{"id":"https://openalex.org/W2016455533","doi":"https://doi.org/10.1038/305551a0","title":"A 5\u2032-flanking sequence essential for progesterone regulation of an ovalbumin fusion gene","display_name":"A 5\u2032-flanking sequence essential for progesterone regulation of an ovalbumin fusion gene","publication_year":1983,"publication_date":"1983-10-01","ids":{"openalex":"https://openalex.org/W2016455533","doi":"https://doi.org/10.1038/305551a0","mag":"2016455533","pmid":"https://pubmed.ncbi.nlm.nih.gov/6621702"},"language":"en","primary_location":{"id":"doi:10.1038/305551a0","doi":"https://doi.org/10.1038/305551a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/305551a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058951640","display_name":"Douglas C. Dean","orcid":"https://orcid.org/0000-0002-6581-7463","observed_orcids":["https://orcid.org/0000-0002-6581-7463"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas C. Dean","raw_affiliation_strings":["Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA","Department of Cell Biology, Baylor College of Medicine Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Cell Biology, Baylor College of Medicine Houston, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070767781","display_name":"Brian J. Knoll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian J. Knoll","raw_affiliation_strings":["Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA","Department of Cell Biology, Baylor College of Medicine Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Cell Biology, Baylor College of Medicine Houston, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058819901","display_name":"Mary E. Riser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary E. Riser","raw_affiliation_strings":["Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA","Department of Cell Biology, Baylor College of Medicine Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Cell Biology, Baylor College of Medicine Houston, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057978718","display_name":"Bert W. O\u2019Malley","orcid":"https://orcid.org/0000-0003-3332-1399","observed_orcids":["https://orcid.org/0000-0003-3332-1399"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bert W. O'Malley","raw_affiliation_strings":["Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA","Department of Cell Biology, Baylor College of Medicine Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Cell Biology, Baylor College of Medicine Houston, USA","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":15.4895,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.99449457,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"305","issue":"5934","first_page":"551","last_page":"554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.040800001472234726,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovalbumin-gene","display_name":"ovalbumin gene","score":0.8209999799728394},{"id":"https://openalex.org/keywords/5-flanking-region","display_name":"5'-flanking region","score":0.9210000038146973},{"id":"https://openalex.org/keywords/progesterone-regulation","display_name":"progesterone regulation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/steroid-hormone-receptors","display_name":"steroid hormone receptors","score":0.671999990940094},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/chicken-oviduct","display_name":"chicken oviduct","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.7942936420440674},{"id":"https://openalex.org/C2777129507","wikidata":"https://www.wikidata.org/wiki/Q36857","display_name":"Oviduct","level":2,"score":0.7051181793212891},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6684648394584656},{"id":"https://openalex.org/C2776888042","wikidata":"https://www.wikidata.org/wiki/Q422137","display_name":"Steroid hormone","level":3,"score":0.5982798933982849},{"id":"https://openalex.org/C51445715","wikidata":"https://www.wikidata.org/wiki/Q410477","display_name":"Hormone response element","level":5,"score":0.5556396245956421},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48177167773246765},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4770623743534088},{"id":"https://openalex.org/C2779544216","wikidata":"https://www.wikidata.org/wiki/Q411546","display_name":"Steroid hormone receptor","level":5,"score":0.4535346031188965},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45166850090026855},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4489702880382538},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4338458478450775},{"id":"https://openalex.org/C98717036","wikidata":"https://www.wikidata.org/wiki/Q14872994","display_name":"Progesterone receptor","level":5,"score":0.42695218324661255},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42245903611183167},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.41282370686531067},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.39133620262145996},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1818913221359253},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13677740097045898},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13325661420822144},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0905560851097107},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.08944499492645264},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004274","descriptor_name":"DNA, Recombinant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004274","descriptor_name":"DNA, Recombinant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004274","descriptor_name":"DNA, Recombinant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/305551a0","doi":"https://doi.org/10.1038/305551a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/305551a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:6621702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6621702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1598530978","https://openalex.org/W1674268758","https://openalex.org/W1964636049","https://openalex.org/W1971222138","https://openalex.org/W1973454389","https://openalex.org/W1973903022","https://openalex.org/W1975509826","https://openalex.org/W1983145743","https://openalex.org/W1984513339","https://openalex.org/W1984887177","https://openalex.org/W1986592101","https://openalex.org/W2012719011","https://openalex.org/W2018197588","https://openalex.org/W2029693258","https://openalex.org/W2048800387","https://openalex.org/W2053168644","https://openalex.org/W2057939038","https://openalex.org/W2062059447","https://openalex.org/W2066160869","https://openalex.org/W2066816287","https://openalex.org/W2068477421","https://openalex.org/W2069969581","https://openalex.org/W2071958238","https://openalex.org/W2079570313","https://openalex.org/W2089031185","https://openalex.org/W2091417035","https://openalex.org/W2097563956","https://openalex.org/W2113208052","https://openalex.org/W2137583334"],"related_works":["https://openalex.org/W2111638403","https://openalex.org/W1593454126","https://openalex.org/W2150488964","https://openalex.org/W78192158","https://openalex.org/W2232087955","https://openalex.org/W1532668225","https://openalex.org/W121824230","https://openalex.org/W1598530978","https://openalex.org/W1989555252","https://openalex.org/W2047708586"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}