{"id":"https://openalex.org/W2016381427","doi":"https://doi.org/10.1074/jbc.m413566200","title":"Crystal Structure of the Cysteine-rich Secretory Protein Stecrisp Reveals That the Cysteine-rich Domain Has a K+ Channel Inhibitor-like Fold","display_name":"Crystal Structure of the Cysteine-rich Secretory Protein Stecrisp Reveals That the Cysteine-rich Domain Has a K+ Channel Inhibitor-like Fold","publication_year":2005,"publication_date":"2005-03-25","ids":{"openalex":"https://openalex.org/W2016381427","doi":"https://doi.org/10.1074/jbc.m413566200","mag":"2016381427","pmid":"https://pubmed.ncbi.nlm.nih.gov/15596436"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m413566200","doi":"https://doi.org/10.1074/jbc.m413566200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m413566200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m413566200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027130874","display_name":"Min Guo","orcid":"https://orcid.org/0000-0003-4450-4270","observed_orcids":["https://orcid.org/0000-0003-4450-4270"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Guo","raw_affiliation_strings":["Key Laboratory of Structural Biology, Department of Molecular and Cell Biology, School of Life Sciences, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, China","University of Science and Technology of China, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structural Biology, Department of Molecular and Cell Biology, School of Life Sciences, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101405214","display_name":"Maikun Teng","orcid":"https://orcid.org/0000-0003-4621-826X","observed_orcids":["https://orcid.org/0000-0003-4621-826X"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Maikun Teng","raw_affiliation_strings":["Key Laboratory of Structural Biology, Chinese Academy of Sciences, Department of Molecular and Cell Biology, School of Life Sciences, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China","University of Science and Technology of China, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structural Biology, Chinese Academy of Sciences, Department of Molecular and Cell Biology, School of Life Sciences, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China","institution_ids":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"raw_affiliation_string":"University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044083934","display_name":"Liwen Niu","orcid":"https://orcid.org/0000-0003-1217-1782","observed_orcids":["https://orcid.org/0000-0003-1217-1782"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liwen Niu","raw_affiliation_strings":["Key Laboratory of Structural Biology, Chinese Academy of Sciences, Department of Molecular and Cell Biology, School of Life Sciences, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China","University of Science and Technology of China, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structural Biology, Chinese Academy of Sciences, Department of Molecular and Cell Biology, School of Life Sciences, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China","institution_ids":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"raw_affiliation_string":"University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100426155","display_name":"Qun Liu","orcid":"https://orcid.org/0000-0002-1179-290X","observed_orcids":["https://orcid.org/0000-0002-1179-290X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qun Liu","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080610184","display_name":"Qingqiu Huang","orcid":"https://orcid.org/0000-0002-3783-3001","observed_orcids":["https://orcid.org/0000-0002-3783-3001"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingqiu Huang","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024966093","display_name":"Quan Hao","orcid":"https://orcid.org/0000-0002-9642-0514","observed_orcids":["https://orcid.org/0000-0002-9642-0514"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quan Hao","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5044083934"],"corresponding_institution_ids":["https://openalex.org/I126520041","https://openalex.org/I19820366"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.8323,"has_fulltext":false,"cited_by_count":152,"citation_normalized_percentile":{"value":0.97702009,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"280","issue":"13","first_page":"12405","last_page":"12412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cysteine-rich-secretory-proteins","display_name":"cysteine-rich secretory proteins","score":0.9810000061988831},{"id":"https://openalex.org/keywords/trimeresurus-stejnegeri","display_name":"Trimeresurus stejnegeri","score":0.8500000238418579},{"id":"https://openalex.org/keywords/snake-venom","display_name":"snake venom","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cysteine-rich-domain","display_name":"cysteine-rich domain","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ion-channel-block","display_name":"ion channel blockade","score":0.7720000147819519},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.7630000114440918},{"id":"https://openalex.org/keywords/hinge","display_name":"hinge","score":0.4650000035762787},{"id":"https://openalex.org/keywords/substrate-binding-site","display_name":"substrate binding site","score":0.7250000238418579},{"id":"https://openalex.org/keywords/sperm-egg-fusion","display_name":"sperm-egg fusion","score":0.6809999942779541},{"id":"https://openalex.org/keywords/innate-host-defense","display_name":"innate host defense","score":0.7260000109672546},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.625}],"concepts":[{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.8434263467788696},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5034341216087341},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.4107087254524231},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3818672299385071},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3648858666419983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2661491632461548},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002845","descriptor_name":"Chromatography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003435","descriptor_name":"Crotalid Venoms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m413566200","doi":"https://doi.org/10.1074/jbc.m413566200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m413566200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:15596436","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15596436","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:hub.hku.hk:10722/91897","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/91897","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m413566200","doi":"https://doi.org/10.1074/jbc.m413566200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m413566200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W614374080","https://openalex.org/W1520730837","https://openalex.org/W1591680814","https://openalex.org/W1871924278","https://openalex.org/W1980714687","https://openalex.org/W1982479137","https://openalex.org/W1990282724","https://openalex.org/W1994647150","https://openalex.org/W1995017064","https://openalex.org/W1998238795","https://openalex.org/W2001641653","https://openalex.org/W2003788979","https://openalex.org/W2004995735","https://openalex.org/W2008479070","https://openalex.org/W2010825420","https://openalex.org/W2013083986","https://openalex.org/W2016666932","https://openalex.org/W2017957136","https://openalex.org/W2021628860","https://openalex.org/W2021639324","https://openalex.org/W2022058405","https://openalex.org/W2023569157","https://openalex.org/W2040586404","https://openalex.org/W2045678903","https://openalex.org/W2047919626","https://openalex.org/W2048959283","https://openalex.org/W2050352895","https://openalex.org/W2055716990","https://openalex.org/W2061761037","https://openalex.org/W2063047703","https://openalex.org/W2067308419","https://openalex.org/W2071471652","https://openalex.org/W2077847057","https://openalex.org/W2078019319","https://openalex.org/W2078200016","https://openalex.org/W2079040627","https://openalex.org/W2082517674","https://openalex.org/W2082964758","https://openalex.org/W2086514248","https://openalex.org/W2090282166","https://openalex.org/W2096778527","https://openalex.org/W2097807494","https://openalex.org/W2100320834","https://openalex.org/W2100767681","https://openalex.org/W2104024569","https://openalex.org/W2106315897","https://openalex.org/W2108819608","https://openalex.org/W2115595474","https://openalex.org/W2118006267","https://openalex.org/W2130284909","https://openalex.org/W2132897471","https://openalex.org/W2147329466","https://openalex.org/W2148205059","https://openalex.org/W2167689124","https://openalex.org/W2168401998","https://openalex.org/W2168467894","https://openalex.org/W2170532211","https://openalex.org/W2299271935"],"related_works":["https://openalex.org/W2030116431","https://openalex.org/W2039678871","https://openalex.org/W2041879464","https://openalex.org/W2090835600","https://openalex.org/W2049095919","https://openalex.org/W2040586404","https://openalex.org/W2166658567","https://openalex.org/W1968219289","https://openalex.org/W1980835782","https://openalex.org/W2903504014"],"abstract_inverted_index":{"Stecrisp":[0],"from":[1,169],"Trimeresurus":[2],"stejnegeri":[3],"snake":[4],"venom":[5],"belongs":[6],"to":[7,20,41,83],"a":[8,52,59,62,123,175,200,212,216],"family":[9],"of":[10,29,38,56,68,85,101,126,150,193,208,221,225],"cysteine-rich":[11,63],"secretory":[12],"proteins":[13,55],"(CRISP)":[14],"that":[15,46,84,122],"have":[16],"various":[17],"functions":[18],"related":[19],"sperm-egg":[21],"fusion,":[22],"innate":[23],"host":[24],"defense,":[25],"and":[26,61,70,76,128,136,158,184,218],"the":[27,35,79,105,111,155,163,170,189,204,222,226],"blockage":[28],"ion":[30,194],"channels.":[31],"Here":[32],"we":[33],"present":[34],"crystal":[36],"structure":[37,207],"stecrisp":[39,47,209],"refined":[40],"1.6-angstrom":[42],"resolution.":[43],"It":[44],"shows":[45],"contains":[48],"three":[49],"regions,":[50],"namely":[51],"PR-1":[53,80,112,165,171],"(pathogenesis-related":[54],"group1)":[57],"domain,":[58,172],"hinge,":[60],"domain":[64,81,113],"(CRD).":[65],"A":[66],"conformation":[67],"solvent-exposed":[69,201],"-conserved":[71],"residues":[72],"(His60,":[73],"Glu75,":[74],"Glu96,":[75],"His115)":[77],"in":[78,88,110,118,134,154,199,203],"similar":[82,176],"their":[86],"counterparts":[87],"homologous":[89,119],"structures":[90],"suggests":[91],"they":[92],"may":[93,131],"share":[94],"some":[95],"molecular":[96],"mechanism.":[97],"Three":[98],"flexible":[99],"loops":[100],"hypervariable":[102],"sequence":[103],"surrounding":[104],"possible":[106,190],"substrate":[107],"binding":[108],"site":[109],"show":[114],"an":[115],"evident":[116],"difference":[117],"structures,":[120],"implying":[121],"great":[124],"diversity":[125],"species-":[127],"substrate-specific":[129],"interactions":[130],"be":[132],"involved":[133],"recognition":[135],"catalysis.":[137],"The":[138,206],"hinge":[139],"is":[140,159],"fixed":[141],"by":[142,148],"two":[143,179],"crossed":[144],"disulfide":[145],"bonds":[146],"formed":[147],"four":[149],"ten":[151],"characteristic":[152],"cysteines":[153],"carboxyl-terminal":[156],"region":[157],"important":[160],"for":[161,188,215],"stabilizing":[162],"N-terminal":[164],"domain.":[166],"Spatially":[167],"separated":[168],"CRD":[173],"possesses":[174],"fold":[177],"with":[178],"K+":[180],"channel":[181,195],"inhibitors":[182],"(Bgk":[183],"Shk).":[185],"Several":[186],"candidates":[187],"functional":[191,219],"sites":[192],"blocking":[196],"are":[197],"located":[198],"loop":[202],"CRD.":[205],"will":[210],"provide":[211],"prototypic":[213],"architecture":[214],"structural":[217],"exploration":[220],"diverse":[223],"members":[224],"CRISP":[227],"family.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}