{"id":"https://openalex.org/W2016453061","doi":"https://doi.org/10.1073/pnas.87.12.4697","title":"Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts.","display_name":"Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts.","publication_year":1990,"publication_date":"1990-06-01","ids":{"openalex":"https://openalex.org/W2016453061","doi":"https://doi.org/10.1073/pnas.87.12.4697","mag":"2016453061","pmid":"https://pubmed.ncbi.nlm.nih.gov/2352944"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.87.12.4697","doi":"https://doi.org/10.1073/pnas.87.12.4697","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.87.12.4697","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/54184","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012238055","display_name":"David C. Heimbrook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D C Heimbrook","raw_affiliation_strings":["Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045239984","display_name":"Steven M. Stirdivant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S M Stirdivant","raw_affiliation_strings":["Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056479118","display_name":"Janet D. Ahern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J D Ahern","raw_affiliation_strings":["Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022168864","display_name":"Nancy L. Balishin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N L Balishin","raw_affiliation_strings":["Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022982281","display_name":"Denis R. Patrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D R Patrick","raw_affiliation_strings":["Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111549828","display_name":"Gwynneth M. Edwards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G M Edwards","raw_affiliation_strings":["Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079821454","display_name":"Deborah Defeo-Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Defeo-Jones","raw_affiliation_strings":["Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113683120","display_name":"D J FitzGerald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D J FitzGerald","raw_affiliation_strings":["Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111569932","display_name":"Ira Pastan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I Pastan","raw_affiliation_strings":["Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017507332","display_name":"Allen I. Oliff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Oliff","raw_affiliation_strings":["Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Research, Merck Sharp &amp; Dohme Research Laboratories, West Point, PA 19486","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1285764155"],"apc_list":null,"apc_paid":null,"fwci":4.0818,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.94618971,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"87","issue":"12","first_page":"4697","last_page":"4701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.859000027179718},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.7570000290870667},{"id":"https://openalex.org/keywords/nude-mice","display_name":"nude mice","score":0.4519999921321869},{"id":"https://openalex.org/keywords/a431-cells","display_name":"A431 cells","score":0.7609999775886536},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.6119999885559082},{"id":"https://openalex.org/keywords/therapeutic-window","display_name":"therapeutic window","score":0.5149999856948853},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.7129999995231628},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6620000004768372},{"id":"https://openalex.org/keywords/cysteine-substitution","display_name":"cysteine substitution","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C182179738","wikidata":"https://www.wikidata.org/wiki/Q907386","display_name":"Pseudomonas exotoxin","level":4,"score":0.8938403129577637},{"id":"https://openalex.org/C125555471","wikidata":"https://www.wikidata.org/wiki/Q14908037","display_name":"TGF alpha","level":4,"score":0.7692844867706299},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.611736536026001},{"id":"https://openalex.org/C2778723905","wikidata":"https://www.wikidata.org/wiki/Q408649","display_name":"Exotoxin","level":3,"score":0.5487077236175537},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.4790321886539459},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4729216694831848},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.42006632685661316},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.411484032869339},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40678834915161133},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.33251357078552246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3212934136390686},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2629649043083191},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.22684785723686218},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.17922323942184448},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.174337238073349},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16756239533424377},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000097668","descriptor_name":"Pseudomonas aeruginosa Exotoxin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097668","descriptor_name":"Pseudomonas aeruginosa Exotoxin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097668","descriptor_name":"Pseudomonas aeruginosa Exotoxin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097668","descriptor_name":"Pseudomonas aeruginosa Exotoxin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005098","descriptor_name":"Exotoxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005098","descriptor_name":"Exotoxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005098","descriptor_name":"Exotoxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005098","descriptor_name":"Exotoxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005098","descriptor_name":"Exotoxins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005098","descriptor_name":"Exotoxins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005098","descriptor_name":"Exotoxins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005098","descriptor_name":"Exotoxins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015291","descriptor_name":"Transforming Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015291","descriptor_name":"Transforming Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015291","descriptor_name":"Transforming Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015291","descriptor_name":"Transforming Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015291","descriptor_name":"Transforming Growth Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015291","descriptor_name":"Transforming Growth Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015291","descriptor_name":"Transforming Growth Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015291","descriptor_name":"Transforming Growth Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036002","descriptor_name":"ADP Ribose Transferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036002","descriptor_name":"ADP Ribose Transferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036002","descriptor_name":"ADP Ribose Transferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036002","descriptor_name":"ADP Ribose Transferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.87.12.4697","doi":"https://doi.org/10.1073/pnas.87.12.4697","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.87.12.4697","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:2352944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2352944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:47774","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC54184","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:54184","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/54184","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:54184","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/54184","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5400000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1548193792","https://openalex.org/W1560827962","https://openalex.org/W1567148937","https://openalex.org/W1808358553","https://openalex.org/W1871697173","https://openalex.org/W1921583691","https://openalex.org/W1968763311","https://openalex.org/W1973071934","https://openalex.org/W1977490774","https://openalex.org/W1981668588","https://openalex.org/W1985033077","https://openalex.org/W1985749328","https://openalex.org/W2003998013","https://openalex.org/W2008954260","https://openalex.org/W2010640454","https://openalex.org/W2012330612","https://openalex.org/W2012939559","https://openalex.org/W2014335282","https://openalex.org/W2023711780","https://openalex.org/W2026578950","https://openalex.org/W2040469480","https://openalex.org/W2069159434","https://openalex.org/W2072767834","https://openalex.org/W2082540596","https://openalex.org/W2087372557","https://openalex.org/W2102838769","https://openalex.org/W2114918609","https://openalex.org/W2122280772","https://openalex.org/W2140375000","https://openalex.org/W2156783211","https://openalex.org/W2171515720","https://openalex.org/W2337344701","https://openalex.org/W2410470293","https://openalex.org/W4239872543"],"related_works":["https://openalex.org/W2413325023","https://openalex.org/W2053404437","https://openalex.org/W1917568389","https://openalex.org/W1550052423","https://openalex.org/W2745560200","https://openalex.org/W1158774821","https://openalex.org/W1991811755","https://openalex.org/W1543909608","https://openalex.org/W1563995190","https://openalex.org/W2222693430"],"abstract_inverted_index":{"Transforming":[0],"growth":[1,61,247],"factor":[2,62],"alpha":[3,18,40],"(TGF":[4],"alpha)-Pseudomonas":[5],"exotoxin":[6,29],"40":[7],"(PE40)":[8],"is":[9],"a":[10,22,102,131,154,236],"chimeric":[11],"protein":[12,70],"consisting":[13],"of":[14,26,38,45,68,105,133,205,245],"an":[15,52,72],"N-terminal":[16],"TGF":[17,32,39,50,91,134,174,196],"domain":[19],"fused":[20],"to":[21,90,224],"C-terminal":[23],"40-kDa":[24],"segment":[25],"the":[27,35,42,66,138,203,243],"Pseudomonas":[28],"A":[30],"protein.":[31],"alpha-PE40":[33,51,135,147,175,197],"exhibits":[34],"receptor-binding":[36],"activity":[37,44],"and":[41,84],"cell-killing":[43],"PE40.":[46],"These":[47,232],"properties":[48],"make":[49],"effective":[53],"cytotoxic":[54],"agent":[55,74],"for":[56,156,242],"cells":[57,112,123,163,209],"that":[58,113,124,210,235],"possess":[59,114],"epidermal":[60],"receptors":[63],"(EGFR).":[64],"However,":[65],"utility":[67],"this":[69,95],"as":[71,251],"anticancer":[73,252],"has":[75],"been":[76],"unclear":[77],"because":[78],"many":[79],"normal":[80,225],"tissues":[81,226],"express":[82],"EGFR":[83,115,212],"may":[85],"be":[86],"damaged":[87],"by":[88,143],"exposure":[89],"alpha-PE40.":[92],"To":[93],"address":[94],"issue,":[96],"we":[97],"injected":[98],"nude":[99],"mice":[100,206],"with":[101,117,130,151,173,179],"lethal":[103],"inoculum":[104],"either":[106],"A431":[107,184],"or":[108,116,150],"HT29":[109,190],"human":[110],"tumor":[111,122,162,208],"Chinese":[118],"hamster":[119],"ovary":[120],"(CHO)":[121],"lack":[125,211],"EGFR.":[126],"Animals":[127],"were":[128],"treated":[129,172],"derivative":[132],"in":[136,240],"which":[137],"cysteine":[139],"residues":[140],"are":[141],"replaced":[142],"alanine,":[144],"termed":[145],"\"TGF":[146],"delta":[148,176,198],"cys,\"":[149],"saline":[152],"once":[153],"day":[155],"5":[157],"days.":[158],"Mice":[159],"bearing":[160,207],"EGFR+":[161],"lived":[164],"significantly":[165],"(P":[166],"less":[167],"than":[168],"0.001)":[169],"longer":[170],"when":[171],"cys":[177,199],"compared":[178],"saline-treated":[180],"controls":[181],"(median":[182,213],"survival:":[183,214],"cells,":[185,191,216],"51.5":[186],"vs.":[187,193,218],"25.5":[188],"days;":[189],"101":[192],"47.5":[194],"days).":[195,220],"did":[200],"not":[201],"prolong":[202],"survival":[204],"CHO":[215],"15.5":[217],"19.5":[219],"The":[221],"only":[222],"toxicity":[223],"was":[227],"mild":[228],"periportal":[229],"hepatic":[230],"necrosis.":[231],"studies":[233],"indicate":[234],"therapeutic":[237],"window":[238],"exists":[239],"vivo":[241],"use":[244],"some":[246],"factor-toxin":[248],"fusion":[249],"proteins":[250],"agents.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
