{"id":"https://openalex.org/W2016401253","doi":"https://doi.org/10.1016/j.jmb.2005.07.075","title":"Structural Basis of the Drug-binding Specificity of Human Serum Albumin","display_name":"Structural Basis of the Drug-binding Specificity of Human Serum Albumin","publication_year":2005,"publication_date":"2005-08-27","ids":{"openalex":"https://openalex.org/W2016401253","doi":"https://doi.org/10.1016/j.jmb.2005.07.075","mag":"2016401253","pmid":"https://pubmed.ncbi.nlm.nih.gov/16169013"},"language":"en","primary_location":{"id":"doi:10.1016/j.jmb.2005.07.075","doi":"https://doi.org/10.1016/j.jmb.2005.07.075","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jmb.2005.07.075","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043875949","display_name":"Jamie Ghuman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jamie Ghuman","raw_affiliation_strings":["Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074544006","display_name":"Patricia A. Zunszain","orcid":"https://orcid.org/0000-0001-8853-5680","observed_orcids":["https://orcid.org/0000-0001-8853-5680"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patricia A. Zunszain","raw_affiliation_strings":["Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030437058","display_name":"I. Petitpas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Isabelle Petitpas","raw_affiliation_strings":["Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083463607","display_name":"Ananyo A. Bhattacharya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ananyo A. Bhattacharya","raw_affiliation_strings":["Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026222199","display_name":"Masaki Otagiri","orcid":"https://orcid.org/0000-0001-6244-3825","observed_orcids":["https://orcid.org/0000-0001-6244-3825"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Otagiri","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030440789","display_name":"Stephen Curry","orcid":"https://orcid.org/0000-0002-0552-8870","observed_orcids":["https://orcid.org/0000-0002-0552-8870"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Stephen Curry","raw_affiliation_strings":["Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030440789"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":11.7697,"has_fulltext":false,"cited_by_count":1973,"citation_normalized_percentile":{"value":0.99418908,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"353","issue":"1","first_page":"38","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":1.0},{"id":"https://openalex.org/keywords/drug-binding","display_name":"drug binding","score":0.7580000162124634},{"id":"https://openalex.org/keywords/binding-specificity","display_name":"binding specificity","score":0.7720000147819519},{"id":"https://openalex.org/keywords/protein-ligand-complex","display_name":"protein-ligand complex","score":0.7390000224113464},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.546999990940094},{"id":"https://openalex.org/keywords/drug-binding-sites","display_name":"drug binding sites","score":0.6579999923706055},{"id":"https://openalex.org/keywords/fatty-acid-binding","display_name":"fatty acid binding","score":0.7350000143051147},{"id":"https://openalex.org/keywords/binding-site-flexibility","display_name":"binding site flexibility","score":0.5479999780654907},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.41100001335144043},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2778597219","wikidata":"https://www.wikidata.org/wiki/Q11721976","display_name":"Human serum albumin","level":2,"score":0.7891702055931091},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6825404167175293},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.6548750996589661},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6169301867485046},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.6051456928253174},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4907756745815277},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4811864495277405},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.4720255434513092},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.46358439326286316},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34133437275886536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2653372883796692},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19888657331466675}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019814","descriptor_name":"Myristic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jmb.2005.07.075","doi":"https://doi.org/10.1016/j.jmb.2005.07.075","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jmb.2005.07.075","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:16169013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16169013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:epubs.cclrc.ac.uk:work/58343","doi":null,"is_oa":false,"landing_page_url":"http://purl.org/net/epubs/work/58343","pdf_url":null,"source":{"id":"https://openalex.org/S4306400334","display_name":"Science and Technology Facilities Council","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I162524378","host_organization_name":"Science and Technology Facilities Council","host_organization_lineage":["https://openalex.org/I162524378"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320334759","display_name":"Deutsches Elektronen-Synchrotron","ror":"https://ror.org/01js2sh04"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W38677942","https://openalex.org/W255996521","https://openalex.org/W275442183","https://openalex.org/W1481913971","https://openalex.org/W1504651650","https://openalex.org/W1517566065","https://openalex.org/W1545078134","https://openalex.org/W1566111314","https://openalex.org/W1926647429","https://openalex.org/W1963820948","https://openalex.org/W1964900539","https://openalex.org/W1965540847","https://openalex.org/W1973238993","https://openalex.org/W1977637254","https://openalex.org/W1980078657","https://openalex.org/W1988240997","https://openalex.org/W1995017064","https://openalex.org/W1996495207","https://openalex.org/W1997295916","https://openalex.org/W2001114523","https://openalex.org/W2001641653","https://openalex.org/W2002731325","https://openalex.org/W2010233441","https://openalex.org/W2011472036","https://openalex.org/W2013083986","https://openalex.org/W2014477053","https://openalex.org/W2023242541","https://openalex.org/W2026447666","https://openalex.org/W2032246301","https://openalex.org/W2035515130","https://openalex.org/W2040430892","https://openalex.org/W2041780922","https://openalex.org/W2047867647","https://openalex.org/W2049684731","https://openalex.org/W2065954013","https://openalex.org/W2066170860","https://openalex.org/W2072734611","https://openalex.org/W2075440166","https://openalex.org/W2086575000","https://openalex.org/W2088519487","https://openalex.org/W2090289796","https://openalex.org/W2093021792","https://openalex.org/W2101919995","https://openalex.org/W2105898915","https://openalex.org/W2125121216","https://openalex.org/W2126588926","https://openalex.org/W2153337821","https://openalex.org/W2165419593","https://openalex.org/W2168229944","https://openalex.org/W2186752877","https://openalex.org/W2235700303","https://openalex.org/W2324955203","https://openalex.org/W2403641661","https://openalex.org/W2411583389","https://openalex.org/W2414678497","https://openalex.org/W2523003005"],"related_works":["https://openalex.org/W2922833592","https://openalex.org/W2037419278","https://openalex.org/W2073904707","https://openalex.org/W2047147332","https://openalex.org/W4252787323","https://openalex.org/W1987269510","https://openalex.org/W2007589629","https://openalex.org/W2020150601","https://openalex.org/W7099293164","https://openalex.org/W2055485868"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":98},{"year":2025,"cited_by_count":95},{"year":2024,"cited_by_count":122},{"year":2023,"cited_by_count":134},{"year":2022,"cited_by_count":124},{"year":2021,"cited_by_count":113},{"year":2020,"cited_by_count":106},{"year":2019,"cited_by_count":117},{"year":2018,"cited_by_count":113},{"year":2017,"cited_by_count":133},{"year":2016,"cited_by_count":133},{"year":2015,"cited_by_count":110},{"year":2014,"cited_by_count":100},{"year":2013,"cited_by_count":101},{"year":2012,"cited_by_count":74}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
