr:80/article/JAKO200710103472291.pdf","source":{"id":"https://openalex.org/S58514918","display_name":"BMB Reports","issn_l":"1976-6696","issn":["1976-6696","1976-670X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","kci-registered","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319427","host_organization_name":"Korean Society for Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4310319427"],"host_organization_lineage_names":["Korean Society for Biochemistry and Molecular Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMB Reports","raw_type":"journal-article"},{"id":"pmid:17244487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17244487","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry and molecular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.5483/bmbrep.2007.40.1.088","doi":"https://doi.org/10.5483/bmbrep.2007.40.1.088","is_oa":true,"landing_page_url":"https://doi.org/10.5483/bmbrep.2007.40.1.088","pdf_url":"http://koreascience.or.kr:80/article/JAKO200710103472291.pdf","source":{"id":"https://openalex.org/S58514918","display_name":"BMB Reports","issn_l":"1976-6696","issn":["1976-6696","1976-670X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","kci-registered","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319427","host_organization_name":"Korean Society for Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4310319427"],"host_organization_lineage_names":["Korean Society for Biochemistry and Molecular Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMB Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8274910028","display_name":null,"funder_award_id":"KRF-2005-005-J15001","funder_id":"https://openalex.org/F4320327953","funder_display_name":"Ministry of Education and Human Resources Development"}],"funders":[{"id":"https://openalex.org/F4320327953","display_name":"Ministry of Education and Human Resources Development","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016457314.pdf","grobid_xml":"https://content.openalex.org/works/W2016457314.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1577572535","https://openalex.org/W1904627166","https://openalex.org/W1969133782","https://openalex.org/W1976264434","https://openalex.org/W1982270701","https://openalex.org/W1986663284","https://openalex.org/W1996815463","https://openalex.org/W1998585620","https://openalex.org/W2001562320","https://openalex.org/W2008038069","https://openalex.org/W2012001366","https://openalex.org/W2033613642","https://openalex.org/W2044164946","https://openalex.org/W2064558057","https://openalex.org/W2073259535","https://openalex.org/W2083169533","https://openalex.org/W2086713654","https://openalex.org/W2088820083","https://openalex.org/W2093629370","https://openalex.org/W2101189183","https://openalex.org/W2107398206","https://openalex.org/W2107462315","https://openalex.org/W2115097918","https://openalex.org/W2138382474","https://openalex.org/W2143640552","https://openalex.org/W2154401382","https://openalex.org/W2163394733"],"related_works":["https://openalex.org/W2088820083","https://openalex.org/W2258087137","https://openalex.org/W2033613642","https://openalex.org/W2046649601","https://openalex.org/W1501356074","https://openalex.org/W2980660809","https://openalex.org/W2128878911","https://openalex.org/W2134410622","https://openalex.org/W2024160852","https://openalex.org/W1671601265"],"abstract_inverted_index":{"Matrix":[0],"metalloproteinase-9":[1],"(MMP-9)":[2],"plays":[3],"a":[4,51,88,165],"pivotal":[5],"role":[6],"in":[7,15,23,48,73,91,147,164],"the":[8,16,36,39,61,66,74,97,102,137],"turnover":[9],"of":[10,18,38,50,65,79,83,99,104],"extracellular":[11],"matrix":[12],"(ECM)":[13],"and":[14,20,28,101,109,136],"migration":[17],"normal":[19,26],"tumor":[21,110],"cells":[22,49],"response":[24],"to":[25,70,87,119,159],"physiologic":[27],"numerous":[29],"pathologic":[30],"conditions.":[31],"Here,":[32],"we":[33],"show":[34],"that":[35,60,131,156],"transcription":[37],"MMP-9":[40,67,84,92,124,138,145,161],"gene":[41,68,162],"is":[42,141],"induced":[43],"by":[44],"lipopolysaccharide":[45],"(LPS)":[46],"stimulation":[47],"macrophage":[52,167],"lineage":[53],"(RAW":[54],"264.7":[55,149],"cells).":[56],"We":[57],"provide":[58],"evidence":[59],"NF-kappaB":[62,80,135,157],"binding":[63,81],"site":[64,82],"contributes":[69,158],"its":[71],"expression":[72,163],"LPS-signaling":[75],"pathway,":[76],"since":[77],"mutation":[78],"promoter":[85,93,139],"leads":[86],"dramatic":[89],"reduction":[90],"activation.":[94],"In":[95,151],"addition,":[96],"degradation":[98],"IkappaBalpha,":[100],"presences":[103],"myeloid":[105],"differentiation":[106],"protein":[107],"(MyD88)":[108],"necrosis":[111],"factor":[112],"receptor-associated":[113],"kinase":[114],"6":[115],"(TRAF6)":[116],"were":[117],"found":[118],"be":[120],"required":[121],"for":[122,143],"LPS-activated":[123,144],"expression.":[125],"Chromatin":[126],"immunoprecipitation":[127],"(ChIP)":[128],"assays":[129],"showed":[130],"functional":[132],"interaction":[133],"between":[134],"element":[140],"necessary":[142],"induction":[146],"RAW":[148],"cells.":[150],"conclusion,":[152],"our":[153],"observations":[154],"demonstrate":[155],"LPS-induced":[160],"mouse":[166],"cell":[168],"line.":[169]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}