{"id":"https://openalex.org/W2016407412","doi":"https://doi.org/10.1126/science.2646709","title":"Genetic Control of Differentiation of the Caenorhabditis elegans Touch Receptor Neurons","display_name":"Genetic Control of Differentiation of the Caenorhabditis elegans Touch Receptor Neurons","publication_year":1989,"publication_date":"1989-02-24","ids":{"openalex":"https://openalex.org/W2016407412","doi":"https://doi.org/10.1126/science.2646709","mag":"2016407412","pmid":"https://pubmed.ncbi.nlm.nih.gov/2646709"},"language":"en","primary_location":{"id":"doi:10.1126/science.2646709","doi":"https://doi.org/10.1126/science.2646709","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.2646709","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2016407412"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074638214","display_name":"Martin Chalfie","orcid":"https://orcid.org/0000-0002-9079-7046","observed_orcids":["https://orcid.org/0000-0002-9079-7046"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Chalfie","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, NY 10027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, NY 10027","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030835514","display_name":"Macy Au-Fliegner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Macy Au","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, NY 10027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, NY 10027","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":1.2461,"has_fulltext":false,"cited_by_count":341,"citation_normalized_percentile":{"value":0.78843627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"243","issue":"4894","first_page":"1027","last_page":"1033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.8593999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.8593999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.09120000153779984,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9049999713897705},{"id":"https://openalex.org/keywords/touch-receptor-neurons","display_name":"touch receptor neurons","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"cell fate determination","score":0.6899999976158142},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.8669999837875366},{"id":"https://openalex.org/keywords/mechanosensing","display_name":"mechanosensing","score":0.6869999766349792},{"id":"https://openalex.org/keywords/sensory-neuron-development","display_name":"sensory neuron development","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.8966562747955322},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7433714270591736},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6587916612625122},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.5811148285865784},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.5716365575790405},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5639582276344299},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.551969051361084},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.539802074432373},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4859994351863861},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.48013731837272644},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43982911109924316},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.41914495825767517}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002107","descriptor_name":"Caenorhabditis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002107","descriptor_name":"Caenorhabditis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002107","descriptor_name":"Caenorhabditis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008465","descriptor_name":"Mechanoreceptors","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D014110","descriptor_name":"Touch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.2646709","doi":"https://doi.org/10.1126/science.2646709","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.2646709","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:2646709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2646709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1277903771","display_name":null,"funder_award_id":"GM 30997","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1853090517","https://openalex.org/W1904905451","https://openalex.org/W1944127002","https://openalex.org/W1948927501","https://openalex.org/W1966433657","https://openalex.org/W1968343429","https://openalex.org/W1971170993","https://openalex.org/W1981773006","https://openalex.org/W1981839201","https://openalex.org/W1983904941","https://openalex.org/W1986006829","https://openalex.org/W1989952069","https://openalex.org/W1994010104","https://openalex.org/W1997000340","https://openalex.org/W2007755249","https://openalex.org/W2008290466","https://openalex.org/W2008657400","https://openalex.org/W2011389479","https://openalex.org/W2015100891","https://openalex.org/W2021181211","https://openalex.org/W2027249250","https://openalex.org/W2047791752","https://openalex.org/W2057104531","https://openalex.org/W2072570820","https://openalex.org/W2094764721","https://openalex.org/W2128940002","https://openalex.org/W2129835543","https://openalex.org/W2136497239","https://openalex.org/W2145857160","https://openalex.org/W2151285918","https://openalex.org/W2156033174","https://openalex.org/W2157957502","https://openalex.org/W2159128394","https://openalex.org/W2160938187","https://openalex.org/W2161328767","https://openalex.org/W2162614457","https://openalex.org/W2167889770","https://openalex.org/W2168656510","https://openalex.org/W2319879001","https://openalex.org/W2413644217"],"related_works":["https://openalex.org/W1499629129","https://openalex.org/W1978924087","https://openalex.org/W2057952525","https://openalex.org/W2167108743","https://openalex.org/W2008290466","https://openalex.org/W2148659320","https://openalex.org/W1765015712","https://openalex.org/W2056130705","https://openalex.org/W2007755249","https://openalex.org/W1882028762"],"abstract_inverted_index":{"The":[0,102,153],"genetic":[1],"control":[2],"of":[3,18,24,61,69,91,109,124,133,136,144,155],"neuronal":[4],"differentiation":[5,90],"has":[6,35],"been":[7,36],"studied":[8],"by":[9,43,96],"examining":[10],"mutations":[11],"that":[12,46,146],"affect":[13],"the":[14,19,25,53,62,67,72,77,89,92,131,137,156],"development":[15],"and":[16],"function":[17],"six":[20],"touch":[21,57,73,79,93,121,138,157,164],"receptor":[22],"neurons":[23],"nematode":[26],"Caenorhabditis":[27],"elegans.":[28],"By":[29],"screening":[30],"for":[31,56,66,130],"touch-insensitive":[32],"mutants,":[33],"it":[34],"possible":[37],"to":[38],"identify":[39],"18":[40],"genes":[41,63,105,116,127,158],"(represented":[42],"417":[44],"mutations)":[45],"are":[47,64,81,106,128,147,179],"required":[48],"at":[49],"various":[50],"stages":[51],"in":[52,71,114,150],"developmental":[54],"program":[55],"cell":[58,74,165],"differentiation.":[59],"Two":[60],"needed":[65,129],"generation":[68],"precursors":[70],"lineages;":[75],"without":[76],"precursors,":[78],"cells":[80],"not":[82],"made.":[83],"A":[84],"third":[85],"gene,":[86],"mec-3,":[87],"specifies":[88],"cells,":[94,139],"probably":[95],"acting":[97],"as":[98,141],"a":[99,142],"transcription":[100],"factor.":[101],"remaining":[103],"15":[104],"likely":[107],"targets":[108],"mec-3":[110],"action;":[111],"mutants":[112],"defective":[113],"these":[115,125,151],"have":[117],"nonfunctioning,":[118],"yet":[119],"differentiated,":[120],"cells.":[122,152],"Some":[123],"latter":[126],"formation":[132],"cell-specific":[134],"components":[135],"such":[140],"set":[143],"microtubules":[145],"only":[148],"found":[149],"study":[154],"should":[159],"help":[160],"us":[161],"understand":[162],"how":[163,169,176],"fate":[166],"is":[167,172],"determined,":[168],"microtubule":[170],"form":[171],"specified,":[173],"and,":[174],"perhaps,":[175],"mechanical":[177],"stimuli":[178],"transduced.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}