{"id":"https://openalex.org/W2016417841","doi":"https://doi.org/10.1074/jbc.m700074200","title":"RUNX1-RUNX1 Homodimerization Modulates RUNX1 Activity and Function","display_name":"RUNX1-RUNX1 Homodimerization Modulates RUNX1 Activity and Function","publication_year":2007,"publication_date":"2007-03-14","ids":{"openalex":"https://openalex.org/W2016417841","doi":"https://doi.org/10.1074/jbc.m700074200","mag":"2016417841","pmid":"https://pubmed.ncbi.nlm.nih.gov/17355962"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m700074200","doi":"https://doi.org/10.1074/jbc.m700074200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m700074200","pdf_url":"http://www.jbc.org/article/S002192581747431X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192581747431X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012050790","display_name":"Donglan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donglan Li","raw_affiliation_strings":["Department of Medicine, University of Illinois, Chicago, Illinois 60612, USA","Department of Medicine, University of Illinois, Chicago, Illinois 60612 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Illinois, Chicago, Illinois 60612, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Medicine, University of Illinois, Chicago, Illinois 60612 USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079965354","display_name":"Kislay Kumar Sinha","orcid":"https://orcid.org/0000-0002-6978-4611","observed_orcids":["https://orcid.org/0000-0002-6978-4611"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kislay K. Sinha","raw_affiliation_strings":["Department of Medicine, University of Illinois, Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Illinois, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069511421","display_name":"Maher Abdul\u2010Hay","orcid":"https://orcid.org/0000-0003-1041-7689","observed_orcids":["https://orcid.org/0000-0003-1041-7689"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maher A. Hay","raw_affiliation_strings":["Department of Medicine, University of Illinois, Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Illinois, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104109570","display_name":"Ciro Roberto Rinaldi","orcid":"https://orcid.org/0000-0003-0598-1816","observed_orcids":["https://orcid.org/0000-0003-0598-1816"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ciro R. Rinaldi","raw_affiliation_strings":["Department of Medicine, University of Illinois, Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Illinois, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049987484","display_name":"Yogen Saunthararajah","orcid":"https://orcid.org/0000-0002-9757-1031","observed_orcids":["https://orcid.org/0000-0002-9757-1031"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yogen Saunthararajah","raw_affiliation_strings":["Department of Medicine, University of Illinois, Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Illinois, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064016623","display_name":"Giuseppina Nucifora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Giuseppina Nucifora","raw_affiliation_strings":["Department of Medicine, University of Illinois, Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Illinois, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064016623"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.0513,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.78100529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"282","issue":"18","first_page":"13542","last_page":"13551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8252000212669373,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8252000212669373,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.06669999659061432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.06289999932050705,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/runx1","display_name":"RUNX1","score":1.0},{"id":"https://openalex.org/keywords/homodimerization","display_name":"homodimerization","score":0.847000002861023},{"id":"https://openalex.org/keywords/c-terminal-interaction","display_name":"C-terminal interaction","score":0.6890000104904175},{"id":"https://openalex.org/keywords/transcription-factor-activity","display_name":"transcription factor activity","score":0.6710000038146973},{"id":"https://openalex.org/keywords/hematopoietic-differentiation","display_name":"hematopoietic differentiation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.7289999723434448},{"id":"https://openalex.org/keywords/gene-fusion","display_name":"gene fusion","score":0.7559999823570251},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.9539999961853027},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/chromatin-regulation","display_name":"chromatin regulation","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2778193527","wikidata":"https://www.wikidata.org/wiki/Q15320451","display_name":"RUNX1","level":4,"score":0.9485162496566772},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6027089357376099},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5744101405143738},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.5057246685028076},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4894043505191803},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4819307327270508},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.4333263635635376},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4084659516811371},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36250758171081543},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3460771441459656},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34478291869163513},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3228743076324463},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3224661946296692}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m700074200","doi":"https://doi.org/10.1074/jbc.m700074200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m700074200","pdf_url":"http://www.jbc.org/article/S002192581747431X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:17355962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17355962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.lincoln.ac.uk:12422","doi":null,"is_oa":false,"landing_page_url":"http://eprints.lincoln.ac.uk/id/eprint/12422/1/17355962","pdf_url":null,"source":{"id":"https://openalex.org/S4377196275","display_name":"Lincoln Repository (University of Lincoln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I51532219","host_organization_name":"University of Lincoln","host_organization_lineage":["https://openalex.org/I51532219"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/24333853","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/RUNX1-RUNX1_homodimerization_modulates_RUNX1_activity_and_function/24333853","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m700074200","doi":"https://doi.org/10.1074/jbc.m700074200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m700074200","pdf_url":"http://www.jbc.org/article/S002192581747431X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G142245217","display_name":null,"funder_award_id":"HL79580","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G151787196","display_name":"A Mouse Model of Myelodysplastic Syndrome Progression","funder_award_id":"R01HL079580","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2176983760","display_name":"Role of EVI1 Modifications in Cell Transformation","funder_award_id":"R01CA096448","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2577938698","display_name":null,"funder_award_id":"CA96448","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3516823720","display_name":"Inactivating EVI1 for the Treatment of Myelodysplastic *","funder_award_id":"R01HL082935","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4577385331","display_name":null,"funder_award_id":"R01   HL 72691","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4917175344","display_name":null,"funder_award_id":"HL 082935","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G631482048","display_name":"TEL, AML1, and TEL/AML1 in Hematopoiesis","funder_award_id":"R01HL072691","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016417841.pdf","grobid_xml":"https://content.openalex.org/works/W2016417841.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W32506313","https://openalex.org/W123071911","https://openalex.org/W155663183","https://openalex.org/W221180449","https://openalex.org/W273146513","https://openalex.org/W1480442988","https://openalex.org/W1487144489","https://openalex.org/W1524671781","https://openalex.org/W1526184968","https://openalex.org/W1541919983","https://openalex.org/W1739103212","https://openalex.org/W1829757075","https://openalex.org/W1875148047","https://openalex.org/W1946913806","https://openalex.org/W1969474327","https://openalex.org/W1970746316","https://openalex.org/W1972130478","https://openalex.org/W1974042841","https://openalex.org/W1979895333","https://openalex.org/W1982721874","https://openalex.org/W1991665242","https://openalex.org/W1991766825","https://openalex.org/W2025545218","https://openalex.org/W2040840283","https://openalex.org/W2045712095","https://openalex.org/W2046753134","https://openalex.org/W2056560239","https://openalex.org/W2057317196","https://openalex.org/W2068160448","https://openalex.org/W2070345664","https://openalex.org/W2074333479","https://openalex.org/W2080373144","https://openalex.org/W2081057019","https://openalex.org/W2084051071","https://openalex.org/W2085033687","https://openalex.org/W2086083531","https://openalex.org/W2088690410","https://openalex.org/W2088736283","https://openalex.org/W2093149606","https://openalex.org/W2095510686","https://openalex.org/W2102088029","https://openalex.org/W2107900913","https://openalex.org/W2108073709","https://openalex.org/W2110890687","https://openalex.org/W2110953702","https://openalex.org/W2124597426","https://openalex.org/W2131080367","https://openalex.org/W2132749685","https://openalex.org/W2137276155","https://openalex.org/W2138483214","https://openalex.org/W2148033929","https://openalex.org/W2149787089","https://openalex.org/W2161743101","https://openalex.org/W2165787335","https://openalex.org/W2170425393","https://openalex.org/W2185541313","https://openalex.org/W2294291334","https://openalex.org/W2333486152"],"related_works":["https://openalex.org/W2591613481","https://openalex.org/W1989182431","https://openalex.org/W1975607610","https://openalex.org/W4417002187","https://openalex.org/W2109673299","https://openalex.org/W1989269504","https://openalex.org/W1987724535","https://openalex.org/W2068180510","https://openalex.org/W2153450791","https://openalex.org/W7005341559"],"abstract_inverted_index":{"RUNX1":[0,22,44,87,128,132,139,176],"(AML1,":[1],"CBFalpha2,":[2],"PEBP2alphaB)":[3],"is":[4,18,45,72,158,164],"a":[5,25,90],"transcription":[6],"factor":[7],"essential":[8],"for":[9],"the":[10,13,64,68,101,104,155,173],"establishment":[11],"of":[12,67,103,118,124,175],"hematopoietic":[14,29,79,116,119],"stem":[15],"cell.":[16],"It":[17],"generally":[19],"thought":[20],"that":[21,27,86,138,153],"exists":[23],"as":[24,169],"monomer":[26],"regulates":[28,100],"differentiation":[30,117,179],"by":[31,51,127,160,166],"interacting":[32],"with":[33],"tissue-specific":[34],"factors":[35,151],"and":[36,70,81,110,144,150,152],"its":[37,41,112],"DNA":[38],"consensus":[39],"through":[40,89],"N":[42,65],"terminus.":[43],"frequently":[46],"altered":[47,165],"in":[48,106,171],"human":[49],"leukemia":[50],"gene":[52,108,161],"fusions":[53,162],"or":[54,163],"point":[55,167],"mutations.":[56],"In":[57],"general,":[58],"these":[59],"alterations":[60],"do":[61],"not":[62],"affect":[63],"terminus":[66,95],"protein,":[69],"it":[71],"unclear":[73],"how":[74],"they":[75],"consistently":[76],"lead":[77],"to":[78,114,142,177],"transformation":[80],"leukemia.":[82],"Here":[83],"we":[84],"report":[85],"homodimerizes":[88],"mechanism":[91],"involving":[92],"C":[93],"terminus-C":[94],"interaction.":[96],"This":[97,135],"RUNX1-RUNX1":[98],"interaction":[99],"activity":[102],"protein":[105],"reporter":[107],"assays":[109],"modulates":[111],"ability":[113,174],"induce":[115],"cell":[120],"lines.":[121],"The":[122],"promoters":[123],"genes":[125],"regulated":[126],"often":[129],"contain":[130],"multiple":[131],"binding":[133],"sites.":[134],"arrangement":[136],"suggests":[137],"could":[140,180],"homodimerize":[141],"bring":[143],"hold":[145],"together":[146],"distant":[147],"chromatin":[148],"sites":[149],"if":[154],"dimerization":[156],"region":[157],"removed":[159],"mutations,":[168],"observed":[170],"leukemia,":[172],"regulate":[178],"be":[181],"impaired.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}