{"id":"https://openalex.org/W2016407604","doi":"https://doi.org/10.1002/ardp.200500161","title":"Cyanoacetic Acid Hydrazones of 3\u2010(and 4\u2010)Acetylpyridine and Some Derived Ring Systems as Potential Antitumor and Anti\u2010HCV Agents","display_name":"Cyanoacetic Acid Hydrazones of 3\u2010(and 4\u2010)Acetylpyridine and Some Derived Ring Systems as Potential Antitumor and Anti\u2010HCV Agents","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2016407604","doi":"https://doi.org/10.1002/ardp.200500161","mag":"2016407604","pmid":"https://pubmed.ncbi.nlm.nih.gov/16411172"},"language":"en","primary_location":{"id":"doi:10.1002/ardp.200500161","doi":"https://doi.org/10.1002/ardp.200500161","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ardp.200500161","pdf_url":null,"source":{"id":"https://openalex.org/S174911965","display_name":"Archiv der Pharmazie","issn_l":"0365-6233","issn":["0365-6233","0376-0367","1521-4184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archiv der Pharmazie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064398506","display_name":"Soad A. El-Hawash","orcid":"https://orcid.org/0000-0002-2956-0787","observed_orcids":["https://orcid.org/0000-0002-2956-0787"]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Soad A. M. EL\u2010Hawash","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt. SoadHawash@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt. SoadHawash@yahoo.com","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101071118","display_name":"Abeer E. Abdel Wahab","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abeer E. Abdel Wahab","raw_affiliation_strings":["Genetic Engineering and Biotechnology Research Institute(GEBRI), Mubarak City for Scientific Research and Technology Application, Borg El-Arab, Alexandria, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Engineering and Biotechnology Research Institute(GEBRI), Mubarak City for Scientific Research and Technology Application, Borg El-Arab, Alexandria, Egypt","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012172467","display_name":"Maha El Demellawy","orcid":"https://orcid.org/0000-0002-3535-1607","observed_orcids":["https://orcid.org/0000-0002-3535-1607"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maha A. El\u2010Demellawy","raw_affiliation_strings":["Genetic Engineering and Biotechnology Research Institute(GEBRI), Mubarak City for Scientific Research and Technology Application, Borg El-Arab, Alexandria, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Engineering and Biotechnology Research Institute(GEBRI), Mubarak City for Scientific Research and Technology Application, Borg El-Arab, Alexandria, Egypt","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064398506"],"corresponding_institution_ids":["https://openalex.org/I84524832"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":1.1178,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.73180885,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"339","issue":"1","first_page":"14","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dihydrothiazoles","display_name":"dihydrothiazoles","score":0.9660000205039978},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7509999871253967},{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":0.7639999985694885},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.8529999852180481},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.7850000262260437},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C2778062582","wikidata":"https://www.wikidata.org/wiki/Q1146963","display_name":"Cyanoacetic acid","level":2,"score":0.726078450679779},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7220470309257507},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5862980484962463},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5074908137321472},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.48605257272720337},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24283775687217712},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11882182955741882},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011083","descriptor_name":"Polycyclic Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011083","descriptor_name":"Polycyclic Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ardp.200500161","doi":"https://doi.org/10.1002/ardp.200500161","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ardp.200500161","pdf_url":null,"source":{"id":"https://openalex.org/S174911965","display_name":"Archiv der Pharmazie","issn_l":"0365-6233","issn":["0365-6233","0376-0367","1521-4184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archiv der Pharmazie","raw_type":"journal-article"},{"id":"pmid:16411172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16411172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archiv der Pharmazie","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W128094615","https://openalex.org/W954280178","https://openalex.org/W1535189264","https://openalex.org/W1540828223","https://openalex.org/W1894026278","https://openalex.org/W1904924870","https://openalex.org/W1967474030","https://openalex.org/W1975404394","https://openalex.org/W2007006038","https://openalex.org/W2010721624","https://openalex.org/W2012758910","https://openalex.org/W2016954185","https://openalex.org/W2023350867","https://openalex.org/W2044976783","https://openalex.org/W2059430451","https://openalex.org/W2061191594","https://openalex.org/W2064163763","https://openalex.org/W2068431603","https://openalex.org/W2071313281","https://openalex.org/W2072313859","https://openalex.org/W2077776437","https://openalex.org/W2087867836","https://openalex.org/W2091640377","https://openalex.org/W2093899515","https://openalex.org/W2115286600","https://openalex.org/W2118909720","https://openalex.org/W2146126160","https://openalex.org/W2155208683","https://openalex.org/W2156353135","https://openalex.org/W2159248510","https://openalex.org/W2164195423","https://openalex.org/W2164693472","https://openalex.org/W2174352312","https://openalex.org/W2337879013","https://openalex.org/W2404149874","https://openalex.org/W2411913712","https://openalex.org/W2950050124","https://openalex.org/W2953100787"],"related_works":["https://openalex.org/W2949889060","https://openalex.org/W4406618110","https://openalex.org/W2018546419","https://openalex.org/W2133897093","https://openalex.org/W2114394163","https://openalex.org/W2139332418","https://openalex.org/W2064223447","https://openalex.org/W2805397264","https://openalex.org/W2270198807","https://openalex.org/W7098599500"],"abstract_inverted_index":{"Two":[0],"new":[1],"acetylpyridinehydrazones":[2],"derived":[3,21],"from":[4],"cyanoacetic":[5,12],"acid":[6,13],"hydrazide":[7],"have":[8],"been":[9],"synthesized":[10],"namely:":[11],"(1-pyridin-3":[14],"or":[15,25],"4-yl-ethylidene)":[16],"hydrazides":[17],"(1a,b).":[18],"and":[19,28,39,43,154],"some":[20],"ring":[22],"systems:":[23],"2-imino":[24],"2-oxo-2H-chromenes":[26],"(2a,b":[27],"3a,b),":[29],"substituted":[30,33,36,40],"2-thioxo-2,3-dihydrothiazoles":[31],"(4a-d),":[32],"2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-ones":[34],"(5a-d),":[35],"dihydrothiazoles":[37],"(7a,b),":[38],"2-oxo-1,2-dihydropyridines":[41],"(8a-d":[42],"9a,b).":[44],"Fifteen":[45],"compounds":[46,108,141],"were":[47,109,142],"evaluated":[48],"for":[49,111],"their":[50,112],"anticancer":[51],"activity":[52,162],"using":[53,132],"the":[54,60,116,130,133,146,150],"USA-NCI":[55],"in-vitro":[56,113],"screening":[57],"program.":[58],"Among":[59],"tested":[61],"compounds,":[62],"8d":[63],"exhibited":[64,87],"a":[65,88],"high":[66],"value":[67,90],"of":[68,75,91,118,144,148],"percent":[69,92],"tumor":[70,93],"growth":[71,94],"inhibition":[72,95],"at":[73,96,156],"concentrations":[74],"10(-5)":[76],"to":[77],"10(-7)":[78],"M":[79],"in":[80,122],"all":[81],"cancer":[82],"cell":[83,126],"lines,":[84],"while":[85],"8b":[86],"significant":[89],"concentration":[97,159],"<10(-8":[98],")M":[99],"against":[100],"non-small":[101],"cells":[102],"lung":[103],"HOP-92.":[104],"In":[105],"addition,":[106],"nine":[107],"investigated":[110],"effect":[114],"on":[115],"replication":[117,147],"hepatitis-C":[119],"virus":[120,131],"(HCV)":[121],"HepG2":[123],"hepatocellular":[124],"carcinoma":[125],"line":[127],"infected":[128],"with":[129],"reverse":[134],"transcription":[135],"polymerase":[136],"chain":[137],"reaction":[138],"technique.":[139],"Six":[140],"capable":[143],"inhibiting":[145],"both":[149],"HCV":[151],"RNA":[152],"(+)-":[153],"(-)-strands":[155],"5-100":[157],"microg/mL":[158],"range.":[160],"The":[161],"order":[163],"was":[164],"7b":[165],">":[166,170,172,174],"1b":[167],"=":[168],"3a":[169],"4c":[171],"7a":[173],"5c.":[175]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
