{"id":"https://openalex.org/W2016395083","doi":"https://doi.org/10.3109/15563658209025736","title":"EMIT-st Drug Detection System for Screening of Barbiturates and Benzodiazepines in Serum","display_name":"EMIT-st Drug Detection System for Screening of Barbiturates and Benzodiazepines in Serum","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W2016395083","doi":"https://doi.org/10.3109/15563658209025736","mag":"2016395083","pmid":"https://pubmed.ncbi.nlm.nih.gov/6752436"},"language":"en","primary_location":{"id":"doi:10.3109/15563658209025736","doi":"https://doi.org/10.3109/15563658209025736","is_oa":false,"landing_page_url":"https://doi.org/10.3109/15563658209025736","pdf_url":null,"source":{"id":"https://openalex.org/S4210198581","display_name":"Journal of Toxicology Clinical Toxicology","issn_l":"0731-3810","issn":["0731-3810","1097-9875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315681","host_organization_name":"Marcel Dekker","host_organization_lineage":["https://openalex.org/P4310315681"],"host_organization_lineage_names":["Marcel Dekker"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology: Clinical Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068885742","display_name":"R. H. Drost","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R. H. Drost","raw_affiliation_strings":["Center for Human Toxicology State University of Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Toxicology State University of Utrecht, Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110021595","display_name":"Th. A. Plomp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"T. A. Plomp","raw_affiliation_strings":["Center for Human Toxicology State University of Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Toxicology State University of Utrecht, Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113608977","display_name":"R. A. A. Maes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R. A.A. Maes","raw_affiliation_strings":["Center for Human Toxicology State University of Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Toxicology State University of Utrecht, Netherlands","institution_ids":["https://openalex.org/I193662353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I193662353"],"apc_list":null,"apc_paid":null,"fwci":1.7343,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.81684142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"3","first_page":"303","last_page":"312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14199","display_name":"Historical and Scientific Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzyme-immunoassay","display_name":"enzyme immunoassay","score":0.7879999876022339},{"id":"https://openalex.org/keywords/barbiturates","display_name":"barbiturates","score":0.9520000219345093},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":1.0},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.8320000171661377},{"id":"https://openalex.org/keywords/serum","display_name":"serum","score":0.6039999723434448},{"id":"https://openalex.org/keywords/secobarbital","display_name":"secobarbital","score":0.996999979019165},{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":1.0},{"id":"https://openalex.org/keywords/assay-precision","display_name":"assay precision","score":0.9070000052452087},{"id":"https://openalex.org/keywords/assay-specificity","display_name":"assay specificity","score":0.6909999847412109},{"id":"https://openalex.org/keywords/assay-sensitivity","display_name":"assay sensitivity","score":0.6949999928474426},{"id":"https://openalex.org/keywords/temperature-effects","display_name":"temperature effects","score":0.4690000116825104},{"id":"https://openalex.org/keywords/medical-toxicology","display_name":"clinical toxicology","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C2777327472","wikidata":"https://www.wikidata.org/wiki/Q414788","display_name":"Secobarbital","level":3,"score":0.8908648490905762},{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.7342966794967651},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.7250765562057495},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5206546187400818},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.5092781782150269},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4638497829437256},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4572553038597107},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.44807884097099304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42755427956581116},{"id":"https://openalex.org/C3020081911","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Serum concentration","level":2,"score":0.4201186001300812},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3714229464530945},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21117666363716125},{"id":"https://openalex.org/C2776755955","wikidata":"https://www.wikidata.org/wiki/Q409632","display_name":"Pentobarbital","level":2,"score":0.14489036798477173},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001463","descriptor_name":"Barbiturates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008403","descriptor_name":"Mass Screening","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008832","descriptor_name":"Microchemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/15563658209025736","doi":"https://doi.org/10.3109/15563658209025736","is_oa":false,"landing_page_url":"https://doi.org/10.3109/15563658209025736","pdf_url":null,"source":{"id":"https://openalex.org/S4210198581","display_name":"Journal of Toxicology Clinical Toxicology","issn_l":"0731-3810","issn":["0731-3810","1097-9875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315681","host_organization_name":"Marcel Dekker","host_organization_lineage":["https://openalex.org/P4310315681"],"host_organization_lineage_names":["Marcel Dekker"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology: Clinical Toxicology","raw_type":"journal-article"},{"id":"pmid:6752436","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6752436","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of toxicology. Clinical toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1861084504","https://openalex.org/W1866645300","https://openalex.org/W1996514181","https://openalex.org/W2121674083","https://openalex.org/W2142438007","https://openalex.org/W2152474399","https://openalex.org/W2222522355","https://openalex.org/W2403376862"],"related_works":["https://openalex.org/W2154294393","https://openalex.org/W1508513547","https://openalex.org/W2070667137","https://openalex.org/W1531414789","https://openalex.org/W2329608002","https://openalex.org/W1929182494","https://openalex.org/W2099980399","https://openalex.org/W7098475812","https://openalex.org/W2095790066","https://openalex.org/W2143155152"],"abstract_inverted_index":{"The":[0,16,105],"determination":[1],"of":[2,22,33,43,57,101,109,120,137,143,153,160,189,207,219],"barbiturates":[3,123,173,212],"and":[4,18,39,47,61,70,107,124,174,180],"benzodiazepines":[5,175],"in":[6,167],"serum":[7,35,40,118],"using":[8],"the":[9,19,34,55,76,84,110,144,161,172,178,186,190,195,205,208],"EMIT-st":[10,111,196],"drug":[11],"detection":[12,187],"system":[13],"is":[14,213],"reported.":[15],"within-day":[17],"day-to-day":[20],"precision":[21],"this":[23],"assay":[24,78,112],"was":[25,113,132,156,169],"investigated":[26,114],"by":[27,82,115],"replicate":[28],"analysis":[29,63],"(n":[30],"=":[31],"20)":[32],"negative":[36],"(no":[37],"drug)":[38],"positive":[41,130,148],"control":[42],"secobarbital":[44],"(8.0":[45],"micrograms/mL)":[46],"diazepam":[48],"(1.0":[49],"microgram/mL),":[50],"respectively.":[51],"In":[52,192],"all":[53],"cases":[54],"coefficients":[56],"variation":[58],"for":[59,64,140,158,171,211],"intra-":[60],"interday":[62],"both":[65],"drugs":[66],"were":[67],"between":[68],"9":[69],"15%.":[71],"No":[72],"temperature":[73,100],"influence":[74],"on":[75],"benzodiazepine":[77],"could":[79],"be":[80,223],"observed":[81],"running":[83],"tests":[85,197],"at":[86,98,134,150,183],"temperatures":[87],"ranging":[88],"from":[89],"20":[90],"to":[91,177,200],"25":[92],"degrees":[93,103],"C":[94],"as":[95,97],"well":[96],"a":[99,135,151,217],"23":[102],"C.":[104],"specificity":[106],"sensitivity":[108],"measuring":[116],"various":[117],"concentrations":[119,184],"14":[121,145],"different":[122,126],"15":[125,162],"benzodiazepines.":[127,163],"A":[128,147,164],"definitive":[129],"response":[131,168],"obtained":[133,157],"level":[136],"10":[138,159],"micrograms/mL":[139],"5":[141],"out":[142],"barbiturates.":[146],"result":[149],"concentration":[152],"1":[154],"microgram/mL":[155],"good":[165],"correlation":[166],"found":[170],"compared":[176],"HPLC":[179],"GC":[181],"procedures":[182],"above":[185],"limit":[188],"assay.":[191],"our":[193],"opinion":[194],"are":[198],"useful":[199],"clinical":[201],"toxicological":[202],"practice.":[203],"However,":[204],"applicability":[206],"screenings":[209],"test":[210],"limited":[214],"since":[215],"only":[216],"number":[218],"these":[220],"compounds":[221],"can":[222],"detected.":[224]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}