{"id":"https://openalex.org/W2016406333","doi":"https://doi.org/10.1248/bpb.31.212","title":"Human Cathelicidin CAP18/LL-37 Changes Mast Cell Function toward Innate Immunity","display_name":"Human Cathelicidin CAP18/LL-37 Changes Mast Cell Function toward Innate Immunity","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2016406333","doi":"https://doi.org/10.1248/bpb.31.212","mag":"2016406333","pmid":"https://pubmed.ncbi.nlm.nih.gov/18239275"},"language":"en","primary_location":{"id":"doi:10.1248/bpb.31.212","doi":"https://doi.org/10.1248/bpb.31.212","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.31.212","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/31/2/31_2_212/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/bpb/31/2/31_2_212/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032929578","display_name":"Mino Yoshioka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mino Yoshioka","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070302842","display_name":"Nobuyuki Fukuishi","orcid":"https://orcid.org/0000-0002-9315-6121","observed_orcids":["https://orcid.org/0000-0002-9315-6121"]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Fukuishi","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059099183","display_name":"Yuichi Kubo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichi Kubo","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053426876","display_name":"Hiroyuki Yamanobe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Yamanobe","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005493700","display_name":"Kanae Ohsaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kanae Ohsaki","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021740502","display_name":"Yoshiko Kawasoe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiko Kawasoe","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064506318","display_name":"Mana Murata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mana Murata","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002752844","display_name":"Aya Ishizumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aya Ishizumi","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007916982","display_name":"Yumiko Nishii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yumiko Nishii","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037951576","display_name":"Nobuaki Matsui","orcid":"https://orcid.org/0000-0002-4252-2072","observed_orcids":["https://orcid.org/0000-0002-4252-2072"]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuaki Matsui","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108391922","display_name":"Masaaki Akagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Akagi","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I89098413"],"apc_list":null,"apc_paid":null,"fwci":2.8116,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.90299017,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"31","issue":"2","first_page":"212","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.4968000054359436,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.4968000054359436,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.42260000109672546,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.039900001138448715,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ll-37","display_name":"LL-37","score":0.9309999942779541},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9919999837875366},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.7990000247955322},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9319999814033508},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":1.0},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9559999704360962},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.828000009059906},{"id":"https://openalex.org/keywords/gram-negative-infections","display_name":"gram-negative bacterial infection","score":0.7459999918937683},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.6570000052452087},{"id":"https://openalex.org/keywords/host-defense-against-bacterial-infection","display_name":"host defense against bacteria","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C2777379352","wikidata":"https://www.wikidata.org/wiki/Q24739493","display_name":"Cathelicidin","level":4,"score":0.8934364318847656},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.8118306398391724},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.7123420238494873},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.6182392239570618},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6095010042190552},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5882251858711243},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5629767775535583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5296223759651184},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49223199486732483},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.4767954349517822},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.47228580713272095},{"id":"https://openalex.org/C122862929","wikidata":"https://www.wikidata.org/wiki/Q18048437","display_name":"Interleukin 33","level":4,"score":0.4691818058490753},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4574413299560547},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.45247331261634827},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43783196806907654},{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.4165581464767456},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.27858635783195496},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.20567581057548523},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08217442035675049}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001619","descriptor_name":"beta-N-Acetylhexosaminidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054804","descriptor_name":"Cathelicidins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/bpb.31.212","doi":"https://doi.org/10.1248/bpb.31.212","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.31.212","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/31/2/31_2_212/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:18239275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18239275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/bpb.31.212","doi":"https://doi.org/10.1248/bpb.31.212","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.31.212","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/31/2/31_2_212/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016406333.pdf","grobid_xml":"https://content.openalex.org/works/W2016406333.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1491097392","https://openalex.org/W1514540900","https://openalex.org/W1519633296","https://openalex.org/W1521327967","https://openalex.org/W1522866020","https://openalex.org/W1578768687","https://openalex.org/W1586925433","https://openalex.org/W1656645373","https://openalex.org/W1791079802","https://openalex.org/W1860703355","https://openalex.org/W1897669056","https://openalex.org/W1969637288","https://openalex.org/W1977160855","https://openalex.org/W1978926805","https://openalex.org/W1979959836","https://openalex.org/W1980364406","https://openalex.org/W1995744610","https://openalex.org/W2008152503","https://openalex.org/W2019503048","https://openalex.org/W2021280158","https://openalex.org/W2039615146","https://openalex.org/W2040222540","https://openalex.org/W2051142131","https://openalex.org/W2053044114","https://openalex.org/W2064103590","https://openalex.org/W2079168625","https://openalex.org/W2081166085","https://openalex.org/W2091344501","https://openalex.org/W2111522106","https://openalex.org/W2112649783","https://openalex.org/W2114769066","https://openalex.org/W2127855108","https://openalex.org/W2131567916","https://openalex.org/W2132195151","https://openalex.org/W2136212808","https://openalex.org/W2140313585","https://openalex.org/W2149501430","https://openalex.org/W2161733562","https://openalex.org/W2169759699","https://openalex.org/W4229662491","https://openalex.org/W4229688459"],"related_works":["https://openalex.org/W2056957880","https://openalex.org/W2790646706","https://openalex.org/W2229777956","https://openalex.org/W2164128280","https://openalex.org/W2121143282","https://openalex.org/W2341563491","https://openalex.org/W4239447145","https://openalex.org/W2103998318","https://openalex.org/W2126250477","https://openalex.org/W2067778091"],"abstract_inverted_index":{"The":[0],"antimicrobial":[1],"peptide":[2],"LL-37":[3,19,71,99,111,159,179],"is":[4,52],"generated":[5],"from":[6,120],"skin":[7,31],"keratinocytes":[8],"during":[9],"infection":[10],"of":[11,70,75,80,103,115,138,148,185],"Gram-negative":[12],"bacteria":[13],"and":[14,77,85,106,109,118,128,169],"exerts":[15],"a":[16,58,182],"microbicidal":[17],"effect.":[18],"also":[20,133],"causes":[21],"functional":[22,87],"changes":[23,88],"in":[24,29,34,62,89],"mast":[25,83,121,166,172,201],"cells.":[26,122,202],"Mast":[27],"cells":[28,173],"the":[30,35,63,68,73,78,90,101,113,136,146,162,186],"are":[32],"involved":[33],"innate":[36,175],"immune":[37],"system":[38,93],"response":[39],"against":[40,94,189],"microbial":[41],"infections":[42],"via":[43],"Toll-like":[44],"receptors":[45],"(TLRs),":[46],"such":[47,199],"as":[48,194,200],"TLR4,":[49],"which":[50],"that":[51,98,110,158],"known":[53],"to":[54],"recognize":[55],"lipopolysaccharide":[56],"(LPS),":[57],"bacterial":[59,163,190],"component.":[60],"Thus,":[61],"present":[64],"study,":[65],"we":[66],"examined":[67],"effects":[69],"on":[72,82],"expression":[74],"TLRs":[76],"generation":[79,131],"cytokines":[81,141],"cells,":[84],"considered":[86],"host":[91,187],"defense":[92,188],"bacteria.":[95],"We":[96],"observed":[97],"increased":[100],"level":[102],"TLR4":[104,107,126],"mRNA":[105],"protein,":[108],"induced":[112],"release":[114],"IL-4,":[116],"IL-5":[117],"IL-1beta":[119],"Cross-interaction":[123],"between":[124],"LL-37-triggered":[125],"augmentation":[127,147],"LL-37-inducible":[129,139],"cytokine":[130,150],"was":[132,142,152],"examined.":[134],"Although":[135],"up-regulation":[137],"Th2":[140],"cancelled":[143],"by":[144,192],"LPS,":[145],"pro-inflammatory":[149],"production":[151],"still":[153],"observed.":[154],"These":[155],"findings":[156],"indicate":[157],"co-existing":[160],"with":[161],"component":[164],"switches":[165],"cell":[167],"function":[168],"directs":[170],"human":[171],"toward":[174],"immunity.":[176],"In":[177],"conclusion,":[178],"may":[180],"be":[181],"candidate":[183],"modifier":[184],"entry":[191],"serving":[193],"an":[195],"alarm":[196],"for":[197],"sentinels":[198]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}