{"id":"https://openalex.org/W2016453646","doi":"https://doi.org/10.1159/000010059","title":"Effects of Add-Back Therapy on Bone Mineral Density and Pyridinium Crosslinks in Patients with Endometriosis Treated with Gonadotropin-Releasing Hormone Agonists","display_name":"Effects of Add-Back Therapy on Bone Mineral Density and Pyridinium Crosslinks in Patients with Endometriosis Treated with Gonadotropin-Releasing Hormone Agonists","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2016453646","doi":"https://doi.org/10.1159/000010059","mag":"2016453646","pmid":"https://pubmed.ncbi.nlm.nih.gov/9852390"},"language":"en","primary_location":{"id":"doi:10.1159/000010059","doi":"https://doi.org/10.1159/000010059","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000010059","pdf_url":null,"source":{"id":"https://openalex.org/S207793224","display_name":"Gynecologic and Obstetric Investigation","issn_l":"0378-7346","issn":["0378-7346","1423-002X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic and Obstetric Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057890413","display_name":"Christian Gnoth","orcid":"https://orcid.org/0000-0001-6329-4075","observed_orcids":["https://orcid.org/0000-0001-6329-4075"]},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Gnoth","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Academic Hospital of the University of D\u00fcsseldorf, D\u00fcsseldorf-Benrath, Germany. gnoth@uni-duesseldorf.de","Department of Gynecology and Obstetrics, Academic Hospital of the University of D\u00fcsseldorf, D\u00fcsseldorf-Benrath,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Academic Hospital of the University of D\u00fcsseldorf, D\u00fcsseldorf-Benrath, Germany. gnoth@uni-duesseldorf.de","institution_ids":["https://openalex.org/I4210089242","https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Academic Hospital of the University of D\u00fcsseldorf, D\u00fcsseldorf-Benrath,","institution_ids":["https://openalex.org/I4210089242","https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072442106","display_name":"Katrin G\u00f6dtke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katrin G\u00f6dtke","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Academic Hospital of the University of D\u00fcsseldorf, D\u00fcsseldorf-Benrath,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Academic Hospital of the University of D\u00fcsseldorf, D\u00fcsseldorf-Benrath,","institution_ids":["https://openalex.org/I4210089242","https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046856940","display_name":"Guenter Freundl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Guenter Freundl","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Academic Hospital of the University of D\u00fcsseldorf, D\u00fcsseldorf-Benrath,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Academic Hospital of the University of D\u00fcsseldorf, D\u00fcsseldorf-Benrath,","institution_ids":["https://openalex.org/I4210089242","https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111867545","display_name":"E. Godehardt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eberhardt Godehardt","raw_affiliation_strings":["Department of Thoracic and Cardiovascular Surgery Biostatistics Unit, University of D\u00fcsseldorf, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery Biostatistics Unit, University of D\u00fcsseldorf, and","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043428179","display_name":"Erika Kienle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erika Kienle","raw_affiliation_strings":["Clinical Department, Takeda Pharma, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Department, Takeda Pharma, Aachen, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4175,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.54373059,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"47","issue":"1","first_page":"37","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometriosis","display_name":"endometriosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gnrh-agonist","display_name":"GnRH agonist","score":0.9639999866485596},{"id":"https://openalex.org/keywords/add-back-therapy","display_name":"add-back therapy","score":0.968999981880188},{"id":"https://openalex.org/keywords/ethinyl-estradiol","display_name":"ethinyl estradiol","score":0.9240000247955322},{"id":"https://openalex.org/keywords/desogestrel","display_name":"desogestrel","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pyridinium-crosslinks","display_name":"pyridinium crosslinks","score":0.8759999871253967},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8040000200271606},{"id":"https://openalex.org/keywords/estrogen-deficiency","display_name":"estrogen deficiency","score":0.8920000195503235},{"id":"https://openalex.org/keywords/lumbar-spine","display_name":"lumbar spine","score":0.8330000042915344},{"id":"https://openalex.org/keywords/dysmenorrhea","display_name":"dysmenorrhea","score":0.8489999771118164},{"id":"https://openalex.org/keywords/pelvic-pain","display_name":"pelvic pain","score":0.8769999742507935},{"id":"https://openalex.org/keywords/serum-calcium","display_name":"serum calcium","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2779522080","wikidata":"https://www.wikidata.org/wiki/Q205764","display_name":"Endometriosis","level":2,"score":0.8402765989303589},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6935254335403442},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.6296353936195374},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.5290417075157166},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.44814300537109375},{"id":"https://openalex.org/C2777221202","wikidata":"https://www.wikidata.org/wiki/Q2518436","display_name":"Pyridinium","level":2,"score":0.44448330998420715},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3899412155151367},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3349118232727051},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3342428207397461},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3310016989707947},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21780329942703247},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.09121325612068176},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004715","descriptor_name":"Endometriosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004997","descriptor_name":"Ethinyl Estradiol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016729","descriptor_name":"Leuprolide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016729","descriptor_name":"Leuprolide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017135","descriptor_name":"Desogestrel","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017699","descriptor_name":"Pelvic Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000010059","doi":"https://doi.org/10.1159/000010059","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000010059","pdf_url":null,"source":{"id":"https://openalex.org/S207793224","display_name":"Gynecologic and Obstetric Investigation","issn_l":"0378-7346","issn":["0378-7346","1423-002X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic and Obstetric Investigation","raw_type":"journal-article"},{"id":"pmid:9852390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9852390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic and obstetric investigation","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W80342516","https://openalex.org/W164119867","https://openalex.org/W1591340500","https://openalex.org/W1977603398","https://openalex.org/W1990060114","https://openalex.org/W2001322255","https://openalex.org/W2010701987","https://openalex.org/W2018569828","https://openalex.org/W2073025986","https://openalex.org/W2075980057","https://openalex.org/W2080954233","https://openalex.org/W2089856942","https://openalex.org/W2118043571","https://openalex.org/W2287757320","https://openalex.org/W2343167255","https://openalex.org/W2408707880","https://openalex.org/W2413242429","https://openalex.org/W4295691190"],"related_works":["https://openalex.org/W53565975","https://openalex.org/W2155193637","https://openalex.org/W2398902021","https://openalex.org/W2366599818","https://openalex.org/W2382431012","https://openalex.org/W3126676061","https://openalex.org/W2002108077","https://openalex.org/W2006628041","https://openalex.org/W2141574008","https://openalex.org/W2086213352"],"abstract_inverted_index":{"Treatment":[0],"of":[1,14,29,47,60,66,105,114,145,156],"endometriosis":[2,33],"with":[3,32,38,50],"gonadotropin-releasing":[4],"hormone":[5,41],"agonists":[6],"(GnRHa)":[7],"is":[8],"limited":[9],"to":[10,55,127],"6":[11],"months":[12],"because":[13],"possible":[15],"adverse":[16,58],"effects":[17,59,79],"on":[18],"bone":[19,108,149],"metabolism.":[20],"We":[21],"designed":[22,54],"a":[23,101],"randomized,":[24],"double-blind,":[25],"placebo-controlled,":[26],"prospective":[27],"study":[28],"27":[30],"patients":[31],"who":[34],"were":[35,80],"given":[36],"GnRHa":[37,85,90,121,131],"or":[39],"without":[40],"add-back":[42,133,136],"therapy":[43,137],"(+":[44],"20":[45],"microg":[46],"ethinyl":[48],"estradiol":[49],"0.15":[51],"mg":[52],"desogestrel)":[53],"suppress":[56],"the":[57,64,84,120,130,154,157],"hypoestrogenism":[61],"while":[62],"preserving":[63],"efficacy":[65,155],"GnRHa.":[67,158],"Both":[68],"regimens":[69],"showed":[70],"significant":[71],"improvements":[72],"in":[73,83,119,129],"endometriosis,":[74],"dysmenorrhea,":[75],"and":[76,100,125,147],"pelvic":[77],"pain;":[78],"significantly":[81,95,102,118],"better":[82],"+":[86,91,122,132],"placebo":[87,92,123],"group.":[88,134],"The":[89,135],"group":[93],"had":[94],"higher":[96,103],"serum":[97],"calcium":[98],"levels":[99,113],"loss":[104,144],"lumbar":[106],"spine":[107],"mineral":[109],"density":[110],"(BMD).":[111],"Urinary":[112],"pyridinium":[115],"crosslinks":[116],"increased":[117],"group,":[124],"declined":[126],"normal":[128],"protects":[138],"women":[139],"taking":[140],"GnRHas":[141],"from":[142],"severe":[143],"BMD":[146],"accelerated":[148],"collagen":[150],"resorption,":[151],"but":[152],"reduces":[153]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
