{"id":"https://openalex.org/W2016400567","doi":"https://doi.org/10.1002/1097-0142(19930815)72:4<1386::aid-cncr2820720439>3.0.co;2-j","title":"Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction\u2014primer-introduced restriction analysis","display_name":"Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction\u2014primer-introduced restriction analysis","publication_year":1993,"publication_date":"1993-08-15","ids":{"openalex":"https://openalex.org/W2016400567","doi":"https://doi.org/10.1002/1097-0142(19930815)72:4<1386::aid-cncr2820720439>3.0.co;2-j","mag":"2016400567","pmid":"https://pubmed.ncbi.nlm.nih.gov/8339229"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19930815)72:4<1386::aid-cncr2820720439>3.0.co;2-j","doi":"https://doi.org/10.1002/1097-0142(19930815)72:4<1386::aid-cncr2820720439>3.0.co;2-j","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(19930815)72:4<1386::aid-cncr2820720439>3.0.co;2-j","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010170069","display_name":"Katsuhiko Yoshimoto","orcid":"https://orcid.org/0000-0002-3209-3112","observed_orcids":["https://orcid.org/0000-0002-3209-3112"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuhiko Yoshimoto","raw_affiliation_strings":["Otsuka Department of Clinical and Molecular Nutrition, School of Medicine, University of Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otsuka Department of Clinical and Molecular Nutrition, School of Medicine, University of Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017107236","display_name":"Hiroyuki Iwahana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroyuki Iwahana","raw_affiliation_strings":["Otsuka Department of Clinical and Molecular Nutrition, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otsuka Department of Clinical and Molecular Nutrition, Tokushima, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111039224","display_name":"Ayumi Fukuda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ayumi Fukuda","raw_affiliation_strings":["Otsuka Department of Clinical and Molecular Nutrition, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otsuka Department of Clinical and Molecular Nutrition, Tokushima, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105987055","display_name":"Toshiaki Sano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Sano","raw_affiliation_strings":["First Department of Pathology, School of Medicine, The University of Tokushima, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pathology, School of Medicine, The University of Tokushima, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045658450","display_name":"Mitsuo Itakura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mitsuo Itakura","raw_affiliation_strings":["Otsuka Department of Clinical and Molecular Nutrition, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otsuka Department of Clinical and Molecular Nutrition, Tokushima, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045658450"],"corresponding_institution_ids":[],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":4.8973,"has_fulltext":false,"cited_by_count":140,"citation_normalized_percentile":{"value":0.95853342,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"72","issue":"4","first_page":"1386","last_page":"1393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.47290000319480896,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.47290000319480896,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.3959999978542328,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gsp-oncogene","display_name":"gsp oncogene","score":0.7129999995231628},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.7670000195503235},{"id":"https://openalex.org/keywords/endocrine-tumors","display_name":"endocrine tumors","score":0.9070000052452087},{"id":"https://openalex.org/keywords/growth-hormone-secreting-pituitary-adenoma","display_name":"growth hormone-secreting pituitary adenoma","score":0.9240000247955322},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.8709999918937683},{"id":"https://openalex.org/keywords/parathyroid-neoplasms","display_name":"parathyroid tumors","score":0.6899999976158142},{"id":"https://openalex.org/keywords/pheochromocytoma","display_name":"pheochromocytoma","score":0.925000011920929},{"id":"https://openalex.org/keywords/pancreatic-neuroendocrine-tumors","display_name":"pancreatic neuroendocrine tumors","score":0.8040000200271606},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2780103800","wikidata":"https://www.wikidata.org/wiki/Q1553018","display_name":"Multiple endocrine neoplasia","level":3,"score":0.6094036102294922},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.5908553004264832},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.5128605365753174},{"id":"https://openalex.org/C2776512331","wikidata":"https://www.wikidata.org/wiki/Q604075","display_name":"Multiple endocrine neoplasia type 2","level":5,"score":0.48943057656288147},{"id":"https://openalex.org/C2781449511","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary tumors","level":2,"score":0.45269590616226196},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.4298710823059082},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.42194488644599915},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.42004796862602234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3881203532218933},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36414003372192383},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.34826600551605225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3433613181114197},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3296361565589905},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3247224688529968},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3055317997932434},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21143019199371338}],"mesh":[{"descriptor_ui":"D000172","descriptor_name":"Acromegaly","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010282","descriptor_name":"Parathyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(19930815)72:4<1386::aid-cncr2820720439>3.0.co;2-j","doi":"https://doi.org/10.1002/1097-0142(19930815)72:4<1386::aid-cncr2820720439>3.0.co;2-j","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(19930815)72:4<1386::aid-cncr2820720439>3.0.co;2-j","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:8339229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8339229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W619572183","https://openalex.org/W1967030529","https://openalex.org/W1974366727","https://openalex.org/W1990401009","https://openalex.org/W1990417842","https://openalex.org/W2004179893","https://openalex.org/W2024342549","https://openalex.org/W2035366130","https://openalex.org/W2039094079","https://openalex.org/W2042316019","https://openalex.org/W2050717506","https://openalex.org/W2051349203","https://openalex.org/W2063494631","https://openalex.org/W2079725434","https://openalex.org/W2083722656","https://openalex.org/W2119965520","https://openalex.org/W2135164183","https://openalex.org/W2246299742","https://openalex.org/W2337777109","https://openalex.org/W2341529017","https://openalex.org/W2434656139","https://openalex.org/W2608200820"],"related_works":["https://openalex.org/W2333084640","https://openalex.org/W1967712914","https://openalex.org/W1988519756","https://openalex.org/W1990401009","https://openalex.org/W2052952739","https://openalex.org/W2028759058","https://openalex.org/W2079725434","https://openalex.org/W2024342549","https://openalex.org/W2001537234","https://openalex.org/W2408351360"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"Gs":[2,43,64,88,150,164],"alpha":[3,44,65,89,151,165],"(Gs":[4],"alpha)":[5],"gene":[6,45],"can":[7],"be":[8],"activated":[9],"to":[10],"the":[11,40,63,77,176,199],"putative":[12],"oncogene":[13],"gsp":[14],"by":[15,71],"specific":[16],"point":[17,55],"mutations":[18,25,56,90,152,166],"at":[19,57,167],"codons":[20,58],"201":[21,59],"or":[22,60,161],"227.":[23],"Such":[24],"have":[26],"been":[27],"reported":[28],"in":[29,46,93,155,175,198],"growth":[30],"hormone":[31],"(GH)-secreting":[32],"pituitary":[33,97,184],"adenomas":[34,98,139],"and":[35,111,134,189],"thyroid":[36,127,187],"tumors.":[37,206],"To":[38],"clarify":[39],"role":[41,174],"of":[42,62,76,83,95,100,105,125,130,136,141,148,178,182,201,204],"human":[47],"endocrine":[48,120,158,205],"tumors,":[49,157,160],"197":[50],"tumors":[51,128],"were":[52,69,91,153],"screened":[53],"for":[54],"227":[61],"gene.":[66],"METHODS:":[67],"Mutations":[68],"detected":[70,154],"primer-introduced":[72],"restriction":[73],"analysis":[74],"(PIRA)":[75],"polymerase":[78],"chain":[79],"reaction":[80],"(PCR)":[81],"product":[82],"genomic":[84],"DNA.":[85],"RESULTS:":[86],"These":[87],"present":[92],"4":[94,107,124],"53":[96],"(4":[99,129],"43":[101],"GH-secreting":[102,183],"adenomas;":[103],"1":[104,135],"these":[106,149,168],"was":[108],"a":[109,115,173,179],"GH-":[110],"prolactin-secreting":[112],"adenoma":[113],"from":[114],"patient":[116],"with":[117],"familial":[118],"multiple":[119],"neoplasia":[121],"Type":[122],"1),":[123],"66":[126],"30":[131],"papillary":[132,186],"carcinomas),":[133],"19":[137],"adrenocortical":[138,190],"(1":[140],"6":[142],"aldosterone-secreting":[143],"adenomas).":[144],"In":[145],"contrast,":[146],"none":[147],"parathyroid":[156],"pancreatic":[159],"pheochromocytomas.":[162],"CONCLUSIONS:":[163],"two":[169],"loci":[170],"may":[171],"play":[172],"pathogenesis":[177,200],"small":[180],"population":[181],"adenomas,":[185,191],"carcinomas,":[188],"but":[192],"that":[193],"they":[194],"are":[195],"not":[196],"involved":[197],"other":[202],"types":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}