{"id":"https://openalex.org/W2016439613","doi":"https://doi.org/10.1006/jmbi.1998.1776","title":"Dimer-to-tetramer transformation: loop excision dramatically alters structure and stability of the ROP four \u03b1-helix bundle protein","display_name":"Dimer-to-tetramer transformation: loop excision dramatically alters structure and stability of the ROP four \u03b1-helix bundle protein","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W2016439613","doi":"https://doi.org/10.1006/jmbi.1998.1776","mag":"2016439613","pmid":"https://pubmed.ncbi.nlm.nih.gov/9642076"},"language":"en","primary_location":{"id":"doi:10.1006/jmbi.1998.1776","doi":"https://doi.org/10.1006/jmbi.1998.1776","is_oa":false,"landing_page_url":"https://doi.org/10.1006/jmbi.1998.1776","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057492741","display_name":"Michael W. Lassalle","orcid":"https://orcid.org/0009-0002-2310-9052","observed_orcids":["https://orcid.org/0009-0002-2310-9052"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael W Lassalle","raw_affiliation_strings":["Institut f\u00fcr Physikalische Chemie, der Westf\u00e4lischen Wilhelms-Universit\u00e4t, Schlossplatz 4/7, M\u00fcnster, 48149, Germany","Institut f\u00fcr Physikalische Chemie, der Westf\u00e4lischen Wilhelms-Universit\u00e4t, Schlo\u00dfplatz 4/7 48149 M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Physikalische Chemie, der Westf\u00e4lischen Wilhelms-Universit\u00e4t, Schlossplatz 4/7, M\u00fcnster, 48149, Germany","institution_ids":["https://openalex.org/I22465464"]},{"raw_affiliation_string":"Institut f\u00fcr Physikalische Chemie, der Westf\u00e4lischen Wilhelms-Universit\u00e4t, Schlo\u00dfplatz 4/7 48149 M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113733186","display_name":"Hans\u2010J\u00fcrgen Hinz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hans-J\u00fcrgen Hinz","raw_affiliation_strings":["Institut f\u00fcr Physikalische Chemie, der Westf\u00e4lischen Wilhelms-Universit\u00e4t, Schlo\u00dfplatz 4/7 48149 M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Physikalische Chemie, der Westf\u00e4lischen Wilhelms-Universit\u00e4t, Schlo\u00dfplatz 4/7 48149 M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082724826","display_name":"H. Wenzel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20121455","display_name":"Bielefeld University","ror":"https://ror.org/02hpadn98","country_code":"DE","type":"education","lineage":["https://openalex.org/I20121455"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Herbert Wenzel","raw_affiliation_strings":["Lehrstuhl f\u00fcr Biochemie Universit\u00e4t Bielefeld, Universit\u00e4tsstra\u00dfe 33615 Bielefeld, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lehrstuhl f\u00fcr Biochemie Universit\u00e4t Bielefeld, Universit\u00e4tsstra\u00dfe 33615 Bielefeld, Germany","institution_ids":["https://openalex.org/I20121455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086180613","display_name":"Metaxia Vlassi","orcid":"https://orcid.org/0000-0003-0931-2660","observed_orcids":["https://orcid.org/0000-0003-0931-2660"]},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Metaxia Vlassi","raw_affiliation_strings":["N.C.S.R. \u201cDemokritos\u201d, 15310 Ag. Paraskevi-Attikis P.O.Box 60228, 15310 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N.C.S.R. \u201cDemokritos\u201d, 15310 Ag. Paraskevi-Attikis P.O.Box 60228, 15310 Athens, Greece","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031019280","display_name":"Michael Kokkinidis","orcid":"https://orcid.org/0000-0002-3112-6904","observed_orcids":["https://orcid.org/0000-0002-3112-6904"]},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Michael Kokkinidis","raw_affiliation_strings":["Foundation for Research and Technology-Hellas, Institute of Molecular Biology & Biotechnology, P.O.Box 1527 71110 Heraklion Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation for Research and Technology-Hellas, Institute of Molecular Biology & Biotechnology, P.O.Box 1527 71110 Heraklion Crete, Greece","institution_ids":["https://openalex.org/I8901234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015817324","display_name":"Giovanni Cesareni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Cesareni","raw_affiliation_strings":["Dipartimento Biologia, II Universit\u00e0 Degli Studi di Roma, Tor Vergata 00173 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Biologia, II Universit\u00e0 Degli Studi di Roma, Tor Vergata 00173 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5113733186"],"corresponding_institution_ids":["https://openalex.org/I22465464"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":1.4533,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.8098965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"279","issue":"4","first_page":"987","last_page":"1000"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rop-protein","display_name":"Rop protein","score":0.9200000166893005},{"id":"https://openalex.org/keywords/homotetramer","display_name":"homotetramer","score":0.6150000095367432},{"id":"https://openalex.org/keywords/homodimer","display_name":"homodimer","score":0.8899999856948853},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.75},{"id":"https://openalex.org/keywords/cooperative-unfolding","display_name":"cooperative unfolding","score":0.6830000281333923},{"id":"https://openalex.org/keywords/heat-capacity-change","display_name":"heat capacity change","score":0.7110000252723694},{"id":"https://openalex.org/keywords/two-state-unfolding","display_name":"two-state unfolding","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2778886173","wikidata":"https://www.wikidata.org/wiki/Q53832","display_name":"Tetramer","level":3,"score":0.9612432718276978},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.7786228656768799},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.7263647317886353},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6950623989105225},{"id":"https://openalex.org/C3288061","wikidata":"https://www.wikidata.org/wiki/Q161064","display_name":"Enthalpy","level":2,"score":0.595094621181488},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.5052431225776672},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.48566997051239014},{"id":"https://openalex.org/C203087120","wikidata":"https://www.wikidata.org/wiki/Q372229","display_name":"Helix bundle","level":3,"score":0.4675979018211365},{"id":"https://openalex.org/C146477669","wikidata":"https://www.wikidata.org/wiki/Q334631","display_name":"Gibbs free energy","level":2,"score":0.4590114951133728},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.4225327968597412},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.42065608501434326},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3608991801738739},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.25111252069473267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14259356260299683},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.112938791513443},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07690680027008057},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/jmbi.1998.1776","doi":"https://doi.org/10.1006/jmbi.1998.1776","is_oa":false,"landing_page_url":"https://doi.org/10.1006/jmbi.1998.1776","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:9642076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9642076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W28039676","https://openalex.org/W50041187","https://openalex.org/W183414650","https://openalex.org/W1454386623","https://openalex.org/W1495475575","https://openalex.org/W1505902561","https://openalex.org/W1964259924","https://openalex.org/W1982025927","https://openalex.org/W1993795337","https://openalex.org/W2002195659","https://openalex.org/W2009528324","https://openalex.org/W2009992365","https://openalex.org/W2014853910","https://openalex.org/W2018734661","https://openalex.org/W2021259536","https://openalex.org/W2028317271","https://openalex.org/W2030051164","https://openalex.org/W2035485234","https://openalex.org/W2038910312","https://openalex.org/W2044149388","https://openalex.org/W2047722033","https://openalex.org/W2053621368","https://openalex.org/W2058527555","https://openalex.org/W2058833597","https://openalex.org/W2060421490","https://openalex.org/W2067108102","https://openalex.org/W2089985532","https://openalex.org/W2090827101","https://openalex.org/W2091626873","https://openalex.org/W2093921773","https://openalex.org/W2094582426","https://openalex.org/W2135909366","https://openalex.org/W2149707830","https://openalex.org/W2165355228","https://openalex.org/W2165740393","https://openalex.org/W2166737977","https://openalex.org/W2345384133","https://openalex.org/W2474030298","https://openalex.org/W4285719527","https://openalex.org/W6720380258"],"related_works":["https://openalex.org/W2001403864","https://openalex.org/W2058833597","https://openalex.org/W3165240135","https://openalex.org/W2091626873","https://openalex.org/W2094582426","https://openalex.org/W2067444140","https://openalex.org/W2058972985","https://openalex.org/W2082354918","https://openalex.org/W2163426006","https://openalex.org/W2107643484"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}