{"id":"https://openalex.org/W2016373666","doi":"https://doi.org/10.1073/pnas.0409642102","title":"Midgut epithelial responses of different mosquito\u2013 Plasmodium combinations: The actin cone zipper repair mechanism in Aedes aegypti","display_name":"Midgut epithelial responses of different mosquito\u2013 Plasmodium combinations: The actin cone zipper repair mechanism in Aedes aegypti","publication_year":2005,"publication_date":"2005-03-07","ids":{"openalex":"https://openalex.org/W2016373666","doi":"https://doi.org/10.1073/pnas.0409642102","mag":"2016373666","pmid":"https://pubmed.ncbi.nlm.nih.gov/15753303","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/554815"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0409642102","doi":"https://doi.org/10.1073/pnas.0409642102","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0409642102","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC554815","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081752921","display_name":"Lalita Gupta","orcid":"https://orcid.org/0000-0002-0712-8512","observed_orcids":["https://orcid.org/0000-0002-0712-8512"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]},{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Lalita Gupta","raw_affiliation_strings":["Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523; Mosquito Immunity and Vector Competence Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852; and Laboratory of Medical Entomology, Centro de Pesquisas Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz Av, Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-002, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523; Mosquito Immunity and Vector Competence Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852; and Laboratory of Medical Entomology, Centro de Pesquisas Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz Av, Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-002, Brazil","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405286130","https://openalex.org/I52325","https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024718203","display_name":"Sanjeev Kumar","orcid":"https://orcid.org/0000-0003-3866-4593","observed_orcids":["https://orcid.org/0000-0003-3866-4593"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]},{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Sanjeev Kumar","raw_affiliation_strings":["Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523; Mosquito Immunity and Vector Competence Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852; and Laboratory of Medical Entomology, Centro de Pesquisas Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz Av, Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-002, Brazil","Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523; Mosquito Immunity and Vector Competence Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852; and Laboratory of Medical Entomology, Centro de Pesquisas Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz Av, Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-002, Brazil","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405286130","https://openalex.org/I52325","https://openalex.org/I92446798"]},{"raw_affiliation_string":"Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523;","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050790088","display_name":"Yeon Soo Han","orcid":"https://orcid.org/0000-0002-3621-046X","observed_orcids":["https://orcid.org/0000-0002-3621-046X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]},{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Yeon Soo Han","raw_affiliation_strings":["Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523; Mosquito Immunity and Vector Competence Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852; and Laboratory of Medical Entomology, Centro de Pesquisas Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz Av, Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-002, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523; Mosquito Immunity and Vector Competence Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852; and Laboratory of Medical Entomology, Centro de Pesquisas Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz Av, Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-002, Brazil","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405286130","https://openalex.org/I52325","https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091361494","display_name":"Paulo Filemon Paolucci Pimenta","orcid":"https://orcid.org/0000-0002-0158-2482","observed_orcids":["https://orcid.org/0000-0002-0158-2482"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]},{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Paulo F. P. Pimenta","raw_affiliation_strings":["Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523; Mosquito Immunity and Vector Competence Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852; and Laboratory of Medical Entomology, Centro de Pesquisas Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz Av, Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-002, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523; Mosquito Immunity and Vector Competence Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852; and Laboratory of Medical Entomology, Centro de Pesquisas Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz Av, Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-002, Brazil","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405286130","https://openalex.org/I52325","https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033723381","display_name":"Carolina V. Barillas-Mury","orcid":"https://orcid.org/0000-0002-4039-6199","observed_orcids":["https://orcid.org/0000-0002-4039-6199"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]},{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Carolina Barillas-Mury","raw_affiliation_strings":["Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523; Mosquito Immunity and Vector Competence Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852; and Laboratory of Medical Entomology, Centro de Pesquisas Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz Av, Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-002, Brazil","Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523; Mosquito Immunity and Vector Competence Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852; and Laboratory of Medical Entomology, Centro de Pesquisas Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz Av, Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-002, Brazil","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405286130","https://openalex.org/I52325","https://openalex.org/I92446798"]},{"raw_affiliation_string":"Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523;","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.8489,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.97794849,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"102","issue":"11","first_page":"4010","last_page":"4015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium","display_name":"Plasmodium","score":0.6959999799728394},{"id":"https://openalex.org/keywords/aedes-aegypti","display_name":"Aedes aegypti","score":0.9229999780654907},{"id":"https://openalex.org/keywords/anopheles-stephensi","display_name":"Anopheles stephensi","score":1.0},{"id":"https://openalex.org/keywords/plasmodium-gallinaceum","display_name":"Plasmodium gallinaceum","score":0.9350000023841858},{"id":"https://openalex.org/keywords/plasmodium-berghei","display_name":"Plasmodium berghei","score":1.0},{"id":"https://openalex.org/keywords/epithelial-repair","display_name":"epithelial repair","score":0.7730000019073486},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.9660000205039978},{"id":"https://openalex.org/keywords/peroxidase","display_name":"peroxidase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/tyrosine-nitration","display_name":"tyrosine nitration","score":0.9070000052452087},{"id":"https://openalex.org/keywords/3-nitrotyrosine","display_name":"nitrotyrosine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mosquito-parasite-interactions","display_name":"mosquito-parasite interactions","score":0.6899999976158142},{"id":"https://openalex.org/keywords/malaria-vectors","display_name":"malaria vectors","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C150149183","wikidata":"https://www.wikidata.org/wiki/Q1940081","display_name":"Midgut","level":3,"score":0.896405816078186},{"id":"https://openalex.org/C2777775583","wikidata":"https://www.wikidata.org/wiki/Q1148004","display_name":"Aedes aegypti","level":3,"score":0.844878077507019},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.825366735458374},{"id":"https://openalex.org/C2780478335","wikidata":"https://www.wikidata.org/wiki/Q4115863","display_name":"Anopheles stephensi","level":4,"score":0.6431769728660583},{"id":"https://openalex.org/C2777237215","wikidata":"https://www.wikidata.org/wiki/Q65021","display_name":"Plasmodium berghei","level":3,"score":0.6224344372749329},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5524512529373169},{"id":"https://openalex.org/C2781375639","wikidata":"https://www.wikidata.org/wiki/Q158597","display_name":"Anopheles","level":3,"score":0.48623624444007874},{"id":"https://openalex.org/C2778675580","wikidata":"https://www.wikidata.org/wiki/Q614956","display_name":"Plasmodium (life cycle)","level":3,"score":0.4118238091468811},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.25011974573135376},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23391494154930115},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.10006856918334961},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000330","descriptor_name":"Aedes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000330","descriptor_name":"Aedes","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006790","descriptor_name":"Host-Parasite Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010961","descriptor_name":"Plasmodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1073/pnas.0409642102","doi":"https://doi.org/10.1073/pnas.0409642102","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0409642102","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:171352","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC554815","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:15753303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15753303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:554815","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC554815/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:arca.fiocruz.br:icict/6751","doi":null,"is_oa":false,"landing_page_url":"https://arca.fiocruz.br/handle/icict/6751","pdf_url":null,"source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:www.arca.fiocruz.br:icict/6751","doi":null,"is_oa":false,"landing_page_url":"https://www.arca.fiocruz.br/handle/icict/6751","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ","raw_type":"publishedVersion"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:171352","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC554815","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2812171122","display_name":"THE MOSQUITO IMMUNE RESPONSE AND MALARIA TRANSMISSION","funder_award_id":"R01AI045573","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309627","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1498806970","https://openalex.org/W1858519831","https://openalex.org/W1967381079","https://openalex.org/W1974992925","https://openalex.org/W1977008662","https://openalex.org/W1993312139","https://openalex.org/W1993446304","https://openalex.org/W2004465989","https://openalex.org/W2009911844","https://openalex.org/W2010023832","https://openalex.org/W2019211309","https://openalex.org/W2028773457","https://openalex.org/W2033856139","https://openalex.org/W2041693687","https://openalex.org/W2056926316","https://openalex.org/W2061543317","https://openalex.org/W2064233285","https://openalex.org/W2068567819","https://openalex.org/W2079223597","https://openalex.org/W2089550565","https://openalex.org/W2093765409","https://openalex.org/W2098429428","https://openalex.org/W2333945626"],"related_works":["https://openalex.org/W2019211309","https://openalex.org/W1977008662","https://openalex.org/W2033856139","https://openalex.org/W2142633440","https://openalex.org/W2008145323","https://openalex.org/W2098429428","https://openalex.org/W2079223597","https://openalex.org/W1985742078","https://openalex.org/W4289965611","https://openalex.org/W1498806970"],"abstract_inverted_index":{"In":[0,92],"vivo":[1],"responses":[2,181],"of":[3,10,70,111,119,141,149,182,191,203,206],"midgut":[4,48,96,131],"epithelial":[5,71,180],"cells":[6,77],"to":[7,57,194],"ookinete":[8],"invasion":[9],"three":[11],"different":[12,183],"vector-parasite":[13,172],"combinations,":[14],"Aedes":[15],"aegypti-Plasmodium":[16],"gallinaceum,":[17,24],"Anopheles":[18],"stephensi-Plasmodium":[19],"berghei,":[20],"and":[21,32,42,53,153,162],"A.":[22,40,43,73,93,142],"stephensi-P.":[23],"were":[25,165],"directly":[26],"compared":[27],"by":[28,78,85,100,144],"using":[29],"enzymatic":[30],"markers":[31],"immunofluorescence":[33],"stainings.":[34],"Our":[35],"studies":[36,176],"indicate":[37,177],"that,":[38],"in":[39,67,168],"aegypti":[41],"stephensi":[44,74,143],"ookinetes":[45],"traverse":[46],"the":[47,58,95,109,117,120,126,130,169,179,201],"via":[49],"an":[50,79],"intracellular":[51],"route":[52],"inflict":[54],"irreversible":[55],"damage":[56],"invaded":[59,84],"cells.":[60,139],"These":[61,160,175],"two":[62,171],"mosquito":[63],"species":[64],"differ,":[65],"however,":[66,164],"their":[68],"mechanisms":[69],"repair.":[72],"detaches":[75],"damaged":[76],"actin-mediated":[80],"budding-off":[81],"mechanism":[82,106],"when":[83],"either":[86],"P.":[87,90,145],"berghei":[88,146],"or":[89],"gallinaceum.":[91],"aegypti,":[94],"epithelium":[97],"is":[98],"repaired":[99],"a":[101,112],"unique":[102],"actin":[103,114],"cone":[104],"zipper":[105],"that":[107,122,178,199],"involves":[108],"formation":[110],"cone-shaped":[113],"aggregate":[115],"at":[116],"base":[118],"cell":[121],"closes":[123],"sequentially,":[124],"expelling":[125],"cellular":[127],"contents":[128],"into":[129],"lumen":[132],"as":[133],"it":[134],"brings":[135],"together":[136],"healthy":[137],"neighboring":[138],"Invasion":[140],"induced":[147,167],"expression":[148],"nitric":[150],"oxide":[151],"synthase":[152],"peroxidase":[154],"activities,":[155],"which":[156],"mediate":[157],"tyrosine":[158],"nitration.":[159],"enzymes":[161],"nitrotyrosine,":[163],"not":[166,187],"other":[170],"combinations":[173,185],"examined.":[174],"mosquito-parasite":[184],"are":[186,209],"universal.":[188],"The":[189],"implications":[190],"these":[192],"observations":[193],"validate":[195],"animal":[196],"experimental":[197],"systems":[198],"reflect":[200],"biology":[202],"natural":[204],"vectors":[205],"human":[207],"malarias":[208],"discussed.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}