{"id":"https://openalex.org/W2016454360","doi":"https://doi.org/10.1590/s0004-282x2013000300002","title":"Natalizumab adverse events are rare in patients with multiple sclerosis","display_name":"Natalizumab adverse events are rare in patients with multiple sclerosis","publication_year":2013,"publication_date":"2013-03-01","ids":{"openalex":"https://openalex.org/W2016454360","doi":"https://doi.org/10.1590/s0004-282x2013000300002","mag":"2016454360","pmid":"https://pubmed.ncbi.nlm.nih.gov/23563711"},"language":"en","primary_location":{"id":"doi:10.1590/s0004-282x2013000300002","doi":"https://doi.org/10.1590/s0004-282x2013000300002","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0004-282x2013000300002","pdf_url":"https://www.scielo.br/j/anp/a/wNtQCBMgDpmXfKJbswRNWyS/?lang=en&format=pdf","source":{"id":"https://openalex.org/S166523383","display_name":"Arquivos de Neuro-Psiquiatria","issn_l":"0004-282X","issn":["0004-282X","1678-4227"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos de Neuro-Psiquiatria","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.scielo.br/j/anp/a/wNtQCBMgDpmXfKJbswRNWyS/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020111272","display_name":"Y\u00e1ra Dadalti Fragoso","orcid":"https://orcid.org/0000-0001-8726-089X","observed_orcids":["https://orcid.org/0000-0001-8726-089X"]},"institutions":[{"id":"https://openalex.org/I4210140372","display_name":"Universidade Metropolitana de Santos","ror":"https://ror.org/035mpnm25","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210140372"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Y\u00e1ra Dadalti Fragoso","raw_affiliation_strings":["Universidade Metropolitana de Santos (UNIMES), Brazil","Universidade Metropolitana de Santos (UNIMES), Santos, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Metropolitana de Santos (UNIMES), Brazil","institution_ids":["https://openalex.org/I4210140372"]},{"raw_affiliation_string":"Universidade Metropolitana de Santos (UNIMES), Santos, SP, Brazil","institution_ids":["https://openalex.org/I4210140372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046110936","display_name":"Soniza Vieira Alves\u2010Leon","orcid":"https://orcid.org/0000-0002-1538-6730","observed_orcids":["https://orcid.org/0000-0002-1538-6730"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Soniza Vieira Alves-Leon","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro (UFRJ), Brazil","Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Brazil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110228525","display_name":"Walter Oleschko Arruda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Walter Oleschko Arruda","raw_affiliation_strings":["Universidade Federal do Paran\u00e1 (UFPR), Brazil","Universidade Federal do Parana (UFPR), Curitiba, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Paran\u00e1 (UFPR), Brazil","institution_ids":["https://openalex.org/I52418104"]},{"raw_affiliation_string":"Universidade Federal do Parana (UFPR), Curitiba, PR, Brazil","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100800276","display_name":"Margarete de Jesus Carvalho","orcid":"https://orcid.org/0009-0006-5640-7821","observed_orcids":["https://orcid.org/0009-0006-5640-7821"]},"institutions":[{"id":"https://openalex.org/I4210143330","display_name":"Faculdade de Medicina do ABC","ror":"https://ror.org/047s7ag77","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210143330"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Margarete de Jesus Carvalho","raw_affiliation_strings":["Faculdade de Medicina do ABC (FMABC), Brazil","Faculdade de Medicina do ABC (FMABC), Santo Andre, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Medicina do ABC (FMABC), Brazil","institution_ids":["https://openalex.org/I4210143330"]},{"raw_affiliation_string":"Faculdade de Medicina do ABC (FMABC), Santo Andre, SP, Brazil","institution_ids":["https://openalex.org/I4210143330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050188820","display_name":"Elizabeth Regina Comini-Frota","orcid":"https://orcid.org/0000-0002-2702-0402","observed_orcids":["https://orcid.org/0000-0002-2702-0402"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Elizabeth Regina Comini-Frota","raw_affiliation_strings":["Universidade Federal de Minas Gerais (UFMG), Brazil","Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Minas Gerais (UFMG), Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032140683","display_name":"\u00c9ber Castro Corr\u00eaa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u00c9ber Castro Corr\u00eaa","raw_affiliation_strings":["CLINEN, Neurologia e Endocrionologia, Brazil","CLINEN, Neurologia e Endocrionologia, Brasilia, DF, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CLINEN, Neurologia e Endocrionologia, Brazil","institution_ids":[]},{"raw_affiliation_string":"CLINEN, Neurologia e Endocrionologia, Brasilia, DF, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101762957","display_name":"Maria L\u00facia Brito Ferreira","orcid":"https://orcid.org/0000-0002-6136-4612","observed_orcids":["https://orcid.org/0000-0002-6136-4612"]},"institutions":[{"id":"https://openalex.org/I4210160961","display_name":"Hospital da Restaura\u00e7\u00e3o","ror":"https://ror.org/04skjvf92","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210160961"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Lucia Brito Ferreira","raw_affiliation_strings":["Hospital da Restaura\u00e7\u00e3o, Brazil","Hospital da Restauracao, Recife, PE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital da Restaura\u00e7\u00e3o, Brazil","institution_ids":["https://openalex.org/I4210160961"]},{"raw_affiliation_string":"Hospital da Restauracao, Recife, PE, Brazil","institution_ids":["https://openalex.org/I4210160961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088327598","display_name":"Paulo Diniz da Gama","orcid":"https://orcid.org/0000-0003-2585-1074","observed_orcids":["https://orcid.org/0000-0003-2585-1074"]},"institutions":[{"id":"https://openalex.org/I98466806","display_name":"Pontif\u00edcia Universidade Cat\u00f3lica de S\u00e3o Paulo","ror":"https://ror.org/00sfmx060","country_code":"BR","type":"education","lineage":["https://openalex.org/I98466806"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paulo Diniz da Gama","raw_affiliation_strings":["Pontif\u00edcia Universidade Cat\u00f3lica de S\u00e3o Paulo (PUC-SP), Brazil","Pontificia Universidade Catolica de Sao Paulo (PUC-SP), Sorocaba, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pontif\u00edcia Universidade Cat\u00f3lica de S\u00e3o Paulo (PUC-SP), Brazil","institution_ids":["https://openalex.org/I98466806"]},{"raw_affiliation_string":"Pontificia Universidade Catolica de Sao Paulo (PUC-SP), Sorocaba, SP, Brazil","institution_ids":["https://openalex.org/I98466806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038535180","display_name":"Sidney Gomes","orcid":"https://orcid.org/0000-0002-9744-5916","observed_orcids":["https://orcid.org/0000-0002-9744-5916"]},"institutions":[{"id":"https://openalex.org/I4210114248","display_name":"Benefic\u00eancia Portuguesa de S\u00e3o Paulo","ror":"https://ror.org/02d7mxj93","country_code":"BR","type":"nonprofit","lineage":["https://openalex.org/I4210114248"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sidney Gomes","raw_affiliation_strings":["Hospital Benefic\u00eancia Portuguesa de S\u00e3o Paulo; Hospital Paulistano, Brazil","Hospital Beneficencia Portuguesa de Sao Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Benefic\u00eancia Portuguesa de S\u00e3o Paulo; Hospital Paulistano, Brazil","institution_ids":["https://openalex.org/I4210114248"]},{"raw_affiliation_string":"Hospital Beneficencia Portuguesa de Sao Paulo","institution_ids":["https://openalex.org/I4210114248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084286476","display_name":"Marcus Vin\u00edcius Magno Gon\u00e7alves","orcid":"https://orcid.org/0000-0002-9127-7886","observed_orcids":["https://orcid.org/0000-0002-9127-7886","https://orcid.org/0000-0002-3274-4472","https://orcid.org/0000-0002-0958-6242"]},"institutions":[{"id":"https://openalex.org/I4210100389","display_name":"Universidade da Regi\u00e3o de Joinville","ror":"https://ror.org/00je1p681","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210100389"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcus Vinicius Magno Gon\u00e7alves","raw_affiliation_strings":["Universidade da Regi\u00e3o de Joinville (UNIVILLE), Brazil","Universidade da Regiao de Joinville (UNIVILLE), Joinville, SC, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade da Regi\u00e3o de Joinville (UNIVILLE), Brazil","institution_ids":["https://openalex.org/I4210100389"]},{"raw_affiliation_string":"Universidade da Regiao de Joinville (UNIVILLE), Joinville, SC, Brazil","institution_ids":["https://openalex.org/I4210100389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042529430","display_name":"Damacio Ram\u00f3n Kaimen-Maciel","orcid":"https://orcid.org/0000-0002-8699-0636","observed_orcids":["https://orcid.org/0000-0002-8699-0636"]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Damacio Ram\u00f3n Kaimen-Maciel","raw_affiliation_strings":["Universidade Estadual de Londrina (UEL), Brazil","Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Estadual de Londrina (UEL), Brazil","institution_ids":["https://openalex.org/I127110123"]},{"raw_affiliation_string":"Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046995565","display_name":"Mar\u00eda Fernanda Mendes","orcid":"https://orcid.org/0000-0003-3983-6019","observed_orcids":["https://orcid.org/0000-0003-3983-6019"]},"institutions":[{"id":"https://openalex.org/I4210112182","display_name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo","ror":"https://ror.org/01z6qpb13","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210112182"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Fernanda Mendes","raw_affiliation_strings":["Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo (FCMSCSP), Brazil","Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo (FCMSCSP), Sao Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo (FCMSCSP), Brazil","institution_ids":["https://openalex.org/I4210112182"]},{"raw_affiliation_string":"Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo (FCMSCSP), Sao Paulo, SP, Brazil","institution_ids":["https://openalex.org/I4210112182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053554330","display_name":"Rog\u00e9rio Rizo Morales","orcid":"https://orcid.org/0000-0002-8960-1026","observed_orcids":["https://orcid.org/0000-0002-8960-1026"]},"institutions":[{"id":"https://openalex.org/I80850581","display_name":"Universidade Federal de Uberl\u00e2ndia","ror":"https://ror.org/04x3wvr31","country_code":"BR","type":"education","lineage":["https://openalex.org/I80850581"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rogerio Rizo Morales","raw_affiliation_strings":["Universidade Federal de Uberl\u00e2ndia (UFU), Brazil","Universidade Federal de Uberlandia (UFU), Uberlandia, MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Uberl\u00e2ndia (UFU), Brazil","institution_ids":["https://openalex.org/I80850581"]},{"raw_affiliation_string":"Universidade Federal de Uberlandia (UFU), Uberlandia, MG, Brazil","institution_ids":["https://openalex.org/I80850581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110013537","display_name":"Andr\u00e9 Luiz Muniz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119789","display_name":"Hospital S\u00e3o Rafael","ror":"https://ror.org/02f38b560","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210119789"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andre Muniz","raw_affiliation_strings":["Hospital S\u00e3o Rafael de Salvador, Brazil","Hospital Sao Rafael de Salvador, Salvador, BA, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital S\u00e3o Rafael de Salvador, Brazil","institution_ids":["https://openalex.org/I4210119789"]},{"raw_affiliation_string":"Hospital Sao Rafael de Salvador, Salvador, BA, Brazil","institution_ids":["https://openalex.org/I4210119789"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013100015","display_name":"Pedro Rippel Salgado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122558511","display_name":"Universidade Federal de Mato Grosso do Sul","ror":"https://ror.org/0366d2847","country_code":"BR","type":"education","lineage":["https://openalex.org/I122558511"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Pedro Rippel Salgado","raw_affiliation_strings":["Universidade Federal de Mato Grosso do Sul (UFMS), Brazil","Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Mato Grosso do Sul (UFMS), Brazil","institution_ids":["https://openalex.org/I122558511"]},{"raw_affiliation_string":"Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil","institution_ids":["https://openalex.org/I122558511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012960163","display_name":"Helo\u00edsa Helena Ruocco","orcid":"https://orcid.org/0000-0001-5394-648X","observed_orcids":["https://orcid.org/0000-0001-5394-648X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heloisa Helena Ruocco","raw_affiliation_strings":["Centro de Atendimento de Esclerose M\u00faltipla, Brazil","Centro de Atendimento de Esclerose Multipla, Jundiai, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Atendimento de Esclerose M\u00faltipla, Brazil","institution_ids":[]},{"raw_affiliation_string":"Centro de Atendimento de Esclerose Multipla, Jundiai, SP, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023267834","display_name":"L\u00edvia Brito Bezerra de Albuquerque","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160961","display_name":"Hospital da Restaura\u00e7\u00e3o","ror":"https://ror.org/04skjvf92","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210160961"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Livia Brito Bezerra de Albuquerque","raw_affiliation_strings":["Hospital da Restaura\u00e7\u00e3o, Brazil","Hospital da Restauracao, Recife, PE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital da Restaura\u00e7\u00e3o, Brazil","institution_ids":["https://openalex.org/I4210160961"]},{"raw_affiliation_string":"Hospital da Restauracao, Recife, PE, Brazil","institution_ids":["https://openalex.org/I4210160961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035048568","display_name":"Joseph Bruno Bidin Brooks","orcid":"https://orcid.org/0000-0002-8295-6326","observed_orcids":["https://orcid.org/0000-0002-8295-6326"]},"institutions":[{"id":"https://openalex.org/I4210140372","display_name":"Universidade Metropolitana de Santos","ror":"https://ror.org/035mpnm25","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210140372"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Joseph Bruno Bidin Brooks","raw_affiliation_strings":["Universidade Metropolitana de Santos (UNIMES), Brazil","Universidade Metropolitana de Santos (UNIMES), Santos, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Metropolitana de Santos (UNIMES), Brazil","institution_ids":["https://openalex.org/I4210140372"]},{"raw_affiliation_string":"Universidade Metropolitana de Santos (UNIMES), Santos, SP, Brazil","institution_ids":["https://openalex.org/I4210140372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067549740","display_name":"Let\u00edcia F\u00eazer Mansur","orcid":"https://orcid.org/0000-0001-9728-7279","observed_orcids":["https://orcid.org/0000-0001-9728-7279"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Let\u00edcia F\u00eazer","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro (UFRJ), Brazil","Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Brazil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063327153","display_name":"Sergio Georgetto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sergio Georgetto","raw_affiliation_strings":["Universidade Estadual de Londrina (UEL), Brazil","Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Estadual de Londrina (UEL), Brazil","institution_ids":["https://openalex.org/I127110123"]},{"raw_affiliation_string":"Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079114312","display_name":"Josiane Mendes Lopes","orcid":"https://orcid.org/0000-0003-0128-4618","observed_orcids":["https://orcid.org/0000-0003-0128-4618"]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Josiane Lopes","raw_affiliation_strings":["Universidade Estadual de Londrina (UEL), Brazil","Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Estadual de Londrina (UEL), Brazil","institution_ids":["https://openalex.org/I127110123"]},{"raw_affiliation_string":"Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014115279","display_name":"Fab\u00edola Rachid Malfetano","orcid":"https://orcid.org/0000-0002-8275-3801","observed_orcids":["https://orcid.org/0000-0002-8275-3801"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fab\u00edola Rachid Malfetano","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro (UFRJ), Brazil","Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Brazil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081421465","display_name":"Isabella D\u2019Andrea Meira","orcid":"https://orcid.org/0000-0001-9507-6849","observed_orcids":["https://orcid.org/0000-0001-9507-6849"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Isabella D'Andrea Meira","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro (UFRJ), Brazil","Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Brazil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108432656","display_name":"Celso Luis Silva Oliveira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140372","display_name":"Universidade Metropolitana de Santos","ror":"https://ror.org/035mpnm25","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210140372"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Celso Luis Silva Oliveira","raw_affiliation_strings":["Universidade Metropolitana de Santos (UNIMES), Brazil","Universidade Metropolitana de Santos (UNIMES), Santos, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Metropolitana de Santos (UNIMES), Brazil","institution_ids":["https://openalex.org/I4210140372"]},{"raw_affiliation_string":"Universidade Metropolitana de Santos (UNIMES), Santos, SP, Brazil","institution_ids":["https://openalex.org/I4210140372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055689852","display_name":"Francisco Tomaz Meneses de Oliveira","orcid":"https://orcid.org/0000-0002-5987-9940","observed_orcids":["https://orcid.org/0000-0002-5987-9940"]},"institutions":[{"id":"https://openalex.org/I4210114248","display_name":"Benefic\u00eancia Portuguesa de S\u00e3o Paulo","ror":"https://ror.org/02d7mxj93","country_code":"BR","type":"nonprofit","lineage":["https://openalex.org/I4210114248"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Francisco Tomaz Meneses de Oliveira","raw_affiliation_strings":["Hospital Benefic\u00eancia Portuguesa de S\u00e3o Paulo; Hospital Paulistano, Brazil","Hospital Beneficencia Portuguesa de Sao Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Benefic\u00eancia Portuguesa de S\u00e3o Paulo; Hospital Paulistano, Brazil","institution_ids":["https://openalex.org/I4210114248"]},{"raw_affiliation_string":"Hospital Beneficencia Portuguesa de Sao Paulo","institution_ids":["https://openalex.org/I4210114248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061872684","display_name":"Fabiana Safanelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100389","display_name":"Universidade da Regi\u00e3o de Joinville","ror":"https://ror.org/00je1p681","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210100389"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fabiana Safanelli","raw_affiliation_strings":["Universidade da Regi\u00e3o de Joinville (UNIVILLE), Brazil","Universidade da Regiao de Joinville (UNIVILLE), Joinville, SC, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade da Regi\u00e3o de Joinville (UNIVILLE), Brazil","institution_ids":["https://openalex.org/I4210100389"]},{"raw_affiliation_string":"Universidade da Regiao de Joinville (UNIVILLE), Joinville, SC, Brazil","institution_ids":["https://openalex.org/I4210100389"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069269104","display_name":"Massaco Satomi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122558511","display_name":"Universidade Federal de Mato Grosso do Sul","ror":"https://ror.org/0366d2847","country_code":"BR","type":"education","lineage":["https://openalex.org/I122558511"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Massaco Satomi","raw_affiliation_strings":["Universidade Federal de Mato Grosso do Sul (UFMS), Brazil","Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Mato Grosso do Sul (UFMS), Brazil","institution_ids":["https://openalex.org/I122558511"]},{"raw_affiliation_string":"Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil","institution_ids":["https://openalex.org/I122558511"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":14,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":200,"currency":"USD","value_usd":200},"apc_paid":{"value":200,"currency":"USD","value_usd":200},"fwci":1.3844,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.80478231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"71","issue":"3","first_page":"137","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natalizumab","display_name":"natalizumab","score":1.0},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8610000014305115},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.9850000143051147},{"id":"https://openalex.org/keywords/infusion-therapy","display_name":"infusion therapy","score":0.5889999866485596},{"id":"https://openalex.org/keywords/drug-related-adverse-events","display_name":"drug-related adverse events","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C2781004633","wikidata":"https://www.wikidata.org/wiki/Q386119","display_name":"Natalizumab","level":3,"score":0.9858916997909546},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.9113561511039734},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7876206040382385},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6627484560012817},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4036377966403961},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08623632788658142}],"mesh":[{"descriptor_ui":"D000069442","descriptor_name":"Natalizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001938","descriptor_name":"Brazil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1590/s0004-282x2013000300002","doi":"https://doi.org/10.1590/s0004-282x2013000300002","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0004-282x2013000300002","pdf_url":"https://www.scielo.br/j/anp/a/wNtQCBMgDpmXfKJbswRNWyS/?lang=en&format=pdf","source":{"id":"https://openalex.org/S166523383","display_name":"Arquivos de Neuro-Psiquiatria","issn_l":"0004-282X","issn":["0004-282X","1678-4227"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos de Neuro-Psiquiatria","raw_type":"journal-article"},{"id":"pmid:23563711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23563711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos de neuro-psiquiatria","raw_type":"Journal Article"},{"id":"pmh:oai:scielo:S0004-282X2013000300137","doi":null,"is_oa":true,"landing_page_url":"http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000300137","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos de Neuro-Psiquiatria v.71 n.3 2013","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:2658843","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000300137","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arquivos de Neuro-Psiquiatria v.71 n.3 2013","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1590/s0004-282x2013000300002","doi":"https://doi.org/10.1590/s0004-282x2013000300002","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0004-282x2013000300002","pdf_url":"https://www.scielo.br/j/anp/a/wNtQCBMgDpmXfKJbswRNWyS/?lang=en&format=pdf","source":{"id":"https://openalex.org/S166523383","display_name":"Arquivos de Neuro-Psiquiatria","issn_l":"0004-282X","issn":["0004-282X","1678-4227"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos de Neuro-Psiquiatria","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016454360.pdf","grobid_xml":"https://content.openalex.org/works/W2016454360.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1561057973","https://openalex.org/W1701993624","https://openalex.org/W1895561430","https://openalex.org/W1988357566","https://openalex.org/W1996787636","https://openalex.org/W2012331528","https://openalex.org/W2032017965","https://openalex.org/W2037391412","https://openalex.org/W2044022462","https://openalex.org/W2050017740","https://openalex.org/W2056494951","https://openalex.org/W2073710417","https://openalex.org/W2077391034","https://openalex.org/W2084656277","https://openalex.org/W2087589796","https://openalex.org/W2111714917","https://openalex.org/W2123289342","https://openalex.org/W2150617926","https://openalex.org/W4253822685"],"related_works":["https://openalex.org/W2565772585","https://openalex.org/W7212240611","https://openalex.org/W2218006635","https://openalex.org/W3187407609","https://openalex.org/W2751712578","https://openalex.org/W2863078660","https://openalex.org/W2074099214","https://openalex.org/W568467962","https://openalex.org/W2027769620","https://openalex.org/W4287512399"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"the":[3,6,41,55,124,136],"prevalence":[4],"and":[5],"profile":[7,102],"of":[8,12,44,60,103,110,126,138],"adverse":[9],"events":[10],"(AE)":[11],"natalizumab":[13,106],"in":[14,33,48,54],"patients":[15,27,39,65,73,111],"with":[16,28],"multiple":[17],"sclerosis":[18],"(MS).":[19],"METHODS:":[20],"Data":[21,36],"collection":[22],"from":[23,37],"neurologists":[24],"attending":[25,40],"to":[26,121,132],"MS":[29,46,133],"at":[30],"specialized":[31,139],"units":[32,47,134],"Brazil.":[34],"RESULTS:":[35],"103":[38],"infusion":[42],"centers":[43],"16":[45],"9":[49],"Brazilian":[50],"states":[51],"were":[52,80],"included":[53],"study.":[56],"The":[57,101],"total":[58],"number":[59],"infusions":[61],"was":[62],"1,042.":[63],"Seventy-nine":[64],"(76.7%)":[66],"did":[67],"not":[68,91],"present":[69],"any":[70],"AE.":[71,78,117],"Twenty-four":[72],"(23.3%)":[74],"presented":[75],"only":[76,115],"mild":[77,116],"There":[79],"three":[81,88],"major":[82],"AE,":[83],"including":[84],"two":[85],"deaths.":[86],"These":[87],"occurrences,":[89],"although":[90],"necessarily":[92],"being":[93],"drug-related,":[94],"must":[95],"be":[96,130],"taken":[97],"into":[98],"consideration.":[99],"CONCLUSION:":[100],"AEs":[104],"for":[105],"shows":[107],"that":[108],"97%":[109],"have":[112],"none":[113],"or":[114],"However,":[118],"still":[119],"due":[120],"safety":[122],"worries,":[123],"use":[125],"this":[127],"medication":[128],"should":[129],"restricted":[131],"under":[135],"care":[137],"neurologists.":[140]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}