{"id":"https://openalex.org/W2016392617","doi":"https://doi.org/10.1097/olq.0b013e31817dfdb8","title":"A Summary of Preclinical Topical Microbicide Vaginal Safety and Chlamydial Efficacy Evaluations in a Pigtailed Macaque Model","display_name":"A Summary of Preclinical Topical Microbicide Vaginal Safety and Chlamydial Efficacy Evaluations in a Pigtailed Macaque Model","publication_year":2008,"publication_date":"2008-09-17","ids":{"openalex":"https://openalex.org/W2016392617","doi":"https://doi.org/10.1097/olq.0b013e31817dfdb8","mag":"2016392617","pmid":"https://pubmed.ncbi.nlm.nih.gov/18607310"},"language":"en","primary_location":{"id":"doi:10.1097/olq.0b013e31817dfdb8","doi":"https://doi.org/10.1097/olq.0b013e31817dfdb8","is_oa":false,"landing_page_url":"https://doi.org/10.1097/olq.0b013e31817dfdb8","pdf_url":null,"source":{"id":"https://openalex.org/S170339494","display_name":"Sexually Transmitted Diseases","issn_l":"0148-5717","issn":["0148-5717","1537-4521"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexually Transmitted Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113539039","display_name":"Dorothy L. Patton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dorothy L. Patton","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Box 356460, University of Washington, Seattle, WA 98195-6460, USA. dpatton@u.washington.edu","Dorothy L. Patton, PhD, Department of Obstetrics and Gynecology, Box 356460, University of Washington, Seattle, WA 98195-6460. E-mail: [email\u00a0protected]","the Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Box 356460, University of Washington, Seattle, WA 98195-6460, USA. dpatton@u.washington.edu","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Dorothy L. Patton, PhD, Department of Obstetrics and Gynecology, Box 356460, University of Washington, Seattle, WA 98195-6460. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"the Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035131067","display_name":"YVONNE T. COSGROVE SWEENEY","orcid":"https://orcid.org/0000-0002-3892-9814","observed_orcids":["https://orcid.org/0000-0002-3892-9814"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yvonne T. Cosgrove Sweeney","raw_affiliation_strings":["the Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113552908","display_name":"Kathleen J. Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen J. Paul","raw_affiliation_strings":["the Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113539039"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":2.147,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.86648409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"35","issue":"10","first_page":"889","last_page":"897"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.2190999984741211,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topical-microbicides","display_name":"topical microbicides","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chlamydia-trachomatis","display_name":"Chlamydia trachomatis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/nonhuman-primate-model","display_name":"nonhuman primate model","score":0.8679999709129333},{"id":"https://openalex.org/keywords/sti-prevention","display_name":"STD prevention","score":0.8019999861717224},{"id":"https://openalex.org/keywords/colposcopy","display_name":"colposcopy","score":0.6549999713897705},{"id":"https://openalex.org/keywords/vaginal-ph","display_name":"vaginal pH","score":0.9599999785423279},{"id":"https://openalex.org/keywords/vaginal-microbiota","display_name":"vaginal microbiota","score":0.8259999752044678},{"id":"https://openalex.org/keywords/product-reformulation","display_name":"product reformulation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/hiv-prevention","display_name":"HIV prevention","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9397708177566528},{"id":"https://openalex.org/C197746943","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Microbicide","level":3,"score":0.812391996383667},{"id":"https://openalex.org/C2778950215","wikidata":"https://www.wikidata.org/wiki/Q177601","display_name":"Macaque","level":2,"score":0.4797207713127136},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.43396836519241333},{"id":"https://openalex.org/C2777744392","wikidata":"https://www.wikidata.org/wiki/Q5880","display_name":"Vagina","level":2,"score":0.4186929762363434},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1211923360824585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000282","descriptor_name":"Administration, Intravaginal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000891","descriptor_name":"Anti-Infective Agents, Local","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000891","descriptor_name":"Anti-Infective Agents, Local","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000891","descriptor_name":"Anti-Infective Agents, Local","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000891","descriptor_name":"Anti-Infective Agents, Local","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002689","descriptor_name":"Chlamydia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002690","descriptor_name":"Chlamydia Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002690","descriptor_name":"Chlamydia Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008254","descriptor_name":"Macaca nemestrina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012749","descriptor_name":"Sexually Transmitted Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012749","descriptor_name":"Sexually Transmitted Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014621","descriptor_name":"Vagina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/olq.0b013e31817dfdb8","doi":"https://doi.org/10.1097/olq.0b013e31817dfdb8","is_oa":false,"landing_page_url":"https://doi.org/10.1097/olq.0b013e31817dfdb8","pdf_url":null,"source":{"id":"https://openalex.org/S170339494","display_name":"Sexually Transmitted Diseases","issn_l":"0148-5717","issn":["0148-5717","1537-4521"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexually Transmitted Diseases","raw_type":"journal-article"},{"id":"pmid:18607310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18607310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexually transmitted diseases","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G227530972","display_name":null,"funder_award_id":"RR00166","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G441119068","display_name":"STDS PREVENTION - PRIMATE UNIT","funder_award_id":"n01ai095388-001","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6952987319","display_name":"National Primate Research Center","funder_award_id":"P51RR000166","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G899292159","display_name":null,"funder_award_id":"N01-AI-95388","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000857099","display_name":"Washington National Primate Research Center","funder_award_id":"P51OD010425","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000905702","display_name":"WaNPRC Macaca nemestrina SPF Breeding Colony","funder_award_id":"U42OD011123","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W75541830","https://openalex.org/W1490061028","https://openalex.org/W1599418840","https://openalex.org/W1960028163","https://openalex.org/W1968697195","https://openalex.org/W1982594489","https://openalex.org/W1989151456","https://openalex.org/W2001213681","https://openalex.org/W2008147905","https://openalex.org/W2023813499","https://openalex.org/W2042779858","https://openalex.org/W2053944682","https://openalex.org/W2071868312","https://openalex.org/W2079118745","https://openalex.org/W2083475630","https://openalex.org/W2095576314","https://openalex.org/W2096077458","https://openalex.org/W2119782456","https://openalex.org/W2147922084","https://openalex.org/W2161357149","https://openalex.org/W2326332219","https://openalex.org/W2397714194"],"related_works":["https://openalex.org/W2015169312","https://openalex.org/W2040801028","https://openalex.org/W2079118745","https://openalex.org/W2019320607","https://openalex.org/W2724938182","https://openalex.org/W2125877263","https://openalex.org/W2391792619","https://openalex.org/W1971527450","https://openalex.org/W2095576314","https://openalex.org/W2081168640"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,218],"development":[2],"of":[3,15,53,65,75,114,162,231],"topical":[4,54,232],"microbicides":[5],"represents":[6],"a":[7,43,58,73,169,239],"new":[8],"and":[9,19,31,50,86,88,106,143,176,192,200,222],"exciting":[10],"field":[11],"in":[12,57,104,172,244],"the":[13,112,124,130,151,229,245],"prevention":[14],"sexually":[16],"transmitted":[17],"diseases,":[18],"it":[20],"is":[21,225],"especially":[22],"important":[23],"that":[24],"candidate":[25,164],"products":[26,119,137,180,196,209],"undergo":[27],"rigorous":[28],"preclinical":[29,47,220],"safety":[30,49,81,158,203,221],"efficacy":[32,51,92,141,223],"testing":[33],"before":[34],"advancing":[35],"to":[36,117,134,150,227],"clinical":[37],"trials.":[38],"METHODS:":[39],"We":[40,127],"have":[41],"developed":[42],"standardized":[44],"protocol":[45],"for":[46,79,91,148,160,242],"vaginal":[48,80,84,173],"assessment":[52],"microbicide":[55,233],"candidates":[56],"nonhuman":[59],"primate":[60],"model.":[61],"Over":[62],"7":[63],"years":[64],"funding":[66],"under":[67],"an":[68],"NIH":[69],"contract,":[70],"we":[71,100,155],"evaluated":[72],"total":[74],"28":[76,163],"test":[77],"compounds":[78,90],"(via":[82],"colposcopy,":[83],"pH,":[85,174],"microflora)":[87],"9":[89],"against":[93,213],"cervical":[94,214],"chlamydial":[95,215],"infection.":[96,216],"In":[97],"this":[98],"article,":[99],"describe":[101],"our":[102,108,115],"methods":[103],"detail":[105],"summarize":[107],"results,":[109],"particularly":[110],"noting":[111],"ability":[113],"model":[116,224],"distinguish":[118],"with":[120,183],"deleterious":[121],"effects":[122],"on":[123],"cervicovaginal":[125],"environment.":[126],"also":[128],"outline":[129],"specific":[131],"criteria":[132],"used":[133],"determine":[135],"which":[136,144,235],"should":[138,145],"move":[139],"into":[140],"trials":[142],"be":[146],"recommended":[147],"reformulation":[149],"manufacturer.":[152],"RESULTS:":[153],"Overall,":[154],"noted":[156],"acceptable":[157,202],"profiles":[159,204],"24":[161],"products.":[165],"Common":[166],"findings":[167,187],"included":[168],"transient":[170],"decrease":[171],"petechiae,":[175],"mild":[177],"erythema.":[178],"Four":[179],"were":[181,197],"associated":[182],"significant":[184,240],"adverse":[185],"colposcopic":[186],"including":[188],"blisters,":[189],"epithelial":[190],"abrasions,":[191],"friability;":[193],"all":[194],"4":[195],"successfully":[198],"reformulated":[199],"showed":[201,210],"at":[205],"lower":[206],"concentrations.":[207],"No":[208],"complete":[211],"protection":[212],"CONCLUSIONS:":[217],"macaque":[219],"critical":[226],"maintaining":[228],"pace":[230],"development,":[234],"could":[236],"ultimately":[237],"offer":[238],"opportunity":[241],"intervention":[243],"global":[246],"HIV/AIDS":[247],"epidemic.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
