{"id":"https://openalex.org/W2016378599","doi":"https://doi.org/10.1111/j.1528-1157.2000.tb02945.x","title":"Therapeutic Safety Monitoring: What to Look for and When to Look for It","display_name":"Therapeutic Safety Monitoring: What to Look for and When to Look for It","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W2016378599","doi":"https://doi.org/10.1111/j.1528-1157.2000.tb02945.x","mag":"2016378599","pmid":"https://pubmed.ncbi.nlm.nih.gov/11092611"},"language":"en","primary_location":{"id":"doi:10.1111/j.1528-1157.2000.tb02945.x","doi":"https://doi.org/10.1111/j.1528-1157.2000.tb02945.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1528-1157.2000.tb02945.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1528-1157.2000.tb02945.x","source":{"id":"https://openalex.org/S203153751","display_name":"Epilepsia","issn_l":"0013-9580","issn":["0013-9580","1528-1157","1528-1167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsia","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1528-1157.2000.tb02945.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080677331","display_name":"Cynthia L. Harden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cynthia L. Harden","raw_affiliation_strings":["Comprehensive Epilepsy Center, Weill Cornell Campus of New York Presbyterian Hospital, New York, New York 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Epilepsy Center, Weill Cornell Campus of New York Presbyterian Hospital, New York, New York 10021, USA","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080677331"],"corresponding_institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"],"apc_list":{"value":4360,"currency":"USD","value_usd":4360},"apc_paid":null,"fwci":0.5228,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.48363636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"41","issue":"s8","first_page":"S37","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.6133000254631042,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.6133000254631042,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.3698999881744385,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pharmacovigilance","display_name":"pharmacovigilance","score":0.7919999957084656},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8999999761581421},{"id":"https://openalex.org/keywords/drug-hypersensitivity","display_name":"drug hypersensitivity","score":0.640999972820282},{"id":"https://openalex.org/keywords/stevens-johnson-syndrome","display_name":"Stevens-Johnson syndrome","score":0.9879999756813049},{"id":"https://openalex.org/keywords/toxic-epidermal-necrolysis","display_name":"toxic epidermal necrolysis","score":1.0},{"id":"https://openalex.org/keywords/idiosyncratic-adverse-drug-reactions","display_name":"idiosyncratic drug reactions","score":0.7889999747276306},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/aplastic-anemia","display_name":"aplastic anemia","score":0.8149999976158142},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/phenytoin","display_name":"phenytoin","score":0.8389999866485596},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9959999918937683},{"id":"https://openalex.org/keywords/felbamate","display_name":"felbamate","score":0.7929999828338623},{"id":"https://openalex.org/keywords/endocrine-adverse-effects","display_name":"endocrine adverse effects","score":0.6460000276565552},{"id":"https://openalex.org/keywords/thyroid-function","display_name":"thyroid function","score":0.6769999861717224},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.9980000257492065},{"id":"https://openalex.org/keywords/peripheral-nerve-conduction","display_name":"peripheral nerve conduction","score":0.847000002861023},{"id":"https://openalex.org/keywords/carbamazepine","display_name":"carbamazepine","score":0.9710000157356262}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8493151664733887},{"id":"https://openalex.org/C2779253243","wikidata":"https://www.wikidata.org/wiki/Q410412","display_name":"Carbamazepine","level":3,"score":0.8016970157623291},{"id":"https://openalex.org/C2778337148","wikidata":"https://www.wikidata.org/wiki/Q410400","display_name":"Phenytoin","level":3,"score":0.6958023309707642},{"id":"https://openalex.org/C2780664588","wikidata":"https://www.wikidata.org/wiki/Q1878682","display_name":"Toxic epidermal necrolysis","level":2,"score":0.6308572888374329},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.5914241671562195},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5207248330116272},{"id":"https://openalex.org/C2781011581","wikidata":"https://www.wikidata.org/wiki/Q421301","display_name":"Felbamate","level":4,"score":0.4983234405517578},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.4917629063129425},{"id":"https://openalex.org/C2778802184","wikidata":"https://www.wikidata.org/wiki/Q410346","display_name":"Lamotrigine","level":3,"score":0.4335397183895111},{"id":"https://openalex.org/C2993291352","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid function","level":3,"score":0.4143102467060089},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.36898618936538696},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.35609298944473267},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28517946600914},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.1349894404411316},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077206","descriptor_name":"Gabapentin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077213","descriptor_name":"Lamotrigine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077236","descriptor_name":"Topiramate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020888","descriptor_name":"Vigabatrin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020888","descriptor_name":"Vigabatrin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1528-1157.2000.tb02945.x","doi":"https://doi.org/10.1111/j.1528-1157.2000.tb02945.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1528-1157.2000.tb02945.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1528-1157.2000.tb02945.x","source":{"id":"https://openalex.org/S203153751","display_name":"Epilepsia","issn_l":"0013-9580","issn":["0013-9580","1528-1157","1528-1167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsia","raw_type":"journal-article"},{"id":"pmid:11092611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11092611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1528-1157.2000.tb02945.x","doi":"https://doi.org/10.1111/j.1528-1157.2000.tb02945.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1528-1157.2000.tb02945.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1528-1157.2000.tb02945.x","source":{"id":"https://openalex.org/S203153751","display_name":"Epilepsia","issn_l":"0013-9580","issn":["0013-9580","1528-1157","1528-1167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8600000143051147,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016378599.pdf","grobid_xml":"https://content.openalex.org/works/W2016378599.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W144999395","https://openalex.org/W219357105","https://openalex.org/W1499314947","https://openalex.org/W1526841369","https://openalex.org/W1850930954","https://openalex.org/W1965417826","https://openalex.org/W1970437622","https://openalex.org/W1971852835","https://openalex.org/W1972866555","https://openalex.org/W1974164830","https://openalex.org/W1974240362","https://openalex.org/W1975571625","https://openalex.org/W1977307548","https://openalex.org/W1980812622","https://openalex.org/W1981342606","https://openalex.org/W1985793907","https://openalex.org/W1988166239","https://openalex.org/W1988270676","https://openalex.org/W1989801730","https://openalex.org/W1991303488","https://openalex.org/W1992369074","https://openalex.org/W1992452728","https://openalex.org/W1996183096","https://openalex.org/W1998149903","https://openalex.org/W1998982477","https://openalex.org/W1999160102","https://openalex.org/W2003427665","https://openalex.org/W2004219430","https://openalex.org/W2004637762","https://openalex.org/W2006360693","https://openalex.org/W2012499060","https://openalex.org/W2017526230","https://openalex.org/W2019721337","https://openalex.org/W2019961375","https://openalex.org/W2020541526","https://openalex.org/W2023162470","https://openalex.org/W2026719249","https://openalex.org/W2027547026","https://openalex.org/W2030013578","https://openalex.org/W2038730671","https://openalex.org/W2039674635","https://openalex.org/W2043354111","https://openalex.org/W2045973735","https://openalex.org/W2047678706","https://openalex.org/W2050264182","https://openalex.org/W2052224830","https://openalex.org/W2057743042","https://openalex.org/W2060087267","https://openalex.org/W2062907092","https://openalex.org/W2066152119","https://openalex.org/W2067249871","https://openalex.org/W2067488182","https://openalex.org/W2067518187","https://openalex.org/W2067931578","https://openalex.org/W2073141598","https://openalex.org/W2073272416","https://openalex.org/W2074139384","https://openalex.org/W2076651937","https://openalex.org/W2078714147","https://openalex.org/W2082775261","https://openalex.org/W2082862941","https://openalex.org/W2084486276","https://openalex.org/W2093010178","https://openalex.org/W2093386232","https://openalex.org/W2094982830","https://openalex.org/W2098849296","https://openalex.org/W2100309335","https://openalex.org/W2101727684","https://openalex.org/W2104188485","https://openalex.org/W2106877628","https://openalex.org/W2107727842","https://openalex.org/W2114390763","https://openalex.org/W2117449343","https://openalex.org/W2124767926","https://openalex.org/W2128399472","https://openalex.org/W2129644042","https://openalex.org/W2132683781","https://openalex.org/W2136143199","https://openalex.org/W2137361770","https://openalex.org/W2148667829","https://openalex.org/W2150289308","https://openalex.org/W2162594619","https://openalex.org/W2170363676","https://openalex.org/W2261908315","https://openalex.org/W2320058521","https://openalex.org/W2322086287","https://openalex.org/W2332527204","https://openalex.org/W2400100835","https://openalex.org/W2464016664","https://openalex.org/W2466874533","https://openalex.org/W3190290111","https://openalex.org/W4243058034","https://openalex.org/W4244997956","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2279227546","https://openalex.org/W2001686065","https://openalex.org/W2171583595","https://openalex.org/W2035693899","https://openalex.org/W2063203490","https://openalex.org/W4230704871","https://openalex.org/W1957303870","https://openalex.org/W2984101457","https://openalex.org/W4366231668","https://openalex.org/W2280395870"],"abstract_inverted_index":{"This":[0],"review":[1],"focuses":[2],"on":[3,46,174],"the":[4,135,139,146,170],"safety":[5],"problems":[6],"associated":[7,100,108],"with":[8,73,101,109,127],"antiepileptic":[9],"drugs":[10],"(AEDs)":[11],"as":[12,118],"revealed":[13],"by":[14,89,153,179],"laboratory":[15],"testing":[16],"and":[17,29,31,34,42,60,93,95,103,122,166,169,181],"clinical":[18],"examination.":[19],"There":[20],"are":[21,40,91,131,183],"two":[22],"classes":[23],"of":[24,141],"side":[25,115],"effects:":[26],"(a)":[27],"common":[28,41,92],"mild":[30,104],"(b)":[32],"rare":[33,47],"severe.":[35],"Allergic":[36,78],"reactions":[37,66,130],"to":[38,52,67,75,134],"AEDs":[39,68,90,143],"usually":[43],"mild.":[44],"However,":[45],"occasions,":[48],"they":[49],"can":[50],"progress":[51],"more":[53],"severe":[54,154],"cutaneous":[55],"disorders,":[56],"including":[57,160],"Stevens-Johnson":[58],"syndrome":[59],"toxic":[61],"epidermal":[62],"necrolysis.":[63],"Severe":[64],"allergic":[65],"range":[69],"from":[70],"immune":[71],"responses":[72],"fever":[74],"multiorgan":[76],"dysfunction.":[77],"rashes":[79],"may":[80],"be":[81],"genetically":[82],"or":[83],"immunologically":[84],"determined.":[85],"Laboratory":[86],"abnormalities":[87],"produced":[88,178],"mild,":[94],"include":[96],"hepatic":[97],"enzyme":[98],"elevation":[99,105],"phenytoin":[102,180],"in":[106,145,162],"ammonia":[107],"valproate.":[110],"Serious,":[111],"although":[112],"rare,":[113],"idiosyncratic":[114,155],"effects,":[116],"such":[117],"aplastic":[119],"anemia,":[120],"hepatotoxicity,":[121],"thrombocytopenia,":[123],"have":[124,149],"also":[125,184],"occurred":[126],"AEDs.":[128,137],"These":[129],"largely":[132],"confined":[133],"\"classic\"":[136],"With":[138],"exception":[140],"felbamate,":[142],"approved":[144],"past":[147],"decade":[148],"not":[150],"been":[151],"plagued":[152],"reactions.":[156],"Subtle":[157],"endocrine":[158],"abnormalities,":[159],"variations":[161],"thyroid":[163],"function":[164],"tests":[165],"bone":[167],"metabolism,":[168],"often":[171],"subclinical":[172],"effects":[173],"peripheral":[175],"nerve":[176],"conduction":[177],"carbamazepine,":[182],"examined.":[185]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}